Deep Impression: Audiovisual Deep Residual Networks for Multimodal Apparent Personality Trait Recognition

Here, we develop an audiovisual deep residual network for multimodal apparent personality trait recognition. The network is trained end-to-end for predicting the Big Five personality traits of people from their videos. That is, the network does not require any feature engineering or visual analysis such as face detection, face landmark alignment or facial expression recognition. Recently, the network won the third place in the ChaLearn First Impressions Challenge with a test accuracy of 0.9109

Neon Abundances from a Spitzer/IRS Survey of Wolf-Rayet Stars

We report on neon abundances derived from {\it Spitzer} high resolution spectral data of eight Wolf-Rayet (WR) stars using the forbidden line of [\ion{Ne}{3}] 15.56 microns. Our targets include four WN stars of subtypes 4--7, and four WC stars of subtypes 4--7. We derive ion fraction abundances $\gamma$ of Ne^{2+} for the winds of each star. The ion fraction abundance is a product of the ionization fraction $Q_{\rm i}$ in stage i and the abundance by number ${\cal A}_E$ of element E relative to all nuclei. Values generally consistent with solar are obtained for the WN stars, and values in excess of solar are obtained for the WC stars.Comment: to appear in Astrophysical Journa

Strain localization by shear heating and the development of lithospheric shear zones

Analogue and numerical models show that strong or weak domains in a deforming ductile material cause stress concentrations that may promote strain localization. Such domains commonly occur in the lithosphere through variations in composition or mineral fabric. Here we use a 2D plane-stress, non-Newtonian, viscous model to explore how strain localization develops from an initial isolated weak inclusion. We use a temperature-dependent rheological law for which the material weakens as a result of work done by shear converted to heat. The progress of strain localization follows a power-law growth that is strongly non-linear and may be regarded as an instability. Although this localization mechanism is ultimately limited by thermal diffusion, this parametrization permits a robust criterion for the conditions in which localized shear zones can form within the lithosphere. Shear zones in the lower crust are typically depicted as the downward continuation of faults. We argue that the depth-extent of narrow shear zones within the lithosphere is limited by the stability criteria that we infer from 2D numerical experiments. When applied to the rheological laws for common lithospheric minerals, the combination of temperature and stress-dependence provides a direct means of predicting the depth below which the localization instability does not occur. For an olivine based rheology, the maximum depth at which rapid localization is expected is in the range of ~20 to 60 km, depending on heat flow, strain-rate and water fugacity. We apply our calculations to two major continental strike-slip zones, the San Andreas Fault and North Anatolian Fault, and compare our predicted maximum localization depths with published seismological images. Strain localization in the lower crust requires a dry rheology comparable to plagioclase. Observations that imply localized strain in the uppermost mantle beneath these fault zones are consistent with the localization criteria and the rheological properties of dry olivine

The Neon Abundance of Galactic Wolf-Rayet Stars

The fast, dense winds which characterize Wolf-Rayet (WR) stars obscure their underlying cores, and complicate the verification of evolving core and nucleosynthesis models. Core evolution can be probed by measuring abundances of wind-borne nuclear processed elements, partially overcoming this limitation. Using ground-based mid-infrared spectroscopy and the 12.81um [NeII] emission line measured in four Galactic WR stars, we estimate neon abundances and compare to long-standing predictions from evolved-core models. For the WC star WR121, this abundance is found to be >~11x the cosmic value, in good agreement with predictions. For the three less-evolved WN stars, little neon enhancement above cosmic values is measured, as expected. We discuss the impact of clumping in WR winds on this measurement, and the promise of using metal abundance ratios to eliminate sensitivity to wind density and ionization structure.Comment: Accepted for publication in ApJ; 9 pages, 2 color figures, 4 table

XMM-Newton Detection of Hard X-ray Emission in the Nitrogen-Type Wolf-Rayet Star WR110

We have used the excellent sensitivity of XMM-Newton to obtain the first high-quality X-ray spectrum of a Wolf-Rayet (WR) star which is not known to be a member of a binary system. Our target, the nitrogen-type star WR 110 (= HD 165688) was also observed and detected with the VLA at four different frequencies. The radio data are in excellent agreement with that expected for free-free wind emission. and the ionized mass-loss rate is derived. The X-ray emission measure distribution shows a dominant contribution from cool plasma at kT$_{cool}$ = 0.5 keV (6 MK) which is only weakly absorbed. We argue that this cool emission originates at hundreds of radii if the wind is spherical and homogeneous and derive shock velocities and the X-ray filling factor using radiative shock models. A surprising result is the unambiguous detection of a hard X-ray component clearly seen in the hard-band images and the spectra. This hard component accounts for about half of the observed flux and can be acceptably fitted by a hot optically thin thermal plasma or a power-law model. If the emission is thermal, then a temperature kT$_{hot}$ $\geq$ 3 keV is derived. Such high temperatures are not predicted by current instability-driven wind shock models. We examine several alternatives and show that the hard emission could be accounted for by the WR wind shocking onto a close stellar companion which has so far escaped detection. However, until persuasive evidence for binarity is found we are left with the intriguing possibility that the hard X-ray emission is produced entirely by the Wolf-Rayet star.Comment: 2 tables, 7 figure

Trial Protocol: Using genotype to tailor prescribing of nicotine replacement therapy: a randomised controlled trial assessing impact of communication upon adherence.

BACKGROUND: The behavioural impact of pharmacogenomics is untested; informing smokers of genetic test results for responsiveness to smoking cessation medication may increase adherence to this medication. The objective of this trial is to estimate the impact upon adherence to nicotine replacement therapy (NRT) of informing smokers that their oral dose of NRT has been tailored to a DNA analysis. Hypotheses to be tested are as follows: I Adherence to NRT is greater among smokers informed that their oral dose of NRT is tailored to an analysis of DNA (genotype), compared to one tailored to nicotine dependence questionnaire score (phenotype). II Amongst smokers who fail to quit at six months, motivation to make another quit attempt is lower when informed that their oral dose of NRT was tailored to genotype rather than phenotype. METHODS/DESIGN: An open label, parallel groups randomised trial in which 630 adult smokers (smoking 10 or more cigarettes daily) using National Health Service (NHS) stop smoking services in primary care are randomly allocated to one of two groups:i. NRT oral dose tailored by DNA analysis (OPRM1 gene) (genotype), orii. NRT oral dose tailored by nicotine dependence questionnaire score (phenotype)The primary outcome is proportion of prescribed NRT consumed in the first 28 days following an initial quit attempt, with the secondary outcome being motivation to make another quit attempt, amongst smokers not abstinent at six months. Other outcomes include adherence to NRT in the first seven days and biochemically validated smoking abstinence at six months. The primary outcome will be collected on 630 smokers allowing sufficient power to detect a 7.5% difference in mean proportion of NRT consumed using a two-tailed test at the 5% level of significance between groups. The proportion of all NRT consumed in the first four weeks of quitting will be compared between arms using an independent samples t-test and by estimating the 95% confidence interval for observed between-arm difference in mean NRT consumption (Hypothesis I). Motivation to make another quit attempt will be compared between arms in those failing to quit by six months (Hypothesis II). DISCUSSION: This is the first clinical trial evaluating the behavioural impact on adherence of prescribing medication using genetic rather than phenotypic information. Specific issues regarding the choice of design for trials of interventions of this kind are discussed. TRIAL DETAILS: Funder: Medical Research Council (MRC)Grant number: G0500274. ISRCTN: 14352545. Date trial stated: June 2007. Expected end date: December 2009. Expected reporting date: December 2010.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Quantitative analysis of WC stars: Constraints on neon abundances from ISO/SWS spectroscopy

Neon abundances are derived in four Galactic WC stars -- gamma Vel (WR11, WC8+O7.5III), HD156385 (WR90, WC7), HD192103 (WR135, WC8), and WR146 (WC5+O8) - using mid-infrared fine structure lines obtained with ISO/SWS. Stellar parameters for each star are derived using a non-LTE model atmospheric code (Hillier & Miller 1998) together with ultraviolet (IUE), optical (INT, AAT) and infrared (UKIRT, ISO) spectroscopy. In the case of gamma Vel, we adopt results from De Marco et al. (2000), who followed an identical approach. ISO/SWS datasets reveal the [NeIII] 15.5um line in each of our targets, while [NeII] 12.8um, [SIV] 10.5um and [SIII] 18.7um are observed solely in gamma Vel. Using a method updated from Barlow et al. (1988) to account for clumped winds, we derive Ne/He=3-4x10^-3 by number, plus S/He=6x10^-5 for gamma Vel. Neon is highly enriched, such that Ne/S in gamma Vel is eight times higher than cosmic values. However, observed Ne/He ratios are a factor of two times lower than predictions of current evolutionary models of massive stars. An imprecise mass-loss and distance were responsible for the much greater discrepancy in neon content identified by Barlow et al. Our sample of WC5--8 stars span a narrow range in T* (=55--71kK), with no trend towards higher temperature at earlier spectral type, supporting earlier results for a larger sample by Koesterke & Hamann (1995). Stellar luminosities range from 100,000 to 500,000 Lo, while 10^-5.1 < Mdot/(Mo/yr) < 10^-4.5, adopting clumped winds, in which volume filling factors are 10%. In all cases, wind performance numbers are less than 10, significantly lower than recent estimates. Carbon abundances span 0.08 < C/He < 0.25 by number, while oxygen abundances remain poorly constrained.Comment: 16 pages,7 figures accepted for MNRA

Klebsiella pneumoniae is able to trigger epithelial-mesenchymal transition process in cultured airway epithelial cells

The ability of some bacterial pathogens to activate Epithelial-Mesenchymal Transition normally is a consequence of the persistence of a local chronic inflammatory response or depends on a direct interaction of the pathogens with the host epithelial cells. In this study we monitored the abilities of the K. pneumoniae to activate the expression of genes related to EMT-like processes and the occurrence of phenotypic changes in airway epithelial cells during the early steps of cell infection. We describe changes in the production of intracellular reactive oxygen species and increased HIF-1α mRNA expression in cells exposed to K. pneumoniae infection. We also describe the upregulation of a set of transcription factors implicated in the EMT processes, such as Twist, Snail and ZEB, indicating that the morphological changes of epithelial cells already appreciable after few hours from the K. pneumoniae infection are tightly regulated by the activation of transcriptional pathways, driving epithelial cells to EMT. These effects appear to be effectively counteracted by resveratrol, an antioxidant that is able to exert a sustained scavenging of the intracellular ROS. This is the first report indicating that strains of K. pneumoniae may promote EMT-like programs through direct interaction with epithelial cells without the involvement of inflammatory cells

Comfort radicalism and NEETs: a conservative praxis

Young people who are not in education, employment or training (NEET) are construed by policy makers as a pressing problem about which something should be done. Such young people's lack of employment is thought to pose difficulties for wider society in relation to social cohesion and inclusion and it is feared that they will become a 'lost generation'. This paper(1) draws upon English research, seeking to historicise the debate whilst acknowledging that these issues have a much wider purchase. The notion of NEETs rests alongside longstanding concerns of the English state and middle classes, addressing unruly male working class youth as well as the moral turpitude of working class girls. Waged labour and domesticity are seen as a means to integrate such groups into society thereby generating social cohesion. The paper places the debate within it socio-economic context and draws on theorisations of cognitive capitalism, Italian workerism, as well as emerging theories of antiwork to analyse these. It concludes by arguing that ‘radical’ approaches to NEETs that point towards inequities embedded in the social structure and call for social democratic solutions veer towards a form of comfort radicalism. Such approaches leave in place the dominance of capitalist relations as well as productivist orientations that celebrate waged labour

Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a U.K. tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited).

OBJECTIVE: To evaluate QRISK2 and Framingham cardiovascular disease (CVD) risk scores in a tri-ethnic U.K. population. DESIGN: Cohort study. SETTING: West London. PARTICIPANTS: Randomly selected from primary care lists. Follow-up data were available for 87% of traced participants, comprising 1866 white Europeans, 1377 South Asians, and 578 African Caribbeans, aged 40-69 years at baseline (1998-1991). MAIN OUTCOME MEASURES: First CVD events: myocardial infarction, coronary revascularisation, angina, transient ischaemic attack or stroke reported by participant, primary care or hospital records or death certificate. RESULTS: During follow-up, 387 CVD events occurred in men (14%) and 78 in women (8%). Both scores underestimated risk in European and South Asian women (ratio of predicted to observed risk: European women: QRISK2: 0.73, Framingham: 0.73; South Asian women: QRISK2: 0.52, Framingham: 0.43). In African Caribbeans, Framingham over-predicted in men and women and QRISK2 over-predicted in women. Framingham classified 28% of participants as high risk, predicting 54% of all such events. QRISK2 classified 19% as high risk, predicting 42% of all such events. Both scores performed poorly in identifying high risk African Caribbeans; QRISK2 and Framingham identified as high risk only 10% and 24% of those who experienced events. CONCLUSIONS: Neither score performed consistently well in all ethnic groups. Further validation of QRISK2 in other multi-ethnic datasets, and better methods for identifying high risk African Caribbeans and South Asian women, are required