Research inequality in nanomedicine

The 10-90 gap is an idea in the healthcare literature that less than 10% of all research funding goes to solving health problems that are 90% of the global disease burden. This paper examines whether there is inequality in nanotechnology healthcare research (nanomedicine). To understand the inequality in nanomedicine, I conducted a bibliometric review of Web of Science and PubMed databases. Overall there is not large inequality in nanomedicine research. The bibliometric analysis shows that most nanomedicine research is done in high income countries, but their research portfolios extend beyond rich world diseases like Alzheimer’s disease and diabetes to include research on malaria, tuberculosis and HIV/AIDS. Of the nanomedicine articles that are directed towards specific diseases (about 20% in Web of Science and PubMed), the majority of the research (86%) will help both the rich and the poor, while only 7% of the research focuses solely on rich world diseases and 7% focus solely on diseases of poverty. The most researched nanomedicine topic is cancer. It accounts for 16% of nanomedicine literature. Overall less than 20% of nanomedicine research goes to solving health problems that are 50% of the global disease burden. Given nanotechnology is so linked to chemistry and the chemicals industry, the inequality within nanomedicine will impact how those industries supply materials, supplies and information to the various stakeholders involved in nanotechnology and healthcare.<br

Nanotechnology companies in the United States:a web-based content analysis of companies and products for poverty alleviation

This study analyzes the goals, nanotechnology experience, corporate social responsibility and products of 50 USA-based companies  working with nanotechnology to see if they are developing products that help low-income populations. Out of the top 50 R&D companies that publish and patent nanotechnology research in agri-food, energy and water sectors, 18 of them do not mention nanotechnology on their websites. The other 32 companies discuss nanotechnology in varying degrees. However, only two of the companies relate their nanotechnology R&D to poverty alleviation. Even though few companies refer to poverty alleviation, 30 firms of the sample have some type of corporate social responsibility programs. From the study, we cannot definitively conclude that nanotechnology is a technology only for wealthy consumers, but we do find that the companies analyzed do not give much attention to pro-poor nanotechnology

Stationed for Disaster

A hybrid architectural model for combatting the social injustice of natural disasters in urban coastal cities: civic infrastructure in New Orleans, Louisiana

Plasma Dynamics

Contains reports on two research projects.WADC Contract AF33(616)-3984Servomechanisms Research Laborator

Echangeur de chaleur “air-terre” pour la climatisation passive de locaux : Etude de cas réalisée au Burkina Faso

An Earth Air Heat Exchanger is a novel way to cool and heat buildings using the ground temperature. Earth Air Heat Exchangers are cheaper and they use less energy than traditional air conditioning. These factors make it a perfect technology to cool houses and buildings in Burkina Faso, a developing country with a major indoor cooling demand. This study shows that in Burkina Faso it is possible to build a simple EAHX to cool down ambient air by 10°C which in turn can cool down a room by 1°C-5°C. The EAHX will be 30 meters long, buried 1.5 meters in the ground and use a ventilator with a flow rate of 90 m3/h. In total the EAHX will cost CFA 300,000 ($US 600)

Geographical trends in research: a preliminary analysis on authors' affiliations

In the last decade, research literature reached an enormous volume with an unprecedented current annual increase of 1.5 million new publications. As research gets ever more global and new countries and institutions, either from academia or corporate environment, start to contribute with their share, it is important to monitor this complex scenario and understand its dynamics. We present a study on a conference proceedings dataset extracted from Springer Nature Scigraph that illustrates insightful geographical trends and highlights the unbalanced growth of competitive research institutions worldwide. Results emerged from our micro and macro analysis show that the distributions among countries of institutions and papers follow a power law, and thus very few countries keep producing most of the papers accepted by high-tier conferences. In addition, we found that the annual and overall turnover rate of the top 5, 10 and 25 countries is extremely low, suggesting a very static landscape in which new entries struggle to emerge. Finally, we highlight the presence of an increasing gap between the number of institutions initiating and overseeing research endeavours (i.e. first and last authors' affiliations) and the total number of institutions participating in research. As a consequence of our analysis, the paper also discusses our experience in working with affiliations: an utterly simple matter at first glance, that is instead revealed to be a complex research and technical challenge yet far from being solved

Effect of progressive mandibular advancement on pharyngeal airway size in anesthetized adults.

BACKGROUND: General anesthesia in adult humans is associated with narrowing or complete closure of the pharyngeal airway. The purpose of this study was to determine the effect of progressive mandibular advancement on pharyngeal airway size in normal adults during intravenous infusion of propofol for anesthesia. METHODS: Magnetic resonance imaging was performed in nine normal adults during wakefulness and during propofol anesthesia. A commercially available intraoral appliance was used to manually advance the mandible. Images were obtained during wakefulness without the appliance and during anesthesia with the participants wearing the appliance under three conditions: without mandibular advancement, advancement to 50% maximum voluntary advancement, and maximum advancement. Using computer software, airway area and maximum anteroposterior and lateral airway diameters were measured on the axial images at the level of the soft palate, uvula, tip of the epiglottis, and base of the epiglottis. RESULTS: Airway area across all four airway levels decreased during anesthesia without mandibular advancement compared with airway area during wakefulness (P \u3c 0.007). Across all levels, airway area at 50% advancement during anesthesia was less than that at centric occlusion during wakefulness (P = 0.06), but airway area with maximum advancement during anesthesia was similar to that during wakefulness (P = 0.64). In general, anteroposterior and lateral airway diameters during anesthesia without mandibular advancement were decreased compared with wakefulness and were restored to their wakefulness values with 50% and/or maximal advancement. CONCLUSIONS: Maximum mandibular advancement during propofol anesthesia is required to restore the pharyngeal airway to its size during wakefulness in normal adults

Plasma Dynamics

Contains reports on four research projects

Field Scale Variability of Nitrogen and δ15N in Soil and Plants

Understanding the factors that influence soil and plant nitrogen (N) spatial variability may improve our ability to develop management systems that maximize productivity and minimize environmental hazards. The objective of this study was to determine the field (65 ha) scale spatial variability of N and δ15N in soil and corn (Zea mays). Soil, grain, and stover samples were collected from grids that ranged in size from 30 by 30 m to 60 by 60 m. Plant samples, collected following physiological maturity in 1995, were analyzed for total N and δ15N. Soil samples, collected prior to planting in the spring of 1995 and 1996, were analyzed for inorganic‐N, total N, and δ15N. All parameters showed strong spatial relationships. In an undrained portion of the field containing somewhat poorly and poorly drained soils there was a net loss of 95 kg N ha‐1, while in an adjacent area that was tile drained there was a net gain of 98 kg N ha‐1. Denitrification and N mineralization most likely were responsible for losses and gains, respectively. Differences between the N balances of these areas (193 kg N ha‐1) provide a relative measure of the impact of tile drainage on plant N availability and greenhouse gas production in a wet year

Probing complex RNA structures by mechanical force

RNA secondary structures of increasing complexity are probed combining single molecule stretching experiments and stochastic unfolding/refolding simulations. We find that force-induced unfolding pathways cannot usually be interpretated by solely invoking successive openings of native helices. Indeed, typical force-extension responses of complex RNA molecules are largely shaped by stretching-induced, long-lived intermediates including non-native helices. This is first shown for a set of generic structural motifs found in larger RNA structures, and then for Escherichia coli's 1540-base long 16S ribosomal RNA, which exhibits a surprisingly well-structured and reproducible unfolding pathway under mechanical stretching. Using out-of-equilibrium stochastic simulations, we demonstrate that these experimental results reflect the slow relaxation of RNA structural rearrangements. Hence, micromanipulations of single RNA molecules probe both their native structures and long-lived intermediates, so-called "kinetic traps", thereby capturing -at the single molecular level- the hallmark of RNA folding/unfolding dynamics.Comment: 9 pages, 9 figure