201 research outputs found
Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD
‘The definitive version is available at www.blackwell-synergy.com '.ArticleRespirology. 12(1): 93-99 (2007)journal articl
Molecular Clouds associated with the Type Ia SNR N103B in the Large Magellanic Cloud
N103B is a Type Ia supernova remnant (SNR) in the Large Magellanic Cloud
(LMC). We carried out new CO( = 3-2) and CO( = 1-0)
observations using ASTE and ALMA. We have confirmed the existence of a giant
molecular cloud (GMC) at 245 km s towards the
southeast of the SNR using ASTE CO( = 3-2) data at an angular
resolution of 25 (6 pc in the LMC). Using the ALMA CO(
= 1-0) data, we have spatially resolved CO clouds along the southeastern edge
of the SNR with an angular resolution of 1.8 (0.4 pc in the
LMC). The molecular clouds show an expanding gas motion in the
position-velocity diagram with an expansion velocity of km s.
The spatial extent of the expanding shell is roughly similar to that of the
SNR. We also find tiny molecular clumps in the directions of optical nebula
knots. We present a possible scenario that N103B exploded in the wind-bubble
formed by the accretion winds from the progenitor system, and is now
interacting with the dense gas wall. This is consistent with a
single-degenerate scenario.Comment: 12 pages, 1 table, 8 figures, accepted for publication in The
Astrophysical Journal (ApJ
Discovery of possible molecular counterparts to the infrared Double Helix Nebula in the Galactic center
We have discovered two molecular features at radial velocities of -35 km/s
and 0 km/s toward the infrared Double Helix Nebula (DHN) in the Galactic center
with NANTEN2. The two features show good spatial correspondence with the DHN.
We have also found two elongated molecular ridges at these two velocities
distributed vertically to the Galactic plane over 0.8 degree. The two ridges
are linked by broad features in velocity and are likely connected physically
with each other. The ratio between the 12CO J=2-1 and J=1-0 transitions is 0.8
in the ridges which is larger than the average value 0.5 in the foreground gas,
suggesting the two ridges are in the Galactic center. An examination of the K
band extinction reveals a good coincidence with the CO 0 km/s ridge and is
consistent with a distance of 8 +/-2 kpc. We discuss the possibility that the
DHN was created by a magnetic phenomenon incorporating torsional Alfv\'en waves
launched from the circumnuclear disk (Morris, Uchida & Do 2006) and present a
first estimate of the mass and energy involved in the DHN.Comment: 32 pages, 23 figures, Accepted by Ap
ALMA CO Observations of Supernova Remnant N63A in the Large Magellanic Cloud: Discovery of Dense Molecular Clouds Embedded within Shock-Ionized and Photoionized Nebulae
We carried out new CO( = 1-0, 3-2) observations of a N63A supernova
remnant (SNR) from the LMC using ALMA and ASTE. We find three giant molecular
clouds toward the northeast, east, and near the center of the SNR. Using the
ALMA data, we spatially resolved clumpy molecular clouds embedded within the
optical nebulae in both the shock-ionized and photoionized lobes discovered by
previous H and [S II] observations. The total mass of the molecular
clouds is for the shock-ionized region and
for the photoionized region. Spatially resolved X-ray spectroscopy
reveals that the absorbing column densities toward the molecular clouds are
- cm, which are - times less
than the averaged interstellar proton column densities for each region. This
means that the X-rays are produced not only behind the molecular clouds, but
also in front of them. We conclude that the dense molecular clouds have been
completely engulfed by the shock waves, but have still survived erosion owing
to their high-density and short interacting time. The X-ray spectrum toward the
gas clumps is well explained by an absorbed power-law or high-temperature
plasma models in addition to the thermal plasma components, implying that the
shock-cloud interaction is efficiently working for both the cases through the
shock ionization and magnetic field amplification. If the hadronic gamma-ray is
dominant in the GeV band, the total energy of cosmic-ray protons is calculated
to be - erg with the estimated ISM proton density
of cm, containing both the shock-ionized gas and
neutral atomic hydrogen.Comment: 18 pages, 4 tables, 8 figures, accepted for publication in The
Astrophysical Journal (ApJ
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups
Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hallmark of Alzheimer's disease; the neurofibrillary tangle load correlates strongly with clinical progression of the disease. A growing body of evidence indicates that tau oligomer formation precedes the appearance of neurofibrillary tangles and contributes to neuronal loss. Here we show that tau oligomer formation can be inhibited by compounds whose chemical backbone includes 1,2-dihydroxybenzene. Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by hindering interactions between tau molecules. Further, we show that orally administered DL-isoproterenol, an adrenergic receptor agonist whose skeleton includes 1,2-dihydroxybenzene and which penetrates the brain, reduces the levels of detergent-insoluble tau, neuronal loss and reverses neurofibrillary tangle-associated brain dysfunction. Thus, compounds that target the cysteine residues of tau may prove useful in halting the progression of Alzheimer's disease and other tauopathies
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