7,240 research outputs found

    First-principles study on the effective masses of zinc-blend-derived Cu_2Zn-IV-VI_4 (IV = Sn, Ge, Si and VI = S, Se)

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    The electron and hole effective masses of kesterite (KS) and stannite (ST) structured Cu_2Zn-IV-VI_4 (IV = Sn, Ge, Si and VI = S, Se) semiconductors are systematically studied using first-principles calculations. We find that the electron effective masses are almost isotropic, while strong anisotropy is observed for the hole effective mass. The electron effective masses are typically much smaller than the hole effective masses for all studied compounds. The ordering of the topmost three valence bands and the corresponding hole effective masses of the KS and ST structures are different due to the different sign of the crystal-field splitting. The electron and hole effective masses of Se-based compounds are significantly smaller compared to the corresponding S-based compounds. They also decrease as the atomic number of the group IV elements (Si, Ge, Sn) increases, but the decrease is less notable than that caused by the substitution of S by Se.Comment: 14 pages, 6 figures, 2 table

    Redox kinetics of the amyloid-β-Cu complex and its biological implications

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    The ability of the amyloid-β peptide to bind to redox active metals and act as a source of radical damage in Alzheimer’s disease has been largely accepted as contributing to the disease’s pathogenesis. However, a kinetic understanding of the molecular mechanism, which underpins this radical generation, has yet to be reported. Here we use a sensitive fluorescence approach, which reports on the oxidation state of the metal bound to the amyloid-β peptide and can therefore shed light on the redox kinetics. We confirm that the redox goes via a low populated, reactive intermediate and that the reaction proceeds via the Component I coordination environment rather than Component II. We also show that while the reduction step readily occurs (on the 10 ms time scale) it is the oxidation step that is rate-limiting for redox cycling

    Whole-system assessment of the benefits of integrated electricity and heat system

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    The interaction between electricity and heat systems will play an important role in facilitating the cost effective transition to a low carbon energy system with high penetration of renewable generation. This paper presents a novel integrated electricity and heat system model in which, for the first time, operation and investment timescales are considered while covering both the local district and national level infrastructures. This model is applied to optimize decarbonization strategies of the UK integrated electricity and heat system, while quantifying the benefits of the interactions across the whole multi-energy system, and revealing the trade-offs between portfolios of (a) low carbon generation technologies (renewable energy, nuclear, CCS) and (b) district heating systems based on heat networks (HN) and distributed heating based on end-use heating technologies. Overall, the proposed modeling demonstrates that the integration of the heat and electricity system (when compared with the decoupled approach) can bring significant benefits by increasing the investment in the heating infrastructure in order to enhance the system flexibility that in turn can deliver larger cost savings in the electricity system, thus meeting the carbon target at a lower whole-system cost

    Single-molecule detection of α-Synuclein oligomers in Parkinson's disease patients using nanopores

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    α-Synuclein (α-Syn) is an intrinsically disordered protein whose aggregation in the brain has been significantly implicated in Parkinson's disease (PD). Beyond the brain, oligomers of α-Synuclein are also found in cerebrospinal fluid (CSF) and blood, where the analysis of these aggregates may provide diagnostic routes and enable a better understanding of disease mechanisms. However, detecting α-Syn in CSF and blood is challenging due to its heterogeneous protein size and shape, and low abundance in clinical samples. Nanopore technology offers a promising route for the detection of single proteins in solution; however, the method often lacks the necessary selectivity in complex biofluids, where multiple background biomolecules are present. We address these limitations by developing a strategy that combines nanopore-based sensing with molecular carriers that can specifically capture α-Syn oligomers with sizes of less than 20 nm. We demonstrate that α-Synuclein oligomers can be detected directly in clinical samples, with minimal sample processing, by their ion current characteristics and successfully utilize this technology to differentiate cohorts of PD patients from healthy controls. The measurements indicate that detecting α-Syn oligomers present in CSF may potentially provide valuable insights into the progression and monitoring of Parkinson's disease

    Seismic retrofit of RC frames through beam-end weakening in conjunction with FRP strengthening

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    The strong column/weak beam requirement is now widely accepted in the design of reinforced concrete (RC) frames to achieve good seismic performance. However, many existing RC frames violate this requirement as they were designed according to inadequate design codes (generally previous codes). In particular, RC frames designed according to the previous Chinese codes for seismic design are likely to violate this requirement as the contribution of a cast-in-place floor slab in tension is not included in assessing the moment capacity of the beam in negative bending. This paper proposes three promising beam weakening techniques in combination with FRP strengthening to achieve this strong column/weak beam hierarchy and presents the preliminary results of an ongoing study into the effectiveness of and design procedures for the proposed techniques
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