Northward field excursions in Saturn’s magnetotail and their relationship to magnetospheric periodicities

We present results from an investigation of Cassini encounters with Saturn’s magnetotail current sheet, using magnetic field and plasma data. In the first of two intervals shown, small periodic changes in the north-south component of the magnetic field are matched by periodic density enhancements associated with the plasma sheet center. In the second interval, a large plasmoid signature is observed set against a background of small-scale current sheet motions. We interpret the quasi-periodic small field deflections and density enhancements as large-scale wave-like motion of the current sheet. We stress that plasmoid signatures are of a clearly different character and occur much less frequently

Fulminating amoebic colitis treated by colectomy

No Abstrac

Non-equilibrium melting of colloidal crystals in confinement

We report on a novel and flexible experiment to investigate the non-equilibrium melting behaviour of model crystals made from charged colloidal spheres. In a slit geometry polycrystalline material formed in a low salt region is driven by hydrostatic pressure up an evolving gradient in salt concentration and melts at large salt concentration. Depending on particle and initial salt concentration, driving velocity and the local salt concentration complex morphologic evolution is observed. Crystal-melt interface positions and the melting velocity are obtained quantitatively from time resolved Bragg- and polarization microscopic measurements. A simple theoretical model predicts the interface to first advance, then for balanced drift and melting velocities to become stationary at a salt concentration larger than the equilibrium melting concentration. It also describes the relaxation of the interface to its equilibrium position in a stationary gradient after stopping the drive in different manners. We further discuss the influence of the gradient strength on the resulting interface morphology and a shear induced morphologic transition from polycrystalline to oriented single crystalline material before melting

Expression of connexins in human preimplantation embryos in vitro

Intercellular communication via gap junctions is required to coordinate developmental processes in the mammalian embryo. We have investigated if the connexin (Cx) isoforms known to form gap junctions in rodent preimplantation embryos are also expressed in human embryos, with the aim of identifying species differences in communication patterns in early development. Using a combination of polyA PCR and immunocytochemistry we have assessed the expression of Cx26, Cx31, Cx32, Cx40, Cx43 and Cx45 which are thought to be important in early rodent embryos. The results demonstrate that Cx31 and Cx43 are the main connexin isoforms expressed in human preimplantation embryos and that these isoforms are co-expressed in the blastocyst. Cx45 protein is expressed in the blastocyst but the protein may be translated from a generally low level of transcripts: which could only be detected in the PN to 4-cell embryos. Interestingly, Cx40, which is expressed by the extravillous trophoblast in the early human placenta, was not found to be expressed in the blastocyst trophectoderm from which this tissue develops. All of the connexin isoforms in human preimplantation embryos are also found in rodents pointing to a common regulation of these connexins in development of rodent and human early embryos and perhaps other species

Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer

BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) is involved in the regulation of a variety of biologic processes, including neurotransmission, muscle contraction, and liver glucose metabolism, via purinergic receptors. In nonrandomized studies involving patients with different tumor types including non-small-cell lung cancer (NSCLC), ATP infusion appeared to inhibit loss of weight and deterioration of quality of life (QOL) and performance status. We conducted a randomized clinical trial to evaluate the effects of ATP in patients with advanced NSCLC (stage IIIB or IV). METHODS: Fifty-eight patients were randomly assigned to receive either 10 intravenous 30-hour ATP infusions, with the infusions given at 2- to 4-week intervals, or no ATP. Outcome parameters were assessed every 4 weeks until 28 weeks. Between-group differences were tested for statistical significance by use of repeated-measures analysis, and reported P values are two-sided. RESULTS: Twenty-eight patients were allocated to receive ATP treatment and 30 received no ATP. Mean weight changes per 4-week period were -1.0 kg (95% confidence interval [CI] = -1.5 to -0.5) in the control group and 0.2 kg (95% CI = -0.2 to +0.6) in the ATP group (P =.002). Serum albumin concentration declined by -1.2 g/L (95% CI= -2.0 to -0.4) per 4 weeks in the control group but remained stable (0.0 g/L; 95% CI = -0.3 to +0.3) in the ATP group (P =.006). Elbow flexor muscle strength declined by -5.5% (95% CI = -9.6% to -1. 4%) per 4 weeks in the control group but remained stable (0.0%; 95% CI= -1.4% to +1.4%) in the ATP group (P =.01). A similar pattern was observed for knee extensor muscles (P =.02). The effects of ATP on body weight, muscle strength, and albumin concentration were especially marked in cachectic patients (P =.0002, P =.0001, and P =. 0001, respectively, for ATP versus no ATP). QOL score changes per 4-week period in the ATP group showed overall less deterioration than in the control group-physical scores (-0.2% versus -2.4%; P =. 0002); functional scores (+0.4% versus -5.5%; P =.02); psychologic scores (-0.7% versus -2.4%; P =.11); overall QOL score (+0.1% versus -3.5%; P =.0001). CONCLUSIONS: This randomized trial demonstrates that ATP has beneficial effects on weight, muscle strength, and QOL in patients with advanced NSCLC

Properties of the Intermediate Mass Fragment Emission Source in the 270 MeV 3-He + 232-Th Reaction

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Fractal Structures and Scaling Laws in the Universe: Statistical Mechanics of the Self-Gravitating Gas

Fractal structures are observed in the universe in two very different ways. Firstly, in the gas forming the cold interstellar medium in scales from 10^{-4} pc till 100 pc. Secondly, the galaxy distribution has been observed to be fractal in scales up to hundreds of Mpc. We give here a short review of the statistical mechanical (and field theoretical) approach developed by us. We consider a non-relativistic self-gravitating gas in thermal equilibrium at temperature T inside a volume V. The statistical mechanics of such system has special features and, as is known, the thermodynamical limit does not exist in its customary form. Moreover, the treatments through microcanonical, canonical and grand canonical ensembles yield different results.We present here for the first time the equation of state for the self-gravitating gas in the canonical ensemble. We find that it has the form p = [N T/ V] f(eta), where p is the pressure, N is the number of particles and \eta \equiv {G m^2 N \over V^{1/3} T}. The N \to\infty and V \to\infty limit exists keeping \eta fixed. We compute the function f(\eta) using Monte Carlo simulations and for small eta analytically. We compute the thermodynamic quantities of the system as free energy, entropy, chemical potential, specific heat, compressibility and speed of sound. We reproduce the well-known gravitational phase transition associated to the Jeans' instability. Namely, a gaseous phase for eta < eta_c and a condensed phase for eta > eta_c. Moreover, we derive the precise behaviour of the physical quantities near the transition. In particular, the pressure vanishes as p \sim(eta_c-eta)^B with B \sim 0.2 and eta_c \sim 1.6 and the energy fluctuations diverge as \sim(eta_c-eta)^{B-1}. The speed of sound decreases monotonically and approaches the value sqrt{T/6} at the transition.Comment: Invited paper to the special issue of the `Journal of Chaos, Solitons and Fractals': `Superstrings, M, F, S...theory', M. S El Naschie and C. Castro, Editors. Latex file, 16 pages plus three .ps figure

The discontinuous nature of chromospheric activity evolution

Chromospheric activity has been thought to decay smoothly with time and, hence, to be a viable age indicator. Measurements in solar type stars in open clusters seem to point to a different conclusion: chromospheric activity undergoes a fast transition from Hyades level to that of the Sun after about 1 Gyr of main--sequence lifetime and any decaying trend before or after this transition must be much less significant than the short term variations.Comment: 6 pages, 1 figure, to be published in Astrophysics and Space Scienc

Boost-Invariant Running Couplings in Effective Hamiltonians

We apply a boost-invariant similarity renormalization group procedure to a light-front Hamiltonian of a scalar field phi of bare mass mu and interaction term g phi^3 in 6 dimensions using 3rd order perturbative expansion in powers of the coupling constant g. The initial Hamiltonian is regulated using momentum dependent factors that approach 1 when a cutoff parameter Delta tends to infinity. The similarity flow of corresponding effective Hamiltonians is integrated analytically and two counterterms depending on Delta are obtained in the initial Hamiltonian: a change in mu and a change of g. In addition, the interaction vertex requires a Delta-independent counterterm that contains a boost invariant function of momenta of particles participating in the interaction. The resulting effective Hamiltonians contain a running coupling constant that exhibits asymptotic freedom. The evolution of the coupling with changing width of effective Hamiltonians agrees with results obtained using Feynman diagrams and dimensional regularization when one identifies the renormalization scale with the width. The effective light-front Schroedinger equation is equally valid in a whole class of moving frames of reference including the infinite momentum frame. Therefore, the calculation described here provides an interesting pattern one can attempt to follow in the case of Hamiltonians applicable in particle physics.Comment: 24 pages, LaTeX, included discussion of finite x-dependent counterterm

Influence of thermal fluctuations on quantum phase transitions in one-dimensional disordered systems: Charge density waves and Luttinger liquids

The low temperature phase diagram of 1D weakly disordered quantum systems like charge or spin density waves and Luttinger liquids is studied by a \emph{full finite temperature} renormalization group (RG) calculation. For vanishing quantum fluctuations this approach is amended by an \emph{exact} solution in the case of strong disorder and by a mapping onto the \emph{Burgers equation with noise} in the case of weak disorder, respectively. At \emph{zero} temperature we reproduce the quantum phase transition between a pinned (localized) and an unpinned (delocalized) phase for weak and strong quantum fluctuations, respectively, as found previously by Fukuyama or Giamarchi and Schulz. At \emph{finite} temperatures the localization transition is suppressed: the random potential is wiped out by thermal fluctuations on length scales larger than the thermal de Broglie wave length of the phason excitations. The existence of a zero temperature transition is reflected in a rich cross-over phase diagram of the correlation functions. In particular we find four different scaling regions: a \emph{classical disordered}, a \emph{quantum disordered}, a \emph{quantum critical} and a \emph{thermal} region. The results can be transferred directly to the discussion of the influence of disorder in superfluids. Finally we extend the RG calculation to the treatment of a commensurate lattice potential. Applications to related systems are discussed as well.Comment: 19 pages, 7 figure