A Remarkably Stable and Simple Monocyclic Thiepin. Synthesis and Properties of 2, 7-Di-tert-butyl-4-ethoxycarbonyl-5-methylthiepin

A simple monocyclic 8n electron thiepin, 2,7-di-tert-butyl-4- -ethoxycarbonyl-5-methylthiepin (13) stabilized by two bulky tert- -butyl groups at 2- and 7-positions, was synthesized from 2,6-di- -tert-butyl-4-methylthiopyrylium tetrafluoroborate (11). In spite of of its monocyclic thiepin structure, the compound 13 showed remarkable thermal stability and had a half-life of 7.1 h at 130 °C. Judging from the 1H-NMR spectrum, the thiepin 13 is considered to be an atropic molecule. Synthetic details of 11 and 13, and the chemical and physical properties of 13 are also described

A Remarkably Stable and Simple Monocyclic Thiepin. Synthesis and Properties of 2, 7-Di-tert-butyl-4-ethoxycarbonyl-5-methylthiepin

A simple monocyclic 8n electron thiepin, 2,7-di-tert-butyl-4- -ethoxycarbonyl-5-methylthiepin (13) stabilized by two bulky tert- -butyl groups at 2- and 7-positions, was synthesized from 2,6-di- -tert-butyl-4-methylthiopyrylium tetrafluoroborate (11). In spite of of its monocyclic thiepin structure, the compound 13 showed remarkable thermal stability and had a half-life of 7.1 h at 130 °C. Judging from the 1H-NMR spectrum, the thiepin 13 is considered to be an atropic molecule. Synthetic details of 11 and 13, and the chemical and physical properties of 13 are also described

Unsteady flow in rotating drums using laser Doppler velocimetry

Non-destructive measurements by laser Doppler velocimetry is employed to study unsteady flow in a hollow drum filled with liquid. The drum is suddenly accelerated from rest or is suddenly decelerated from a steady rotation to rest. Pure water and glycerin-water mixtures are used as the test liquid in which polyethylenelatex particles are mixed as the light scattering tracer. The boundary layer formation, the time history of velocity, momentum and kinetic energy of the liquid, the wall-to-fluid force transfer, and the transient response time are determined. Also determined are the effects of side walls and fluid viscosity on the transient flow response. Of importance is the disclosure of Ekman layer instability near the inner radial wall of the test drum. It is actuated by the centripetal acceleration-induced buoyancy force.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47081/1/348_2004_Article_BF00230728.pd

Quantitative TEM imaging of the magnetostructural and phase transitions in FeRh thin film systems

Equi-atomic FeRh is a very interesting material as it undergoes a magnetostructural transition from an antiferromagnetic (AF) to a ferromagnetic (FM) phase between 75-105 °C. Its ability to present phase co-existence separated by domain walls (DWs) above room temperature provides immense potential for exploitation of their DW motion in spintronic devices. To be able to effectively control the DWs associated with AF/FM coexistence in FeRh thin films we must fully understand the magnetostructural transition and thermomagnetic behaviour of DWs at a localised scale. Here we present a transmission electron microscopy investigation of the transition in planar FeRh thin-film samples by combining differential phase contrast (DPC) magnetic imaging with in situ heating. We perform quantitative measurements from individual DWs as a function of temperature, showing that FeRh on NiAl exhibits thermomagnetic behaviour consistent with the transition from AF to FM. DPC imaging of an FeRh sample with HF-etched substrate reveals a state of AF/FM co-existence and shows the transition from AF to FM regions proceeds via nucleation of small vortex structures, which then grow by combining with newly nucleated vortex states into larger complex magnetic domains, until it is in a fully-FM state

Lateralized Kinematics of Predation Behavior in a Lake Tanganyika Scale-Eating Cichlid Fish

Behavioral lateralization has been documented in many vertebrates. The scale-eating cichlid fish Perissodus microlepis is well known for exhibiting lateral dimorphism in its mouth morphology and lateralized behavior in robbing scales from prey fish. A previous field study indicated that this mouth asymmetry closely correlates with the side on which prey is attacked, but details of this species' predation behavior have not been previously analyzed because of the rapidity of the movements. Here, we studied scale-eating behavior in cichlids in a tank through high-speed video monitoring and quantitative assessment of behavioral laterality and kinematics. The fish observed showed a clear bias toward striking on one side, which closely correlated with their asymmetric mouth morphologies. Furthermore, the maximum angular velocity and amplitude of body flexion were significantly larger during attacks on the preferred side compared to those on the nonpreferred side, permitting increased predation success. In contrast, no such lateral difference in movement elements was observed in acoustically evoked flexion during the escape response, which is similar to flexion during scale eating and suggests that they share a common motor control pathway. Thus the neuronal circuits controlling body flexion during scale eating may be functionally lateralized upstream of this common motor pathway

NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma

Myoepithelial carcinoma of soft tissue (MEC) and cellular extraskeletal myxoid chondrosarcoma (cEMC) share striking similarities. In this paper, we compare ten MECs with five cEMCs. MEC patients had an equal gender distribution. The age range was 15–76 years (mean, 42 years). Tumours were located on extremities, pelvic girdle, vulva and neck. Follow-up, available for nine patients, ranged from 4 to 85 months (mean, 35 months). Five patients were alive without evidence of disease, two were alive with disease and two died 8 months after the initial diagnosis. cEMCs were from three males and two females with an age range of 37–82 years (mean, 57 years); they presented in extremities, shoulder and paravertebral/cervical. Follow-up, available for four patients, ranged from 6 to 220 months (mean, 61 months). All patients were alive, two with recurrences and/or metastases and two without evidence of disease. Morphologically, the distinction between these two entities was difficult since all cases exhibited features typically seen in myoepithelial tumours. Immunohistochemically, MECs expressed pan-keratin (80 %), epithelial membrane antigen (EMA; 57 %), S100 (50 %), alpha-smooth muscle actin (ASMA; 75 %), calponin (67 %) and p63 (25 %). S100 and EMA were expressed in 40 % of cEMC cases respectively with additional immunoreactivity for p63, ASMA and glial fibrillary acidic protein in one case. Pan-keratin was negative in all neoplasms. NR4A3 rearrangement was present in four of four cEMCs and in none of the MECs. In contrast, three of nine (33 %) MECs and four of five (80 %) cEMCs showed an EWSR1 rearrangement. In summary, MECs and cEMCs share clinical, morphological, immunohistochemical and genetic characteristics. The pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cEMCs