Tropical forager gastrophagy and its implications for extinct hominin diets

Reconstruction of extinct hominin diets is currently a topic of much interest and debate, facilitated by new methods such as the analysis of dental calculus. It has been proposed, based on chemical analyses of calculus, that Neanderthals self-medicated, yet this conclusion has been questioned. Gastrophagy has been suggested as an alternative explanation for the Neanderthal data, based on ethnographic analogies, which show this practice to have been widespread in traditional extant Homo sapiens diets, and nutritional evidence for its benefits at high latitudes. Here we expand the discussion of the potential importance of gastrophagy in human evolution by considering its role for an extant group of tropical foragers, the Hadza of Tanzania, and questioning its role in the diets of extinct tropical hominin species. Gastrophagy is frequently practiced among the Hadza and adult men in particular consume substantial, seasonally variable, amounts of prey guts. In addition to the important fact that gastrophagy is not a rare event, this demographic information may be useful in interpreting evidence from archaeological samples. The consumption of semi-digested chyme would have allowed extinct hominins to gain calories from plant sources without the cost of digesting them, possibly contributing to the encephalisation and shrinking of the gut in genus Homo. As an easy to process food-source, chyme could have likewise been an important food source for the old and the young, potentially playing a part in reducing inter-birth intervals and increasing reproductive success in our lineage. Thus gastrophagy may have played a key part in human evolution and its potentially confounding signal should be considered in future dietary reconstructions.We would like to thank The Calleva Foundation (LTB & CBS), The Human Origins Research Fund, NHM (LTB & CBS), The Leakey Foundation (JCB & BMW), Wenner-Gren Foundation (BMW), & the National Science Foundation (BMW) for funding.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.jasrep.2015.09.02

Tropical forager gastrophagy and its implications for extinct hominin diets

Reconstruction of extinct hominin diets is currently a topic of much interest and debate, facilitated by new methods such as the analysis of dental calculus. It has been proposed, based on chemical analyses of calculus, that Neanderthals self-medicated, yet this conclusion has been questioned. Gastrophagy has been suggested as an alternative explanation for the Neanderthal data, based on ethnographic analogies, which show this practice to have been widespread in traditional extant Homo sapiens diets, and nutritional evidence for its benefits at high latitudes. Here we expand the discussion of the potential importance of gastrophagy in human evolution by considering its role for an extant group of tropical foragers, the Hadza of Tanzania, and questioning its role in the diets of extinct tropical hominin species. Gastrophagy is frequently practiced among the Hadza and adult men in particular consume substantial

POLÍTICAS DE FINANCIAMENTO DA EDUCAÇÃO BÁSICA: A VALORIZAÇÃO DOS PROFISSIONAIS DO MAGISTÉRIO NA REDE MUNICIPAL DE ENSINO DE SÃO MATEUS/ES

Esta dissertação tem como objetivo analisar a gestão dos recursos do Fundeb e sua influência nas políticas de valorização dos profissionais do magistério no Município de São Mateus/ES, no período de 2007 a 2015, buscando verificar como o fundo contribuiu para assegurar essas políticas. Para isso, analisamos as legislações de regulamentação do financiamento da educação, de implantação do Fundef e do Fundeb e as normas que asseguram a carreira do magistério do Município estudado. A metodologia utilizada de pesquisa foi qualitativa, apresentando reflexões acerca do financiamento da educação básica, com base em levantamento bibliográfico e documental. Para discussão e análise, realizamos em um primeiro momento estudo das características e políticas de financiamento no Brasil e as influências do Estado burocrático para a efetivação dessas políticas. Em seguida, analisamos os dados financeiros e educacionais do Município relacionados aos fundos e as políticas implantadas no que dizem respeito a valorização do magistério após o Fundeb. Realizamos ainda, estudos da interferência dos recursos destinados à educação na oferta de matrículas na Rede Municipal. Concluiu-se que, o Fundeb se constitui em instrumento efetivo para a garantia de políticas positivas de valorização do magistério implantadas no Município de São Mateus, principalmente no que se refere ao Plano de Cargos, Carreira e Remuneração o que consequentemente incentivou a busca por formação inicial e continuada por parte dos profissionais da educação

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.

We hypothesized that key antiproliferative target genes for the vitamin D receptor (VDR) were repressed by an epigenetic mechanism in prostate cancer cells resulting in apparent hormonal insensitivity. To explore this possibility, we examined nuclear receptor corepressor expression in a panel of nonmalignant and malignant cell lines and primary cultures, and found frequently elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). For example, PC-3 and DU-145 prostate cancer cell lines had 1.8-fold and twofold increases in SMRT mRNA relative to normal PrEC cells (P<0.05). Similarly, 10/15 primary tumour cultures (including three matched to normal cells from the same donors) had elevated SMRT mRNA levels; generally NCoR1 and Alien were not as commonly elevated. Corepressor proteins often have associated histone deacetylases (HDAC) and reflectively the antiproliferative action of 1alpha,25(OH)2D3 can be restored by cotreatment with low doses of HDAC inhibitors such as trichostatin A (TSA, 15 nM) to induce apoptosis in prostate cancer cell lines. To decipher the transcriptional events that lead to these cellular responses, we undertook gene expression studies in PC-3 cells after cotreatment of 1alpha,25(OH)2D3 plus TSA after 6 h. Examination of known VDR target genes and cDNA microarray analyses revealed cotreatment of 1alpha,25(OH)2D3 plus TSA cooperatively upregulated eight (out of 1176) genes, including MAPK-APK2 and GADD45alpha. MRNA and protein time courses and inhibitor studies confirmed these patterns of regulation. Subsequently, we knocked down SMRT levels in PC-3 cells using a small interfering RNA (siRNA) approach and found that GADD45alpha induction by 1alpha,25(OH)2D3 alone became very significantly enhanced. The same distortion of gene responsiveness, with repressed induction of GADD45alpha was found in primary tumour cultures compared and to matched peripheral zone (normal) cultures from the same donor. These data demonstrate that elevated SMRT levels are common in prostate cancer cells, resulting in suppression of target genes associated with antiproliferative action and apparent 1alpha,25(OH)2D3-insensitivity. This can be targeted therapeutically by combination treatments with HDAC inhibitors

Isotopic variation of parity violation in atomic ytterbium

We report on measurements of atomic parity violation, made on a chain of ytterbium isotopes with mass numbers A=170, 172, 174, and 176. In the experiment, we optically excite the 6s2 1S0 -> 5d6s 3D1 transition in a region of crossed electric and magnetic fields, and observe the interference between the Stark- and weak-interaction-induced transition amplitudes, by making field reversals that change the handedness of the coordinate system. This allows us to determine the ratio of the weak-interaction-induced electric-dipole (E1) transition moment and the Stark-induced E1 moment. Our measurements, which are at the 0.5% level of accuracy for three of the four isotopes measured, allow a definitive observation of the isotopic variation of the weak-interaction effects in an atom, which is found to be consistent with the prediction of the Standard Model. In addition, our measurements provide information about an additional Z' boson.Comment: 19 pages, 4 figures, 2 table

Menstrual cycle phase does not predict political conservatism

Recent authors have reported a relationship between women's fertility status, as indexed by menstrual cycle phase, and conservatism in moral, social and political values. We conducted a survey to test for the existence of a relationship between menstrual cycle day and conservatism. 2213 women reporting regular menstrual cycles provided data about their political views. Of these women, 2208 provided information about their cycle date, 1260 provided additional evidence of reliability in self-reported cycle date, and of these, 750 also indicated an absence of hormonal disruptors such as recent hormonal contraception use, breastfeeding or pregnancy. Cycle day was used to estimate day-specific fertility rate (probability of conception); political conservatism was measured via direct self-report and via responses to the "Moral Foundations” questionnaire. We also recorded relationship status, which has been reported to interact with menstrual cycle phase in determining political preferences. We found no evidence of a relationship between estimated cyclical fertility changes and conservatism, and no evidence of an interaction between relationship status and cyclical fertility in determining political attitudes. Our findings were robust to multiple inclusion/exclusion criteria and to different methods of estimating fertility and measuring conservatism. In summary, the relationship between cycle-linked reproductive parameters and conservatism may be weaker or less reliable than previously thought

Making the link between critical appraisal, thinking and analysis

Nursing has become an all-graduate profession; as such, student nurses must develop their skills of critical analysis. The need to develop critical analytical thinking has been identified as the single most important skill in undergraduate education and reaching the academic requirements of level six study. In degree-level healthcare programmes, students are frequently asked to complete a structured critical appraisal of research. This paper examines how critical appraisal activities can be an opportunity for students to develop transferable critical thinking skills. Critical appraisal teaches objectivity, reflection, logic and discipline, which encourage students to think critically in both theory and practice.N/

Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study

This study was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, Dr. and Mrs. Lee Iu Cheung Fund, and Hackney Primary Care Trust (PCT)

Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves

peer-reviewedBackground There is a need to improve vaccination against respiratory pathogens in calves by stimulation of local immunity at the site of pathogen entry at an early stage in life. Ideally such a vaccine preparation would not be inhibited by the maternally derived antibodies. Additionally, localized immune response at the site of infection is also crucial to control infection at the site of entry of virus. The present study investigated the response to an intranasal bovine parainfluenza 3 virus (BPI3V) antigen preparation encapsulated in PLGA (poly dl-lactic-co-glycolide) nanoparticles in the presence of pre-existing anti-BPI3V antibodies in young calves and comparing it to a commercially available BPI3V respiratory vaccine. Results There was a significant (P < 0.05) increase in BPI3V-specific IgA in the nasal mucus of the BPI3V nanoparticle vaccine group alone. Following administration of the nanoparticle vaccine an early immune response was induced that continued to grow until the end of study and was not observed in the other treatment groups. Virus specific serum IgG response to both the nanoparticle vaccine and commercial live attenuated vaccine showed a significant (P < 0.05) rise over the period of study. However, the cell mediated immune response observed didn’t show any significant rise in any of the treatment groups. Conclusion Calves administered the intranasal nanoparticle vaccine induced significantly greater mucosal IgA responses, compared to the other treatment groups. This suggests an enhanced, sustained mucosal-based immunological response to the BPI3V nanoparticle vaccine in the face of pre-existing antibodies to BPI3V, which are encouraging and potentially useful characteristics of a candidate vaccine. However, ability of nanoparticle vaccine in eliciting cell mediated immune response needs further investigation. More sustained local mucosal immunity induced by nanoparticle vaccine has obvious potential if it translates into enhanced protective immunity in the face of virus outbreak

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line

Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates induce changes in sodium ion channel currents known to be associated with neuropathic pain. Twenty VZV isolates were studied blind from 11 PHN and 9 non-PHN subjects. Viruses were propagated in the MeWo cell line from which cell-free virus was harvested and applied to the ND7/23-Nav1.8 rat DRG x mouse neuroblastoma hybrid cell line which showed constitutive expression of the exogenous Nav 1.8, and endogenous expression of Nav 1.6 and Nav 1.7 genes all encoding sodium ion channels the dysregulation of which is associated with a range of neuropathic pain syndromes. After 72 hrs all three classes of VZV gene transcripts were detected in the absence of infectious virus. Single cell sodium ion channel recording was performed after 72 hr by voltage-clamping. PHN-associated VZV significantly increased sodium current amplitude in the cell line when compared with non-PHN VZV, wild-type (Dumas) or vaccine VZV strains ((POka, Merck and GSK). These sodium current increases were unaffected by acyclovir pre-treatment but were abolished by exposure to Tetrodotoxin (TTX) which blocks the TTX-sensitive fast Nav 1.6 and Nav 1.7 channels but not the TTX-resistant slow Nav 1.8 channel. PHN-associated VZV sodium current increases were therefore mediated in part by the Nav 1.6 and Nav 1.7 sodium ion channels. An additional observation was a modest increase in message levels of both Nav1.6 and Nav1.7 mRNA but not Nav 1.8 in PHN virally infected cells