270 research outputs found
Feedback at the Working Surface: A Joint X-ray and Low-Frequency Radio Spectral Study of the Cocoon Shock in Cygnus A
Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells
First LOFAR results on galaxy clusters
Deep radio observations of galaxy clusters have revealed the existence of
diffuse radio sources related to the presence of relativistic electrons and
weak magnetic fields in the intracluster volume. The role played by this
non-thermal intracluster component on the thermodynamical evolution of galaxy
clusters is debated, with important implications for cosmological and
astrophysical studies of the largest gravitationally bound structures of the
Universe. The low surface brightness and steep spectra of diffuse cluster radio
sources make them more easily detectable at low-frequencies. LOFAR is the first
instrument able to detect diffuse radio emission in hundreds of massive galaxy
clusters up to their formation epoch. We present the first observations of
clusters imaged by LOFAR and the huge perspectives opened by this instrument
for non-thermal cluster studies.Comment: Proceedings of the 2012 week of the French Society of Astronomy and
Astrophysics (SF2A) held in Nice, June 5th-8t
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Detector Description and Performance for the First Coincidence Observations between LIGO and GEO
For 17 days in August and September 2002, the LIGO and GEO interferometer
gravitational wave detectors were operated in coincidence to produce their
first data for scientific analysis. Although the detectors were still far from
their design sensitivity levels, the data can be used to place better upper
limits on the flux of gravitational waves incident on the earth than previous
direct measurements. This paper describes the instruments and the data in some
detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial
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American thoracic society/national heart, lung, and blood institute asthma-chronic obstructive pulmonary disease overlap workshop report
Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent) including dyspnea and a productive cough. On the basis of age and smoking history, it is often easy to distinguish between asthma andCOPD. However, some patients have features compatible with both diseases. Because clinical studies typically exclude these patients, their underlying disease mechanisms and appropriate treatment remain largely uncertain. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the American Thoracic Society, convened a workshop of investigators in San Francisco, California on May 14, 2016. At the workshop, current understanding of asthma-COPD overlap was discussed among clinicians, pathologists, radiologists, epidemiologists, and investigators with expertise in asthma and COPD. They considered knowledge gaps in our understanding of asthma-COPD overlap and identified strategies and research priorities that will advance its understanding. This report summarizes those discussions
A Theory for the High-T_c Cuprates: Anomalous Normal-State and Spectroscopic Properties, Phase Diagram, and Pairing
A theory of highly correlated layered superconducting materials isapplied for
the cuprates. Differently from an independent-electron approximation, their
low-energy excitations are approached in terms of auxiliary particles
representing combinations of atomic-like electron configurations, where the
introduction of a Lagrange Bose field enables treating them as bosons or
fermions. The energy spectrum of this field accounts for the tendency of
hole-doped cuprates to form stripe-like inhomogeneities. Consequently, it
induces a different analytical behavior for auxiliary particles corresponding
to "antinodal" and "nodal" electrons, enabling the existence of different
pairing temperatures at T^* and T_c. This theory correctly describes the
observed phase diagram of the cuprates, including the non-Fermi-liquid to FL
crossover in the normal state, the existence of Fermi arcs below T^* and of a
"marginal-FL" critical behavior above it. The qualitative anomalous behavior of
numerous physical quantities is accounted for, including kink- and
waterfall-like spectral features, the drop in the scattering rates below T^*
and more radically below T_c, and an effective increase in the density of
carriers with T and \omega, reflected in transport, optical and other
properties. Also is explained the correspondence between T_c, the
resonance-mode energy, and the "nodal gap".Comment: 28 pages, 7 figure
Experimental Lagos bat virus infection in straw-colored fruit bats: A suitable model for bat rabies in a natural reservoir species
Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our understanding of lyssavirus pathogenesis in a natural bat host, an experimental model using straw-colored fruit bats (Eidolon helvum) and Lagos bat virus, an endemic lyssavirus in this species, was developed. To determine the lowest viral dose resulting in 100% productive infection, bats in five groups (four bats per group) were inoculated intramuscularly with one of five doses, ranging from 100.1 to 104.1 median tissue culture infectious dose (TCID50). More bats died due to the development of rabies after the middle dose (102.1 TCID50, 4/4 bats) than after lower (101.1, 2/4; 101.1, 2/4) or higher (103.1, 2/4; 104.1, 2/4) doses of virus. In the two highest dose groups, 4/8 bats developed rabies. Of those bats that remained healthy 3/4 bats seroconverted, suggesting that high antigen loads can trigger a strong immune response that abrogates a productive infection. In contrast, in the two lowest dose groups, 3/8 bats developed rabies, 1/8 remained healthy and seroconverted and 4/8 bats remained healthy and did not seroconvert, suggesting these doses are too low to reliably induce infection. The main lesion in all clinically affected bats was meningoencephalitis associated with lyssavirus-positive neurons. Lyssavirus antigen was detected in tongue epithelium (5/11 infected bats) rather than in salivary gland epithelium (0/11), suggesting viral excretion via the tongue. Thus, intramuscular inoculation of 102.1 TCID50 of Lagos bat virus into straw-colored fruit bats is a suitable m
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