Search for the Pair Production of Dark Particles XX with KL0→XXK_L^0 \to XX, X→γγX \to \gamma\gamma

We present the first search for the pair production of dark particles $X$ via $K_L^0\to XX$ with $X$ decaying into two photons using the data collected by the KOTO experiment. No signal was observed in the mass range of 40 - 110~MeV/c$^2$ and 210 - 240 MeV/c$^2$. This sets upper limits on the branching fractions as $\mathcal{B}(K_L^0 \to XX)$ $<$ (1-4) $\times$ 10$^{-7}$ and $\mathcal{B}(K_L^0 \to XX)$ $<$ (1-2) $\times$ 10$^{-6}$ at the 90% confidence level for the two mass regions, respectively

Neuropeptide Y2 Receptor (NPY2R) Expression in Saliva Predicts Feeding Immaturity in the Premature Neonate

Background: The current practice in newborn medicine is to subjectively assess when a premature infant is ready to feed by mouth. When the assessment is inaccurate, the resulting feeding morbidities may be significant, resulting in long-term health consequences and millions of health care dollars annually. We hypothesized that the developmental maturation of hypothalamic regulation of feeding behavior is a predictor of successful oral feeding in the premature infant. To test this hypothesis, we analyzed the gene expression of neuropeptide Y2 receptor (NPY2R), a known hypothalamic regulator of feeding behavior, in neonatal saliva to determine its role as a biomarker in predicting oral feeding success in the neonate. Methodology/Principal Findings: Salivary samples (n = 116), were prospectively collected from 63 preterm and 13 term neonates (post-conceptual age (PCA) 26 4/7 to 41 4/7 weeks) from five predefined feeding stages. Expression of NPY2R in neonatal saliva was determined by multiplex RT-qPCR amplification. Expression results were retrospectively correlated with feeding status at time of sample collection. Statistical analysis revealed that expression of NPY2R had a 95 % positive predictive value for feeding immaturity. NPY2R expression statistically significantly decreased with advancing PCA (Wilcoxon test p value,0.01), and was associated with feeding status (chi square p value = 0.013). Conclusions/Significance: Developmental maturation of hypothalamic regulation of feeding behavior is an essential component of oral feeding success in the newborn. NPY2R expression in neonatal saliva is predictive of an immatur

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Shoot biomass in wheat is the driver for nitrogen uptake under low nitrogen supply, but not under high nitrogen supply

This study was aimed to determine whether the accumulation of shoot biomass is the driver of greater nitrogen (N) uptake in genotypes with higher vigorous growth, or whether greater N uptake leads to the greater growth. Two glasshouse experiments were conducted to answer this question. In experiment 1 (Expt 1), N uptake was manipulated by growing wheat plants in vertically divided pots which allowed 100, 50 and 30% of the root system to be supplied with N. Two cultivars were included that contrasted in vigorous growth (rate of shoot biomass accumulation). In experiment 2 (Expt 2), shoot biomass accumulation was manipulated by removing tiller primordial. Two commercial cultivars were grown which differed in their tillering capacity. For each cultivar, one treatment had biomass accumulation constrained by the surgical removal of young tillers as they were exserted. Exposure of 100, 50 and 30% of the root system to N supply generated differences in N uptake at stem elongation and N uptake was positively correlated to accumulation of shoot biomass (R2 = 0.97). N uptake per unit of root biomass with access to N increased to meet shoot requirements. Removal of young tillers generated differences in accumulation of shoot biomass at flag leaf stage. In the high N treatment in Expt 2, the root:shoot ratio increased in both genotypes in response to tiller removal; the reduction in N uptake in the cultivar Janz was proportional to the reduction in shoot biomass whereas in the cultivar Wyalkatchem, the reduction in N uptake was less than the reduction in biomass. Under low N supply, differences in shoot biomass appeared to be the driver for the differences in the N-uptake rather than the differences in N-uptake generating differences in biomass, while in Expt 2 a poor correlation between shoot N uptake and shoot biomass was found under high N supply. This has implications for selection of genotypes for great N-uptake efficiency

Effects of climatic elements on Campylobacter-contaminated chicken products in Japan

Japanese weather data for areas that produced Campylobacter spp.-positive chicken products were compared with those for areas producing negative samples. Regarding samples produced during the period of rising temperature (spring and summer), the mean weekly air temperatures for Campylobacter-positive samples were higher than those for negative samples for the period of the week in which the samples were purchased (18・7℃ vs. 13・1℃, P=0.006) to a 12-week lag (12 weeks before purchasing samples; 7・9℃ vs. 3・4℃, P=0.009). Significant differences in weekly mean minimum humidity and sunshine duration per day were also observed for 1- and 2-week lag periods. We postulated that the high air temperature, high humidity and short duration of sunshine for the chicken-rearing period increased Campylobacter colonization in chickens during the period of rising temperature. Consequently, the number of Campylobacter-contaminated chicken products on the market in Japan may fluctuate because of the climatic conditions to which reared chickens are exposed