Tracking echovirus eleven outbreaks in Guangdong, China

In April 2019, a suspect cluster of enterovirus cases was reported in a neonatology department in Guangdong, China, resulting in five deaths. We aimed to investigate the pathogen profiles in fatal cases, the circulation and transmission pattern of the viruses by combining metatranscriptomic, phylogenetic, and epidemiological analyses. Metatranscriptomic sequencing was used to characterize the enteroviruses. Clinical and environmental surveillance in the local population was performed to understand the prevalence and genetic diversity of the viruses in the local population. The possible source(s), evolution, transmission, and recombination of the viruses were investigated by incorporating genomes from the current outbreak, from local retrospective surveillance, and from public databases. Metatranscriptomic analysis identified Echovirus 11 (E11) in three fatal cases. Seroprevalence of neutralization antibody to E11 was 35 to 44 per cent in 3–15 age groups of general population, and the viruses were associated with various clinical symptoms. From the viral phylogeny, nosocomial transmissions were identified and all E11 2019 outbreak strains were closely related with E11 strains circulating in local population 2017–19. Frequent recombination occurred among the 2019 Guangdong E11 outbreak strains and various genotypes in enterovirus B species. This study provides an example of combining advanced genetic technology and epidemiological surveillance in pathogen diagnosis, source(s), and transmission tracing during an infectious disease outbreak. The result highlights the hidden E11 circulation and the risk of viral transmission and infection in the young age population in China. Frequent recombination between Guangdong-like strains and other enterovirus genotypes also implies the prevalence of these emerging E11 strains

The boundary element method for elasticity problems with concentrated loads based on displacement singular elements

The boundary element method (BEM) has been implemented in elasticity problems very successfully because of its high accuracy. However, there are very few investigations about BEM with concentrated loads. The displacement at the concentrated load point is infinite and traditional elements will lead inaccurate results near the concentrated load point. This paper proposes two types of displacement singular elements to approximate the displacement near concentrated load point, and high accuracy can be obtained without refinement. The second type of displacement singular element is a general element type, which can work well for both problems with or without boundary concentrated loads. Numerical examples have been studied and compared with results obtained by traditional BEM and finite element method (FEM) to show the necessary of the proposed methods

Search for the Rare Decays J/Psi --> Ds- e+ nu_e, J/Psi --> D- e+ nu_e, and J/Psi --> D0bar e+ e-

We report on a search for the decays J/Psi --> Ds- e+ nu_e + c.c., J/Psi --> D- e+ nu_e + c.c., and J/Psi --> D0bar e+ e- + c.c. in a sample of 5.8 * 10^7 J/Psi events collected with the BESII detector at the BEPC. No excess of signal above background is observed, and 90% confidence level upper limits on the branching fractions are set: B(J/Psi --> Ds- e+ nu_e + c.c.)<4.8*10^-5, B(J/Psi --> D- e+ nu_e + c.c.) D0bar e+ e- + c.c.)<1.1*10^-5Comment: 10 pages, 4 figure

Study of J/psi decays to Lambda Lambdabar and Sigma0 Sigma0bar

The branching ratios and Angular distributions for J/psi decays to Lambda Lambdabar and Sigma0 Sigma0bar are measured using BESII 58 million J/psi.Comment: 11 pages, 5 figure

A coupled 3D isogeometric and discrete element approach for modelling interactions between structures and granular matters

A three-dimensional (3D) isogeometric/discrete-element coupling method is presented for modelling contact/impact between structures and particles. This method takes advantages of the geometry smoothness and exactness of isogeometric analysis (IGA) for continuous solid media and the effectiveness and flexibility of the discrete element method (DEM) for particulate matters. The coupling procedure for handling interactions between IGA elements and discrete elements (DEs) includes global search, local search and interaction calculation. In the global search, the CGRID method is modified to detect potential contact pairs between IGA elements and DEs based on their bounding box representations. The strong convex hull property of a NURBS control mesh plays an important part in the bounding box representation of IGA elements. In the local search, the proposed approach treats each spherical DE centroid as a slave node and the contact surface of each IGA element as the master surface. The projection of a DE centroid onto an IGA element contact surface is solved by modifying the simplex method and Brent iterations. The contact force between an IGA element and a DE is determined from their penetration by using a (nonlinear) penalty function based method. The whole coupled system is solved by the explicit time integration within a updated Lagrangian scheme. Finally, three impact examples, including the impact of two symmetric bars, a tube onto a footing strip, and an assembly of granular particles to a tailor rolled blank, are simulated in elastic regime to assess the accuracy and applicability of the proposed method

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 &times; 10-11 to 5.0 &times; 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 &times; 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation

Partial wave analyses of J/psi to gamma pi^+ pi^- and gamma pi^0 pi^0

Results are presented on J/psi radiative decays to pi^+pi^- and pi^0pi^0 based on a sample of 58M J/psi events taken with the BESII detector. Partial wave analyses are carried out using the relativistic covariant tensor amplitude method in the 1.0 to 2.3 GeV/c^2 pipi mass range. There are conspicuous peaks due to the f_2(1270) and two 0^++ states in the 1.45 and 1.75 GeV/c^2 mass regions. The first 0^++ state has a mass of 1466\pm 6\pm 20 MeV/c^2, a width of 108^{+14}_{-11}\pm 25 MeV/c^2, and a branching fraction B(J/psi \to \gamma f_0(1500) \to\gamma \pi^+\pi^-) = (0.67\pm0.02\pm0.30) \times 10^{-4}. Spin 0 is strongly preferred over spin 2. The second 0^++ state peaks at 1765^{+4}_{-3}\pm 13 MeV/c^2 with a width of 145\pm8\pm69 MeV/c^2. If this 0^++ is interpreted as coming from f_0(1710), the ratio of its branching fractions to pipi and K\bar K is 0.41^{+0.11}_{-0.17}.Comment: 9 pages, 6 figure