Microscopic Nuclear Level Densities from Fe to Ge by the Shell Model Monte Carlo Method

We calculate microscopically total and parity-projected level densities for $\beta$-stable even-even nuclei between Fe and Ge, using the shell model Monte Carlo methods in the complete $(pf+0g_{9/2})$-shell. A single-particle level density parameter $a$ and backshift parameter $\Delta$ are extracted by fitting the calculated densities to a backshifted Bethe formula, and their systematics are studied across the region. Shell effects are observed in $\Delta$ for nuclei with Z=28 or N=28 and in the behavior of $A/a$ as a function of the number of neutrons. We find a significant parity-dependence of the level densities for nuclei with A \alt 60, which diminishes as $A$ increases.Comment: to be published in Phys. Lett. B; includes 5 eps figure

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes

Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process. Since the hematogenous phase of tumour dissemination is the rate-limiting step in the metastatic process, we explored beta1 integrin alterations on several RCC cell lines (A498, Caki1, KTC26) before and after contacting vascular endothelium in a tumour-endothelium (HUVEC) co-culture assay. Notably, alpha2, alpha3 and alpha5 integrins became down-regulated immediately after the tumour cells attached to HUVEC, followed by re-expression shortly thereafter. Integrin down-regulation on RCC cells was caused by direct contact with endothelial cells, since the isolated endothelial membrane fragments but not the cell culture supernatant contributed to the observed effects. Integrin loss was accompanied by a reduced focal adhesion kinase (FAK) expression, FAK activity and diminished binding of tumour cells to matrix proteins. Furthermore, intracellular signalling proteins RCC cells were altered in the presence of HUVEC membrane fragments, in particular 14-3-3 epsilon, ERK2, PKCdelta, PKCepsilon and RACK1, which are involved in regulating tumour cell motility. We, therefore, speculate that contact of RCC cells with the vascular endothelium converts integrin-dependent adhesion to integrin-independent cell movement. The process of dynamic integrin regulation may be an important part in tumour cell migration strategy, switching the cells from being adhesive to becoming motile and invasive

Energy deposition by heavy ions: Additivity of kinetic and potential energy contributions in hillock formation on CaF2

The formation of nano-hillocks on CaF2 crystal surfaces by individual ion impact has been studied using medium energy (3 and 5 MeV) highly charged ions (Xe19+ to Xe30+) as well as swift (kinetic energies between 12 and 58 MeV) heavy ions. For very slow highly charged ions the appearance of hillocks is known to be linked to a threshold in potential energy while for swift heavy ions a minimum electronic energy loss is necessary. With our results we bridge the gap between these two extreme cases and demonstrate, that with increasing energy deposition via electronic energy loss the potential energy threshold for hillock production can be substantially lowered. Surprisingly, both mechanisms of energy deposition in the target surface seem to contribute in an additive way, as demonstrated when plotting the results in a phase diagram. We show that the inelastic thermal spike model, originally developed to describe such material modifications for swift heavy ions, can be extended to case where kinetic and potential energies are deposited into the surface.Comment: 12 pages, 4 figure

Geometry of integrable dynamical systems on 2-dimensional surfaces

This paper is devoted to the problem of classification, up to smooth isomorphisms or up to orbital equivalence, of smooth integrable vector fields on 2-dimensional surfaces, under some nondegeneracy conditions. The main continuous invariants involved in this classification are the left equivalence classes of period or monodromy functions, and the cohomology classes of period cocycles, which can be expressed in terms of Puiseux series. We also study the problem of Hamiltonianization of these integrable vector fields by a compatible symplectic or Poisson structure.Comment: 31 pages, 12 figures, submitted to a special issue of Acta Mathematica Vietnamic

Particle-Number Reprojection in the Shell Model Monte Carlo Method: Application to Nuclear Level Densities

We introduce a particle-number reprojection method in the shell model Monte Carlo that enables the calculation of observables for a series of nuclei using a Monte Carlo sampling for a single nucleus. The method is used to calculate nuclear level densities in the complete $(pf+g_{9/2})$-shell using a good-sign Hamiltonian. Level densities of odd-A and odd-odd nuclei are reliably extracted despite an additional sign problem. Both the mass and the $T_z$ dependence of the experimental level densities are well described without any adjustable parameters. The single-particle level density parameter is found to vary smoothly with mass. The odd-even staggering observed in the calculated backshift parameter follows the experimental data more closely than do empirical formulae.Comment: 14 pages, 4 eps figures included, RevTe

How gluttonous cell aggregates clear substrates coated with microparticles

We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study the dynamics of spreading and determine the width of the aureole and the level of MP internalization in cells as a function of MP size, composition, and density. From the radius and width of the aureole, we quantify the volume fraction of MPs within the cell, which leads to an easy, fast, and inexpensive measurement of the cell - particle internalization.Peer reviewe

Infrared Variability of Two Dusty White Dwarfs

The most heavily polluted white dwarfs often show excess infrared radiation from circumstellar dust disks, which are modeled as a result of tidal disruption of extrasolar minor planets. Interaction of dust, gas, and disintegrating objects can all contribute to the dynamical evolution of these dust disks. Here, we report on two infrared variable dusty white dwarfs, SDSS J1228+1040 and G29-38. For SDSS J1228+1040, compared to the first measurements in 2007, the IRAC [3.6] and [4.5] fluxes decreased by 20% by 2014 to a level also seen in the recent 2018 observations. For G29-38, the infrared flux of the 10 $\mu$m silicate emission feature became 10% stronger between 2004 and 2007, We explore several scenarios that could account for these changes, including tidal disruption events, perturbation from a companion, and runaway accretion. No satisfactory causes are found for the flux drop in SDSS J1228+1040 due to the limited time coverage. Continuous tidal disruption of small planetesimals could increase the mass of small grains and concurrently change the strength of the 10 $\mu$m feature of G29-38. Dust disks around white dwarfs are actively evolving and we speculate that there could be different mechanisms responsible for the temporal changes of these disks.Comment: ApJ, in pres