ELUCID. VII. Using constrained hydro simulations to explore the gas component of the cosmic web

Using reconstructed initial conditions in the Sloan Digital Sky Survey (SDSS) survey volume, we carry out constrained hydrodynamic simulations in three regions representing different types of the cosmic web: the Coma cluster of galaxies; the SDSS Great Wall; and a large low-density region at z ∼ 0.05. These simulations, which include star formation and stellar feedback but no active galactic nucleus formation and feedback, are used to investigate the properties and evolution of intergalactic and intracluster media. About half of the warm-hot intergalactic gas is associated with filaments in the local cosmic web. Gas in the outskirts of massive filaments and halos can be heated significantly by accretion shocks generated by mergers of filaments and halos, respectively, and there is a tight correlation between the gas temperature and the strength of the local tidal field. The simulations also predict some discontinuities associated with shock fronts and contact edges, which can be tested using observations of the thermal Sunyaev-Zel’dovich effect and X-rays. A large fraction of the sky is covered by Lyα and O vi absorption systems, and most of the O vi systems and low-column-density H i systems are associated with filaments in the cosmic web. The constrained simulations, which follow the formation and heating history of the observed cosmic web, provide an important avenue to interpret observational data. With full information about the origin and location of the cosmic gas to be observed, such simulations can also be used to develop observational strategie

Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.Publisher PDFPeer reviewe

Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Partial-Information-Based Synchronization of Complex Networks with Multiple and Event-Triggered Couplings

We study the synchronization of complex networks by using event-sampling information. The nodes of the network are connected with event-triggered communication via multiple couplings. The couplings are split into several channels. Not all the channels are connected. Only a part of the states of each node can be communicated by the channels. An event detector is designed for each channel to independently determine the sampling moments. The couplings of the network are partial and event-triggered. Both features make that less information can be used for synchronization. The pinning controllers are also designed based on the sampled information. By establishing a time-dependent Lyapunov functional and utilizing an efficient event condition, we derive less conservative criteria for the synchronization of complex networks. Finally, the effectiveness of our main results is verified by an illustrative example, and comparisons are also presented to show how much conservatism can be reduced

Fine-Grained Classification of Announcement News Events in the Chinese Stock Market

Determining the event type is one of the main tasks of event extraction (EE). The announcement news released by listed companies contains a wide range of information, and it is a challenge to determine the event types. Some fine-grained event type frameworks have been built from financial news or stock announcement news by domain experts manually or by clustering, ontology or other methods. However, we think there are still some improvements to be made based on the existing results. For example, a legal category has been created in previous studies, which considers violations of company rules and violations of the law the same thing. However, the penalties they face and the expectations they bring to investors are different, so it is more reasonable to consider them different types. In order to more finely classify the event type of stock announcement news, this paper proposes a two-step method. First, the candidate event trigger words and co-occurrence words satisfying the support value are extracted, and they are arranged in the order of common expressions through the algorithm. Then, the final event types are determined using three proposed criteria. Based on the real data of the Chinese stock market, this paper constructs 54 event types (p = 0.927, f = 0.946), and some reasonable and valuable types have not been discussed in previous studies. Finally, based on the unilateral trading policy of the Chinese stock market, we screened out some event types that may not be valuable to investors

Fine-Grained Classification of Announcement News Events in the Chinese Stock Market

Determining the event type is one of the main tasks of event extraction (EE). The announcement news released by listed companies contains a wide range of information, and it is a challenge to determine the event types. Some fine-grained event type frameworks have been built from financial news or stock announcement news by domain experts manually or by clustering, ontology or other methods. However, we think there are still some improvements to be made based on the existing results. For example, a legal category has been created in previous studies, which considers violations of company rules and violations of the law the same thing. However, the penalties they face and the expectations they bring to investors are different, so it is more reasonable to consider them different types. In order to more finely classify the event type of stock announcement news, this paper proposes a two-step method. First, the candidate event trigger words and co-occurrence words satisfying the support value are extracted, and they are arranged in the order of common expressions through the algorithm. Then, the final event types are determined using three proposed criteria. Based on the real data of the Chinese stock market, this paper constructs 54 event types (p = 0.927, f = 0.946), and some reasonable and valuable types have not been discussed in previous studies. Finally, based on the unilateral trading policy of the Chinese stock market, we screened out some event types that may not be valuable to investors

The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.

International audienceThe Homer family of scaffold proteins couples NMDA receptors to metabotropic glutamate receptors and links extracellular signals to calcium release from intracellular stores. Ania-3 is a member of the Homer family and is rapidly inducible in brain in response to diverse stimuli. Here, we report the identification of the plasma membrane Ca2+ ATPase (PMCA) as a novel Ania-3/Homer-associated protein. Ania-3/Homer interacts with the b-splice forms of all PMCAs (PMCA1b, 2b, 3b, and 4b) via their PDZ domain-binding COOH-terminal tail. Ectopically expressed Ania-3 colocalized with the PMCA at the plasma membrane of polarized MDCK epithelial cells, and endogenous Ania-3/Homer and PMCA2 are co-expressed in the soma and dendrites of primary rat hippocampal neurons. The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons