745 research outputs found

    Teacher Retention: A Phenomenological Study on the Experiences of White Male Teachers in an Urban Secondary School

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    The purpose of this transcendental phenomenological study was to discover the commonalities and factors of retention for White male teachers at an urban secondary school. The focus was on the experiences of the White male teachers at an urban secondary school in Virginia. This research is an examination of the experiences and perceptions of White male teachers. The data included interviews, focus groups, and letter writing to fill the gap in literature for teacher retention in urban schools. The research questions included what are the lived experiences of White male teachers in urban secondary schools and why do they choose to work in the urban school setting? In addition, what are the common issues White male teachers share in an urban secondary school and what are the causes for them to stay or leave the teaching profession? The theoretical framework used is social impact theory and self-determination theory. The results of the data provided new literature for teacher retention in the urban school setting. The findings of this study revealed the lived experiences of White male teachers working in an urban secondary school in Virginia had connections to the school, built relationships, incorporated technology in the classroom, and struggled financially. White male teachers also experienced lack of respect from both students and administration, too much cell phone use, chronic absenteeism and tardiness, and student disengagement. Overall, the motivation and causes of why these teachers stay in the teaching field are seeing students succeed and being a positive influence. The motivation of them leaving the teaching profession were not enough pay and student disengagement

    Ultrafast spatio-temporal dynamics of terahertz generation by ionizing two-color femtosecond pulses in gases

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    We present a combined theoretical and experimental study of spatio-temporal propagation effects in terahertz (THz) generation in gases using two-color ionizing laser pulses. The observed strong broadening of the THz spectra with increasing gas pressure reveals the prominent role of spatio-temporal reshaping and of a plasma-induced blue-shift of the pump pulses in the generation process. Results obtained from (3+1)-dimensional simulations are in good agreement with experimental findings and clarify the mechanisms responsible for THz emission

    Quantum-mechanical wavepacket transport in quantum cascade laser structures

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    We present a viewpoint of the transport process in quantum cascade laser structures in which spatial transport of charge through the structure is a property of coherent quantum-mechanical wavefunctions. In contrast, scattering processes redistribute particles in energy and momentum but do not directly cause spatial motion of charge.Comment: 6 pages, 5 figures included in tex, to appear in Physical Review

    Vibronic excitations of large molecules in solution studied by two-color pump–probe experiments on the 20 fs time scale

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    The ultrafast vibronic response of organic dye molecules in solution is studied in pump–probe experiments with 30 fs excitation pulses resonant to S0–Sn transitions. The molecular dynamics is probed either by pulses at the same spectral position or by 20 fs pulses overlapping with both the S0–S1 absorption and emission bands. Three contributions on distinctly different time scales are observed in the temporally and spectrally resolved two-color measurements. In the regime below 50 fs, a strong coherent coupling of the S0–Sn and the S0–S1 transitions occurs that is due to coherent vibrational motions in the electronic ground state. This signal is superimposed on the fast bleaching of the electronic ground state, resulting in a steplike increase of transmission. In the range of the S0–S1 emission band, one finds a subsequent picosecond rise of transmission that is due to stimulated emission from vibronic S1 states. The data demonstrate that the relaxation of Sn states directly populated by the pump pulses is much faster than the buildup of stimulated emission. This gives insight into different steps of intramolecular vibronic redistribution and is compared to the Sn–S1 relaxation in other molecules

    Inherently Interpretable Multi-Label Classification Using Class-Specific Counterfactuals

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    Interpretability is essential for machine learning algorithms in high-stakes application fields such as medical image analysis. However, high-performing black-box neural networks do not provide explanations for their predictions, which can lead to mistrust and suboptimal human-ML collaboration. Post-hoc explanation techniques, which are widely used in practice, have been shown to suffer from severe conceptual problems. Furthermore, as we show in this paper, current explanation techniques do not perform adequately in the multi-label scenario, in which multiple medical findings may co-occur in a single image. We propose Attri-Net, an inherently interpretable model for multi-label classification. Attri-Net is a powerful classifier that provides transparent, trustworthy, and human-understandable explanations. The model first generates class-specific attribution maps based on counterfactuals to identify which image regions correspond to certain medical findings. Then a simple logistic regression classifier is used to make predictions based solely on these attribution maps. We compare Attri-Net to five post-hoc explanation techniques and one inherently interpretable classifier on three chest X-ray datasets. We find that Attri-Net produces high-quality multi-label explanations consistent with clinical knowledge and has comparable classification performance to state-of-the-art classification models.Comment: Accepted to MIDL 202

    Ultrafast modulation of electronic structure by coherent phonon excitations

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    Femtosecond x-ray absorption spectroscopy with a laser-driven high-harmonic source is used to map ultrafast changes of x-ray absorption by femtometer- scale coherent phonon displacements. In LiBH4, displacements along an Ag phonon mode at 10 THz are induced by impulsive Raman excitation and give rise to oscillatory changes of x-ray absorption at the Li K edge. Electron density maps from femtosecond x-ray diffraction data show that the electric field of the pump pulse induces a charge transfer from the BH4− to neighboring Li+ ions, resulting in a differential Coulomb force that drives lattice vibrations in this virtual transition state

    Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability

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    <p>Abstract</p> <p>Background</p> <p>Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control of cellular growth and differentiation. Increasing evidence suggests that mutations in PTP genes are associated with human malignancies. For example, mutational analysis of the tyrosine phosphatase (PTP) gene superfamily uncovered genetic alterations in about 26% of colorectal tumors. Since in these studies tumors have not been stratified according to genetic instability status we hypothesized that colorectal tumors characterized by high-level of microsatellite instability (MSI-H) might show an increased frequency of frameshift mutations in those PTP genes that harbor long mononucleotide repeats in their coding region (cMNR).</p> <p>Results</p> <p>Using bioinformatic analysis we identified 16 PTP candidate genes with long cMNRs that were examined for genetic alterations in 19 MSI-H colon cell lines, 54 MSI-H colorectal cancers, and 17 MSI-H colorectal adenomas. Frameshift mutations were identified only in 6 PTP genes, of which PTPN21 show the highest mutation frequency at all in MSI-H tumors (17%).</p> <p>Conclusion</p> <p>Although about 32% of MSI-H tumors showed at least one affected PTP gene, and cMNR mutation rates in PTPN21, PTPRS, and PTPN5 are higher than the mean mutation frequency of MNRs of the same length, mutations within PTP genes do not seem to play a common role in MSI tumorigenesis, since no cMNR mutation frequency reached statistical significance and therefore, failed prediction as a Positive Selective Target Gene.</p
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