424 research outputs found
De Broglie Wavelength of a Nonlocal Four-Photon
Superposition is one of the most distinct features of quantum theory and has
been demonstrated in numerous realizations of Young's classical double-slit
interference experiment and its analogues. However, quantum entanglement - a
significant coherent superposition in multiparticle systems - yields phenomena
that are much richer and more interesting than anything that can be seen in a
one-particle system. Among them, one important type of multi-particle
experiments uses path-entangled number-states, which exhibit pure higher-order
interference and allow novel applications in metrology and imaging such as
quantum interferometry and spectroscopy with phase sensitivity at the
Heisenberg limit or quantum lithography beyond the classical diffraction limit.
Up to now, in optical implementations of such schemes lower-order interference
effects would always decrease the overall performance at higher particle
numbers. They have thus been limited to two photons. We overcome this
limitation and demonstrate a linear-optics-based four-photon interferometer.
Observation of a four-particle mode-entangled state is confirmed by
interference fringes with a periodicity of one quarter of the single-photon
wavelength. This scheme can readily be extended to arbitrary photon numbers and
thus represents an important step towards realizable applications with
entanglement-enhanced performance.Comment: 19 pages, 4 figures, submitted on November 18, 200
Stimulated emission of polarization-entangled photons
Entangled photon pairs -- discrete light quanta that exhibit non-classical
correlations -- play a crucial role in quantum information science (for example
in demonstrations of quantum non-locality and quantum cryptography). At the
macroscopic optical field level non-classical correlations can also be
important, as in the case of squeezed light, entangled light beams and
teleportation of continuous quantum variables. Here we use stimulated
parametric down-conversion to study entangled states of light that bridge the
gap between discrete and macroscopic optical quantum correlations. We
demonstrate experimentally the onset of laser-like action for entangled
photons. This entanglement structure holds great promise in quantum information
science where there is a strong demand for entangled states of increasing
complexity.Comment: 5 pages, 4 figures, RevTeX
A semiconductor source of triggered entangled photon pairs?
The realisation of a triggered entangled photon source will be of great
importance in quantum information, including for quantum key distribution and
quantum computation. We show here that: 1) the source reported in ``A
semiconductor source of triggered entangled photon pairs''[1. Stevenson et al.,
Nature 439, 179 (2006)]} is not entangled; 2) the entanglement indicators used
in Ref. 1 are inappropriate, relying on assumptions invalidated by their own
data; and 3) even after simulating subtraction of the significant quantity of
background noise, their source has insignificant entanglement.Comment: 5 pages in pre-print format, 1 tabl
Von Bezold assimilation effect reverses in stereoscopic conditions
Lightness contrast and lightness assimilation are opposite phenomena: in contrast,
grey targets appear darker when bordering bright surfaces (inducers) rather than dark ones; in
assimilation, the opposite occurs. The question is: which visual process favours the occurrence
of one phenomenon over the other? Researchers provided three answers to this question. The
first asserts that both phenomena are caused by peripheral processes; the second attributes their
occurrence to central processes; and the third claims that contrast involves central processes,
whilst assimilation involves peripheral ones. To test these hypotheses, an experiment on an IT
system equipped with goggles for stereo vision was run. Observers were asked to evaluate the
lightness of a grey target, and two variables were systematically manipulated: (i) the apparent
distance of the inducers; and (ii) brightness of the inducers. The retinal stimulation was kept
constant throughout, so that the peripheral processes remained the same. The results show that
the lightness of the target depends on both variables. As the retinal stimulation was kept constant, we
conclude that central mechanisms are involved in both lightness contrast and lightness assimilation
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate cilia function, governed in part by the activity of intraflagellar transport (IFT). In articular cartilage, primary cilia length is increased and hedgehog signaling activated in osteoarthritis (OA). Here, we examine primary cilia length with exposure to the quintessential inflammatory cytokine interleukin-1 (IL-1), which is up-regulated in OA. We then test the hypothesis that the cilium is involved in mediating the downstream inflammatory response. Primary chondrocytes treated with IL-1 exhibited a 50 % increase in cilia length after 3 h exposure. IL-1-induced cilia elongation was also observed in human fibroblasts. In chondrocytes, this elongation occurred via a protein kinase A (PKA)-dependent mechanism. G-protein coupled adenylate cyclase also regulated the length of chondrocyte primary cilia but not downstream of IL-1. Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2. However, in cells with a mutation in IFT88 whereby the cilia structure is lost, this response to IL-1 was significantly attenuated and, in the case of nitric oxide, completely abolished. Inhibition of IL-1-induced cilia elongation by PKA inhibition also attenuated the chemokine response. These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA
Experimental investigation of the entanglement-assisted entropic uncertainty principle
The uncertainty principle, which bounds the uncertainties involved in
obtaining precise outcomes for two complementary variables defining a quantum
particle, is a crucial aspect in quantum mechanics. Recently, the uncertainty
principle in terms of entropy has been extended to the case involving quantum
entanglement. With previously obtained quantum information for the particle of
interest, the outcomes of both non-commuting observables can be predicted
precisely, which greatly generalises the uncertainty relation. Here, we
experimentally investigated the entanglement-assisted entropic uncertainty
principle for an entirely optical setup. The uncertainty is shown to be near
zero in the presence of quasi-maximal entanglement. The new uncertainty
relation is further used to witness entanglement. The verified entropic
uncertainty relation provides an intriguing perspective in that it implies the
uncertainty principle is not only observable-dependent but is also
observer-dependent.Comment: 14 pages, 5 figure
Species-specified VOC emissions derived from a gridded study in the Pearl River Delta, China
This study provides a top-down approach to establish an emission inventory of volatile organic compounds (VOC) based on ambient measurements, by combining the box model and positive matrix factorization (PMF) model. Species-specified VOC emissions, source contributions, and spatial distributions are determined based on regional-scale gridded measurements between September 2008 to December 2009 in the Pearl River Delta (PRD), China. The most prevalent anthropogenic species in the PRD was toluene estimated by the box model to be annual emissions of 167.8 ± 100.5 Gg, followed by m,p-xylene (68.0 ± 45.0 Gg), i-pentane (49.2 ± 40.0 Gg), ethene (47.6 ± 27.6 Gg), n-butane (47.5 ± 40.7 Gg), and benzene (46.8 ± 29.0 Gg). Alkanes such as propane, i-butane, and n-pentane were 2–8 times higher in box model than emission inventories (EI). Species with fewer emissions were highly variable between EI and box model results. Hotspots of VOC emissions were identified in southwestern PRD and port areas, which were not reflected by bottom-up EI. This suggests more research is needed for VOC emissions in the EI, especially for fuel evaporation, industrial operations and marine vessels. The species-specified top-down method can help improve the quality of these emission inventories
The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription
Expression of viral proteins causes important epigenetic changes leading to abnormal cell growth. Whether viral proteins directly target histone methyltransferases (HMTs), a key family enzyme for epigenetic regulation, and modulate their enzymatic activities remains elusive. Here we show that the E6 proteins of both low-risk and high-risk human papillomavirus (HPV) interact with three coactivator HMTs, CARM1, PRMT1 and SET7, and downregulate their enzymatic activities in vitro and in HPV-transformed HeLa cells. Furthermore, these three HMTs are required for E6 to attenuate p53 transactivation function. Mechanistically, E6 hampers CARM1- and PRMT1-catalyzed histone methylation at p53-responsive promoters, and suppresses the binding of p53 to chromatinized DNA independently of E6-mediated p53 degradation. p53 pre-methylated at lysine-372 (p53K372 mono-methylation) by SET7 protects p53 from E6-induced degradation. Consistently, E6 downregulates p53K372 mono-methylation and thus reduces p53 protein stability. As a result of the E6-mediated inhibition of HMT activity, expression of p53 downstream genes is suppressed. Together, our results not only reveal a clever approach for the virus to interfere with p53 function, but also demonstrate the modulation of HMT activity as a novel mechanism of epigenetic regulation by a viral oncoprotein
CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses
The Hedgehog (Hh) morphogen directs distinct cell responses according to its distinct signalling levels. Hh signalling stabilizes transcription factor cubitus interruptus (Ci) by prohibiting SCFSlimb-dependent ubiquitylation and proteolysis of Ci. How graded Hh signalling confers differential SCFSlimb-mediated Ci proteolysis in responding cells remains unclear. Here, we show that in COP9 signalosome (CSN) mutants, in which deneddylation of SCFSlimb is inactivated, Ci is destabilized in low-to-intermediate Hh signalling cells. As a consequence, expression of the low-threshold Hh target gene dpp is disrupted, highlighting the critical role of CSN deneddylation on low-to-intermediate Hh signalling response. The status of Ci phosphorylation and the level of E1 ubiquitin-activating enzyme are tightly coupled to this CSN regulation. We propose that the affinity of substrate–E3 interaction, ligase activity and E1 activity are three major determinants for substrate ubiquitylation and thereby substrate degradation in vivo
Universal high work function flexible anode for simplified ITO-free organic and perovskite light-emitting diodes with ultra-high efficiency
Flexible transparent electrode materials such as conducting polymers, silver nanowires, carbon nanotubes and graphenes are being investigated as possible replacements for conventional brittle inorganic electrodes. However, they have critical drawbacks of low work function (WF), resulting in a high hole injection barrier to an overlying semiconducting layer in simplified organic or organic-inorganic hybrid perovskite light-emitting diodes (OLEDs or PeLEDs). Here, we report a new anode material (AnoHIL) that has multifunction of both an anode and a hole injection layer (HIL) as a single layer. The AnoHIL has easy WF tunability up to 5.8 eV and thus makes ohmic contact without any HIL. We applied our anodes to simplified OLEDs, resulting in very high efficiency (62% ph el(-1) for single and 88% ph el(-1) for tandem). The AnoHIL showed a similar tendency in simplified PeLEDs, implying universal applicability to various optoelectronics. We also demonstrated large-area flexible lightings using our anodes. Our results provide a significant step toward the next generation of high-performance simplified indium tin oxide (ITO)-free light-emitting diodes.
- …