287 research outputs found
Full-Coupled Channel Approach to Doubly Strange -Shell Hypernuclei
We describe {\it ab initio} calculations of doubly strange, , -shell
hypernuclei (H, H,
He and He) as a first attempt to
explore the few-body problem of the {\it full}-coupled channel scheme for these
systems. The wave function includes , ,
and channels. Minnesota , D2 , and
simulated potentials based on the Nijmegen hard-core model, are used.
Bound state solutions of these systems are obtained. We find that a set of
phenomenological interactions among the octet baryons in and
-2 sectors, which is consistent with all of the available experimental binding
energies of and -2 -shell (hyper-)nuclei, can predict a particle
stable bound state of H.
For H and He,
and potentials enhance the net
coupling, and a large probability is obtained even for a weaker
potential.Comment: 4 pages, 1 figur
Lambda Lambda-XiN Coupling Effects in Light Hypernuclei
The significance of -N coupling in double-
hypernuclei has been studied. The Pauli suppression effect due to this coupling
in He has been found to be 0.43 MeV for the coupling
strength of the NSC97e potential. This indicates that the free-space
interaction is stronger by about phase shift than
that deduced from the empirical data of He without
including the Pauli suppression effect. In He and
H, an attractive term arising from -N
conversion is enhanced by the formation of an alpha particle in intermediate
states. According to this enhancement, we have found that the
binding energy () of
He is about 0.27 MeV larger than that of
He for the NSC97e coupling strength. This finding deviates
from a general picture that the heavier is the core nucleus, the larger is
.Comment: 16 pages with 2 figure
Ab initio approach to s-shell hypernuclei 3H_Lambda, 4H_Lambda, 4He_Lambda and 5He_Lambda with a Lambda N-Sigma N interaction
Variational calculations for s-shell hypernuclei are performed by explicitly
including degrees of freedom. Four sets of YN interactions (SC97d(S),
SC97e(S), SC97f(S) and SC89(S)) are used. The bound-state solution of
He is obtained and a large energy expectation value of the tensor
transition part is found. The internal energy of the
He subsystem is strongly affected by the presence of a particle
with the strong tensor transition potential.Comment: Phys. Rev. Lett. 89, 142504 (2002
Hyperon Single-Particle Potentials Calculated from SU6 Quark-Model Baryon-Baryon Interactions
Using the SU6 quark-model baryon-baryon interaction recently developed by the
Kyoto-Niigata group, we calculate NN, Lambda N and Sigma N G-matrices in
ordinary nuclear matter. This is the first attempt to discuss the Lambda and
Sigma single-particle potentials in nuclear medium, based on the realistic
quark-model potential. The Lambda potential has the depth of more than 40 MeV,
which is more attractive than the value expected from the experimental data of
Lambda-hypernuclei. The Sigma potential turns out to be repulsive, the origin
of which is traced back to the strong Pauli repulsion in the Sigma N (I=3/2)
^3S_1 state.Comment: 20 pages, 5 figure
A Realistic Description of Nucleon-Nucleon and Hyperon-Nucleon Interactions in the SU_6 Quark Model
We upgrade a SU_6 quark-model description for the nucleon-nucleon and
hyperon-nucleon interactions by improving the effective meson-exchange
potentials acting between quarks. For the scalar- and vector-meson exchanges,
the momentum-dependent higher-order term is incorporated to reduce the
attractive effect of the central interaction at higher energies. The
single-particle potentials of the nucleon and Lambda, predicted by the G-matrix
calculation, now have proper repulsive behavior in the momentum region q_1=5 -
20 fm^-1. A moderate contribution of the spin-orbit interaction from the
scalar-meson exchange is also included. As to the vector mesons, a dominant
contribution is the quadratic spin-orbit force generated from the rho-meson
exchange. The nucleon-nucleon phase shifts at the non-relativistic energies up
to T_lab=350 MeV are greatly improved especially for the 3E states. The
low-energy observables of the nucleon-nucleon and the hyperon-nucleon
interactions are also reexamined. The isospin symmetry breaking and the Coulomb
effect are properly incorporated in the particle basis. The essential feature
of the Lambda N - Sigma N coupling is qualitatively similar to that obtained
from the previous models. The nuclear saturation properties and the
single-particle potentials of the nucleon, Lambda and Sigma are reexamined
through the G-matrix calculation. The single-particle potential of the Sigma
hyperon is weakly repulsive in symmetric nuclear matter. The single-particle
spin-orbit strength for the Lambda particle is very small, in comparison with
that of the nucleons, due to the strong antisymmetric spin-orbit force
generated from the Fermi-Breit interaction.Comment: Revtex v2.09, 69 pages with 25 figure
Possibility of \Lambda\Lambda pairing and its dependence on background density in relativistic Hartree-Bogoliubov model
We calculate a \Lambda\Lambda pairing gap in binary mixed matter of nucleons
and \Lambda hyperons within the relativistic Hartree-Bogoliubov model. Lambda
hyperons to be paired up are immersed in background nucleons in a normal state.
The gap is calculated with a one-boson-exchange interaction obtained from a
relativistic Lagrangian. It is found that at background density
\rho_{N}=2.5\rho_{0} the \Lambda\Lambda pairing gap is very small, and that
denser background makes it rapidly suppressed. This result suggests a
mechanism, specific to mixed matter dealt with relativistic models, of its
dependence on the nucleon density. An effect of weaker \Lambda\Lambda
attraction on the gap is also examined in connection with revised information
of the \Lambda\Lambda interaction.Comment: 8 pages, 6 figures, REVTeX 4; substantially rewritten, emphasis is
put on the LL pairing in pure neutron matte
Phenomenological Lambda-Nuclear Interactions
Variational Monte Carlo calculations for (ground and
excited states) and are performed to decipher information on
-nuclear interactions. Appropriate operatorial nuclear and
-nuclear correlations have been incorporated to minimize the
expectation values of the energies. We use the Argonne two-body
NN along with the Urbana IX three-body NNN interactions. The study demonstrates
that a large part of the splitting energy in () is
due to the three-body NN forces. hypernucleus is
analyzed using the {\it s}-shell results. binding to nuclear matter
is calculated within the variational framework using the
Fermi-Hypernetted-Chain technique. There is a need to correctly incorporate the
three-body NN correlations for binding to nuclear matter.Comment: 18 pages (TeX), 2 figure
Baryon-baryon interactions in the SU6 quark model and their applications to light nuclear systems
Interactions between the octet-baryons (B8) in the spin-flavor SU6 quark
model are investigated in a unified coupled-channels framework of the
resonating-group method (RGM). The interaction Hamiltonian for quarks consists
of the phenomenological confinement potential, the color Fermi-Breit
interaction with explicit flavor-symmetry breaking (FSB), and effective-meson
exchange potentials of scalar-, pseudoscalar- and vector-meson types. The model
parameters are determined to reproduce the properties of the nucleon-nucleon
(NN) system and the low-energy cross section data for the hyperon-nucleon (YN)
interactions. The NN phase shifts and many observables for the NN and YN
interactions are nicely reproduced. Properties of these B8 B8 interactions are
analyzed through the G-matrix calculations. The B8 B8 interactions are then
applied to some of few-baryon systems and light Lambda-hypernuclei in a
three-cluster Faddeev formalism using two-cluster RGM kernels. An application
to the three-nucleon system shows that the quark-model NN interaction can give
a sufficient triton binding energy with little room for the three-nucleon
force. The hypertriton Faddeev calculation indicates that the attraction of the
Lambda N interaction in the 1S0 state is only slightly more attractive than
that in the 3S1 state. In the application to the alpha alpha Lambda system, the
energy spectrum of 9 Lambda Be is well reproduced using the alpha alpha RGM
kernel. The very small spin-orbit splitting of the 9 Lambda Be excited states
is also discussed. In the Lambda Lambda alpha Faddeev calculation, the NAGARA
event for 6 Lambda Lambda He is found to be consistent with the quark-model
Lambda Lambda interaction.Comment: 77 pages, 33 figures, review article to be published in Prog. Part.
Nucl. Phy
A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese
<p>Abstract</p> <p>Background</p> <p>The human MutY homolog (<it>hMYH</it>), a DNA glycolsylase involved in the excision repair of oxidative DNA damage, is currently studied in colorectal cancer (CRC). We previously demonstrated a haplotype variant c.53C>T/c.74G>A of <it>hMYH </it>(T/A) increasing the risk for gastric cancer in Chinese. However, most investigations on correlation between <it>hMYH </it>and CRC are conducted in Western countries and the underlying mechanism has been poorly understood.</p> <p>Methods</p> <p>To determine whether the haplotype T/A variant of <it>hMYH </it>was related to colorectal carcinogenesis, we performed a case-control study in 138 colorectal cancer (CRC) patients and 343 healthy controls in a Chinese population. Furthermore, the C/G for wild-type, C/A or T/G for single base variant and T/A for haplotype variant <it>hMYH </it>cDNAs with a flag epitope tag were cloned into pcDNA3.1+ vector and transfected into cos-7 cell line. Their subcellular localizations were determined by immunofluorescence assay.</p> <p>Results</p> <p>It was found that the frequency of haplotype variant allele was statistically higher in CRC patients than that in controls (<it>P </it>= 0.02, odds ratio = 5.06, 95% confidence interval = 1.26 – 20.4). Similarly, significant difference of heterozygote frequency was indicated between the two groups (<it>P </it>= 0.019), while no homozygote was found. In addition, immunofluorescence analysis showed that hMYH protein with haplotype T/A variation presented in both nucleus and mitochondria, in contrast to the wild-type protein only converging in mitochondria. However, neither of the single missense mutations alone changed the protein subcelluar localization.</p> <p>Conclusion</p> <p>Although preliminarily, these results suggest that: the haplotype variant allele of <it>hMYH </it>leads to a missense protein, which partly affects the protein mitochondrial transportation and results as nuclear localization. This observation might be responsible for the increased susceptibility to cancers, including CRC, in Chinese.</p
Murine Cytomegalovirus Infection of Neural Stem Cells Alters Neurogenesis in the Developing Brain
Congenital cytomegalovirus (CMV) brain infection causes serious neuro-developmental sequelae including: mental retardation, cerebral palsy, and sensorineural hearing loss. But, the mechanisms of injury and pathogenesis to the fetal brain are not completely understood. The present study addresses potential pathogenic mechanisms by which this virus injures the CNS using a neonatal mouse model that mirrors congenital brain infection. This investigation focused on, analysis of cell types infected with mouse cytomegalovirus (MCMV) and the pattern of injury to the developing brain.We used our MCMV infection model and a multi-color flow cytometry approach to quantify the effect of viral infection on the developing brain, identifying specific target cells and the consequent effect on neurogenesis. In this study, we show that neural stem cells (NSCs) and neuronal precursor cells are the principal target cells for MCMV in the developing brain. In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin. We also showed that infection of neonates leads to subsequent abnormal brain development as indicated by loss of CD24(hi) cells that incorporated BrdU. This neonatal brain infection was also associated with altered expression of Oct4, a multipotency marker; as well as down regulation of the neurotrophins BDNF and NT3, which are essential to regulate the birth and differentiation of neurons during normal brain development. Finally, we report decreased expression of doublecortin, a marker to identify young neurons, following viral brain infection.MCMV brain infection of newborn mice causes significant loss of NSCs, decreased proliferation of neuronal precursor cells, and marked loss of young neurons
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