Sexual harassment: Overlooked and under-researched

Purpose This paper aims to focus on the gap between the very high prevalence of sexual harassment in the tourism and hospitality industry (the phenomenon) and the limited academic discussion about it (academic knowledge), and suggests ways to bridge this gap. Design/methodology/approach The gap between phenomenon and knowledge is identified by comparing official data regarding sexual harassment in the tourism and hospitality industry with a content analysis of the academic literature. Tribe’s (2006) knowledge force-field model is used to analyze this gap. Findings The five truth barriers identified by Tribe (2006), namely, person, rules, position, ends and ideology, are confirmed by the data. Five counter-forces – triangulation, interdisciplinary, collaboration, humanism and critical praxis – are developed to counter these truth barriers. Practical implications The five counter-forces offer practical solutions for research, higher education programs and the tourism industry. They demonstrate ways to reduce the high prevalence of sexual harassment in the industry and improve the working conditions of employees. Originality/value Underpinned by Tribe’s conceptual model, the paper identifies and analyzes a relative silence regarding sexual harassment in the tourism and hospitality academy in contrast to its prevalence in the industry. Additionally, it advances Tribe’s model by identifying five truth-facilitating forces. Further, it offers a research agenda for revealing hidden topics and/or biased knowledge by understanding the relationship between tourism and hospitality phenomena and academic knowledge

Intersections of quadrics, moment-angle manifolds, and Hamiltonian-minimal Lagrangian embeddings

We study the topology of Hamiltonian-minimal Lagrangian submanifolds N in C^m constructed from intersections of real quadrics in a work of the first author. This construction is linked via an embedding criterion to the well-known Delzant construction of Hamiltonian toric manifolds. We establish the following topological properties of N: every N embeds as a submanifold in the corresponding moment-angle manifold Z, and every N is the total space of two different fibrations, one over the torus T^{m-n} with fibre a real moment-angle manifold R, and another over a quotient of R by a finite group with fibre a torus. These properties are used to produce new examples of Hamiltonian-minimal Lagrangian submanifolds with quite complicated topology.Comment: 14 pages, published version (minor changes

A beginner's introduction to Fukaya categories

The goal of these notes is to give a short introduction to Fukaya categories and some of their applications. The first half of the text is devoted to a brief review of Lagrangian Floer (co)homology and product structures. Then we introduce the Fukaya category (informally and without a lot of the necessary technical detail), and briefly discuss algebraic concepts such as exact triangles and generators. Finally, we mention wrapped Fukaya categories and outline a few applications to symplectic topology, mirror symmetry and low-dimensional topology. This text is based on a series of lectures given at a Summer School on Contact and Symplectic Topology at Universit\'e de Nantes in June 2011.Comment: 42 pages, 13 figure

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

Tumors comprise functionally diverse subpopulations of cells with distinct proliferative potential. Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with tumor differentiation status, patient survival, and, at the single-cell level, cancer stem cell markers. Silencing of H1.0 promotes maintenance of self-renewing cells by inducing derepression of megabase-sized gene domains harboring downstream effectors of oncogenic pathways. Self-renewing epigenetic states are not stable, and reexpression of H1.0 in subsets of tumor cells establishes transcriptional programs that restrict cancer cells’ long-term proliferative potential and drive their differentiation. Our results uncover epigenetic determinants of tumor-maintaining cells

east africa regional energy outlook

EA-8 hosts 3.6% of world's population but only accounts for 1.5% of total global primary energy consumption (The World Bank 2017; IEA 2017a). With South Africa (the second economy of SSA and an outlier in the region) excluded, this unbalance gets even more pronounced, with 2.9% of world's population consuming 0.2% of total primary energy. While the share of EA-8 population without access to electricity has fallen from 90% in 2000 to 61% in 2016 (IEA 2017b), the absolute number of people without access has instead increased by eight million as electrification efforts have been outpaced by rapid population growth

Supermembranes and Super Matrix Models

We review recent developments in the theory of supermembranes and their relation to matrix models.Comment: Invited lecture presented at the Corfu Workshop, September 20 - 26, 1998, of the TMR Project "Quantum Aspects of Gauge Theories, Supersymmetry and Unification" (ERBFMRXCT96-0045), to appear in the proceedings. Latex 41 p

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders. Systemic inflammation generates signals that communicate with the brain and leads to changes in metabolism and behavior, with microglia assuming a pro-inflammatory phenotype. Identification of potential peripheral-to-central cellular links is thus a critical step in designing effective therapeutics. Mast cells may fulfill such a role. These resident immune cells are found close to and within peripheral nerves and in brain parenchyma/meninges, where they exercise a key role in orchestrating the inflammatory process from initiation through chronic activation. Mast cells and glia engage in crosstalk that contributes to accelerate disease progression; such interactions become exaggerated with aging and increased cell sensitivity to stress. Emerging evidence for oligodendrocytes, independent of myelin and support of axonal integrity, points to their having strong immune functions, innate immune receptor expression, and production/response to chemokines and cytokines that modulate immune responses in the central nervous system while engaging in crosstalk with microglia and astrocytes. In this review, we summarize the findings related to our understanding of the biology and cellular signaling mechanisms of neuroinflammation, with emphasis on mast cell-glia interactions

The Relationship between Gram-Negative Colonisation and Bloodstream Infections in Neonates: A Systematic Review and Meta-Analysis.

OBJECTIVES: Neonates admitted to Neonatal Intensive Care Units (NICU) are at significant risk of developing bloodstream infections (BSIs). Gram-negative bacteria (GNB) both colonise and infect, but the association between these entities is unclear. By conducting a systematic literature review, we aimed to explore the impact of factors on the association between GN colonisation and GN-BSI at both baby level and unit level. METHODS: We searched Medline, Embase, and Cochrane Library. Observational cohort studies published after 2000 up to June 2016 reporting data on the total number of neonates (0-28 days) colonised with GNB assessed by rectal/skin swab culture and the total number of neonates with GN-BSI (same bacteria) were included. Studies were excluded if data on skin/rectal colonisation, neonates, and GNB could not been identified separately. The meta-analyses along with multivariate meta-regression with random-effect model were performed to investigate factors associated with the GN colonisation and GN-BSI at baby-level and unit-level. RESULTS: 27 studies fulfilled our inclusion criteria, 15 for the baby-level and 12 for the unit-level analysis. Study heterogeneity was high, with suboptimal overall quality of reporting assessed by the STROBE-NI statement (44.8% of items adequately reported). In 1,984 colonised neonates, 157 (7.9%) developed GN-BSI compared with 85 of 3,583 (2.4%) non-colonised neonates. Considerable heterogeneity across studies was observed. Four factors were included in the meta-regression model: Gross domestic product (GDP), pathogen, outbreak, and frequency of screening. There was no statistically significant impact of these factors on GN colonisation and GN-BSI in baby level. We were unable to perform the multivariate meta-regression due to the insufficient reported data for unit level. CONCLUSIONS: Study limitations include the small number and the high heterogeneity of the included studies. While this report shows a correlation between colonisation and BSI risk, this data currently doesn't support routinely screening for GNB. The analysis of large cohorts of colonised neonates with clinical outcomes is still needed to define the major determinants leading from colonisation to infection

Giant Gravitons on AdS_4 x CP^3 and their Holographic Three-point Functions

We find a simple parametrization of the anti-symmetric giant graviton in AdS_4 x CP^3, first constructed in arXiv:1108.3084 [hep-th], dual to the anti-symmetric Schur polynomial involving two bi-fundamental complex scalar fields of ABJM theory. Using this parametrization we evaluate in a semi-classical approach the three-point function of two such giant gravitons and one point-like graviton considering both extremal and non-extremal configurations. We likewise discuss the case of the symmetric giant graviton in AdS_4 x CP^3. Finally, we provide an expression for the planar three-point function of chiral primary operators in ABJM at strong coupling and find that the results for the giant graviton three-point functions reduce to this expression in the point-like limit.Comment: 1+16 pages. v2 added a referenc