29 research outputs found
Improved representation of plant functional types and physiology in the Joint UK Land Environment Simulator (JULES v4.2) using plant trait information
Averaging Robertson-Walker Cosmologies
The cosmological backreaction arises when one directly averages the Einstein
equations to recover an effective Robertson-Walker cosmology, rather than
assuming a background a priori. While usually discussed in the context of dark
energy, strictly speaking any cosmological model should be recovered from such
a procedure. We apply the Buchert averaging formalism to linear
Robertson-Walker universes containing matter, radiation and dark energy and
evaluate numerically the discrepancies between the assumed and the averaged
behaviour, finding the largest deviations for an Einstein-de Sitter universe,
increasing rapidly with Hubble rate to a 0.01% effect for h=0.701. For the LCDM
concordance model, the backreaction is of the order of Omega_eff~4x10^-6, with
those for dark energy models being within a factor of two or three. The impacts
at recombination are of the order of 10^-8 and those in deep radiation
domination asymptote to a constant value. While the effective equations of
state of the backreactions in Einstein-de Sitter, concordance and quintessence
models are generally dust-like, a backreaction with an equation of state
w_eff<-1/3 can be found for strongly phantom models.Comment: 18 pages, 11 figures, ReVTeX. Updated to version accepted by JCA
Dark Energy from structure: a status report
The effective evolution of an inhomogeneous universe model in any theory of
gravitation may be described in terms of spatially averaged variables. In
Einstein's theory, restricting attention to scalar variables, this evolution
can be modeled by solutions of a set of Friedmann equations for an effective
volume scale factor, with matter and backreaction source terms. The latter can
be represented by an effective scalar field (`morphon field') modeling Dark
Energy.
The present work provides an overview over the Dark Energy debate in
connection with the impact of inhomogeneities, and formulates strategies for a
comprehensive quantitative evaluation of backreaction effects both in
theoretical and observational cosmology. We recall the basic steps of a
description of backreaction effects in relativistic cosmology that lead to
refurnishing the standard cosmological equations, but also lay down a number of
challenges and unresolved issues in connection with their observational
interpretation.
The present status of this subject is intermediate: we have a good
qualitative understanding of backreaction effects pointing to a global
instability of the standard model of cosmology; exact solutions and
perturbative results modeling this instability lie in the right sector to
explain Dark Energy from inhomogeneities. It is fair to say that, even if
backreaction effects turn out to be less important than anticipated by some
researchers, the concordance high-precision cosmology, the architecture of
current N-body simulations, as well as standard perturbative approaches may all
fall short in correctly describing the Late Universe.Comment: Invited Review for a special Gen. Rel. Grav. issue on Dark Energy, 59
pages, 2 figures; matches published versio
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation
Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI) at genome-wide significance, and two for fasting glucose (FG), none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3) and FG (GCK and G6PC2). The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated
Global Carbon Budget 2018
Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere â the âglobal carbon budgetâ â is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFF) are based on energy statistics and cement production data, while emissions from land use and land-use change (ELUC), mainly deforestation, are based on land use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) and terrestrial CO2 sink (SLAND) are estimated with global process models constrained by observations. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and understanding of the contemporary carbon cycle. All uncertainties are reported as ±1Ï. For the last decade available (2008â2017), EFF was 9.4±0.5âGtCâyrâ1, ELUC 1.5±0.7âGtCâyrâ1, GATM 4.7±0.02âGtCâyrâ1, SOCEAN 2.4±0.5âGtCâyrâ1, and SLAND 3.2±0.8âGtCâyrâ1, with a budget imbalance BIM of 0.5âGtCâyrâ1 indicating overestimated emissions and/or underestimated sinks. For the year 2017 alone, the growth in EFF was about 1.6â% and emissions increased to 9.9±0.5âGtCâyrâ1. Also for 2017, ELUC was 1.4±0.7âGtCâyrâ1, GATM was 4.6±0.2âGtCâyrâ1, SOCEAN was 2.5±0.5âGtCâyrâ1, and SLAND was 3.8±0.8âGtCâyrâ1, with a BIM of 0.3âGtC. The global atmospheric CO2 concentration reached 405.0±0.1âppm averaged over 2017. For 2018, preliminary data for the first 6â9 months indicate a renewed growth in EFF of +2.7â% (range of 1.8â% to 3.7â%) based on national emission projections for China, the US, the EU, and India and projections of gross domestic product corrected for recent changes in the carbon intensity of the economy for the rest of the world. The analysis presented here shows that the mean and trend in the five components of the global carbon budget are consistently estimated over the period of 1959â2017, but discrepancies of up to 1âGtCâyrâ1 persist for the representation of semi-decadal variability in CO2 fluxes. A detailed comparison among individual estimates and the introduction of a broad range of observations show (1) no consensus in the mean and trend in land-use change emissions, (2) a persistent low agreement among the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) an apparent underestimation of the CO2 variability by ocean models, originating outside the tropics. This living data update documents changes in the methods and data sets used in this new global carbon budget and the progress in understanding the global carbon cycle compared with previous publications of this data set (Le QuĂ©rĂ© et al., 2018, 2016, 2015a, b, 2014, 2013). All results presented here can be downloaded from https://doi.org/10.18160/GCP-2018
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency â„0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the fi
Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review
Future water resources for food production in five South Asian river basins and potential of adaptation options â a modelling study
The Indian subcontinent faces a population increase from 1.6 billion in 2000 towards 2 billion around 2050. Therefore, expansion of agricultural area combined with increases in productivity will be necessary to produce the food needed in the future. However, with pressure on water resources already being high, and potential effects of climate change still uncertain, the question rises whether there will be enough water resources available to sustain this production. The objective of this study is to make a spatially explicit quantitative analysis of water requirements and availability for current and future food production in five South Asian basins (Indus, Ganges, Brahmaputra, Godavari and Krishna), in the absence or presence of two different adaptation strategies: an overall improvement in irrigation efficiency, and an increase of reservoir storage capacity. The analysis is performed by using the coupled hydrology and crop production model LPJmL. It is found that the Godavari and Krishna basins will benefit most from an increased storage capacity, whereas in the Ganges and the Indus water scarcity mainly takes place in areas where this additional storage would not provide additional utility. Increasing the irrigation efficiency will be beneficial in all basins, but most in the Indus and Ganges, as it decreases the pressure on groundwater resources and decreases the fraction of food production that would become at risk because of water shortage. A combination of both options seems to be the best strategy in all basins. The large-scale model used in this study is suitable to identify hotspot areas and support the first step in the policy process, but the final design and implementation of adaptation options requires supporting studies at finer scales