Architecture as the Inversion of Architecture

De-architecture is a frame of reference for questioning the nature and practice of architecture in the late 1980s and beyond. The term was invented because, as Picasso once observed, Art is a series of destructions,\u27\u27 and the concept of subtracting from an institutional definition to re-evaluate its purposes seemed an appropriate way to proceed

Revitalizing a 19th Century Industrial Complex into a 21st Century Research and Learning Technology Center

The revitalization and repurposing of the Domino’s Sugar Plant will foster a vibrant and engaged community for the neighborhood in a distinct way differing from the recent history of growth. Williamsburg is located in a north Brooklyn, New York, community that has been struggling for its identity since the 1970’s. The reprogramming of this abandoned industrial site will include the addition of a new technological research center that will contribute to economic growth and stability for the neighborhood. The new jobs will help bring more people into the neighborhood who will be committed to both live and work there. At present, most of the new residents live there due to the neighborhood’s proximity to Manhattan. This project would activate 1,500 feet of waterfront property on the East River and create a greenway that would be a gateway for this community. The greenway will move residents through the new research center, creating an awareness of the developments taking place there. The research center will support a progressive school that will utilize distinctive architectural design coupled with an innovative educational curriculum. The school will be designed with a digital focus that is on the cutting edge of education reform as competitive schools make a neighborhood attractive to families. By bringing in new jobs, creating greenways, new opportunities in education and encouraging occupancy by residents who have a longer-term commitment to the area, the project will help foster a cohesive community that is invested in the Williamsburg neighborhood

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins, formatted with or without the ACE2 collectrin domain, were optimized by Fc-modification. The different Fc-modifications resulted in distinct effects on neutralization and effector functions. H429Y, a point mutation outside the binding sites for FcγRs or complement caused non-covalent oligomerization of the ACE2-Fc decoy proteins, abrogated FcγR interaction and enhanced SARS-CoV-2 neutralization. Another Fc mutation, H429F did not improve virus neutralization but resulted in increased C5b-C9 fixation and transformed ACE2-Fc to a potent mediator of complement-dependent cytotoxicity (CDC) against SARS-CoV-2 spike (S) expressing cells. Furthermore, modification of the Fc-glycan enhanced cell activation via FcγRIIIa. These different immune profiles demonstrate the capacity of Fc-based agents to be engineered to optimize different mechanisms of protection for SARS-CoV-2 and potentially other viral pathogens

Standardised Data on Initiatives – STARDIT: Beta Version

There is currently no standardised way to share information across disciplines about initiatives, including felds such as health, environment, basic science, manufacturing, media and international development. All problems, including complex global problems such as air pollution and pandemics require reliable data sharing between disciplines in order to respond efectively. Current reporting methods also lack information about the ways in which diferent people and organisations are involved in initiatives, making it difcult to collate and appraise data about the most efective ways to involve diferent people. The objective of STARDIT (Standardised Data on Initiatives) is to address current limitations and inconsistencies in sharing data about initiatives. The STARDIT system features standardised data reporting about initiatives, including who has been involved, what tasks they did, and any impacts observed. STARDIT was created to help everyone in the world fnd and understand information about collective human actions, which are referred to as ‘initiatives’. STARDIT enables multiple categories of data to be reported in a standardised way across disciplines, facilitating appraisal of initiatives and aiding synthesis of evidence for the most effective ways for people to be involved in initiatives

De - Architecture

New York189 p.; illus.; gmb.; 24 cm

Green architecture

240 p. : col. ill. ; 26 cm

De-Architecture

New York189 p.: illus.; 27 c