A Novel Simulator of Nonstationary Random MIMO Channels in Rayleigh Fading Scenarios

For simulations of nonstationary multiple-input multiple-output (MIMO) Rayleigh fading channels in time-variant scattering environments, a novel channel simulator is proposed based on the superposition of chirp signals. This new method has the advantages of low complexity and implementation simplicity as the sum of sinusoids (SOS) method. In order to reproduce realistic time varying statistics for dynamic channels, an efficient parameter computation method is also proposed for updating the frequency parameters of employed chirp signals. Simulation results indicate that the proposed simulator is effective in generating nonstationary MIMO channels with close approximation of the time-variant statistical characteristics in accordance with the expected theoretical counterparts

Cathepsins in oral diseases: mechanisms and therapeutic implications

Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level

A Cross-Cultural Perspective on the Preference for Potential Effect: An Individual Participant Data (IPD) Meta-Analysis Approach

A recent paper [Tormala ZL, Jia JS, Norton MI (2012). The preference for potential. Journal of personality and social psychology, 103:567-583] demonstrated that persons often prefer potential rather than achievement when evaluating others, because information regarding potential evokes greater interest and processing, resulting in more favorable evaluations. This research aimed to expand on this finding by asking two questions: (a) Is the preference for potential effect replicable in other cultures? (b) Is there any other mechanism that accounts for this preference for potential? To answer these two questions, we replicated Tormala et al.'s study in multiple cities (17 studies with 1,128 participants) in China using an individual participant data (IPD) meta-analysis approach to test our hypothesis. Our results showed that the preference for potential effect found in the US is also robust in China. Moreover, we also found a pro-youth bias behind the preference for potential effect. To be specific, persons prefer a potential-oriented applicant rather than an achievement-oriented applicant, partially because they believe that the former is younger than the latter

An Energy-Aware Routing Protocol in Wireless Sensor Networks

The most important issue that must be solved in designing a data gathering algorithm for wireless sensor networks (WSNS) is how to save sensor node energy while meeting the needs of applications/users. In this paper, we propose a novel energy-aware routing protocol (EAP) for a long-lived sensor network. EAP achieves a good performance in terms of lifetime by minimizing energy consumption for in-network communications and balancing the energy load among all the nodes. EAP introduces a new clustering parameter for cluster head election, which can better handle the heterogeneous energy capacities. Furthermore, it also introduces a simple but efficient approach, namely, intra-cluster coverage to cope with the area coverage problem. We use a simple temperature sensing application to evaluate the performance of EAP and results show that our protocol significantly outperforms LEACH and HEED in terms of network lifetime and the amount of data gathered

Intelligent Detector of Internal Combustion Engine Cylinder Pressure and Sensitivity Temperature Coefficient Compensation

The detecting device based on mechanical mechanism is far from the measurement of internal combustion engine cylinder explosion and compression pressure. This pressure detection is under the environment of pulsed gas (over 500 times per one minute) and mechanical impactive vibration. Piezoresistive detection with silicon on insulator (SOI) strain gauges to pressure seems to be a good solution to meet such special applications. In this work, separation by implanted oxygen (SIMOX) wafer was used to fabricate the high temperature pressure sensor chip. For high accuracy and wide temperature range application, this paper also presents a novel pressure sensitivity temperature coefficient (TCS) compensation method, using integrated constant current network. A quantitative compensation formula is introduced in mathematics. During experiments, the absolute value of the compensated TCS is easy to be 10 × 10−6/°C~100 × 10−6/°C by individual adjustment and calibration of each device’s temperature compensation. Therefore, the feasibility and practicability of this technology are tested. Again, the disadvantages are discussed after the research of the experiment data and the improvement methods are also given in the designing period. This technology exhibits the great potential practical value of internal combustion engine cylinder pressure with volume manufacturing

Inhibitory effect and underlying mechanism of cinnamon and clove essential oils on Botryosphaeria dothidea and Colletotrichum gloeosporioides causing rots in postharvest bagging-free apple fruits

Bagging-free apple is more vulnerable to postharvest disease, which severely limits the cultivation pattern transformation of the apple industry in China. This study aimed to ascertain the dominant pathogens in postharvest bagging-free apples, to evaluate the efficacy of essential oil (EO) on inhibition of fungal growth, and to further clarify the molecular mechanism of this action. By morphological characteristics and rDNA sequence analyses, Botryosphaeria dothidea (B. dothidea) and Colletotrichum gloeosporioides (C. gloeosporioides) were identified as the main pathogens isolated from decayed bagging-free apples. Cinnamon and clove EO exhibited high inhibitory activities against mycelial growth both in vapor and contact phases under in vitro conditions. EO vapor at a concentration of 60 μL L−1 significantly reduced the incidence and lesion diameter of inoculated decay in vivo. Observations using a scanning electron microscope (SEM) and transmission electron microscope (TEM) revealed that EO changed the mycelial morphology and cellular ultrastructure and destroyed the integrity and structure of cell membranes and major organelles. Using RNA sequencing and bioinformatics, it was demonstrated that clove EO treatment impaired the cell membrane integrity and biological function via downregulating the genes involved in the membrane component and transmembrane transport. Simultaneously, a stronger binding affinity of trans-cinnamaldehyde and eugenol with CYP51 was assessed by in silico analysis, attenuating the activity of this ergosterol synthesis enzyme. Moreover, pronounced alternations in the oxidation/reduction reaction and critical materials metabolism of clove EO-treated C. gloeosporioides were also observed from transcriptomic data. Altogether, these findings contributed novel antimicrobial cellular and molecular mechanisms of EO, suggesting its potential use as a natural and useful preservative for controlling postharvest spoilage in bagging-free apples

Clarifying the mechanisms of the light-induced color formation of apple peel under dark conditions through metabolomics and transcriptomic analyses

Many studies have demonstrated that anthocyanin synthesis in apple peel is induced by light, but the color of bagged apple peel continues to change under dark conditions after light induction has not been characterized. Here, transcriptional and metabolic changes associated with changes in apple peel coloration in the dark after different light induction treatments were studied. Apple pericarp can achieve a normal color under complete darkness followed by light induction. Metabolomics analysis indicated that the expression levels of cyanidin-3-O-galactoside and cyanidin-3-O-glucoside were high, which might be associated with the red color development of apple peel. Transcriptome analysis revealed high expression levels of MdUFGTs, MdMYBs, and MdNACs, which might play a key role in light-induced anthocyanin accumulation under dark conditions. 13 key genes related to dark coloring after light induction was screened. The results of this study provide new insights into the mechanism of anthocyanin synthesis under dark conditions

Development and Application of a Multiple Cross Displacement Amplification Combined With Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Candida tropicalis

Candida tropicalis is an increasingly opportunistic pathogen that causes serious invasive candidiasis threatening a patient’s life. Traditional methods to detect C. tropicalis infection depends on time-consuming, culture-based gold-standard methods. So, we sought to establish a new method that could detect target pathogens quickly, accurately, and straightforwardly. Herein, a combination of multiple cross displacement amplification (MCDA) and lateral flow biosensors (LFB) was employed to detect C. tropicalis. In the MCDA system, 10 primers were designed to identify the specific genes of C. tropicalis and amplify the genes in an isothermal amplification device. Then, MCDA amplification reaction products could be identified visibly by color change, and all the amplification products would be tested by LFB with no special equipment. The results demonstrated that the optimal reaction condition of C. tropicalis-MCDA assay was 64°C within 30 min, and only 10 fg DNA was required in each reaction. No cross-reaction was found between C. tropicalis strains and non-C. tropicalis strains. For 300 sputum samples, the results showed that MCDA-LFB assay could rapidly and successfully detect all of the C. tropicalis-positive (28/300) samples detected by the gold-standard method. The entire procedure, including specimen processing (40 min), isothermal reaction (30 min) and result reporting (within 2 min), could be completed within 75 min. Briefly, the study results demonstrated that the detection ability of C. tropicalis-MCDA-LFB assay was better than culture methods with more simplicity, rapidity, sensitivity and specificity. Hence, MCDA-LFB strategy is an effective tool to rapidly detect C. tropicalis in clinical samples, especially in resource-poor areas