1,867 research outputs found
Radio Supernova SN 1998bw and Its Relation to GRB 980425
SN 1998bw is an unusual Type Ic supernova that may be associated with the
-ray burst GRB 980425. We use a synchrotron self-absorption model for
its radio emission to deduce that the synchrotron-emitting gas is expanding
into a circumstellar medium of approximately density profile, at a
speed comparable to the speed of light. We assume that the efficiencies of
production of relativistic electrons and magnetic field are constant through
the evolution. The circumstellar density is consistent with that expected
around the massive star core thought to be the progenitor of SN 1998bw. The
explosion energy in material moving with velocity is ergs, with some preference for the high values. The rise in
the radio light curves observed at days 20-40 is inferred to be the result of a
rise in the energy of the blast wave by a factor . Interaction with a
jump in the ambient density is not consistent with the observed evolution. We
infer that the boost in energy is from a shell of matter from the explosion
that catches up with the decelerating shock front. Both the high explosion
energy and the nature of the energy input to the blast wave are difficult to
reconcile with energy input from the shock-accelerated high velocity ejecta
from a supernova. The implication is that there is irregular energy input from
a central engine, which is the type of model invoked for normal -ray
bursts. The link between SN 1998bw and GRB 980425 is thus strengthened.Comment: 21 pages, 9 figures, revised version to appear in Ap
Smell you later - the repelling effect of secondary plant compounds against water voles and common voles
Fischer, D., Prokop, A., Wink, M., Mattes, H., Jacob, J
Neutron-induced background in the CONUS experiment
CONUS is a novel experiment aiming at detecting elastic neutrino nucleus
scattering in the fully coherent regime using high-purity Germanium (Ge)
detectors and a reactor as antineutrino () source. The detector setup
is installed at the commercial nuclear power plant in Brokdorf, Germany, at a
very small distance to the reactor core in order to guarantee a high flux of
more than 10/(scm). For the experiment, a good
understanding of neutron-induced background events is required, as the neutron
recoil signals can mimic the predicted neutrino interactions. Especially
neutron-induced events correlated with the thermal power generation are
troublesome for CONUS. On-site measurements revealed the presence of a thermal
power correlated, highly thermalized neutron field with a fluence rate of
(74530)cmd. These neutrons that are produced by nuclear
fission inside the reactor core, are reduced by a factor of 10 on
their way to the CONUS shield. With a high-purity Ge detector without shield
the -ray background was examined including highly thermal power
correlated N decay products as well as -lines from neutron
capture. Using the measured neutron spectrum as input, it was shown, with the
help of Monte Carlo simulations, that the thermal power correlated field is
successfully mitigated by the installed CONUS shield. The reactor-induced
background contribution in the region of interest is exceeded by the expected
signal by at least one order of magnitude assuming a realistic ionization
quenching factor of 0.2.Comment: 28 pages, 28 figure
Psychopharmacologic Treatment of Children Prenatally Exposed to Drugs of Abuse
Objective
This pilot study compared the pharmacologic treatment history and clinical outcomes observed in pediatric outpatients with psychiatric disorders exposed to drugs of abuse in utero to those of an age-matched, sex-matched and psychiatric disorder-matched, non-drug-exposed group.
Methods
In this matched cohort study, medical records of children treated at an academic, child and adolescent psychiatry outpatient clinic were reviewed. Children with caregiver-reported history of prenatal drug exposure were compared with a non-drug-exposed control group being cared for by the same providers. Patients were rated with the Clinical Global Impressions—Severity scale (CGI-S) throughout treatment. The changes in pre-treatment and post-treatment CGI-S scores and the total number of medication trials were determined between groups.
Results
The drug-exposed group (n = 30) had a higher total number of lifetime medication trials compared with the non-drug-exposed group (n = 28) and were taking significantly more total medications, at their final assessment. Unlike the non-drug-exposed group, the drug-exposed group demonstrated a lack of clinical improvement.
Conclusions
These results suggest that in utero drug-exposed children may be more treatment-refractory to or experience greater side effects from the pharmacologic treatment of psychiatric disorders than controls, although we cannot determine if early environment or drugs exposure drives these findings
Hot gas and dust in a protostellar cluster near W3(OH
We used the IRAM Interferometer to obtain sub-arcsecond resolution
observations of the high-mass star-forming region W3(OH) and its surroundings
at a frequency of 220 GHz. With the improved angular resolution, we distinguish
3 peaks in the thermal dust continuum emission originating from the hot core
region about 6 arcsec (0.06 pc) east of W3(OH). The dust emission peaks are
coincident with known radio continuum sources, one of which is of non-thermal
nature. The latter source is also at the center of expansion of a powerful
bipolar outflow observed in water maser emission. We determine the hot core
mass to be 15 solar masses based on the integrated dust continuum emission.
Simultaneously many molecular lines are detected allowing the analysis of the
temperature structure and the distribution of complex organic molecules in the
hot core. From HNCO lines, spanning a wide range of excitation, two 200 K
temperature peaks are found coincident with dust continuum emission peaks
suggesting embedded heating sources within them.Comment: 12 pages, 3 figure
Pearling: stroke segmentation with crusted pearl strings
We introduce a novel segmentation technique, called Pearling, for the semi-automatic extraction of idealized models of networks of strokes (variable width curves) in images. These networks may for example represent roads in an aerial photograph, vessels in a medical scan, or strokes in a drawing. The operator seeds the process by selecting representative areas of good (stroke interior) and bad colors. Then, the operator may either provide a rough trace through a particular path in the stroke graph or simply pick a starting point (seed) on a stroke and a direction of growth. Pearling computes in realtime the centerlines of the strokes, the bifurcations, and the thickness function along each stroke, hence producing a purified medial axis transform of a desired portion of the stroke graph. No prior segmentation or thresholding is required. Simple gestures may be used to trim or extend the selection or to add branches. The realtime performance and reliability of Pearling results from a novel disk-sampling approach, which traces the strokes by optimizing the positions and radii of a discrete series of disks (pearls) along the stroke. A continuous model is defined through subdivision. By design, the idealized pearl string model is slightly wider than necessary to ensure that it contains the stroke boundary. A narrower core model that fits inside the stroke is computed simultaneously. The difference between the pearl string and its core contains the boundary of the stroke and may be used to capture, compress, visualize, or analyze the raw image data along the stroke boundary
Methanol in W3(H2O) and Surrounding Regions
We present the results of an interferometric study of 38 millimeter-wave
lines of CH3OH in the region around the water maser source W3(H2O) and a region
extending about 30" to the south and west of the hydroxyl maser source W3(OH).
The methanol emitting region around W3(H2O) has an extent of 2.0" x 1.2"
(4400 x 2600 AU). The density is of order 1.e7 cm-3, sufficient to thermalize
most of the methanol lines. The kinetic temperature is approximately 140 K and
the methanol fractional abundance greater than 1.e-6, indicative of a high
degree of grain mantle evaporation. The W3(H2O) source contains sub-structure,
with peaks corresponding to the TW source and Wyrowski's B/C, separated by 2500
AU in projection. The kinematics are consistent with these being distinct
protostellar cores in a wide binary orbit and a dynamical mass for the region
of a few tens of Mo.
The extended methanol emission to the southwest of W3(OH) is seen strongly
only from the lowest excitation lines and from lines known elsewhere to be
class I methanol masers, namely the 84.5 GHz 5(-1)-4(0)E and 95.2 GHz
8(0)-7(1)A+ lines. Within this region there are two compact clumps, which we
denote as swA and swB, each about 15" (0.16 pc projected distance) away from
W3(OH). Excitation analysis of these clumps indicates the presence of lines
with inverted populations but only weak amplification. The sources swA and swB
appear to have kinetic temperatures of order 50-100 K and densities of order
1.e5 - 1.e6 cm-3. The methanol fractional abundance for the warmer clump is of
order 1.e-7, suggestive of partial grain mantle evaporation. The clumping
occurs on mass scales of order 1 Mo.Comment: 28 pages including 6 figures and 4 tables, accepted by Ap
A case of solitary kidney with duplex collecting systems and renal vascular variants in an adult male cadaver
We describe a unique solitary kidney with duplex collecting system and vascular variation observed in an 86-year-old white male formaldehyde- and phenol-fixed cadaver during routine academic dissection. The left renal fossa was empty with an intact adrenal gland, and the right renal fossa contained a fused renal mass with apparent polarity between the superior and inferior regions and two renal pelves converging into a single ureter. There were three right renal arteries supplying the renal mass; the superior and middle arteries were noted to be postcaval and the inferior artery was precaval. There were also two right renal veins draining into the inferior vena cava and following a regional distribution with the superior vein draining the inferior portion of the renal mass. Despite generally being asymptomatic, the detection of renal anatomical variants is clinically important for appropriate patient management and surgical interventions
Complete Draft Genome Sequence of the Actinobacterium Nocardiopsis sinuspersici UTMC102 (DSM 45277T), Which Produces Serine Protease.
Tokovenko B, Rückert C, Kalinowski J, et al. Complete Draft Genome Sequence of the Actinobacterium Nocardiopsis sinuspersici UTMC102 (DSM 45277T), Which Produces Serine Protease. Genome Announc. 2017;5(20): e00362-17.The genome sequence of alkalohalophilic actinobacterium Nocardiopsis sinuspersici UTMC102 is provided. N. sinuspersici UTMC102 produces a highly active serine alkaline protease, and contains at least 11 gene clusters encoding the biosynthesis of secondary metabolites. The N. sinuspersici UTMC102 genome was assembled into a single chromosomal scaffold
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
<p>Abstract</p> <p>Background</p> <p>Anti-Aβ immunotherapy is a promising approach to the prevention and treatment of Alzheimer's disease (AD) currently in clinical trials. There is extensive evidence, both in mice and humans that a significant adverse event is the occurrence of microhemorrhages. Also, vasogenic edema was reported in phase 2 of a passive immunization clinical trial. In order to overcome these vascular adverse effects it is critical that we understand the mechanism(s) by which they occur.</p> <p>Methods</p> <p>We have examined the matrix metalloproteinase (MMP) protein degradation system in two previously published anti-Aβ immunotherapy studies. The first was a passive immunization study in which we examined 22 month old APPSw mice that had received anti-Aβ antibodies for 1, 2 or 3 months. The second is an active vaccination study in which we examined 16 month old APPSw/NOS2-/- mice treated with Aβ vaccination for 4 months.</p> <p>Results</p> <p>There is a significant activation of the MMP2 and MMP9 proteinase degradation systems by anti-Aβ immunotherapy, regardless of whether this is delivered through active vaccination or passive immunization. We have characterized this activation by gene expression, protein expression and zymography assessment of MMP activity.</p> <p>Conclusions</p> <p>Since the MMP2 and MMP9 systems are heavily implicated in the pathophysiology of intracerbral hemorrhage, these data may provide a potential mechanism of microhemorrhage due to immunotherapy. Increased activity of the MMP system, therefore, is likely to be a major factor in increased microhemorrhage occurrence.</p
- …