Deep Chandra Monitoring Observations of NGC 4649: II. Wide-Field Hubble Space Telescope Imaging of the Globular Clusters

We present g and z photometry and size estimates for globular clusters (GCs) in the massive Virgo elliptical NGC 4649 (M60) using a five-pointing Hubble Space Telescope/Advanced Camera for Surveys mosaic. The metal-poor GCs show a monotonic negative metallicity gradient of (-0.43 +/- 0.10) dex per dex in radius over the full radial range of the data, out to ~ 24 kpc. There is evidence for substantial color substructure among the metal-rich GCs. The metal-poor GCs have typical sizes ~ 0.4 pc larger than the metal-rich GCs out to large galactocentric distances (~> 20 kpc), favoring an intrinsic explanation for the size difference rather than projection effects. There is no clear relation between half-light radius and galactocentric distance beyond ~ 15 kpc, suggesting that the sizes of GCs are not generically set by tidal limitation. Finally, we identify ~ 20 candidate ultra-compact dwarfs that extend down to surprisingly faint absolute magnitudes (M_z ~ -8.5), and may bridge the gap between this class and "extended clusters" in the Local Group. Three of the brighter candidates have published radial velocities and can be confirmed as bona fide ultra-compact dwarfs; follow-up spectroscopy will determine the nature of the remainder of the candidates.Comment: ApJ in press. For redacted long table 1, see: http://www.pa.msu.edu/~strader/4649/table.te

Emergence of a Dynamic Super-Structural Order Integrating Antiferroelectric and Antiferrodistortive Competing Instabilities in EuTiO3

Microscopic structural instabilities of EuTiO3 single crystal were investigated by synchrotron x-ray diffraction. Antiferrodistortive (AFD) oxygen octahedral rotational order was observed alongside Ti derived antiferroelectric (AFE) distortions. The competition between the two instabilities is reconciled through a cooperatively modulated structure allowing both to coexist. The electric and magnetic field effect on the modulated AFD order shows that the origin of large magnetoelectric coupling is based upon the dynamic equilibrium between the AFD - antiferromagnetic interactions versus the electric polarization - ferromagnetic interactions

Limit of metastability for liquid and vapor phases of water

We report the limits of superheating of water and supercooling of vapor from Monte Carlo simulations using microscopic models with configurational enthalpy as the order parameter. The superheating limit is well reproduced. The vapor is predicted to undergo spinodal decomposition at a temperature of Tspvap=46??10??C (0??Câ???Tspvapâ???100??C) under 1 atm. The water-water network begins to form at the supercooling limit of the vapor. Three-dimensional water-water and cavity-cavity unbroken networks are interwoven at critically superheated liquid water; if either network breaks, the metastable state changes to liquid or vapor.open0

Surface-Wave Based Model for Estimation of Discontinuity Depth in Concrete

In this paper, we propose an accurate and practical model for the estimation of surface-breaking discontinuity (i.e., crack) depth in concrete through quantitative characterization of surface-wave transmission across the discontinuity. The effects of three different mixture types (mortar, normal strength concrete, and high strength concrete) and four different simulated crack depths on surface-wave transmission were examined through experiments carried out on lab-scale concrete specimens. The crack depth estimation model is based on a surface-wave spectral energy approach that is capable of taking into account a wide range of wave frequencies. The accuracy of the proposed crack depth estimation model is validated by root mean square error analysis of data from repeated spectral energy transmission ratio measurements for each specimen

Microfluidic Electrical Sorting of Particles Based on Shape in a Spiral Microchannel

Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation. (C) 2014 AIP Publishing LLC

Intermolecular Diels-Alder Cycloaddition for the Construction of Bicyclo[2.2.2]diazaoctane Structures: Formal Synthesis of Brevianamide B and Premalbrancheamide

A stereoselective intermolecular Diels-Alder cycloaddition of an intermediate pyrazinone with both achiral and chiral acrylate-derived dienophiles provides rapid access to the bicyclo[2.2.2]diazaoctane core shared among several prenylated indole alkaloids. The product derived from cydoaddition with 2-nitroacrylate required an additional five to six synthetic operations to intercept established precursors to premalbrancheamide and brevianamide B. The chemistry detailed in this manuscript constitutes a formal total synthesis (12 steps each) of these [2.2.2]diazabicyclic natural products from proline methyl ester

Lead Optimization of 7-benzyloxy 2-(4′-pyridylmethyl)Thio Isoflavone Aromatase Inhibitors

Aromatase, the enzyme responsible for estrogen biosynthesis, is a particularly attractive target in the treatment of hormone-dependent breast cancer. The synthesis and biological evaluation of a series of 2-(4′-pyridylmethyl)thio, 7-alkyl- or aryl-substituted isoflavones as potential aromatase inhibitors are described. The isoflavone derivatives demonstrate IC50 values from 79 to 553 nM and compete with the endogenous substrate, androstenedione. Data supporting the ability of these analogs to suppress aromatase enzyme activity in the SK-BR-3 breast cancer cell line are also presented

Software Modules for the Proximity-1 Space Link Interleaved Time Synchronization (PITS) Protocol

The Proximity-1 Space Link Interleaved Time Synchronization (PITS) protocol provides time distribution and synchronization services for space systems. A software prototype implementation of the PITS algorithm has been developed that also provides the test harness to evaluate the key functionalities of PITS with simulated data source and sink. PITS integrates time synchronization functionality into the link layer of the CCSDS Proximity-1 Space Link Protocol. The software prototype implements the network packet format, data structures, and transmit- and receive-timestamp function for a time server and a client. The software also simulates the transmit and receive-time stamp exchanges via UDP (User Datagram Protocol) socket between a time server and a time client, and produces relative time offsets and delay estimates