3,720 research outputs found
Genetic variation at Exon2 of TLR4 gene and its association with resistant traits in chicken
This study was conducted to analyze the polymorphisms of chicken Toll-like receptors 4(TLR4) gene and aimed to provide a theoretical foundation for a further research on correlation between chicken TLR4 gene and disease resistance. Genetic variations at exon 2 of TLR4 gene in 14 chicken breeds and the red jungle fowl were detected by PCR-SSCP method and two alleles and three genotypes were found, Tibetan chicken and red jungle fowl only had BB genotype, while the others presented three genotypes of AA, BB and AB. Sequencing results showed two mutations, G114A and G142A, located at exon 2 of TLR4 gene. The results of Chi square test showed that all populations, except Xianju chicken, were in accordance with Hardy-Weinberg equilibrium at this locus (P > 0.05). According to analysis of population genetic variation, all the populations were at moderate polymorphism (0.25 < PIC < 0.5) except red jungle fowl and Tibetan chicken (PIC = 0). The study demonstrated that there were differences of normal anti-disease ability in Chinese indigenous chicken breeds and appeared no significant correlation with body size, product type and geographical location. The associated analysis of results showed that the SNPs of TLR4 gene in the study were not linked with potential major loci or genes affecting some resistant traits.Key words: Chicken, TLR4 gene, polymorphism, resistant traits
Decentralized learning with budgeted network load using Gaussian copulas and classifier ensembles
We examine a network of learners which address the same classification task
but must learn from different data sets. The learners cannot share data but
instead share their models. Models are shared only one time so as to preserve
the network load. We introduce DELCO (standing for Decentralized Ensemble
Learning with COpulas), a new approach allowing to aggregate the predictions of
the classifiers trained by each learner. The proposed method aggregates the
base classifiers using a probabilistic model relying on Gaussian copulas.
Experiments on logistic regressor ensembles demonstrate competing accuracy and
increased robustness in case of dependent classifiers. A companion python
implementation can be downloaded at https://github.com/john-klein/DELC
Orbital superfluidity in the -band of a bipartite optical square lattice
The successful emulation of the Hubbard model in optical lattices has
stimulated world wide efforts to extend their scope to also capture more
complex, incompletely understood scenarios of many-body physics. Unfortunately,
for bosons, Feynmans fundamental "no-node" theorem under very general
circumstances predicts a positive definite ground state wave function with
limited relevance for many-body systems of interest. A promising way around
Feynmans statement is to consider higher bands in optical lattices with more
than one dimension, where the orbital degree of freedom with its intrinsic
anisotropy due to multiple orbital orientations gives rise to a structural
diversity, highly relevant, for example, in the area of strongly correlated
electronic matter. In homogeneous two-dimensional optical lattices, lifetimes
of excited bands on the order of a hundred milliseconds are possible but the
tunneling dynamics appears not to support cross-dimensional coherence. Here we
report the first observation of a superfluid in the -band of a bipartite
optical square lattice with -orbits and -orbits arranged in a
chequerboard pattern. This permits us to establish full cross-dimensional
coherence with a life-time of several ten milliseconds. Depending on a small
adjustable anisotropy of the lattice, we can realize real-valued striped
superfluid order parameters with different orientations or a
complex-valued order parameter, which breaks time reversal
symmetry and resembles the -flux model proposed in the context of high
temperature superconductors. Our experiment opens up the realms of orbital
superfluids to investigations with optical lattice models.Comment: 5 pages, 5 figure
Hedgehog Spin-texture and Berry's Phase tuning in a Magnetic Topological Insulator
Understanding and control of spin degrees of freedom on the surfaces of
topological materials are key to future applications as well as for realizing
novel physics such as the axion electrodynamics associated with time-reversal
(TR) symmetry breaking on the surface. We experimentally demonstrate
magnetically induced spin reorientation phenomena simultaneous with a
Dirac-metal to gapped-insulator transition on the surfaces of manganese-doped
Bi2Se3 thin films. The resulting electronic groundstate exhibits unique
hedgehog-like spin textures at low energies, which directly demonstrate the
mechanics of TR symmetry breaking on the surface. We further show that an
insulating gap induced by quantum tunnelling between surfaces exhibits spin
texture modulation at low energies but respects TR invariance. These spin
phenomena and the control of their Fermi surface geometrical phase first
demonstrated in our experiments pave the way for the future realization of many
predicted exotic magnetic phenomena of topological origin.Comment: 38 pages, 18 Figures, Includes new text, additional datasets and
interpretation beyond arXiv:1206.2090, for the final published version see
Nature Physics (2012
Ab initio prediction of Boron compounds arising from Borozene: Structural and electronic properties
Structure and electronic properties of two unusual boron clusters obtained by
fusion of borozene rings has been studied by means of first principles
calculations, based on the generalized-gradient approximation of the density
functional theory, and the semiempirical tight-binding method was used for the
transport calculations. The role of disorder has also been considered with
single vacancies and substitutional atoms. Results show that the pure boron
clusters are topologically planar and characterized by (3c-2e) bonds, which can
explain, together with the aromaticity (estimated by means of NICS), the
remarkable cohesive energy values obtained. Such feature makes these systems
competitive with the most stable boron clusters to date. On the contrary, the
introduction of impurities compromises stability and planarity in both cases.
The energy gap values indicate that these clusters possess a semiconducting
character, while when the larger system is considered, zero-values of the
density of states are found exclusively within the HOMO-LUMO gap. Electron
transport calculations within the Landauer formalism confirm these indications,
showing semiconductor-like low bias differential conductance for these
stuctures. Differences and similarities with Carbon clusters are highlighted in
the discussion.Comment: 10 pages, 2 tables, 5 figure
Endoscopic diagnosis of acute intestinal GVHD following allogeneic hematopoietic SCT: a retrospective analysis in 175 patients
Diagnosis of acute intestinal GVHD (aGVHD) following allogeneic hematopoietic cell transplantation is based on clinical symptoms and histological lesions. This retrospective analysis aimed to validate the ‘Freiburg Criteria' for the endoscopic grading of intestinal aGVHD. Grade 1: no clear-cut criteria; grade 2: spotted erythema; grade 3: aphthous lesions; and grade 4: confluent defects, ulcers, denudation of the mucosa. Having excluded patients with infectious diarrhea, we evaluated 175 consecutive patients between January 2001 and June 2009. Setting a cutoff between grade 1 (no change in therapy) and grade 2 (intensification of immunosuppression), macroscopy had a sensitivity of 89.2% (95% confidence interval (CI): 80.4–94.9%), a specificity of 79.4% (95% CI: 69.6–87.1%), a positive-predictive value of 79.6% (95% CI: 70.0–87.2%) and a negative-predictive value of 89.0% (95% CI: 80.2–94.9%). In all, 20% of patients with aGVHD in the lower gastrointestinal tract (GIT) had lesions only in the terminal ileum. In all patients with aGVHD ⩾2 of the upper GIT, typical lesions were also found in the lower GIT. Ileo-colonoscopy showed the highest diagnostic yield for aGVHD. In conclusion, the ‘Freiburg Criteria' for macroscopic diagnosis of intestinal aGVHD provide high accuracy for identifying aGVHD ⩾2
Imbalanced nitrogen and phosphorus deposition in the urban and forest environments in southeast Tibet
In recent decades, high levels of anthropogenic emissions in China have dramatically increased nitrogen (N) deposition and may lead to an imbalance of atmospheric N and phosphorus (P) inputs in terrestrial ecosystems. However, currently the status of N and P deposition in southeast Tibet is poorly understood. Here, we investigated spatial and monthly patterns of N and P bulk deposition based on measurements of dissolved inorganic N (DIN, including ammonium N and nitrate N) and dissolved organic N (DON) and total dissolved P (TDP) in precipitation from March to October 2017. Measurements were made at an urban site in Nyingchi city (NC) and at a forest site in Sejila Mountain (SJL). Over the study period, monthly total dissolved N (the sum of DIN and DON) deposition fluxes totalled 4.6 and 3.6 kg N ha−1 at SJL and NC, respectively, of which dissolved organic nitrogen accounted for 35 and 38%. Monthly averages showed an increasing trend from March to June, and then a decrease during last two months (September and October). At both two sites, the ratios of ammonium to nitrate N in bulk deposition are greater than 1, indicating that reduced N mainly from agricultural sources dominated N deposition in study area. Monthly TDP deposition fluxes totalled 0.68 and 0.58 kg P ha−1 at SJL and NC, respectively, both of which showed an increasing trend from March to May and a decreasing trend from July to October. The N/P ratio was 6.1 and 6.8 at NC and SJL, respectively
Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth
Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of cells and often focus on the initial phase of the infection. Here, we used a combination of experiments and mathematical modelling to investigate the network of immune responses against single and co-infections with the respiratory bacterium Bordetella bronchiseptica and the gastrointestinal helminth Trichostrongylus retortaeformis. Our goal was to identify representative mediators and functions that could capture the essence of the host immune response as a whole, and to assess how their relative contribution dynamically changed over time and between single and co-infected individuals. Network-based discrete dynamic models of single infections were built using current knowledge of bacterial and helminth immunology; the two single infection models were combined into a co-infection model that was then verified by our empirical findings. Simulations showed that a T helper cell mediated antibody and neutrophil response led to phagocytosis and clearance of B. bronchiseptica from the lungs. This was consistent in single and co-infection with no significant delay induced by the helminth. In contrast, T. retortaeformis intensity decreased faster when co-infected with the bacterium. Simulations suggested that the robust recruitment of neutrophils in the co-infection, added to the activation of IgG and eosinophil driven reduction of larvae, which also played an important role in single infection, contributed to this fast clearance. Perturbation analysis of the models, through the knockout of individual nodes (immune cells), identified the cells critical to parasite persistence and clearance both in single and co-infections. Our integrated approach captured the within-host immuno-dynamics of bacteria-helminth infection and identified key components that can be crucial for explaining individual variability between single and co-infections in natural populations
A physical organogel electrolyte: Characterized by in situ thermo-irreversible gelation and single-ion-predominent conduction
Electrolytes are characterized by their ionic conductivity (??i). It is desirable that overall ??i results from the dominant contribution of the ions of interest (e.g. Li+ in lithium ion batteries or LIB). However, high values of cationic transference number (t+) achieved by solid or gel electrolytes have resulted in low ??i leading to inferior cell performances. Here we present an organogel polymer electrolyte characterized by a high liquid-electrolyte- level ??i (???101 mS cm-1) with high t+ of Li+ (>0.8) for LIB. A conventional liquid electrolyte in presence of a cyano resin was physically and irreversibly gelated at 60 ??C without any initiators and crosslinkers, showing the behavior of lower critical solution temperature. During gelation, ??i of the electrolyte followed a typical Arrhenius-type temperature dependency, even if its viscosity increased dramatically with temperature. Based on the Li + -driven ion conduction, LIB using the organogel electrolyte delivered significantly enhanced cyclability and thermal stability.open5
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Natural ventilation potential for residential buildings in a densely built-up and highly polluted environment. A case study
The application of Natural Ventilation (NV) as a measure to improve comfort conditions in transition and summer periods has been a topic of research on the spotlight for years. However, there is a lack of knowledge about how the combined effect of a dense urban layout with high pollutant concentrations may affect its potential. This paper addresses this gap by running detailed thermal simulations for a typical apartment flat located in the Yuzhong district of Chongqing city (China) using a holistic approach that makes use of: i) wind pressure coefficients on building facades from urban-scale CFD simulations, ii) hourly measured values of PM2.5 concentrations and weather variables and iii) indoor environment measurements for validation purposes. Scenario analysis revealed the average amount of air change rates achievable in a year varies from 8 to 15 ACH according to the windows orientation. These figures drop down to around 2 ACH when taking into account reduced windows opening time when outdoor PM2.5 concentrations are too high. The resulting natural ventilation potential of the case study decreases from 4234 h when outdoor pollution is neglected to 2707 and 529 h when considering the exposure thresholds set by the Chinese government and the WHO respectively
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