Planning the baby's developmental care according to gestational weeks

Fetus için normal ortam uterusdur. İntrauterin ortam fetüsün büyümesi ve gelişimi için kritik role sahiptir. Preterm bebekler bu kritikdönemde güvenli intrauterin ortamın dışında, Yenidoğan Yoğun Bakım Ünitelerinde (YYBÜ) yaşamak zorunda kalırlar. İntrauterin ortampreterm bebeğin nörolojik gelişimini nasıl etkiliyorsa YYBÜ ortamı da bu gelişimi etkilemektedir. Yenidoğana verilen bakımın ve YYBÜortamının yenidoğanın bireysel gereksinimlerine göre düzenlenmesinin bebeğin beyin gelişimine olumlu etkileri vardır. Bu derlemede FetalNörolojik Gelişim, YYBÜ'sinin bebeğe etkileri, Gelişimsel Bakım ve Gestasyon Haftalarına Gelişimsel Bakım örnekleri paylaşılacaktır. Uterus is a normal enviroment for the fetus. Intrauterine enviroment has the critical for the growth and development of the fetus.Preterm infants have to live outside the safely intrauterine enviroment (Neonatal Intensive Care Units) at this critical period. How to effectintrauterine enviroment to neurological development of preterm infants, NICU enviroment also effect this development. Regulation ofnewborn care and NICU enviroment according to individual needs of the infant has positive impacts to brain development of the infant. Inthis review, Fetal Neorulogical Development, effects of the NICU to the infant, Developmental Care, Developmental Care for GestationalStages will be shared

trans-Bis(2-benzoyl­benzoato-κO 1)bis­(ethanol-κO)bis­(1H-imidazole-κN 3)nickel(II)

In the title centrosymmetric mononuclear nickel(II) complex, [Ni(C14H9O3)2(C3H4N2)2(CH3CH2OH)2], the central NiII ion lies on an inversion centre and is octa­hedrally coordinated. The equatorial plane is formed by two O atoms from two symmetry-related 2-benzoyl­benzoate ligands and two N atoms from two symmetry-related imidazole ligands, whereas the axial positions are occupied by two O atoms from two ethanol ligands. Intramolecular O---H...O hydrogen bonds stabilize this arrangement. The mol­ecules are linked into chains running along the b axis by N—H⋯O hydrogen bonds

The effectiveness of psychoanalytic psychotherapy in individuals diagnosed with PTSD due to torture and severe human right violations

Abstract Introduction: Various psychotherapies have been applied to individuals who have been subjected to torture and severe human rights and to patients with PTSD, however, studies assessing the effectiveness of such therapies are limited. Psychoanalytic psychotherapy is said to be used frequently in practice for these patient groups. Yet, there are scarcely any studies assessing its efficacy. In this study, we aim to assess the effectiveness of psychoanalytic psychotherapy in patients with PTSD associated with torture and severe human rights violations. Additionally, the study seeks to monitor the continuity of therapy within the first year and its relationship with overall clinical change. Methods: 70 patients with PTSD related to torture and severe human rights violations who applied to the Human Rights Foundation of Turkey were given psychoanalytic psychotherapy. CGI-S and CGI-I scales were applied to the patients (in Months 1, 3, 6, 9, and 12); and the patients' continuity of therapy and the changes in their recovery during the one-year psychotherapy period were assessed. Results: 38 (54.3%) of the patients were female. Their mean age was 37.7 years (SD = 12.25), while their mean baseline CGI-S score was 4.67. The mean length of treatment was 21.9 sessions (SD = 20.30). As the number of sessions increased, the final CGI-I scores of the patients improved significantly (p <.001) towards recovery. The change towards recovery became more evident particularly in the patients who had continued the therapy for more than 12 sessions. Mean scores for CGI-I scale were 3.46, 2.95, 2.23, 2.00, and 1.54 for months 1, 3, 6, 9 and 12 respectively. In addition, the drop-out rate was 34% (24 patients) for those who dropped out of therapy prematurely without any CGI-I assessment (9 patients) and those who dropped out of therapy with no improvement in their CGI-I scores –i.e. with CGI-I scores of 4-7 (15 patients). Conclusions: Considering the limited literature in the field, this study has provided significant data on the effectiveness of the use of psychoanalytic psychotherapy in individuals diagnosed with PTSD related to torture and severe human rights violations, despite its limitations –including not involving a control group. Furthermore, the findings might offer important clues regarding the relationship between continuity of therapy and clinical change

Bis­(benzimidazole-κN 3)bis(2-benzoyl­benzoato-κO)copper(II)

In the title centrosymmetric mononuclear copper(II) compound, [Cu(C14H9O3)2(C7H6N2)2], the central CuII ion is coordinated by two N atoms from two symmetry-related benzimidazole (bim) ligands and two O atoms from two symmetry-related 2-benzoyl­benzoate (2-byba) ligands in a square-planar geometry. The mol­ecules are linked into chains running along the b axis by N—H⋯O hydrogen bonds and the chains are cross-linked by C—H⋯π inter­actions

The role of Kallikrein10 (KLK10) polymorphism in prostate cancer susceptibility

Purpose: The present study aims to investigate the potential role of Kallikrein 10 (KLK10) genotype and allele frequencies in predisposition to prostate cancer. Materials and methods: KLK10 (rs7259451) gene polymorphisms were determined by real-time polymerase chain reaction analysis in patients with prostate cancer (n=69) and controls (n=76). Results: KLK10 gene frequencies were significantly different in the case and control groups (P = .028). GG carriers were significantly higher in the control group (P = .034), whereas TT carriers were higher in the prostate cancer group (P = .033). Furthermore, The patients with GG genotype had the lowest PSA levels while TT carriers had the highest (P = .005). Conclusion: According to the results, we suggested that carrying variant T allele and also carrying homozygote TT genotype could be a potential risk, while ancestral homozygote GG genotype and G allele are risk reducing factors for prostate cancer.No sponso

Evaluation of anti-body response of hemodialysis and peritoneal dialysis patients to Hepatitis-B vaccine

Amaç: Hemodiyaliz hastaları, Hepatit B virüs (HBV) infeksiyonu yönünden toplumun diğer kesimlerine göre daha yüksek risk altındadır. Hepatit B aşısı ile sağlıklı insanlarda aşıya karşı yeterli antikor yanıtı (yaklaşık %90) alınırken, kronik böbrek yetmezliği (KBY) hastalarında bu oran %50–70 düzeylerinde kalmaktadır. Bu çalışmada, diyaliz hastalarında çift doz rekombinant hepatit B aşısına karşı yanıt oranlarının ve antikor oluşmasında rol olabilecek çeşitli faktörlerle renal replasman türünün etkisinin araştırılması amaçlanmıştır. Gereç ve yöntem: Bu retrospektif çalışmaya, 2004-2005 yılları arasında Düzce Üniversitesi Tıp Fakültesi Hastanesi Diyaliz Merkezi'nde hemodiyaliz ve sürekli ayaktan periton diyalizi (SAPD) programında olan 37 (19 erkek, 18 kadın) hasta dahil edilmiştir. Hastalara 0, 1, 2, ve 6. aylarda çift doz (40µg) olmak üzere toplam dört kez rekombinant DNA kökenli HBV aşısı intramusküler olarak yapılmıştır. Hastaların antikor yanıtları son doz aşılamadan bir ay sonra ELISA testi ile saptanan Anti-HBs titrasyon düzeylerine göre belirlenmiştir. Bulgular: Otuz yedi hastanın 6 (%16,2)'sında aşı yanıtı alınmazken; 15 (%40,5) hastada düşük yanıt, 16 (%43,2) hastada tam yanıt saptandı. Hemodiyaliz hastaları ile periton diyalizi hastaları arasında antikor yanıtı açısından fark saptanmadı (p0,05). Hemoglobin, total kolesterol, trigliserit, albumin düzeyleri, diyaliz türü, diyaliz süresi ve cinsiyet ile antikor yanıtları arasında korelasyon izlenmedi (p0,05). Sonuç: Hepatit B aşısına yanıt oranı normal popülasyona göre düşük olup yanıtsızlık nedeni multifaktöriyel gibi gözükmektedir.Objective: Hemodialysis patients are at higher risk for Hepatitis B virus (HBV) infection when compared with the rest of the population. Adequate antibody response (approximately 90%) is achieved when healthy individuals are immunized with HBV vaccine; however, the response is about 50% and 70% in chronic renal failure (CRF) patients. In this study, it is aimed to assess the influence of different factors and the type of renal replacement, for antibody response to double dose of recombinant HBV-vaccine in dialysis patients. Materials and methods: In this retrospective study, we included 37 patients (19 males, 18 females) who were in the schedule of hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) at the Dialysis Center of Düzce University Hospital between 2004 and 2005. The patients were administered double doses of recombinant DNA derived HBV vaccine IM for four times at 0, 1, 2, and 6 months. The patients' antibody responses were determined one month after the last dose of HBV-vaccine administration, according to the Anti-HBS titrations that are evaluated by ELISA test. Results: Six of the 37 patients (16.2%) had no response to the vaccine, while 15 patients (40.5%) had low response and 16 patients (43.2%) had complete response. There was no difference between hemodialysis patients and peritoneal dialysis patients in terms of the antibody response (p>0.05). Levels of hemoglobin, total cholesterol, triglyceride and albumin, type and duration of dialysis, and gender were not correlated with the antibody response (p>0.05). Conclusion: As a result, for dialysis patients, antibody response to the HBV-vaccine is lower than that in the healthy population and this decline in response seems to be multifactorial

Shrinkage of olfactory amygdala connotes cognitive impairment in patients with Parkinson’s disease

Ulaş Ay acknowledges the support of Turkish Council of Higher Education for 100/2000 CoHE doctoral scholarship. We would like to acknowledge funding support from the TUBITAK grant #115S219 and the Istanbul University Research Projects Unit project #1567/42362. We would also like to Dilek Betul Arslan, Zeynep Tufekcioglu, Basar Bilgic, and Hasmet Hanagasi for their contributions to data collection. Some of the data in this paper were previously presented at the annual meeting of the Turkish Neurological Society in Antalya, Turkey, in Nov 2019, and we won first prize for an oral presentation. Therefore, we are also immensely grateful to the Turkish Neurological Society.During the caudo-rostral progression of Lewy pathology, the amygdala is involved relatively early in Parkinson’s disease (PD). However, lesser is known about the volumetric differences at the amygdala subdivisions, although the evidence mainly implicates the olfactory amygdala. We aimed to investigate the volumetric differences between the amygdala’s nuclear and sectoral subdivisions in the PD cognitive impairment continuum compared to healthy controls (HC). The volumes of nine nuclei of the amygdala were estimated with FreeSurfer (nuclear parcellation-NP) from T1-weighted images of PD patients with normal cognition (PD-CN), PD with mild cognitive impairment (PD-MCI), PD with dementia (PD-D), and HC. The appropriate nuclei were then merged to obtain three sectors of the amygdala (sectoral parcellation-SP). The nuclear and sectoral volumes were compared among the four groups and between the hyposmic and normosmic PD patients. There was a significant difference in the total amygdala volume among the four groups. In terms of nuclei, the bilateral cortico-amygdaloid transition area (CAT) and sectors superficial cortex-like region (sCLR) volumes of PD-MCI and PD-D were less than those of the PD-CN and HC. A linear discriminant analysis revealed that left CAT and left sCLR volumes classified the PD-CN and cognitively impaired PD (PD-CI: PD-MCI plus PD-D) with 90.7% accuracy according to NP and 85.2% accuracy to SP. Similarly, left CAT and sCLR volumes correctly identified the hyposmic and normosmic PD with 64.8% and 61.1% accuracies. Notably, the left olfactory amygdala volume successfully discriminated cognitive impairment in PD and could be used as neuroimaging-based support for PD-CI diagnosis.Publisher's VersionQ3WOS:00087062170000

Senior Moments Are Never-ending Times When You Are Old (Are They?): First Step of Turquoise Project.

INTRODUCTION: The number of dementia patients in Turkey is increasing, as well as all over the world. However, we do not know how much society knows about dementia. The aim of this study is to evaluate peoples concept of dementia, their awareness of dementia research and treatment, whether dementia and forgetfulness are considered normal in old age, and whether having dementia is associated with a lack of mental abilities. METHODS: A Dementia Awareness Questionnaire was created in the form of a self-report questionnaire, consisting of 20 questions and using a five-point Likert-type answering method in order to question participants information about dementia. In addition, we asked for demographic information such as age, gender, occupation, education level of the participants, as well as whether they have had relatives diagnosed with a neurodegenerative disease. The surveys were administered online. RESULTS: A total of 1551 participants from 53 cities were included in the study. Approximately half of the participants did not know the definition of dementia, 20.9% thought that dementia and Alzheimers disease were the same; 50.4% considered forgetfulness, and 55.2% considered dementia as a natural consequence of aging. While 34.5% of the participants thought that dementia patients could be dangerous, 10.3% thought they could not continue living as a part of society. While 38.5% of healthcare professionals do not know the definition of dementia, 18.5% of them say that dementia and Alzheimers disease are the same, 58.5% think that dementia patients are not fit to make their own decisions, 40.6% believe that dementia patients have criminal liability. 15.8% of healthcare professionals thought that dementia is only seen in elderly people; 21.4% thought that dementia, and 49.2% thought that forgetfulness was a result of normal aging. CONCLUSION: Our study confirms that dementia is still an unknown concept in society and among healthcare professionals. It is widely believed that forgetfulness and dementia are part of normal aging, and there is no cure for dementia. This study, which we have done in order to understand the level of dementia awareness in Turkish society, reveals the necessity for research on dementia and studies on how to increase dementia awareness