790 research outputs found
Topological non-Hermitian origin of surface Maxwell waves
Maxwell electromagnetism, describing the wave properties of light, was
formulated 150 years ago. More than 60 years ago it was shown that interfaces
between optical media (including dielectrics, metals, negative-index materials)
can support surface electromagnetic waves, which now play crucial roles in
plasmonics, metamaterials, and nano-photonics. Here we show that surface
Maxwell waves at interfaces between homogeneous, isotropic media described by
real permittivities and permeabilities have a purely topological origin
explained by the bulk-boundary correspondence. Importantly, the topological
classification is determined by the helicity operator, which is generically
non-Hermitian even in lossless optical media. The corresponding topological
invariant, which determines the number of surface modes, is a Z4 number (or a
pair of Z2 numbers) describing the winding of the complex helicity spectrum
across the interface. Moreover, there is an additional pair of non-topological
Z2 indices, which describe zones of the TE and TM polarizations at the phase
diagram of surface modes. Our theory provides a new twist and insights for
several areas of wave physics: Maxwell electromagnetism, topological quantum
states, non-Hermitian wave physics, and metamaterials.Comment: 12 pages, 3 figure
Computational Controversy
Climate change, vaccination, abortion, Trump: Many topics are surrounded by
fierce controversies. The nature of such heated debates and their elements have
been studied extensively in the social science literature. More recently,
various computational approaches to controversy analysis have appeared, using
new data sources such as Wikipedia, which help us now better understand these
phenomena. However, compared to what social sciences have discovered about such
debates, the existing computational approaches mostly focus on just a few of
the many important aspects around the concept of controversies. In order to
link the two strands, we provide and evaluate here a controversy model that is
both, rooted in the findings of the social science literature and at the same
time strongly linked to computational methods. We show how this model can lead
to computational controversy analytics that have full coverage over all the
crucial aspects that make up a controversy.Comment: In Proceedings of the 9th International Conference on Social
Informatics (SocInfo) 201
Initial-state dependence in time-dependent density functional theory
Time-dependent density functionals in principle depend on the initial state
of the system, but this is ignored in functional approximations presently in
use. For one electron it is shown there is no initial-state dependence: for any
density, only one initial state produces a well-behaved potential. For two
non-interacting electrons with the same spin in one-dimension, an initial
potential that makes an alternative initial wavefunction evolve with the same
density and current as a ground state is calculated. This potential is
well-behaved and can be made arbitrarily different from the original potential
Metal Surface Energy: Persistent Cancellation of Short-Range Correlation Effects beyond the Random-Phase Approximation
The role that non-local short-range correlation plays at metal surfaces is
investigated by analyzing the correlation surface energy into contributions
from dynamical density fluctuations of various two-dimensional wave vectors.
Although short-range correlation is known to yield considerable correction to
the ground-state energy of both uniform and non-uniform systems, short-range
correlation effects on intermediate and short-wavelength contributions to the
surface formation energy are found to compensate one another. As a result, our
calculated surface energies, which are based on a non-local
exchange-correlation kernel that provides accurate total energies of a uniform
electron gas, are found to be very close to those obtained in the random-phase
approximation and support the conclusion that the error introduced by the
local-density approximation is small.Comment: 5 pages, 1 figure, to appear in Phys. Rev.
Correlation energy of a two-dimensional electron gas from static and dynamic exchange-correlation kernels
We calculate the correlation energy of a two-dimensional homogeneous electron
gas using several available approximations for the exchange-correlation kernel
entering the linear dielectric response of the system.
As in the previous work of Lein {\it et al.} [Phys. Rev. B {\bf 67}, 13431
(2000)] on the three-dimensional electron gas, we give attention to the
relative roles of the wave number and frequency dependence of the kernel and
analyze the correlation energy in terms of contributions from the plane. We find that consistency of the kernel with the electron-pair
distribution function is important and in this case the nonlocality of the
kernel in time is of minor importance, as far as the correlation energy is
concerned. We also show that, and explain why, the popular Adiabatic Local
Density Approximation performs much better in the two-dimensional case than in
the three-dimensional one.Comment: 9 Pages, 4 Figure
Change in Markers of Bone Metabolism with Chemotherapy for Advanced Prostate Cancer: Interleukin-6 Response Is a Potential Early Indicator of Response to Therapy
Men with androgen-independent prostate cancer (AIPC) frequently have bone metastasis. The effects of chemotherapy on markers of bone metabolism have not been well characterized. We conducted a prospective study of patients with AIPC randomized in the first cycle to receive either docetaxel/estramustine or zoledronic acid, a bisphosphonate, to inhibit osteoclastic activity. Here we report the effects of therapy on markers of bone metabolism in these patients following the first cycle of therapy. Serum levels of several indices of bone remodeling were evaluated using commercial enzyme-linked immunosorbent assays. Changes in markers of bone metabolism were compared in patients receiving initial chemotherapy versus bisphosphonate. There was no significant difference in median change in any of the measured bone markers in patients given zoledronic acid when compared to chemotherapy. When comparing responders to nonresponders, overall interleukin-6 (IL-6) decreased by 35% in prostate-specific antigen responders; whereas, IL-6 levels increased by 76% in nonresponders (p = 0.03). Elevated IL-6 levels and reductions in IL-6 levels early in treatment may reflect ultimate clinical response to docetaxel-based regimens.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78145/1/jir.2008.0024.pd
Why are Prices Sticky? Evidence from Business Survey Data
This paper offers new insights on the price setting behaviour of German retail firms using a novel dataset that
consists of a large panel of monthly business surveys from 1991-2006. The firm-level data allows matching changes
in firms' prices to several other firm-characteristics. Moreover, information on price expectations allow analyzing
the determinants of price updating. Using univariate and bivariate ordered probit specifications, empirical menu
cost models are estimated relating the probability of price adjustment and price updating, respectively, to both
time- and state- dependent variables. First, results suggest an important role for state-dependence; changes in
the macroeconomic and institutional environment as well as firm-specific factors are significantly related to the
timing of price adjustment. These findings imply that price setting models should endogenize the timing of price
adjustment in order to generate realistic predictions concerning the transmission of monetary policy. Second, an
analysis of price expectations yields similar results providing evidence in favour of state-dependent sticky plan
models. Third, intermediate input cost changes are among the most important determinants of price adjustment
suggesting that pricing models should explicitly incorporate price setting at different production stages. However, the results show that adjustment to input cost changes takes time indicating "additional stickiness" at the last stage of processing
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths. We found repeat length-dependent transcriptional signatures to be prominent in the striatum, less so in cortex, and minimal in the liver. Coexpression network analyses revealed 13 striatal and 5 cortical modules that correlated highly with CAG length and age, and that were preserved in HD models and sometimes in patients. Top striatal modules implicated mHtt CAG length and age in graded impairment in the expression of identity genes for striatal medium spiny neurons and in dysregulation of cyclic AMP signaling, cell death and protocadherin genes. We used proteomics to confirm 790 genes and 5 striatal modules with CAG length-dependent dysregulation at the protein level, and validated 22 striatal module genes as modifiers of mHtt toxicities in vivo
Unique reporter-based sensor platforms to monitor signalling in cells
Introduction: In recent years much progress has been made in the development of tools for systems biology to study the levels of mRNA and protein, and their interactions within cells. However, few multiplexed methodologies are available to study cell signalling directly at the transcription factor level.
<p/>Methods: Here we describe a sensitive, plasmid-based RNA reporter methodology to study transcription factor activation in mammalian cells, and apply this technology to profiling 60 transcription factors in parallel. The methodology uses two robust and easily accessible detection platforms; quantitative real-time PCR for quantitative analysis and DNA microarrays for parallel, higher throughput analysis.
<p/>Findings: We test the specificity of the detection platforms with ten inducers and independently validate the transcription factor activation.
<p/>Conclusions: We report a methodology for the multiplexed study of transcription factor activation in mammalian cells that is direct and not theoretically limited by the number of available reporters
A machine learning method for the discovery of minimum marker gene combinations for cell type identification from single-cell RNA sequencing
Single-cell genomics is rapidly advancing our knowledge of the diversity of cell phenotypes, including both cell types and cell states. Driven by single-cell/-nucleus RNA sequencing (scRNA-seq), comprehensive cell atlas projects characterizing a wide range of organisms and tissues are currently underway. As a result, it is critical that the transcriptional phenotypes discovered are defined and disseminated in a consistent and concise manner. Molecular biomarkers have historically played an important role in biological research, from defining immune cell types by surface protein expression to defining diseases by their molecular drivers. Here, we describe a machine learning-based marker gene selection algorithm, NS-Forest version 2.0, which leverages the nonlinear attributes of random forest feature selection and a binary expression scoring approach to discover the minimal marker gene expression combinations that optimally capture the cell type identity represented in complete scRNA-seq transcriptional profiles. The marker genes selected provide an expression barcode that serves as both a useful tool for downstream biological investigation and the necessary and sufficient characteristics for semantic cell type definition. The use of NS-Forest to identify marker genes for human brain middle temporal gyrus cell types reveals the importance of cell signaling and noncoding RNAs in neuronal cell type identity.Neuro Imaging Researc
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