30 research outputs found
DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III
- Author
- Ada M. B. Alves
- Adriana S. Azevedo
- Anna M. Y. Yamamura
- B Shrestha
- B Shrestha
- BD Lindenbach
- BS Davis
- DE Clements
- DJ Gubler
- E Konishi
- E Konishi
- EA Henchal
- EA Henchal
- G Colombage
- G Inchauspe
- GE Coelho
- Gisela F. Trindade
- GJ Chang
- GJJ Chang
- I Kurane
- I Stefano
- I Valdés
- J Mota
- JS Boyle
- JT Roehrig
- K Irie
- K Raviprakash
- K Raviprakash
- K Raviprakash
- KR Porter
- L Chen
- L Suksanpaisan
- LE Yauch
- M Simmons
- Marcos S. Freire
- Mauricio Martins Rodrigues
- MC Bonaldo
- MG Guzmán
- MG Teixeira
- MP Ramanathan
- MS Ashok
- Myrna Bonaldo
- N Miller
- PS Caufour
- R Edelman
- R Edelman
- R Putnak
- RG van der Most
- RG van der Most
- Ricardo Galler
- RJ Kuhn
- RJ Phillpotts
- RM Kinney
- RM Nogueira
- RO Jimenez
- S Jaiswal
- SL Alisson
- SM Costa
- SM Costa
- SM Costa
- SO De Paula
- SS Whitehead
- T Kochel
- TJ Chambers
- TJ Kochel
- TP Monath
- W Dejnirattisai
- W Erhardt
- WM Wahala
- Y Lu
- Y Modis
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Two DNA vaccines were constructed encoding the ectodomain (domains I, II and III) of the DENV2 envelope protein (pE1D2) or only its domain III (pE2D2), fused to the human tissue plasminogen activator signal peptide (t-PA). The expression and secretion of recombinant proteins was confirmed in vitro in BHK cells transfected with the two plasmids, detected by immunofluorescence or immunoprecipitation of metabolically labeled gene products, using polyclonal and monoclonal antibodies against DENV2. Besides, results reveal that the ectodomain of the E protein can be efficiently expressed in vivo, in a mammalian system, without the prM protein that is hypothesized to act as a chaperonin during dengue infection. Balb/c mice were immunized with the DNA vaccines and challenged with a lethal dose of DENV2. All pE1D2-vaccinated mice survived challenge, while 45% of animals immunized with the pE2D2 died after infection. Furthermore, only 10% of pE1D2-immunized mice presented some clinical signs of infection after challenge, whereas most of animals inoculated with the pE2D2 showed effects of the disease with high morbidity degrees. Levels of neutralizing antibodies were significantly higher in pE1D2-vaccinated mice than in pE2D2-immunized animals, also suggesting that the pE1D2 vaccine was more protective than the pE2D2
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.
- Author
- Aaronson Neil K
- Adank Muriel A
- Amor David
- Andrews Lesley
- Anjum Uruj
- Aprikian Armen
- Araujo Luis
- Ardern-Jones Audrey
- Arun Banu
- Ausems Margreet GEM
- Awatagiri Kasturi
- Balmana Judith
- Bambury Richard
- Bancroft Elizabeth
- Bancroft Elizabeth K
- Bangma Chris
- Bartlett Marion
- Barwell Julian
- Basevitch Alon
- Bealin Lisa
- Ben-Yehoshua Sagi Josefsberg
- Bermingham Nicola
- Birt Angela
- Bojeson Anders
- Boon Melanie
- Boshari Talia
- Bowman Michelle
- Brady Angela
- Brennhovd Bjorn
- Brewer Carole
- Brice Glen
- Bulman Barbara
- Burgess Lucy
- Burke Jo
- Buys Saundra
- Buys Saundra S
- Caanen BAH
- Capella Gabriel
- Carlsson Stefan
- Castro Elena
- Catto James
- Chamberlain Anthony
- Chapman Cyril
- Chen-Shtoyerman Rakefet
- Chong Michael
- Clowes Virginia
- Cogley Lyn
- Cole Trevor
- Compton Cecilia
- Conner Tom
- Cook Jackie
- Cooney Kathy
- Copakova Lucia
- Cornford Philip
- Costello Philandra
- Cruger Dorthe
- Cummings Carole
- Cybulski Cezary
- D'Mello Lucia
- Davidson Rosemarie
- Davis John W
- Dearing Audrey
- Dearnaley David
- Dechet Christopher
- Devlin Gemma
- Dias Alex
- Dineen Amy
- Domchek Susan
- Donaldson Alan
- Dorkins Huw
- Douglas Fiona
- Duffy Jessica
- Duncan Alexis
- Eccles Diana
- Eccles Diana M
- Eeles Rosalind
- Eeles Rosalind A
- Ekdahl Karl-Johan
- Ellery Natalie
- Esquena Salvador
- Evans D Gareth
- Evans David Gareth
- Evans Gareth
- Everest Sarah
- Eyfjord Jorunn
- Falconer Alison
- Farrell Michael
- Fisas David
- Fleming-Brown D
- Foster Christopher
- Foulkes William
- Friedman Eitan
- Frydenberg Mark
- Gadea Neus
- Gallagher David
- Gallagher Fergal
- Garcia Lynda
- Gay Simona
- George Angela
- Gerdes Anne-Marie
- Ghonge Sujata
- Giri Veda
- Gleeson Margaret
- Glover Wayne
- Goldgar David
- Goncalves Nuno
- Goodman Selina
- Gott Hannah
- Greenhalgh Lynn
- Griebsch C
- Griffiths Julie
- Grindedal Eli Marie
- Gronberg Henrik
- Gross Laura
- Gurasashvili Jana
- Halliday Dorothy
- Hamdy Freddie C
- Hammond Carrie
- Hanslien Eldbjorg
- Hanson Helen
- Harris Marion
- Hart Rachel
- Heaton Tricia
- Helderman-van den Enden A Paula TJM
- Helfand Brian T
- Henderson Alex
- Henrique Rui
- Hill Kathryn
- Hjalm-Eriksson Marie
- Hodgson Shirley
- Hoffman Jonathan
- Homfray Tessa
- Hook Nicole
- Howell Alice
- Howson Joanne
- Huber Camilla
- Hulick Peter
- Hunt Clare
- Ingram Stuart
- Islam Farah
- Jacobs Chris
- James Paul
- Jensen Thomas
- Jobson Irene
- Johannsson Oskar
- Johannsson Oskar Thor
- Kaemba Beckie
- Kast K
- Kaul Karen
- Kemp Zoe
- Khoo Vincent
- Kiemeney Bart
- Kiernan Ingrid
- Kiesel Vicki
- Kirk Judy
- Kockelbergh Roger
- Kohut Kelly
- Kosicka-Slawinska Monika
- Kote-Jarai Zsofia
- Kowtal Pradnya
- Krajc Mateja
- Kulkarni Anju
- Kumar Pardeep
- Lam Jimmy
- Langman Caroline
- Leibovici Dan
- Lilja Hans
- Liljegren Annelie
- Lindeman Geoffrey
- Longmuir Mark
- Lubinski Jan
- Maehle Lovise
- Magnani Tiziana
- Maia Sofia
- Male Alison
- Mascarenhas Lyon
- McBride Donna
- McGaughran Julie
- McGuire Michael
- McKinley Joanne
- Medvik Heidi
- Melville Athalie
- Melzer Ehud
- Mencias Mark
- Mercer Catherine
- Mikropoulos Christos
- Millard Richard
- Miller Cathy
- Millner Alan
- Mitchell Gillian
- Mitra Anita
- Moller Pal
- Mom Jaswant
- Mora Josefina
- Morote Juan
- Morton Catherine
- Moss Cathryn
- Moynihan Clare
- Mulgund Gouri
- Murphy Declan
- Murphy Morgan
- Murthy Vedang
- Myhill Kathryn
- Mzazi Shumikazi
- Nadolski Maria
- Nevitt Louise
- Newcombe Barbara
- Newlin Anna
- Nicholls Cassandra
- Nicolai Nicola
- Nogueira Pedro
- O'Connell Shona
- Obeid Elias
- Offman Judith
- Ogden Chris
- Okoth Linda
- Oldenburg Rogier A
- Oliveira Jorge
- Ong Kai-Ren
- Oosterwijk Jan C
- Osther Palle
- Pachter Nicholas
- Paez Edgar
- Page Elizabeth
- Page Elizabeth C
- Patel Manish
- Patel Nafisa
- Paterson Joan
- Patterson Briony
- Pearce Allison
- Peixoto Ana
- Petelin Lara
- Pichert Gabriella
- Pope Jennifer
- Pope Jenny
- Poplawski Nicola
- Potter Alison
- Poultney Una
- Powers Jacquelyn
- Radice Paolo
- Ramon y Cajal Teresa
- Randhawa Kashmir
- Rees Katie
- Reinholtz Cherylin
- Rennert Gad
- Renton Caroline
- Rhiem Kerstin
- Richardson Kate
- Ringleberg Janneke
- Rosario Derek
- Rosario Derek J
- Rose Sarah
- Rothwell Jeanette
- Rubinstein Wendy S
- Ruijs Marielle WG
- Rustgi Neil
- Salinas Monica
- Sarin Rajiv
- Sattar Ayisha
- Saya Sibel
- Schmutzler Rita
- Schofield Lyn
- Scott Rodney
- Searle Anne
- Seixas Manuela
- Selkirk Christina Hutten
- Shackleton Kylie
- Shanley Sue
- Shaw Adam
- Shevrin Daniel
- Sidat Zahirah
- Side Lucy
- Siguake Kas
- Simon Kate
- Skytte Anne-Bine
- Smyth Courtney
- Snape Katie
- Souto Joao Paulo
- Spigelman Allan
- Stapleton Alan
- Stayner Barbara
- Stefansdottir Vigdis
- Stephenson Robert
- Stoffel Elena
- Stricker Phillip
- Strom Sara
- Suri Mohnish
- Susman Rachel
- Suthers Graeme
- Sutton Vivienne
- Swindle Peter
- Tan Hui Meng
- Taylor Amy
- Taylor Louise
- Taylor Natalie
- Teixeira Manuel
- Teo Soo Hwang
- Thomas Sarah
- Thompson Alan
- Thong Meow Keong
- Tidey Lizzie
- Tischkowitz Marc
- Tomkins Sue
- Tondering Majbritt Kure
- Torokwa Audrey
- Townshend Sharron
- Treherne Katy
- Tricker Karen
- Tripathi Vishakha
- Tucker Katherine
- Umez-Eronini Nkem
- Valdagni Riccardo
- Van As Nicholas
- van Asperen Christi
- van der Luijt Rob B
- van Os Theo
- van Zelst-Stams Wendy
- Vasen Hans
- Venne Vickie
- Vogel Kristen
- Vrecar Alenka
- Walker Lisa
- Ward Robyn
- Watson Michelle
- Watt Cathy
- Weiss Shelly
- Weissman Scott
- Wiggins Jennifer
- Wihler Petra
- Williams Rachel
- Wise Gillian
- Wokolorczyk Dominika
- Woodhouse Christopher
- Yamamura Yuko
- Yesildag Pembe
- Yoon Sook-Yee
- Zgajnar Janez
- Publication venue
- BJU Int
- Publication date
- 26/05/2018
- Field of study
OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhandari A. V.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
- Bilicki Maciej
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Biscans S.
- Bischi M.
- Biscoveanu Andrea Sylvia
- Bisht A.
- Bitossi M.
- Blackburn Kent
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Bogaert G.
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonilla G. S.
- Bonnand Romain
- Booker P.
- Boschi Valerio
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Bozzi A.
- Boër M.
- Bradaschia C.
- Brady Patrick R.
- Braglia Matteo
- Branch A.
- BRANCHESI Marica
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
- Brockill P.
- Brooks Aidan
- Brown D. D.
- Brunett S.
- Bruno G.
- Bruntz Robert
- Bryant J.
- Bucci F.
- Buchanan J.
- Bulashenko Oleg
- Bulik T.
- Bulten H. J.
- Buonanno Alessandra
- Burtnyk K.
- Buscicchio Riccardo
- Buskulic D.
- Bustillo J. Calderón
- Buy Christelle
- Bécsy Bence
- C. Utina Andrei
- Cabourn Davies Gareth
- Cabras Giuseppe
- Cabrita Ricardo
- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane Craig
- Cain III. H. W.
- Callaghan J. D.
- Callister T. A.
- Calloni E.
- Camp J. B.
- Canepa M.
- Caneva Santoro Giada
- Cannavacciuolo M.
- Cannon Kipp C.
- Cao H.
- Capistran L. A.
- Capocasa Eleonora
- Capote E.
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
- Chan M.
- Chan W. L.
- Chandra K.
- Chang I. P.
- Chang R. -J.
- Chang W.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
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- Chessa Piero
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
- Chiarini G.
- Chiba A.
- Chiba R.
- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi M.
- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colleoni Marta
- Collette C. G.
- Collins J.
- Colombo Alberto
- Colpi M.
- Compton C. M.
- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman S. T.
- Coupechoux J. -F.
- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Cowburn B. D.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Dave I.
- Davenport A.
- Davier M.
- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- Dhurandhar S.
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
- Diaz J. Casanueva
- Didio N. A.
- Diego Bonavena Luis
- Dietrich Tim
- Diksha D.
- Ding Jacques
- Divyajyoti
- Dmitriev Artemiy
- Doctor Zoheyr
- Dohmen E.
- Doleva P. P.
- Donahue L.
- Donovan F.
- Dooley Katherine L.
- Dooney T.
- Doravari Suresh
- Dorosh O.
- Drago Marco
- Driggers Jennifer C.
- Drori Y.
- Du H.
- Ducoin J. -G.
- Dunn Liam
- Dupletsa U.
- Duval Hannah
- Duverne P. -A.
- Dwyer S. E.
- Dálya Gergely
- Eassa C.
- Ebersold Michael
- Eckhardt Tobias
- Eddolls Graeme
- Edelman Bruce
- Edo T. B.
- Edy Oliver
- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
- Eka Setyawati Yoshinta
- Elizabeth Ramirez Guevara Karla
- Engelby E.
- Engl A. J.
- Erasmo Peña Arellano Fabián
- Errico L.
- error error
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans C. R.
- Evans Matthew J.
- Evans T. M.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fair H.
- Fairhurst Stephen
- Fan Pinchen
- Farah Amanda M.
- Farr Ben
- Farr Will M.
- Fauchon-Jones E. J.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Feicht J.
- Fejer M. M.
- Fenyvesi Edit
- Ferguson Deborah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Fritschel P.
- Frolov V. V.
- Fujii S.
- Fukunaga I.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Gais J.
- Galaudage S.
- Gallardo S.
- Gamba Rossella
- Ganapathy Dhruva
- Ganguly Apratim
- Gaonkar S. G.
- Garaventa Barbara
- Garcia-Bellido Juan
- García Quirós Cecilio
- García-Núñez C.
- Gardner James W.
- Gardner K. A.
- Gargiulo J.
- Garufi Fabio
- Gasbarra Claudio
- Gateley B.
- Gayathri V.
- Gemme Gianluca
- Gennai Alberto
- George J.
- Gerberding Oliver
- Ghadiri N.
- Ghosh Abhirup
- Ghosh Archisman
- Ghosh Shaon
- Ghosh Shrobana
- Ghosh Suprovo
- Ghosh Tathagata
- Giacoppo L.
- Giaime Joseph
- Giardina K. D.
- Gibson D. R.
- Gier C.
- Giri Priyanka
- Gissi F.
- Gkaitatzis Stamatios
- Glanzer J.
- Gleckl A. E.
- Glotin F.
- Godfrey J.
- Godwin P.
- Goetz Evan
- Goetz Ryan
- Golomb J.
- Goncharov Boris
- Gonzalez Gabriela
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- LIETO ALBERTO. DI.
- LIGO Collaboration
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- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Yasui H.
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- Zheng Yanyan
- Zhong Haowen
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- Zhu Xingjiang
- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
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- Zhang Ya
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions.
- Author
- A Bafica
- A Banerjee
- A Seidel
- AL Cogen
- Anna L. Cogen
- Charles L. Jaffe
- Chrissy H. Roberts
- D Little
- D Montoya
- Deanna A. Hagge
- Diana N. J. Lockwood
- DM Scollard
- E Prado-Montes de Oca
- EA Grice
- FR Zhang
- Kapil D. Neupane
- LD Sibley
- M Boniotto
- M Schenk
- M Wilmes
- M Yamamura
- M Yamamura
- N Auphan
- N Sato
- P Zanger
- PT Liu
- PY Bochud
- PY Bochud
- PY Bochud
- S Joly
- S Okada
- S Vylkova
- Saraswoti Khadge
- SL Walker
- SR Krutzik
- Stephen L. Walker
- T Mutis
- TJ Kang
- TJ Kang
- TJ Kang
- V Nizet
- VP Shetty
- Y Lai
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/11/2012
- Field of study
BACKGROUND: Leprosy, a chronic granulomatous disease affecting the skin and nerves, is caused by Mycobacterium leprae (M. leprae). The type of leprosy developed depends upon the host immune response. Type 1 reactions (T1Rs), that complicate borderline and lepromatous leprosy, are due to an increase in cell-mediated immunity and manifest as nerve damage and skin inflammation. Owing to the increase in inflammation in the skin of patients with T1Rs, we sought to investigate the activation of the innate immune system during reactionary events. Specifically, we investigated the expression levels of human beta-defensins (hBDs) 2 and 3 in the skin of patients with T1Rs, in keratinocytes, and in macrophages stimulated with M. leprae and corticosteroids. RESULTS: Skin biopsies from twenty-three patients with Type 1 reactions were found to have higher transcript levels of hBD3 as compared to fifteen leprosy patients without Type 1 reactions, as measured by qPCR. Moreover, we observed that keratinocytes but not macrophages up-regulated hBD2 and hBD3 in response to M. leprae stimulation in vitro. Corticosteroid treatment of patients with T1Rs caused a suppression of hBD2 and hBD3 in skin biopsies, as measured by qPCR. In vitro, corticosteroids suppressed M. leprae-dependent induction of hBD2 and hBD3 in keratinocytes. CONCLUSIONS: This study demonstrates that hBD3 is induced in leprosy Type 1 Reactions and suppressed by corticosteroids. Furthermore, our findings demonstrate that keratinocytes are responsive to M. leprae and lend support for additional studies on keratinocyte innate immunity in leprosy and T1Rs. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN31894035
Percentage of survival of Balb/c mice immunized with pE1D2 and pE2D2 and challenged with DENV2.
- Author
- Publication venue
- Publication date
- Field of study
<p>Mice were i.m. immunized with two DNA doses and challenged 4 weeks after the first plasmid inoculation. Non-immunized and pcTPA-injected mice followed the same virus infection procedure. Mice were daily monitored and deaths were recorded. Differences between pE1D2- and pE2D2-vaccinated animals were statistical significant (p = 0.0027), as well as between these groups and control animals (p<0.0001). Data represent compilation of two independent experiments, with groups of 10 animals in each test (n = 20).</p
Analysis of the expression <i>in vitro</i> of recombinant proteins.
- Author
- Publication venue
- Publication date
- Field of study
<p>BHK cells were transfected with plasmids pE1D2 (A, D), pE2D2 (B, E) and pcTPA (C, F). Cells were permeabilized, fixed and treated with DENV2 hiperimmune mouse ascitic fluid (A–C) or the monoclonal DENV2 3H5 antibody (D–F), followed by incubation with anti-mouse fluorescein-conjugated goat IgG. Magnification 1000x (A, B, D, E) and 400x (C, F).</p
The morbidity in vaccinated mice after DENV2 challenge.
- Author
- Publication venue
- Publication date
- Field of study
<p>The percentage (A) and degree (B) of morbidity of Balb/c mice immunized with pE1D2, pE2D2 and controls groups (non-immunized and pcTPA-inoculated animals) were analyzed after i.c. challenge with DENV2. Clinical signs of infection, mainly hind leg paralysis, alterations in spinal column and deaths, were monitored during 21 days post challenge (A). Differences in morbidity rates between pE1D2- and pE2D2-vaccinated mice were statistical significant (p<0.0001), as well as between pE1D2 and control animals (p<0.0001). The semi-quantitative analysis of morbidity degrees after virus challenge (B) were performed using a subjective scale ranging from 0 to 3 (0 = none, 1 = mild paralyses in one hind leg or alteration of the spinal column with a small hump, 2 = one severe hind leg paralyses and alteration of the spinal column with a small hump or two severe hind leg paralyses, 3 = two severe hind leg paralyses and deformed spinal column or death). Asterisks indicate statistically significant differences between vaccinated animals and mice inoculated with the control vector pcTPA (* p = 0.0051; ** p = 0.0002; *** p<0.0001). Data represent compilation of two independent experiments, with groups of 10 animals in each test (n = 20).</p