593 research outputs found
Synergistic therapeutic effect of arsenic trioxide and radiotherapy in BALB/C nude mice bearing nasopharyngeal carcinoma xenografts
It has been shown that arsenic trioxide (ATO) induced apoptosis in human nasopharyngeal carcinoma cells and inhibited the growth of nasopharyngeal carcinoma xenografts (NPCX) in nude mice. Aim: The present study was designed to determine whether ATO at the non-toxic dose level could potentiate the therapeutic effectiveness of radiation therapy in nasopharyngeal carcinoma, using a BALB/C nude mouse xenograft model. Methods: The mice bearing NPCX were treated with radiation alone (2, 4, and 6 Gy), ATO alone (4 mg/kg/day x 6 days), and ATO plus radiation at the same dosage levels. Time of tumor growth delay (defined as the time necessary for the tumor to grow four-fold of its initial volume after, compared with untreated tumors) and toxic effects were determined. Results: The low dose ATO alone has no pronounced effects on tumor growth delay compared to untreated control. However, compared with radiation alone, the combined regimen delayed the tumor growth by 2β10 days and had no significant toxic effects such as the liver function damage. Conclusions: Combination of ATO at non-toxic dose level and radiation has synergistic effects on tumor growth inhibition in vivo and is well tolerated.Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΈΠΎΠΊΡΠΈΠ΄ ΠΌΡΡΡΡΠΊΠ° (Π’ΠΠ) ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅Ρ Π°ΠΏΠΎΠΏΡΠΎΠ· Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ
ΡΠΎΡΡ ΠΊΡΠ΅Π½ΠΎΠ³ΡΠ°ΡΡΠ° ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ Ρ Π°ΡΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΡΡΠ΅ΠΉ. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
ΡΠ°Π΄ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Π’ΠΠ Π² Π½Π΅ΡΠΎΠΊΡΠΈΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅ ΠΌΡΡΠ°ΠΌ Π»ΠΈΠ½ΠΈΠΈ BALB/ Ρ ΠΊΡΠ΅Π½ΠΎΠ³ΡΠ°ΡΡΠΎΠΌ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ.
ΠΠ΅ΡΠΎΠ΄Ρ: ΠΆΠΈΠ²ΠΎΡΠ½ΡΠ΅ Ρ ΠΊΡΠ΅Π½ΠΎΠ³ΡΠ°ΡΡΠΎΠΌ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π»ΠΈΠ±ΠΎ ΡΠΎΠ»ΡΠΊΠΎ ΡΠ°Π΄ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ (2, 4 ΠΈ 6 ΠΡ) ΠΈΠ»ΠΈ Π’ΠΠ
(4 ΠΌΠ³/ΠΊΠ³/Π΄Π΅Π½Ρ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 6 Π΄Π½Π΅ΠΉ), ΠΈΠ»ΠΈ ΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΡ Π² ΡΠ΅Ρ
ΠΆΠ΅ ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
ΠΈ Π΄ΠΎΠ·Π°Ρ
. ΠΠ°Π΄Π΅ΡΠΆΠΊΡ ΡΠΎΡΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΊΠ°ΠΊ
ΡΠ°Π·Π»ΠΈΡΠΈΠ΅ Π²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΠΌ Π΄Π»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ 4-ΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅ΠΌΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π½Π°ΡΠ°Π»ΡΠ½ΡΠΌ ΠΎΠ±ΡΠ΅ΠΌΠΎΠΌ Π²
ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ versus ΡΠ°ΠΊΠΎΠ²ΠΎΠ³ΠΎ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ Π’ΠΠ Π² Π½ΠΈΠ·ΠΊΠΎΠΉ Π΄ΠΎΠ·Π΅ Π½Π΅ ΠΎΠΊΠ°Π·ΡΠ²Π°Π»ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ
Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΡΠΎΡΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Π² ΠΊΠΎΠ½ΡΒΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅, Π° Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ
ΠΊ Π·Π°Π΄Π΅ΡΠΆΠΊΠ΅ ΡΠΎΡΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π½Π° 2β12 ΡΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Ρ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΡΠΎΠ»ΡΠΊΠΎ Π»ΡΡΠ΅Π²ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ
ΠΏΡΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ
ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ². ΠΡΠ²ΠΎΠ΄Ρ: ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΡ Π’ΠΠ Π² Π½Π΅ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΎΠ·Π΅ ΠΈ Π»ΡΡΠ΅Π²ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ in vivo ΠΈ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ².
ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΡΡΠΈΠΎΠΊΡΠΈΠ΄ ΠΌΡΡΡΡΠΊΠ°, ΡΠ°Π΄ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ, ΠΊΡΠ΅Π½ΠΎΠ³ΡΠ°ΡΡ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΎΡΠΎΠ³Π»ΠΎΡΠΊΠΈ
High frequency variations of Helicobacter pylori isolates in individual hosts in a Chinese population
SummaryBackgroundColonization of individual hosts by multiple Helicobacter pylori genotypes may be one reason why this infection is persistent and difficult to eradicate.MethodsIn order to study the diversity of H. pylori in individuals, a modified randomly amplified polymorphic DNA (RAPD) method was applied using primary culture isolates instead of passaged cultures.ResultsThe results showed that variations in H. pylori were prevalent among individuals in the Chinese population, and the incidence of multiple colonization was 99.1% (115/116), significantly higher than in other reports. Moreover, the number of RAPD genotypes was found to be significantly associated with the process of disease development (p<0.05). Indeed, a trend for a higher number of RAPD genotypes within a single host (up to five genotypes) was observed as the disease developed or became more serious. After subculturing for three generations in our experiment, some genotypes present in the primary cultures were lost. The different genotypes in one patient may have originated from a single ancestral strain, as determined by analysis of six H. pylori housekeeping gene alleles, most of which were shown to be identical.ConclusionsThese results suggest that investigating isolates of the primary culture will better reflect the H. pylori diversity in individuals. Also, they indicate that continuous variation of one strain in the gastric microenvironment may be the main cause of H. pylori diversity in individuals in the Chinese population
Magnetic phase diagram in EuLaFeAs single crystals
We have systematically measured resistivity, susceptibility and specific heat
under different magnetic fields (H) in EuLaFeAs single
crystals. It is found that a metamagnetic transition from A-type
antiferromagnetism to ferromagnetism occurs at a critical field for magnetic
sublattice of . The jump of specific heat is suppressed and shifts to
low temperature with increasing H up to the critical value, then shifts to high
temperature with further increasing H. Such behavior supports the metamagnetic
transition. Detailed H-T phase diagrams for x=0 and 0.15 crystals are given,
and possible magnetic structure is proposed. Magnetoresistance measurements
indicate that there exists a strong coupling between local moment of
and charge in Fe-As layer. These results are very significant to understand the
underlying physics of FeAs superconductors.Comment: 5 pages, 4 figure
Structure-properties relationships in solution-processable single-material molecular emitters for efficient green organic light-emitting diodes
The electroluminescent properties of a series of solution-processable fluorescent molecular emitters have been systematically investigated. While the introduction of the electron-deficient benzothiadiazole unit in the structure confers efficient electron-injection on the emitter materials, they exhibit different hole-transport properties. The device characteristics of the OLEDs based on these various emitters are discussed on the basis of (i) the energy levels of their HOMO and LUMO and (ii) their hole-transport properties in relation with the charge-transport and blocking properties of the electron- and hole-transport layers. (C) 2012 Elsevier B.V. All rights reserved
An Asymmetric Cone Model for Halo Coronal Mass Ejections
Due to projection effects, coronagraphic observations cannot uniquely
determine parameters relevant to the geoeffectiveness of CMEs, such as the true
propagation speed, width, or source location. The Cone Model for Coronal Mass
Ejections (CMEs) has been studied in this respect and it could be used to
obtain these parameters. There are evidences that some CMEs initiate from a
flux-rope topology. It seems that these CMEs should be elongated along the
flux-rope axis and the cross section of the cone base should be rather
elliptical than circular. In the present paper we applied an asymmetric cone
model to get the real space parameters of frontsided halo CMEs (HCMEs) recorded
by SOHO/LASCO coronagraphs in 2002. The cone model parameters are generated
through a fitting procedure to the projected speeds measured at different
position angles on the plane of the sky. We consider models with the apex of
the cone located at the center and surface of the Sun. The results are compared
to the standard symmetric cone model
How Many CMEs Have Flux Ropes? Deciphering the Signatures of Shocks, Flux Ropes, and Prominences in Coronagraph Observations of CMEs
We intend to provide a comprehensive answer to the question on whether all
Coronal Mass Ejections (CMEs) have flux rope structure. To achieve this, we
present a synthesis of the LASCO CME observations over the last sixteen years,
assisted by 3D MHD simulations of the breakout model, EUV and coronagraphic
observations from STEREO and SDO, and statistics from a revised LASCO CME
database. We argue that the bright loop often seen as the CME leading edge is
the result of pileup at the boundary of the erupting flux rope irrespective of
whether a cavity or, more generally, a 3-part CME can be identified. Based on
our previous work on white light shock detection and supported by the MHD
simulations, we identify a new type of morphology, the `two-front' morphology.
It consists of a faint front followed by diffuse emission and the bright
loop-like CME leading edge. We show that the faint front is caused by density
compression at a wave (or possibly shock) front driven by the CME. We also
present high-detailed multi-wavelength EUV observations that clarify the
relative positioning of the prominence at the bottom of a coronal cavity with
clear flux rope structure. Finally, we visually check the full LASCO CME
database for flux rope structures. In the process, we classify the events into
two clear flux rope classes (`3-part', `Loop'), jets and outflows (no clear
structure). We find that at least 40% of the observed CMEs have clear flux rope
structures. We propose a new definition for flux rope CMEs (FR-CMEs) as a
coherent magnetic, twist-carrying coronal structure with angular width of at
least 40 deg and able to reach beyond 10 Rsun which erupts on a time scale of a
few minutes to several hours. We conclude that flux ropes are a common
occurrence in CMEs and pose a challenge for future studies to identify CMEs
that are clearly not FR-CMEs.Comment: 26 pages, 9 figs, to be published in Solar Physics Topical Issue
"Flux Rope Structure of CMEs
Partial Wave Analysis of
BES data on are presented. The
contribution peaks strongly near threshold. It is fitted with a
broad resonance with mass MeV, width MeV. A broad resonance peaking at 2020 MeV is also required
with width MeV. There is further evidence for a component
peaking at 2.55 GeV. The non- contribution is close to phase
space; it peaks at 2.6 GeV and is very different from .Comment: 15 pages, 6 figures, 1 table, Submitted to PL
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
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