Is meaning fraught with ought?

According to Normativism, what an expression means has immediate implications for how a subject should or may (not) employ that expression. Many view this thesis as imposing substantive constraints upon theories of linguistic meaning. In this paper, I shall not consider that view; instead, I shall address the prior issue of whether or not one should accept Normativism. Against certain recent prominent lines of attack common to a number of different anti-Normativist discussions, I shall defend both the Normativist thesis and an attempt to appeal to a certain platitude in its support

A brief look at the history of the Deaconess Hospital, Edinburgh, 1894–1990

The Deaconess Hospital, Edinburgh, opened in 1894 and was the first establishment of its kind in the UK, maintained and wholly funded as it was by the Reformed Church. Through its 96-year lifetime it changed and evolved to time and circumstance. It was a school: for the training of nurses and deaconesses who took their practical skills all over the world. It was a sanctum: for the sick-poor before the NHS. It was a subsidiary: for the bigger hospitals of Edinburgh after amalgamation into the NHS. It was a specialised centre: as the Urology Department in Edinburgh and the Scottish Lithotripter centre. And now it is currently student accommodation. There is no single source to account for its history. Through the use of original material made available by the Lothian Health Services Archives – including Church of Scotland publications, patient records, a doctor’s casebook and annual reports – we review its conception, purpose, development and running; its fate on joining the NHS, its identity in the latter years and finally its closure

Probing Galaxy Dark Matter Haloes in COSMOS with Weak Lensing Flexion

Current theories of structure formation predict specific density profiles of galaxy dark matter haloes, and with weak gravitational lensing we can probe these profiles on several scales. On small scales, higher-order shape distortions known as flexion add significant detail to the weak lensing measurements. We present here the first detection of a galaxy-galaxy flexion signal in space-based data, obtained using a new Shapelets pipeline introduced here. We combine this higher-order lensing signal with shear to constrain the average density profile of the galaxy lenses in the Hubble Space Telescope COSMOS survey. We also show that light from nearby bright objects can significantly affect flexion measurements. After correcting for the influence of lens light, we show that the inclusion of flexion provides tighter constraints on density profiles than does shear alone. Finally we find an average density profile consistent with an isothermal sphere.Comment: 14 pages, 14 figures. Accepted for publication in MNRA

Effects of Policies Designed to Keep Firearms from High-Risk Individuals

This article summarizes and critiques available evidence from studies published between 1999 and August 2014 on the effects of policies designed to keep firearms from high-risk individuals in the United States. Some prohibitions for high-risk individuals (e.g., those under domestic violence restraining orders, violent misdemeanants) and procedures for checking for more types of prohibiting conditions are associated with lower rates of violence. Certain laws intended to prevent prohibited persons from accessing firearms -- rigorous permit-to-purchase, comprehensive background checks, strong regulation and oversight of gun dealers, and requiring gun owners to promptly report lost or stolen firearms -- are negatively associated with the diversion of guns to criminals. Future research is needed to examine whether these laws curtail nonlethal gun violence and whether the effects of expanding prohibiting conditions for firearm possession are modified by the presence of policies to prevent diversion

The impact of Global Climate Change on Water Quantity and Quality: A System Dynamics Approach to the US-Mexican Transborder Region

The potential impacts of Global Climate Change (GCC) in zones where water is scarce, such as along the US–Mexico border is, and will continue to be, a key concern for the future sustainability of humanity. This paper estimates the variation in quality/quantity water due to climate change and assesses its impact on community development in the US–Mexico border region of the Rio Grande/Rio Bravo Water Basin. To estimate variation in different water quality parameters, we use a conservative model with most probable scenarios for temperature/precipitation produced by the International Panel on Climate Change. We propose a system dynamics model to understand the complex interaction of factors governing the quantity/quality of water and their effects on social and economic conditions. The model simulates, for a 70-year period, policies and decisions that have the potential to improve conditions and prevent risks that may lead to social unrest and hinder economic development

Constraints on the shapes of galaxy dark matter haloes from weak gravitational lensing

We study the shapes of galaxy dark matter haloes by measuring the anisotropy of the weak gravitational lensing signal around galaxies in the second Red-sequence Cluster Survey (RCS2). We determine the average shear anisotropy within the virial radius for three lens samples: all galaxies with 19<m_r'<21.5, and the `red' and `blue' samples, whose lensing signals are dominated by massive low-redshift early-type and late-type galaxies, respectively. To study the environmental dependence of the lensing signal, we separate each lens sample into an isolated and clustered part and analyse them separately. We also measure the azimuthal dependence of the distribution of physically associated galaxies around the lens samples. We find that these satellites preferentially reside near the major axis of the lenses, and constrain the angle between the major axis of the lens and the average location of the satellites to =43.7 deg +/- 0.3 deg for the `all' lenses, =41.7 deg +/- 0.5 deg for the `red' lenses and =42.0 deg +/- 1.4 deg for the `blue' lenses. For the `all' sample, we find that the anisotropy of the galaxy-mass cross-correlation function =0.23 +/- 0.12, providing weak support for the view that the average galaxy is embedded in, and preferentially aligned with, a triaxial dark matter halo. Assuming an elliptical Navarro-Frenk-White (NFW) profile, we find that the ratio of the dark matter halo ellipticity and the galaxy ellipticity f_h=e_h/e_g=1.50+1.03-1.01, which for a mean lens ellipticity of 0.25 corresponds to a projected halo ellipticity of e_h=0.38+0.26-0.25 if the halo and the lens are perfectly aligned. For isolated galaxies of the `all' sample, the average shear anisotropy increases to =0.51+0.26-0.25 and f_h=4.73+2.17-2.05, whilst for clustered galaxies the signal is consistent with zero. (abridged)Comment: 28 pages, 23 figues, accepted for publication in A&

Analytical shear and flexion of Einasto dark matter haloes

N-body simulations predict that dark matter haloes are described by specific density profiles on both galactic- and cluster-sized scales. Weak gravitational lensing through the measurements of their first and second order properties, shear and flexion, is a powerful observational tool for investigating the true shape of these profiles. One of the three-parameter density profiles recently favoured in the description of dark matter haloes is the Einasto profile. We present exact expressions for the shear and the first and second flexions of Einasto dark matter haloes derived using a Mellin-transform formalism in terms of the Fox H and Meijer G functions, that are valid for general values of the Einasto index. The resulting expressions can be written as series expansions that permit us to investigate the asymptotic behaviour of these quantities. Moreover, we compare the shear and flexion of the Einasto profile with those of different mass profiles including the singular isothermal sphere, the Navarro-Frenk-White profile, and the S\'ersic profile. We investigate the concentration and index dependences of the Einasto profile, finding that the shear and second flexion could be used to determine the halo concentration, whilst for the Einasto index the shear and first and second flexions may be employed. We also provide simplified expressions for the weak lensing properties and other lensing quantities in terms of the generalized hypergeometric function.Comment: 14 pages, 3 figures. Accepted for publication in Astronomy and Astrophysic

Accurate Liability Estimation Improves Power in Ascertained Case Control Studies

Linear mixed models (LMMs) have emerged as the method of choice for confounded genome-wide association studies. However, the performance of LMMs in non-randomly ascertained case-control studies deteriorates with increasing sample size. We propose a framework called LEAP (Liability Estimator As a Phenotype, https://github.com/omerwe/LEAP) that tests for association with estimated latent values corresponding to severity of phenotype, and demonstrate that this can lead to a substantial power increase

Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes

We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection