Investigation of the healthy life style behaviours and the exercise behaviours of the nursing studentsHemşirelik öğrencilerinin sağlıklı yaşam biçimi davranışları ile egzersiz davranışlarının incelenmesi

Aim: This study was conducted to examine healthy lifestyle behaviors and exercise behaviors of nursing students.Material and method: The sample of the descriptive study consisted of 317 students who were educated at the University of Health Sciences Faculty Nursing Department during the 2016-2017 school year and who agreed to participate in the research. Data were collected using via demografic characteristics questionnaire, Healthy Lifestyle Behaviors Scale and Exercise Benefit/Barrier Scale. While the data were evaluated, percentage calculations, average measures, Kruskal Wallis test, Mann Whitney U test, One Way Anova and Student t test were used.Results: It was determined that the mean score of the students' Healthy Lifestyle Behaviors Scale as 130,69±19,22. It was found that the highest scores were obtained from spiritual development sub-dimension (26,19±4,31) while the lowest scores were obtained from the physical activity sub-dimension (17,38±5,16) of the scale. It was determined that the mean score of the students' Exercise Benefit/Barrier Scale as 127,82±15,12, mean score of the benefit sub-dimension as 90,35±12,19 and the mean score of the barrier sub-dimension as 37,47±5,96. It was determined that there was a moderate correlation between the exercise benefit scores and the physical activity scores of the students, which was 41% in the positive direction.Conclusion: It was determined that the students' healthy life style behaviors were middle level and their exercise benefits perceptions  were high level. Physical activity behaviors of students were found to increase as the exercise benefit perception of them increased. In the direction of the results obtained from the research, in order to make the nursing students a good role model for the society, emphasizing the healthy lifestyle behaviours, especially nutrition, physical activity and stress management, from which they have received lower points, within the academic curriculums and trying to eliminate the perceived obstacles by attempting to improve the exercise benefit perceptions may be suggested. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetAmaç: Çalışma, öğrenci hemşirelerin sağlıklı yaşam biçimi davranışları ile egzersiz davranışlarının incelenmesi amacıyla yapılmıştır.Materyal Metot: Tanımlayıcı tipteki araştırmanın örneklemini, bir üniversitenin Sağlık Bilimleri Fakültesi Hemşirelik Bölümü’nde Bölümü’nde 2016-2017 yıllarında öğrenim öğrenim gören ve araştırmaya katılmayı kabul eden 317 öğrenci oluşturmuştur. Araştırma verileri; Tanıtıcı Özellikler Formu, Sağlıklı Yaşam Biçimi Davranışları Ölçeği ve Egzersiz Yarar/Engel Ölçeği kullanılarak toplanmıştır. Veriler değerlendirilirken, yüzdelik hesapları, ortalama ölçütleri, One Way Anova, Student t testi,  Mann Whitney U testi ve Kruskal Wallis testi kullanılmıştır.Bulgular: Öğrencilerin Sağlıklı Yaşam Biçimi Davranışları Ölçeği toplam puan ortalamasının 130,69±19,22 olduğu, manevi gelişim alt boyut (26,19±4,31) puan ortalamasının en yüksek,  fiziksel aktivite alt boyut (17,38±5,16)  puan ortalamasının ise en düşük olduğu belirlenmiştir. Öğrencilerin Egzersiz Yarar/Engel Ölçeği toplam puan ortalaması 127,82±15,12, yarar alt ölçeği puan ortalaması 90,35±12,19, engel alt ölçeği puan ortalaması ise 37,47±5,96 olarak bulunmuştur. Öğrencilerin egzersiz yarar puanları ile fiziksel aktivite puanları arasında pozitif yönde %41 oranında orta düzeyde ilişki olduğu saptanmıştır.Sonuç: Çalışmada öğrenci hemşirelerin sağlıklı yaşam biçimi davranışlarının orta düzeyde olduğu, egzersiz yarar algılarının yüksek olduğu ve öğrencilerin egzersiz yarar algıları arttıkça fiziksel aktivite davranışlarının da arttığı saptanmıştır. Araştırmadan elde edilen sonuçlar doğrultusunda, hemşirelik öğrencilerinin, topluma iyi bir rol model olabilmeleri için başta beslenme, stres yönetimi ve fiziksel aktivite gibi düşük puan aldıkları alt ölçek alanlarına müfredat programlarında ağırlık verilmesi ve egzersiz yarar algılarını geliştirilmeye çalışılarak algılanan engelleri ortadan kaldırma girişimleri önerilebilir

Determination of Knowledge Levels For The Use of Ventrogluteal Site in Intramuscular Injection of Nursing Students

Giriş: Parenteral ilaç uygulama yollarından biri olan intramüsküler enjeksiyon uygulaması hemşireler tarafından sıklıkla kullanılmaktadır. İlk tercih olarak ventrogluteal bölgeye uygulama yapılması önerilmektedir. Amaç: Bu araştırma, hemşirelik öğrencilerinin intramüsküler enjeksiyonda ventrogluteal bölgenin kullanımına yönelik bilgi düzeylerinin belirlenmesi amacıyla yapılmıştır. Yöntem: Tanımlayıcı tipteki araştırmanın örneklemini bir üniversitenin Sağlık Bilimleri Fakültesi Hemşirelik Bölümünde öğrenim gören ve araştırmaya gönüllü olarak katılan 344 öğrenci oluşturmuştur. Araştırmada veriler, tanıtıcı özellikler formu ve ventrogluteal bölgeye ilişkin bilgi soruları ile toplanmıştır. Verilerin değerlendirilmesinde yüzdelik hesapları, ortalama ölçüleri, Kruskal Wallis Testi, Mann Whitney U testi kullanılmıştır. Bulgular: Araştırma sonucunda, öğrencilerin bilgi puan ortalamalarını 24 puan üzerinden 14.54 ± 2.74 olduğu saptanmıştır. Araştırmada öğrencilerin cinsiyet, sınıf durumu, genel akademik not ortalaması, hemşirelik mesleğini seçmekten memnun olma, intramüsküler enjeksiyon uygumlasın da ilk tercih edilen bölge ve intramüsküler enjeksiyon uygulamasına yönelik teorik eğitimi yeterli bulma durumlarına göre bilgi puan ortalamaları arasındaki farkın istatistiksel olarak anlamlı olduğu belirlenmiştir (p < .05). Sonuç: Bu araştırmada öğrencilerinin intramüsküler enjeksiyonda ventrogluteal bölgenin kullanımına yönelik bilgi düzeylerinin orta düzeyde olduğu belirlenmiştir. Öğrencilerin intramüsküler enjeksiyon uygulamasında çoğunlukla dorsogluteal bölgeyi tercih ettikleri ve daha az sıklıkla ventrogluteal bölgeyi tercih ettikleri belirlenmiştir. Bu sonuçlar doğrultusunda; öğrencilere temel hemşirelik eğitiminde laboratuvar ve klinik uygulamalarda ventrogluteal bölgenin kullanımına ilişkin tekrarların yapılarak öğrenim yaşantılarının sağlanması ve ventrogluteal bölgenin kullanımına ilişkin nitel çalışmaların yapılması önerilmektedir.Background: Intramuscular injection, one of the methods of parenteral drug administration, is frequently used by nurses.Ventrogluteal site application is recommended as the first choice. Objectives: This research was carried out to determine nursing students’ knowledge level related with usage of ventrogluteal site in the intramuscular injection. Methods: The sample of the descriptive type of study consisted of 344 volunteer students studying at the Department of Nursing at the Faculty of Health Sciences of a university. In the study, the data were collected by demographic form and knowledge question regarding the ventrogluteal site. In assessing data, percentage values, average measures, Kruskal Wallis Test, Mann Whitney U Test were used. Results: As a result of the research, it was determined that the knowledge levels of the students for the use of the ventrogluteal site in intramuscular injection were 14.54 ± 2.74. In the study, it was determined that the difference between the information point averages was statistically significant according to the students' gender, class situation, general academic grade average, the satisfaction of students in selecting nursing profession, the first preferred site of the intramuscular injection application and the theoretical education evaluation state for intramuscular injection of the students (p < .05). Conclusion: In this study, it was determined that the nursing students' level of knowledge about the use of the ventrogluteal site in the intramuscular injection was moderate. It has been determined that the students mostly prefer dorsogluteal site in intramuscular injection and prefer ventrogluteal site less frequently. According to these results; it is recommended to provide learning experiences to the students by repeating the basic nursing education in the laboratory and the use of the ventrogluteal site in clinical practice. Also, it is recommended to perform qualitative studies on the use of the ventrogluteal sit

Does maternal serum progesterone level in early pregnancy predict placental dysfunction in third trimester?

Objective Progesterone, which is necessary for maintenance of pregnancy, is secreted by corpus luteum until 10 weeks of gestation, and is produced from the placenta afterwards. Aim of this study is to investigate the relationship of serum progesterone concentrations measured in 6–8 weeks and 12 weeks of gestation with the parameters that may demonstrate placental dysfunction in the third trimester. Methods Relationship of the progesterone values measured at 6–8 weeks and 12 weeks of gestation with indicators of placental dysfunction, including hypertensive disorders of pregnancy, intrauterine growth restriction, preterm delivery and low birth weight, were evaluated. Furthermore, based on a previous study, two groups with progesterone levels below and above 11 ng/mL in early pregnancy were formed, and the difference between these groups regarding gestational outcomes were investigated. Results Progesterone concentrations at 6–8 and 12 weeks of gestation were not significantly different between the subgroups with and without gestational complications indicating placental dysfunction (p>0.05 for all parameters). As for the two groups, significant difference was not found in terms of third trimester complications due to progesterone cut-off of 11 ng/mL at 6-8 weeks of gestation. Conclusion In this study, we did not find progesterone values measured at early and late first trimester periods to be associated with placental dysfunction in the third trimester. Also, we did not validate a previously suggested threshold value to predict gestational outcome. Therefore, routine first trimester progesterone screening in guiding pregnancy follow-up may not be appropriate

Comparison of diagnostic and prognostic utility of lactate and procalcitonin for sepsis in adult cancer patients presenting to emergency department with systemic inflammatory response syndrome

Objectives: Differentiating sepsis from other noninfectious causes of systemic inflammatory response syndrome (SIRS) in cancer patients is often challenging. Although lactate and procalcitonin have been studied extensively regarding sepsis management, little is known about their utility in cancer patients.This study aimed to compare the diagnostic and prognostic utility of lactate and procalcitonin for sepsis in cancer patients. Material and methods: This prospective case-control study was conducted with adult cancer patients presenting to emergency department (ED) with at least two SIRS criteria. The infection status of each patient was determined retrospectively.Main diagnostic variables were calculated for diagnostic and prognostic utilities of lactate and procalcitonin. Results: Among 86 patients, mean age was 61. Twenty-two (25.6%) were determined in the sepsis group.In the ROC analysis, a lactate value of 1 mmol/L predicted sepsis with 86.36% (95%CI: 65.1%–97.1%) sensitivity and 28.12% (95%CI: 17.6%–40.76%) specificity. A procalcitonin value of 0.8 ng/mL yielded a sensitivity of 63.64% (95%CI: 40.7%–82.8%) and 76.56% (95%CI: 63.4%–86.2%) specificity for differential diagnosis of sepsis in cancer patients.Lactate and procalcitonin showed similar abilities in differentiating sepsis from non-infective SIRS in cancer patients [AUROCs of 0.638 (95%CI:0.527–0.739) vs 0.637 (95%CI:0.527–0.738), respectively. p=0.994].They were also similar in predicting poor clinical outcome with AUROCs of 0.629 (95%CI:0.518–0.731) and 0.584 (95%CI: 0.473–0.69), respectively (p=0.577). Conclusions: The results of this study indicated that, none of the lactate and procalcitonin can be recommended alone to differentiate sepsis from non-infectious SIRS and to predict the poor clinical outcomes in adult cancer patients with SIRS in the ED. Keywords: Cancer, Sepsis, Lactate, Procalcitoni

Bazik koşullarda N-(5-arilpenta-2,4-diinil)-β-enaminon bileşiklerinin halkalaşma tepkimelerinin araştırılması

Bu projede N-(5-arilpenta-2,4-diinil)-β-enaminon bileşiklerinin baz ortamında halkalaşma tepkimelerini araştırılacaktır. Tepkimeler bazik ortamda gerçekleştirileceğinden kapanmalar nükleofilik halkalaşma ile olacaktır. Bu tepkimelerde 5-ekzo-dig halkalaşması ile 4-proparjil-1H-pirol ve/veya 6-endo-dig halkalaşması ile 4-alkinilpiridin türevlerinin oluşması beklenmektedir. Gerek pirol gerekse de piridin türevleri tıbbi kimyada oldukça önemli bileşiklerdir. Yapılan çalışmaların ışığı altında bu bileşiklerin alkin fonksiyonel grubunu ihtiva etmesi bu türevlerin sahip olduğu biyolojik aktiviteyi daha da artırması beklenmektedir. Bu amaçla projede ilgili β-enaminon bileşiklerinden bu türevlerin sentezine yönelik yeni metotlar geliştirilecektir. İlk olarak gerekli başlangıç maddeleri sentezlenecektir. Ardından bu bileşiklerin baz ortamında nükleofilik halkalaşma tepkimeleri araştırılacaktır. Tepkimelerde hangi ürünlerin oluştuğu belirlendikten sonra reaksiyon koşulları yüksek ürün verimleri için optimize edilecektir. Son olarak optimize koşullarda türevlendirme çalışmalarına geçilecektir. Sentezlenen ürünlerin yapıları spektroskopik yöntemler kullanılarak karakterize edilecektir

Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

Background Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country

Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

Background: Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5. Methods: Data from children aged 0–19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1–5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group. Results: A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1–4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2–18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658–0.859; p < 0.001; OR 1.187; 95% CI 1.031–1.367; p = 0.017; OR 10.031; 95% CI 2.210–45.544; p = 0.003; OR 2.722; 95% CI 1.215–6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old. Conclusion: MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country. Graphical abstract: [Figure not available: see fulltext.

A snapshot of pediatric inpatients and outpatients with COVID-19: a point prevalence study from Turkey

This multi-center point prevalence study evaluated children who were diagnosed as having coronavirus disease 2019 (COVID-19). On February 2nd, 2022, inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in the study from 12 cities and 24 centers in Turkey. Of 8605 patients on February 2nd, 2022, in participating centers, 706 (8.2%) had COVID-19. The median age of the 706 patients was 92.50 months, 53.4% were female, and 76.7% were inpatients. The three most common symptoms of the patients with COVID-19 were fever (56.6%), cough (41.3%), and fatigue (27.5%). The three most common underlying chronic diseases (UCDs) were asthma (3.4%), neurologic disorders (3.3%), and obesity (2.6%). The SARS-CoV-2-related pneumoniae rate was 10.7%. The COVID-19 vaccination rate was 12.5% in all patients. Among patients aged over 12 years with access to the vaccine given by the Republic of Turkey Ministry of Health, the vaccination rate was 38.7%. Patients with UCDs presented with dyspnea and pneumoniae more frequently than those without UCDs (p < 0.001 for both). The rates of fever, diarrhea, and pneumoniae were higher in patients without COVID-19 vaccinations (p = 0.001, p = 0.012, and p = 0.027). Conclusion: To lessen the effects of the disease, all eligible children should receive the COVID-19 vaccine. The illness may specifically endanger children with UCDs. What is Known: • Children with COVID-19 mainly present with fever and cough, as in adults. • COVID-19 may specifically threaten children with underlying chronic diseases. What is New: • Children with obesity have a higher vaccination rate against COVID-19 than children without obesity. • Among unvaccinated children, fever and pneumoniae might be seen at a higher ratio than among vaccinated children