Quiloabdomen felino : caso clínico

En este artículo se describe un caso de ascitis quilosa o quiloabdomen en una gata europea de 11 años de edad, que se presentó en la consulta con apatía y un abdomen muy distendido. El análisis del líquido extraído por abdominocentesis confirmó que era líquido quiloso. El objetivo inicial en este tipo de procesos es determinar su etiología; en nuestro caso la presencia de un linfoma en la base del mesenterio observado mediante laparotomía (y posterior evacuación de la efusión quilosa), impedía emitir un pronóstico favorable, ya fuera con la instauración de un tratamiento quirúrgico, quimioterápico o solamente sintomático. La combinación de medidas dietéticas y terapéuticas (antibióticos y fluidoterapia) solo permitió una mejoría temporal del animal, muriendo finalmente con recidiva del proceso y complicaciones posteriores

Complexes of Pd(II) and Pt(II) with 9-Aminoacridine: Reactions with DNA and Study of Their Antiproliferative Activity

Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2 · 2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L = PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction of 9-aminoacridine and the complex [PtCl2(DMSO2]. The capacity of the compounds to modify the secondary and tertiary structures of DNA was evaluated by means of circular dichroism and electrophoretic mobility. Both palladium and platinum compounds proved active in the modification of both the secondary and tertiary DNA structures. AFM images showed noticeable modifications of the morphology of the plasmid pBR322 DNA by the compounds probably due to the intercalation of the complexes between base pairs of the DNA molecule. Finally, the palladium complex was tested for antiproliferative activity against three different human tumor cell lines. The results suggest that the palladium complex of formula [Pd(9AA)(μ-Cl)]2 has significant antiproliferative activity, although it is less active than cisplatin

Hole-hole correlations in the U=∞U=\infty limit of the Hubbard model and the stability of the Nagaoka state

We use exact diagonalisation in order to study the infinite - $U$ limit of the two dimensional Hubbard model. As well as looking at single-particle correlations, such as $n_{{\bf k}\sigma }=\langle c^\dagger _{{\bf k}\sigma }c_{{\bf k}\sigma } \rangle$, we also study {\it N-particle correlation functions} which compare the relative positions of {\it all} the particles in different models. In particular we study 16 and 18-site clusters and compare the charge correlations in the Hubbard model with those of spinless fermions and hard-core bosons. We find that although low densities of holes favour a `locally-ferromagnetic' fermionic description, the correlations at larger densities resemble those of pure hard-core bosons surprisingly well .Comment: 15 pages, REVTE

New data to the valencian flora

Es dóna notícia de la troballa d’algunes localitats noves de plantes amb valor corològic per a la flora dela Comunitat Valenciana, destacant Armeria trachyphylla Lange com a novetat per a la flora valenciana.Data about some new localities of plants with chorological interest for the valencian flora are reported,highlighting Armeria trachyphylla Lange as a new species for the valencian list

Charge and spin ordering, and charge transport properties in a two-dimensional inhomogeneous t-J model

We study a two-dimensional t-J model close to the Ising limit in which charge inhomogeneity is stabilized by an on-site potential e_s, by using diagonalization in a restricted Hilbert space and finite temperature Quantum Monte Carlo. Both site and bond centered stripes are considered and their similitudes and differences are analyzed. The amplitude of charge inhomogeneity is studied as e_s -> 0. Moreover, we show that the anti-phase domain ordering occurs at a much lower temperature than the formation of charge inhomogeneities and charge localization. Hole-hole correlations indicate a metallic behavior of the stripes with no signs of hole attraction. Kinetic energies and current susceptibilities are computed and indications of charge localization are discussed. The study of the doping dependence in the range 0.083 < x < 0.167 suggests that these features are characteristic of the whole underdoped region.Comment: minor changes, to be published in Physical Review

Noves dades per a la flora valenciana

Es dóna notícia de la troballa d"algunes localitats noves de plantes amb valor corològic per a la flora de la Comunitat Valenciana, destacant Armeria trachyphylla Lange com a novetat per a la flora valenciana. Data about some new localities of plants with chorological interest for the valencian flora are reported, highlighting Armeria trachyphylla Lange as a new species for the valencian list

Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity

Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2 · 2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L = PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction of 9-aminoacridine and the complex [PtCl2(DMSO)2]. The capacity of the compounds to modify the secondary and tertiary structures of DNA was evaluated by means of circular dichroism and electrophoretic mobility. Both palladium and platinum compounds proved active in the modification of both the secondary and tertiary DNA structures. AFM images showed noticeable modifications of the morphology of the plasmid pBR322 DNA by the compounds probably due to the intercalation of the complexes between base pairs of the DNA molecule. Finally, the palladium complex was tested for antiproliferative activity against three different human tumor cell lines. The results suggest that the palladium complex of formula [Pd(9AA)(μ-Cl)]2 has significant antiproliferative activity, although it is less active than cisplatin

Mitochondrial fragmentation in excitotoxicity requires ROCK activation

Mitochondria morphology constantly changes through fission and fusion processes that regulate mitochondrial function, and it therefore plays a prominent role in cellular homeostasis. Cell death progression is associated with mitochondrial fission. Fission is mediated by the mainly cytoplasmic Drp1, which is activated by different post-translational modifications and recruited to mitochondria to perform its function. Our research and other studies have shown that in the early moments of excitotoxic insult Drp1 must be nitrosylated to mediate mitochondrial fragmentation in neurons. Nonetheless, mitochondrial fission is a multistep process in which filamentous actin assembly/disassembly and myosin-mediated mitochondrial constriction play prominent roles. Here we establish that in addition to nitric oxide production, excitotoxicity-induced mitochondrial fragmentation also requires activation of the actomyosin regulator ROCK. Although ROCK1 has been shown to phosphorylate and activate Drp1, experiments using phosphor-mutant forms of Drp1 in primary cortical neurons indicate that in excitotoxic conditions, ROCK does not act directly on Drp1 to mediate fission, but may act on the actomyosin complex. Thus, these data indicate that a wider range of signaling pathways than those that target Drp1 are amenable to be inhibited to prevent mitochondrial fragmentation as therapeutic optio

Thermal Conductivity of the Spin Peierls Compound CuGeO_3

The thermal conductivity of the Spin-Peierls (SP) compound CuGeO_3 was measured in magnetic fields up to 16 T. Above the SP transition, the heat transport due to spin excitations causes a peak at around 22 K, while below the transition the spin excitations rapidly diminish and the heat transport is dominated by phonons; however, the main scattering process of the phonons is with spin excitations, which demonstrates itself in an unusual peak in the thermal conductivity at about 5.5 K. This low-temperature peak is strongly suppressed with magnetic fields in excess of 12.5 T.Comment: 6 pages, including 2 postscript figure