Wearable vibrotactile stimulation for upper extremity rehabilitation in chronic stroke: clinical feasibility trial using the VTS Glove

Objective: Evaluate the feasibility and potential impacts on hand function using a wearable stimulation device (the VTS Glove) which provides mechanical, vibratory input to the affected limb of chronic stroke survivors. Methods: A double-blind, randomized, controlled feasibility study including sixteen chronic stroke survivors (mean age: 54; 1-13 years post-stroke) with diminished movement and tactile perception in their affected hand. Participants were given a wearable device to take home and asked to wear it for three hours daily over eight weeks. The device intervention was either (1) the VTS Glove, which provided vibrotactile stimulation to the hand, or (2) an identical glove with vibration disabled. Participants were equally randomly assigned to each condition. Hand and arm function were measured weekly at home and in local physical therapy clinics. Results: Participants using the VTS Glove showed significantly improved Semmes-Weinstein monofilament exam, reduction in Modified Ashworth measures in the fingers, and some increased voluntary finger flexion, elbow and shoulder range of motion. Conclusions: Vibrotactile stimulation applied to the disabled limb may impact tactile perception, tone and spasticity, and voluntary range of motion. Wearable devices allow extended application and study of stimulation methods outside of a clinical setting

Use It and Improve It or Lose It: Interactions between Arm Function and Use in Humans Post-stroke

“Use it and improve it, or lose it” is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored putative non-linear interactions between upper extremity function and use by developing a first-order dynamical model of stroke recovery with longitudinal data from participants receiving constraint induced movement therapy (CIMT) in the EXCITE clinical trial. Using a Bayesian regression framework, we systematically compared this model with competitive models that included, or not, interactions between function and use. Model comparisons showed that the model with the predicted interactions between arm function and use was the best fitting model. Furthermore, by comparing the model parameters before and after CIMT intervention in participants receiving the intervention one year after randomization, we found that therapy increased the parameter that controls the effect of arm function on arm use. Increase in this parameter, which can be thought of as the confidence to use the arm for a given level of function, lead to increase in spontaneous use after therapy compared to before therapy

Planting the Seeds: Orchestral Music Education as a Context for Fostering Growth Mindsets

Growth mindset is an important aspect of children\u27s socioemotional development and is subject to change due to environmental influence. Orchestral music education may function as a fertile context in which to promote growth mindset; however, this education is not widely available to children facing economic hardship. This study examined whether participation in a program of orchestral music education was associated with higher levels of overall growth mindset and greater change in levels of musical growth mindset among children placed at risk by poverty. After at least 2 years of orchestral participation, students reported significantly higher levels of overall growth mindset than their peers; participating students also reported statistically significant increases in musical growth mindset regardless of the number of years that they were enrolled in orchestral music education. These findings have implications for future research into specific pedagogical practices that may promote growth mindset in the context of orchestral music education and more generally for future studies of the extra-musical benefits of high-quality music education

Direct frequency-comb spectroscopy of a dipole-forbidden clock transition in trapped 40Ca+ ions

We demonstrate direct frequency-comb (FC) spectroscopy of the dipole-forbidden 4

GEMS: Galaxy fitting catalogues and testing parametric galaxy fitting codes

In the context of measuring structure and morphology of intermediate redshift galaxies with recent HST/ACS surveys, we tune, test, and compare two widely used fitting codes (GALFIT and GIM2D) for fitting single-component Sersic models to the light profiles of both simulated and real galaxy data. We find that fitting accuracy depends sensitively on galaxy profile shape. Exponential disks are well fit with Sersic models and have small measurement errors, whereas fits to de Vaucouleurs profiles show larger uncertainties owing to the large amount of light at large radii. We find that both codes provide reliable fits and little systematic error, when the effective surface brightness is above that of the sky. Moreover, both codes return errors that significantly underestimate the true fitting uncertainties, which are best estimated with simulations. We find that GIM2D suffers significant systematic errors for spheroids with close companions owing to the difficulty of effectively masking out neighboring galaxy light; there appears to be no work around to this important systematic in GIM2D's current implementation. While this crowding error affects only a small fraction of galaxies in GEMS, it must be accounted for in the analysis of deeper cosmological images or of more crowded fields with GIM2D. In contrast, GALFIT results are robust to the presence of neighbors because it can simultaneously fit the profiles of multiple companions thereby deblending their effect on the fit to the galaxy of interest. We find GALFIT's robustness to nearby companions and factor of >~20 faster runtime speed are important advantages over GIM2D for analyzing large HST/ACS datasets. Finally we include our final catalog of fit results for all 41,495 objects detected in GEMS.Comment: Accepted for publication in ApJS October 2007, v172n2; 25 pages, 16 Figures, 9 Tables; for hi-resolution version, see http://www.mpia.de/homes/bhaeussl/galaxy_fitting.pdf. For results, catalogues and files for code-testing, see http://www.mpia.de/GEMS/fitting_paper.htm

PTSD and Alcohol Use Disorders Predict the Pace of Cellular Aging

Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened pace of epigenetic aging over time (ps \u3c .021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology

Matching scope, purpose and uses of planetary boundaries science

Background: The Planetary Boundaries concept (PBc) has emerged as a key global sustainability concept in international sustainable development arenas. Initially presented as an agenda for global sustainability research, it now shows potential for sustainability governance. We use the fact that it is widely cited in scientific literature (>3500 citations) and an extensively studied concept to analyse how it has been used and developed since its first publication. Design: From the literature that cites the PBc, we select those articles that have the terms 'planetary boundaries' or 'safe operating space' in either title, abstract or keywords. We assume that this literature substantively engages with and develops the PBc. Results: We find that 6% of the citing literature engages with the concept. Within this fraction of the literature we distinguish commentaries—that discuss the context and challenges to implementing the PBc, articles that develop the core biogeophysical concept and articles that apply the concept by translating to sub-global scales and by adding a human component to it. Applied literature adds to the concept by explicitly including society through perspectives of impacts, needs, aspirations and behaviours. Discussion: Literature applying the concept does not yet include the more complex, diverse, cultural and behavioural facet of humanity that is implied in commentary literature. We suggest there is need for a positive framing of sustainability goals—as a Safe Operating Space rather than boundaries. Key scientific challenges include distinguishing generalised from context-specific knowledge, clarifying which processes are generalizable and which are scalable, and explicitly applying complex systems' knowledge in the application and development of the PBc. We envisage that opportunities to address these challenges will arise when more human social dimensions are integrated, as we learn to feed the global sustainability vision with a plurality of bottom-up realisations of sustainability

OMEGA–OSIRIS mapping of emission-line galaxies in A901/2:IV. Extinction of star formation estimators with inclination

We study the effect of inclination on the apparent brightness of star-forming galaxies in spectral passbands that are commonly used as star formation indicators. As diagnostics we use mass-to-light ratios in three passbands: the UV continuum at 280 nm, the Hα emission line, and the FIR 24μ band. We include a study of inclination trends in the IR/UV ratio (‘IRX’) and the IR/Hα ratio. Our sample comprises a few hundred galaxies from the region around the clusters Abell 901/902 with deep data and inclinations measured from outer discs in Hubble Space Telescope images. As a novelty, the Hα- and separately the N ii emission are measured by tunable-filter imaging and encompass galaxies in their entirety. At galaxy stellar masses above log M*/M⊙ ≳ 10 we find trends in the UV and Hα mass-to-light ratio that suggest an inclination-induced attenuation from face-on to edge-on of ∼1 mag and ∼0.7 mag in UV and Hα, respectively, implying that star formation rates of edge-on galaxies would be underestimated by ∼2.5 × in UV and ∼2 × in Hα. We find the luminosities in UV and Hα to be well correlated, but the optical depth of diffuse dust that causes inclination dependence appears to be lower for stars emitting at 280 nm than for gas clouds emitting Balmer lines. For galaxies with log M*/M⊙ ≲ 9.7, we find no measurable effect at >0.1 mag. The absence of an inclination dependence at 24μ confirms that the average galaxy is optically thin in the FIR

OMEGA – OSIRIS Mapping of Emission-line Galaxies in A901/2: II. Environmental influence on integrated star formation properties and AGN activity

We present a study of the star formation and AGN activity for galaxies in CP 15051 the Abell 901/2 multicluster system at z ∼ 0.167 as part of the OSIRIS Mapping of Emission-line Galaxies in A901/2 (OMEGA) survey. Using Tuneable Filter data obtained with the OSIRIS instrument at the Gran Telescopio Canarias, we produce spectra covering the Hα and [NII] spectral lines for more than 400 galaxies. Using optical emission-line diagnostics, we identify a significant number of galaxies hosting AGN, which tend to have high masses and a broad range of morphologies. Moreover, within the environmental densities probed by our study, we find no environmental dependence on the fraction of galaxies hosting AGN. The analysis of the integrated Hα emission shows that the specific star formation rates of a majority of the cluster galaxies are below the field values for a given stellar mass. We interpret this result as evidence for a slow decrease in the star formation activity of star-forming galaxies as they fall into higher density regions, contrary to some previous studies that suggested a rapid truncation of star formation. We find that most of the intermediate- and high-mass spiral galaxies go through a phase in which their star formation is suppressed but still retain significant star formation activity. During this phase, these galaxies tend to retain their spiral morphology while their colours become redder. The presence of this type of galaxies in high-density regions indicates that the physical mechanism responsible for suppressing star formation affects mainly the gas component of the galaxies, suggesting that ram-pressure stripping or starvation is potentially responsible

OMEGA - OSIRIS mapping of emission-line galaxies in A901/2: III. - Galaxy properties across projected phase space in A901/2

We conduct a comprehensive projected phase-space analysis of the A901/2 multicluster system at z ∼ 0.165. Aggregating redshifts from spectroscopy, tunable-filter imaging and prism techniques, we assemble a sample of 856 cluster galaxies reaching 108.5 M⊙ in stellar mass. We look for variations in cluster galaxy properties between virialized and non-virialized regions of projected phase space (PPS). Our main conclusions point to relatively gentle environmental effects, expressed mainly on galaxy gas reservoirs. (1) Stacking the four subclusters in A901/2, we find galaxies in the virialized region are more massive, redder and have marginally higher Sérsic indices, but their half-light radii and Hubble types are not significantly different. (2) After accounting for trends in stellar mass, there is a remaining change in rest-frame colour across PPS. Primarily, the colour difference is due to the absence in the virialized region of galaxies with rest frame B − V 109.85 M⊙) stellar mass. (3) There is an infalling population of lower mass (M⋆ ≤ 109.85 M⊙), relatively blue (B − V < 0.7) elliptical or spheroidal galaxies that are strikingly absent in the virialized region. (4) The number of bona fide star-forming and active galactic nucleus galaxies in the PPS regions is strongly dictated by stellar mass. However, there remains a reduced fraction of star-forming galaxies in the centres of the clusters at fixed stellar mass, consistent with the star formation–density relation in galaxy clusters. (5) There is no change in specific Hα-derived star formation rates of star-forming galaxies at fixed mass across the cluster environment. This suggests that pre-processing of galaxies during infall plays a prominent role in quenching star formation