Towards the integration of urban planning and biodiversity conservation through collaboration

Despite aspirations to halt biodiversity loss by 2020 under the Aichi Biodiversity Targets, urban development continues to negatively impact UK wildlife and habitats. Reasons behind continued biodiversity decline are examined through the use of semi-structured interviews with ecologists, statutory regulators and land developers.. It is found that despite strict legislation and best practice, for both planning and ecology, there is still much room for subjectivity regarding the protection of specific ecological features and the implementation of the mitigation hierarchy. Interviews also revealed that such subjectivity often facilitates the prioritisation of commercial over ecological benefits during site design. Furthermore, many felt an over reliance on the protection of individual animals, as opposed to maintaining functional connectivity for conservation of wider populations was detrimental to both the development industry and ecology. Our findings support the case for further research into the development of innovative geographical information systems to allow spatial deliberation, and collaborative decision-making between the three stakeholder groups

Multi-aperture foveated imaging

Foveated imaging, such as that evolved by biological systems to provide high angular resolution with a reduced space–bandwidth product, also offers advantages for man-made task-specific imaging. Foveated imaging systems using exclusively optical distortion are complex, bulky, and high cost, however. We demonstrate foveated imaging using a planar array of identical cameras combined with a prism array and superresolution reconstruction of a mosaicked image with a foveal variation in angular resolution of 5.9:1 and a quadrupling of the field of view. The combination of low-cost, mass-produced cameras and optics with computational image recovery offers enhanced capability of achieving large foveal ratios from compact, low-cost imaging systems

The contribution of selected non-articular conditions to knee pain severity and associated disability in older adults

SummaryObjectiveTo estimate the contribution of selected non-articular conditions (NACs) to pain severity and functional limitation in community-dwelling older adults with knee pain.DesignPopulation-based, cross-sectional study of 745 adults aged 50 years and over with knee pain. Self-complete questionnaires, clinical history and physical examination were used to identify the presence of selected NACs that could cause pain around the knee. Regression analyses were used to compare levels of knee pain severity (0–20) and functional limitation (0–68) (Western Ontario and McMaster Universities osteoarthritis index physical function subscale [WOMAC-PF]), between those with one or more NACs and those with none (NACs-absent).ResultsTwo hundred and seventy-three (36.6%) participants had at least one NAC: widespread pain, n=159; low back pain with index leg referral, n=102; full-leg pain, n=88; hip arthritis, n=65; prepatellar, infrapatellar or pes anserine bursitis, n=35. The NACs group had significantly higher levels of pain severity and functional limitation than the NACs-absent group: 8.2(±4.6) vs 5.4(±3.8) and 27.9(±15.8) vs 16.8(±13.2), respectively. The groups did not differ with respect to severity of radiographic osteoarthritis (ROA). Having one or more NACs accounted for a significant proportion of the variance in WOMAC scores, above that which could be explained by age, gender, body mass index and severity of ROA.ConclusionNACs appear to be common in older adults with knee pain. They make a significant contribution to knee pain severity and functional limitation and are likely to represent additional, rather than alternative, causes of knee pain/functional limitation to osteoarthritis (OA). These factors should be taken into account in epidemiological studies of knee pain and OA

Improvement of students’ scientific writing in a middle-years science classroom

This thesis illustrates a mixed-methods action-research evaluating impact of selected intervention strategies on writing skills of Science students in a mixed ability year 6 class. Scaffolding, peer/self-assessment and metacognitive journaling were implemented as part of the students’ scheme of work over 3 months. Using interviews, work-samples and anecdotal records, it was established that the students improved their writing skills and self-efficacy towards writing in Science as a result of the use of these strategies

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro

Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to CII (CIIC1 or M2139), a non-arthritogenic mAb to CII (CIIF4) or a control mAb (GAD6). Penetration of cartilage by mAb was determined by immunofluorescence on frozen sections and correlated with changes to the extracellular matrix and chondrocytes by morphometric analysis of sections stained with toluidine blue. The effects of mAbs on matrix components were examined by Fourier transform infrared microspectroscopy (FTIRM). A possible role of Fc-binding was investigated using F(ab)(2 )from CIIC1. All three mAbs to CII penetrated the cartilage explants and CIIC1 and M2139, but not CIIF4, had adverse effects that included proteoglycan loss correlating with mAb penetration, the later development in cultures of an abnormal superficial cellular layer, and an increased proportion of empty chondrons. FTIRM showed depletion and denaturation of CII at the explant surface in the presence of CIIC1 or M2139, which paralleled proteoglycan loss. The effects of F(ab)(2 )were greater than those of intact CIIC1. Our results indicate that mAbs to CII can adversely affect preformed cartilage, and that the specific epitope on CII recognised by the mAb determines both arthritogenicity in vivo and adverse effects in vitro. We conclude that antibodies to CII can have pathogenic effects that are independent of inflammatory mediators or Fc-binding

Relationship between Color and Translucency of Multishaded Dental Composite Resins

The aim of the present study was to compare the translucency of different shades of two highly aesthetic multilayered restorative composite resins. In total nine shades from Esthet.X and ten shades from Filtek Supreme composite resins were chosen. Discs of each shade were prepared (N = 3) and light-cured. Total and diffuse transmittance values for each sample were measured. Statistical analysis showed that the opaque dentine shades of both composites were the least translucent and the enamel shades had the highest translucency. There was a significant decrease in translucency from A2 to C2 of regular body shades and also from A4 to C4 of opaque dentine shades of Esthet.X composite resin. Grey enamel shade had a significantly higher diffuse translucency compared to clear and yellow enamel shades. There was a significant decrease in translucency from A2B to D2B and also in diffuse translucency from A4D to C6D shades of Filtek Supreme composite resin. It can be concluded that the color of the composite resins tested in this study had a significant effect on their translucency. Information on the translucency of different shades of composite resins can be very useful for the clinicians in achieving optimal esthetic restorative outcome

Social Stress and Welfare Problems in Agricultural Animals

Disruptions of an animal\u27s social behaviour can, in some respects at least, mimic the effects of such classical stressors as infection and exposure to low temperatures. For example, Barnett (1958) found enlarged adrenals among wild rats which were subjected to attack by other rats in the laboratory. However, the experience of being attacked was not necessary for this physiological response, as the aggressors showed much the same changes as the victims. In fact Archer (1969) reported heightened adrenocortical activity among individually caged mice simply as a result of their being housed next to other mice, without actual physical contact. If adrenocortical activity is increased by social interaction, it seems reasonable that it should be reduced by solitary confinement. Up to a point this appears to be true for male mice (Brain & Nowell, 1970), but prolonged social isolation, lasting a month or more, may have the opposite effect (Sigg et al., 1966)