Evaluation of sustainable development of the Bohai Sea Rim based on integrated land–sea management: a multi-system coupling and coordination study at coastal, provincial, and city level

Based on the Integrated Land–Sea Management, this study established a theoretical framework for the sustainability of coastal regions by combining sustainable development with coupling coordination theory. The improved coupling coordination model was used to analyze the sustainable development of the Bohai Rim and its coastal provinces and cities from 2006 to 2020. Our implications were as follows: (1) The theoretical framework showed an S-shaped spiral trend, and the empirical results on the Bohai Rim were consistent with the trajectory conclusions. (2) The economic subsystem played a crucial role in the system’s evolution toward sustainable development. (3) The region and city models demonstrated consistent coupling and coordination development degrees. However, the consistency was not completely synchronous. Conscious eco-environmental governance activities can promote benign interactions among systems and improve this relationship. (4) The sustainable development of coastal cities is different from that of the provinces in which they are located. It merely demonstrates their relative status among all coastal cities and does not fully represent the wider region in which they are located. The findings suggest that adaptive policies, whether economic, social or environmental, can promote sustainable development. Economic stimulus policies can promote a transition of sustainable development; in the economic downturn, the adaptive environmental policy is realized by adjusting the relationship between subsystems to promote the coordination of regional systems, preparing for the next sustainable system transition. The established theoretical model and improvised mathematical method can be extended to study various coastal region

Case Report: Step-by-step procedures for total intracorporeal laparoscopic kidney autotransplantation in a patient with distal high-risk upper tract urothelial carcinoma

A 47-year-old man presented to the emergency department with right abdominal pain and a new onset of painless haematuria two weeks earlier. Urine cytology test results suggested urothelial carcinoma. Computed tomography urography (CTU) showed a filling defect in the lower right ureter with right hydronephrosis. Lymphadenopathy and any signs of metastatic disease were absent on CTU. Cystoscopy appeared normal. Creatinine level was also normal before surgery. After the treatment options were discussed, the patient chose to undergo 3D total intracorporeal laparoscopic kidney autotransplantation, bladder cuff excision, and segmental resection of the proximal two-thirds of the ureter based on the membrane anatomy concept. After more than one year of follow-up, the patient was in good health and showed no signs of haematuria. Surveillance cystoscopy and CTU examination showed no evidence of disease recurrence. Therefore, it is reasonable to assume that kidney-sparing surgery may be considered for carefully selected patients with high-grade upper tract urothelial carcinoma

Epidemiology and distribution of cruciate ligament injuries in children and adolescents, with an analysis of risk factors for concomitant meniscal tear

IntroductionTo investigate the epidemiological features and prevalence of cruciate ligament injuries (CLI) in children and adolescents, and to examine the potential risk factors associated with concomitant meniscal tear (MT) among this population.MethodsThe demographic data and injury details of children and adolescents with CLI from Southeast China were analyzed to describe their distribution characteristics, alongside an analysis of the prevalence of MTs, the most frequent complication. In addition, binary logistic analysis was employed to ascertain the risk factors linked to MT in individuals suffering from CLI.ResultsA total of 203 patients with CLI (n = 206) met the inclusion criteria, with a male-to-female ratio of 2.3:1. Notably, a higher proportion of females were aged ≤16 years old compared to males, who predominated in patients aged >16 years (P = 0.001). Among children and adolescents, anterior cruciate ligament (ACL) injuries were the primary type of CLI, accounting for 88.18% (179/203) of all cases. The majority of cases (132/203, 65.02%) were sustained during sports activities, and sprains were the predominant mechanism of injury (176/203, 86.7%). Additionally, the most common associated injury was an MT (157/203, 77.34%). The posterior horn is the most frequently affected site for both medial MT (62.93% out of 73 cases) and lateral MT (70.19% out of 73 cases). Moreover, vertical tears constituted the majority of medial MTs (59.48% out of 116 cases). Furthermore, patients with a higher BMI faced an increased risk of associated MT in comparison to non-overweight patients (88% vs. 73.86%; P = 0.038). Each increase in BMI unit was linked with a 14% higher probability of associated MT occurrence in children and adolescents with CLI (OR = 1.140; P = 0.036).DiscussionACL injuries are a common form of knee ligament injury among children and adolescents, especially those over the age of 16, and are often the result of a sprain. Meniscal posterior horn injury is the most commonly associated injury of youth with CLI. Additionally, overweight or obese people with CLI are at a greater risk of developing MT

First Report from the Asian Rotavirus Surveillance Network

Rotavirus remains the most common cause of severe, dehydrating diarrhea among children worldwide. Several rotavirus vaccines are under development. Decisions about new vaccine introduction will require reliable data on disease impact. The Asian Rotavirus Surveillance Network, begun in 2000 to facilitate collection of these data, is a regional collaboration of 36 hospitals in nine countries or areas that conduct surveillance for rotavirus hospitalizations using a uniform World Health Organization protocol. We summarize the Network's organization and experience from August 2001 through July 2002. During this period, 45% of acute diarrheal hospitalizations among children 0–5 years were attributable to rotavirus, higher than previous estimates. Rotavirus was detected in all sites year-round. This network is a novel, regional approach to surveillance for vaccine-preventable diseases. Such a network should provide increased visibility and advocacy, enable more efficient data collection, facilitate training, and serve as the paradigm for rotavirus surveillance activities in other regions

ClpC, A ATP-Dependent Chloroplast Protease (Clp), Is Involved In Iron Metabolism in Arabidopsis

Iron (Fe) is an essential mineral for plant growth and development. It plays crucial roles in many fundamental processes in cells, such as respiration, photosynthesis. In plant cells, iron is compartmentalized into different organelles, such as chloroplasts, mitochondria and vacuoles for its synthetic functions or storage. Chloroplast, a photosynthetic apparatus, represents one of the organelles possessing the most iron-enriched biochemical reaction systems (photosystem I, photosystem II, cytochrome b6-f complex and ferredoxin) in the plant cell. However, little is to known about the iron metabolism in this organelle.The ATP-dependent Clp protease is widely distributed in bacteria, cyanobacteria, mitochondria and chloroplasts and plays an important role in protein import to chloroplast (literature). In plants, the ATP-dependent Clp protease in chloroplasts is encoded by a nucleus gene ClpC. It is imported into chloroplast and functions in control of chlorophyll b synthesis (Nakagawara et al., 2007). Here, we show that CipC is involved in the iron homeostasis in mesophyll cells. Lesion of ClpC caused leaf chlorosis and growth inhibition, and this phenotype can be rescued by supplying iron. Expression profile analysis showed that the lesion of ClpC significantly increased the expression of AtFRO8 in the leaf, indicating that ClpC might be indirectly involved in the control of the expression of AtFRO8, consequently effect on iron homeostasis in chloroplasts

AtbHLH38 and AtbHLH39 interact with FIT, functioning in control of iron uptake in Arabidopsis

Arabidopsis was used as a model plant to study the molecular regulation mechanism of iron uptake in strategy I plants and two new iron-regulated bHLH proteins (AtbHLH38 and AtbHLH39) have been identified. They showed interaction with FIT, a central regulatory gene involved in regulation iron uptake in Arabidopsis, by yeast-two-hybridization. Expression of FIT/AtbHLH38 or FIT/AtbHLH39 in yeast cells was able to activate GUS expression driven by AtFRO2 (ferric chelate reductase) and AtIRT1 (ferrous transporter) promoters. Overexpression of both FIT and either AtbHLH38 or AtbHLH39 converted the expression of the iron uptake genes AtFRO2 and AtIRT1 from induced to constitutively, and the overexpression plants accumulated more iron in their shoots than the wild type and exhibited more tolerance against iron deficiency. The results indicate that transcription of the iron uptake genes AtFRO2 and AtIRT1 in Arabidopsis is directly regulated by a complex of FIT/AtbHLH38 or FIT/AtbHLH39