Identification of z~>2 Herschel 500 micron sources using color-deconfusion

We present a new method to search for candidate z~>2 Herschel 500{\mu}m sources in the GOODS-North field, using a S500{\mu}m/S24{\mu}m "color deconfusion" technique. Potential high-z sources are selected against low-redshift ones from their large 500{\mu}m to 24{\mu}m flux density ratios. By effectively reducing the contribution from low-redshift populations to the observed 500{\mu}m emission, we are able to identify counterparts to high-z 500{\mu}m sources whose 24{\mu}m fluxes are relatively faint. The recovery of known z~4 starbursts confirms the efficiency of this approach in selecting high-z Herschel sources. The resulting sample consists of 34 dusty star-forming galaxies at z~>2. The inferred infrared luminosities are in the range 1.5x10^12-1.8x10^13 Lsun, corresponding to dust-obscured star formation rates (SFRs) of ~260-3100 Msun/yr for a Salpeter IMF. Comparison with previous SCUBA 850{\mu}m-selected galaxy samples shows that our method is more efficient at selecting high-z dusty galaxies with a median redshift of z=3.07+/-0.83 and 10 of the sources at z~>4. We find that at a fixed luminosity, the dust temperature is ~5K cooler than that expected from the Td-LIR relation at z<1, though different temperature selection effects should be taken into account. The radio-detected subsample (excluding three strong AGN) follows the far-infrared/radio correlation at lower redshifts, and no evolution with redshift is observed out to z~5, suggesting that the far-infrared emission is star formation dominated. The contribution of the high-z Herschel 500{\mu}m sources to the cosmic SFR density is comparable to that of SMG populations at z~2.5 and at least 40% of the extinction-corrected UV samples at z~4 (abridged).Comment: 33 pages in emulateapj format, 24 figures, 2 tables, accepted for publication in the ApJ

Nature and statistical properties of quasar associated absorption systems in the XQ-100 Legacy Survey

We statistically study the physical properties of a sample of narrow absorption line (NAL) systems looking for empirical evidences to distinguish between intrinsic and intervening NALs without taking into account any a priori definition or velocity cut-off. We analyze the spectra of 100 quasars with 3.5 < z$\rm_{em}$ < 4.5, observed with X-shooter/VLT in the context of the XQ-100 Legacy Survey. We detect a $\sim$ 8 $\sigma$ excess in the number density of absorbers within 10,000 km/s of the quasar emission redshift with respect to the random occurrence of NALs. This excess does not show a dependence on the quasar bolometric luminosity and it is not due to the redshift evolution of NALs. It extends far beyond the standard 5000 km/s cut-off traditionally defined for associated absorption lines. We propose to modify this definition, extending the threshold to 10,000 km/s when also weak absorbers (equivalent width < 0.2 \AA) are considered. We infer NV is the ion that better traces the effects of the quasar ionization field, offering the best statistical tool to identify intrinsic systems. Following this criterion we estimate that the fraction of quasars in our sample hosting an intrinsic NAL system is 33 percent. Lastly, we compare the properties of the material along the quasar line of sight, derived from our sample, with results based on close quasar pairs investigating the transverse direction. We find a deficiency of cool gas (traced by CII) along the line of sight associated with the quasar host galaxy, in contrast with what is observed in the transverse direction.Comment: 18 pages, 13 figures, 5 table

T-PHOT: A new code for PSF-matched, prior-based, multiwavelength extragalactic deconfusion photometry

We present T-PHOT, a publicly available software aimed at extracting accurate photometry from low-resolution images of deep extragalactic fields, where the blending of sources can be a serious problem for the accurate and unbiased measurement of fluxes and colours. T-PHOT has been developed within the ASTRODEEP project and it can be considered as the next generation to TFIT, providing significant improvements above it and other similar codes. T-PHOT gathers data from a high-resolution image of a region of the sky, and uses it to obtain priors for the photometric analysis of a lower resolution image of the same field. It can handle different types of datasets as input priors: i) a list of objects that will be used to obtain cutouts from the real high-resolution image; ii) a set of analytical models; iii) a list of unresolved, point-like sources, useful e.g. for far-infrared wavelength domains. We show that T-PHOT yields accurate estimations of fluxes within the intrinsic uncertainties of the method, when systematic errors are taken into account (which can be done thanks to a flagging code given in the output). T-PHOT is many times faster than similar codes like TFIT and CONVPHOT (up to hundreds, depending on the problem and the method adopted), whilst at the same time being more robust and more versatile. This makes it an optimal choice for the analysis of large datasets. In addition we show how the use of different settings and methods significantly enhances the performance. Given its versatility and robustness, T-PHOT can be considered the preferred choice for combined photometric analysis of current and forthcoming extragalactic optical to far-infrared imaging surveys. [abridged]Comment: 23 pages, 20 figures, 2 table

Through the looking GLASS: HST spectroscopy of faint galaxies lensed by the Frontier Fields cluster MACS0717.5+3745

The Grism Lens-Amplified Survey from Space (GLASS) is a Hubble Space Telescope (HST) Large Program, which will obtain 140 orbits of grism spectroscopy of the core and infall regions of 10 galaxy clusters, selected to be among the very best cosmic telescopes. Extensive HST imaging is available from many sources including the CLASH and Frontier Fields programs. We introduce the survey by analyzing spectra of faint multiply-imaged galaxies and $z\gtrsim6$ galaxy candidates obtained from the first seven orbits out of fourteen targeting the core of the Frontier Fields cluster MACS0717.5+3745. Using the G102 and G141 grisms to cover the wavelength range 0.8-1.7$\mu$m, we confirm 4 strongly lensed systems by detecting emission lines in each of the images. For the 9 $z\gtrsim6$ galaxy candidates clear from contamination, we do not detect any emission lines down to a seven-orbit 1$\sigma$ noise level of $\sim$5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. Taking lensing magnification into account, our flux sensitivity reaches $\sim$0.2-5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. These limits over an uninterrupted wavelength range rule out the possibility that the high-$z$ galaxy candidates are instead strong line emitters at lower redshift. These results show that by means of careful modeling of the background - and with the assistance of lensing magnification - interesting flux limits can be reached for large numbers of objects, avoiding pre-selection and the wavelength restrictions inherent to ground-based multi-slit spectroscopy. These observations confirm the power of slitless HST spectroscopy even in fields as crowded as a cluster core.Comment: Accepted by ApJ letters, 8 pages, 4 figures, GLASS website at http://glass.physics.ucsb.ed

Amoxicillin-Clavulanate-Induced Liver Injury

Background and Aims Amoxicillin–clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry. Here, we examined a large cohort of AC-DILI cases and compared features of AC-DILI to those of other drugs. Methods Subjects with suspected DILI were enrolled prospectively, and cases were adjudicated as previously described. Clinical variables and outcomes of patients with AC-DILI were compared to the overall DILIN cohort and to DILI caused by other antimicrobials. Results One hundred and seventeen subjects with AC-DILI were identified from the cohort (n = 1038) representing 11 % of all cases and 24 % of those due to antimicrobial agents (n = 479). Those with AC-DILI were older (60 vs. 48 years, P < 0.001). AC-DILI was more frequent in men than women (62 vs. 39 %) compared to the overall cohort (40 vs. 60 %, P < 0.001). The mean time to symptom onset was 31 days. The Tb, ALT, and ALP were 7 mg/dL, 478, and 325 U/L at onset. Nearly all liver biopsies showed prominent cholestatic features. Resolution of AC-DILI, defined by return of Tb to <2.5 mg/dL, occurred on average 55 days after the peak value. Three female subjects required liver transplantation, and none died due to DILI. Conclusion AC-DILI causes a moderately severe, mixed hepatocellular–cholestatic injury, particularly in older men, unlike DILI in general, which predominates in women. Although often protracted, eventual apparent recovery is typical, particularly for men and usually in women, but three women required liver transplantation

The Grism Lens-Amplified Survey from Space (GLASS). I. Survey overview and first data release

We give an overview of the Grism Lens Amplified Survey from Space (GLASS), a large Hubble Space Telescope program aimed at obtaining grism spectroscopy of the fields of ten massive clusters of galaxies at redshift z=0.308-0.686, including the Hubble Frontier Fields (HFF). The Wide Field Camera 3 yields near infrared spectra of the cluster cores, covering the wavelength range 0.81-1.69mum through grisms G102 and G141, while the Advanced Camera for Surveys in parallel mode provides G800L spectra of the infall regions of the clusters. The WFC3 spectra are taken at two almost orthogonal position angles in order to minimize the effects of confusion. After summarizing the scientific drivers of GLASS, we describe the sample selection as well as the observing strategy and data processing pipeline. We then utilize MACSJ0717.5+3745, a HFF cluster and the first one observed by GLASS, to illustrate the data quality and the high-level data products. Each spectrum brighter than H_AB=23 is visually inspected by at least two co-authors and a redshift is measured when sufficient information is present in the spectra. Furthermore, we conducted a thorough search for emission lines through all the GLASS WFC3 spectra with the aim of measuring redshifts for sources with continuum fainter than H_AB=23. We provide a catalog of 139 emission-line based spectroscopic redshifts for extragalactic sources, including three new redshifts of multiple image systems (one probable, two tentative). In addition to the data itself we also release software tools that are helpful to navigate the data.Comment: ApJ in press. GLASS data available at https://archive.stsci.edu/prepds/glass/ . More info on GLASS available at http://glass.physics.ucsb.edu

Metal abundances and ionization conditions in a possibly dust-free damped Ly-alpha system at z=2.3

We have obtained a high resolution, high S/N UVES spectrum of the bright QSO HE2243-6031 to analyze the damped Ly-alpha system (DLA) observed at z=2.33. The metallicity of this system is 1/12 solar at a neutral hydrogen column density of log N(HI)=20.7. From the observed ratios [Zn/Cr]=-0.01+/-0.05 and [S/Si]=-0.06+/-0.03$ we conclude that dust is very likely absent from the ISM of this protogalaxy. We observe an enhancement of the alpha/Fe-peak ratios of +0.2 dex for various elements, a marked odd-even effect in Mn, and a strong underabundance of N relative to Si and S, [N/Si,S]=-1 at [Si/H]=-0.86. All of these ratios support an environment that is in an early evolutionary stage, where the onset of star formation has begun only shortly before the DLA was observed. We also perform a cloud-by-cloud analysis -- without precedent at high redshift -- and find a tight correlation of all low-ionization species with respect to FeII extending over 2.5 orders of magnitude in N(FeII). We interpret this trend as being due to homogeneous physical conditions (very mild ionization effects, common dust-destruction histories, same chemical composition) and propose that this line of sight encounters absorbing clouds that share a common environment. In addition, photoionization models show that these single clouds are shielded from the external ionizing radiation, so the fraction of ionized gas is small and, except for argon, does not influence the measured metal abundances. The observed AlIII/low-ion ratios suggest the mildly ionized gas occurs in shells surrounding neutral cores of AlII.Comment: To be published in A&

Herschel/PACS far-infrared photometry of two z>4 quasars

We present Herschel far-infrared (FIR) observations of two sub-mm bright quasars at high redshift: SDSS J1148+5251 (z=6.42) and BR 1202-0725 (z=4.69) obtained with the PACS instrument. Both objects are detected in the PACS photometric bands. The Herschel measurements provide additional data points that constrain the FIR spectral energy distributions (SEDs) of both sources, and they emphasise a broad range of dust temperatures in these objects. For lambda_rest ~< 20mu, the two SEDs are very similar to the average SEDs of quasars at low redshift. In the FIR, however, both quasars show excess emission compared to low-z QSO templates, most likely from cold dust powered by vigorous star formation in the QSO host galaxies. For SDSS J1148+5251 we detect another object at 160mu with a distance of ~10 arcseconds from the QSO. Although no physical connection between the quasar and this object can be shown with the available data, it could potentially confuse low-resolution measurements, thus resulting in an overestimate of the FIR luminosity of the z=6.42 quasar.Comment: 4 pages, 3 figures, accepted for publication in the A&A special issue on Hersche

Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug‐Induced Liver Injury Network (DILIN)

Background & AimsBecause of the lack of objective tests to diagnose drug‐induced liver injury (DILI), causality assessment is a matter of debate. Expert opinion is often used in research and industry, but its test–retest reliability is unknown. To determine the test–retest reliability of the expert opinion process used by the Drug‐Induced Liver Injury Network (DILIN).MethodsThree DILIN hepatologists adjudicate suspected hepatotoxicity cases to one of five categories representing levels of likelihood of DILI. Adjudication is based on retrospective assessment of gathered case data that include prospective follow‐up information. One hundred randomly selected DILIN cases were re‐assessed using the same processes for initial assessment but by three different reviewers in 92% of cases.ResultsThe median time between assessments was 938 days (range 140–2352). Thirty‐one cases involved >1 agent. Weighted kappa statistics for overall case and individual agent category agreement were 0.60 (95% CI: 0.50–0.71) and 0.60 (0.52–0.68) respectively. Overall case adjudications were within one category of each other 93% of the time, while 5% differed by two categories and 2% differed by three categories. Fourteen per cent crossed the 50% threshold of likelihood owing to competing diagnoses or atypical timing between drug exposure and injury.ConclusionsThe DILIN expert opinion causality assessment method has moderate interobserver reliability but very good agreement within one category. A small but important proportion of cases could not be reliably diagnosed as ≥50% likely to be DILI.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111130/1/liv12540.pd