Thoughts, Things, and Theories

We to critique the following question: can we have reasonable certainty that the terms in speculative or empirical theories correspond meaningfully to things in the ontological structure of the world, or are they only convenient fictions useful for predicting phenomena? We first justify this question as meaningful, and capable of admitting a meaningful answer. We then analyze question itself with examples from physics and biology. We conclude that we can be reasonably certain that the terms in an empirical theory have some degree of ontological significance, provided that they are directly related to phenomenal experiences. We also suggest that the advance of science can be aided through this understanding. Finally we use these conclusions to analyze the existence of the mind and certain physical structures

On Incompatibilist Free Will

We consider the possibility of defining some kind of activity which meets the intuitive requirements of incompatibilist free will. Our analysis of this will be done in a fashion which in some ways parallels the work of Pink on this matter. We will then consider the evidence of such free will, both from an introspective perspective and from a scientific perspective. In the latter we consider neurological and psychological evidence

Berkeley’s Arguments on Realism and Idealism

We analyse Berkeley's argument that realism cannot be defined, and show that his epistemological assumptions lead to the inevitable conclusion that solipsism is the only definable metaphysics. We conclude with a discussion of what this means for the realism/idealism debate, and also with a discussion of the possibility for apodictic evidence in this matter

Divisibility, Logic, Radical Empiricism, and Metaphysics

We will explore the problem of the manner in which the world may be divided into parts, and how this affects the application of logic. We will also consider how this affects the problem of knowing the world. Such considerations bring us to discuss how the divisibility of the world relates to idealism, realism, and the radical empiricist program of James. The epistemological difficulties sometimes associated with realism will in particular be shown to be in principle the result of misunderstanding the nature of the divisibility of the world. When such divisibility is properly understood, we claim that there is no epistemological dilemma, at least in principle, although of course in practice there may be other difficulties. We conclude by tentatively analyzing these practical difficulties

Priorities for synthesis research in ecology and environmental science

Synthesis research in ecology and environmental science improves understanding, advances theory, identifies research priorities, and supports management strategies by linking data, ideas, and tools. Accelerating environmental challenges increases the need to focus synthesis science on the most pressing questions. To leverage input from the broader research community, we convened a virtual workshop with participants from many countries and disciplines to examine how and where synthesis can address key questions and themes in ecology and environmental science in the coming decade. Seven priority research topics emerged: (1) diversity, equity, inclusion, and justice (DEIJ), (2) human and natural systems, (3) actionable and use-inspired science, (4) scale, (5) generality, (6) complexity and resilience, and (7) predictability. Additionally, two issues regarding the general practice of synthesis emerged: the need for increased participant diversity and inclusive research practices; and increased and improved data flow, access, and skill-building. These topics and practices provide a strategic vision for future synthesis in ecology and environmental science

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified