That is a Habit I Never Had / music by Walter Wilson; words by Walter Wilson

Cover: drawing of a portly African American male smoking a cigar and staring into the distance, where workers toil; photo inset of singers Leighton and Leighton; Publisher: Howley Dresser Co. (New York)https://egrove.olemiss.edu/sharris_b/1051/thumbnail.jp

Supply Order, Lunsford Wilson Company- Holmes Funeral Director

Receipt: Order from Lunsford Wilson Company, Atlanta, Georgia, to be shipped to Holmes Funeral Director, Jacksonville, Florida. Price includes 10% trade discount. Notations on back. Date: August 9, 192

That\u27s a Lot of Bunk / words by Al Wilson, James A. Brennan, and Mack Henshaw

Cover: photo of James Barton, a Caucasian male in blackface; cartoon drawings satirizing ideas such as taxi drivers never cheat or landlords never raise the rent; Publisher: Edward B. Marks Music Co. (New York)https://egrove.olemiss.edu/sharris_d/1050/thumbnail.jp

[Photographs of Scottish Scenery] [Material gráfico proyectable]

Contenido parcial: Loch Achray & Ben Venue 59B ; Path by the Loch Katrine 9 (G.W.W. 3660) ; Glenfinlas 1646 (G.W.W. 3666)Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 2015Fecha de edición ca. 1860-1883

Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning.

IMPORTANCE: Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual grading. Expert-level deep learning systems for automatic OCT segmentation have recently been developed. However, the potential clinical applicability of these systems is largely unknown. OBJECTIVE: To evaluate a deep learning model for whole-volume segmentation of 4 clinically important pathological features and assess clinical applicability. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic study used OCT data from 173 patients with a total of 15 558 B-scans, treated at Moorfields Eye Hospital. The data set included 2 common OCT devices and 2 macular conditions: wet age-related macular degeneration (107 scans) and diabetic macular edema (66 scans), covering the full range of severity, and from 3 points during treatment. Two expert graders performed pixel-level segmentations of intraretinal fluid, subretinal fluid, subretinal hyperreflective material, and pigment epithelial detachment, including all B-scans in each OCT volume, taking as long as 50 hours per scan. Quantitative evaluation of whole-volume model segmentations was performed. Qualitative evaluation of clinical applicability by 3 retinal experts was also conducted. Data were collected from June 1, 2012, to January 31, 2017, for set 1 and from January 1 to December 31, 2017, for set 2; graded between November 2018 and January 2020; and analyzed from February 2020 to November 2020. MAIN OUTCOMES AND MEASURES: Rating and stack ranking for clinical applicability by retinal specialists, model-grader agreement for voxelwise segmentations, and total volume evaluated using Dice similarity coefficients, Bland-Altman plots, and intraclass correlation coefficients. RESULTS: Among the 173 patients included in the analysis (92 [53%] women), qualitative assessment found that automated whole-volume segmentation ranked better than or comparable to at least 1 expert grader in 127 scans (73%; 95% CI, 66%-79%). A neutral or positive rating was given to 135 model segmentations (78%; 95% CI, 71%-84%) and 309 expert gradings (2 per scan) (89%; 95% CI, 86%-92%). The model was rated neutrally or positively in 86% to 92% of diabetic macular edema scans and 53% to 87% of age-related macular degeneration scans. Intraclass correlations ranged from 0.33 (95% CI, 0.08-0.96) to 0.96 (95% CI, 0.90-0.99). Dice similarity coefficients ranged from 0.43 (95% CI, 0.29-0.66) to 0.78 (95% CI, 0.57-0.85). CONCLUSIONS AND RELEVANCE: This deep learning-based segmentation tool provided clinically useful measures of retinal disease that would otherwise be infeasible to obtain. Qualitative evaluation was additionally important to reveal clinical applicability for both care management and research

Is the pharmacy profession innovative enough?: meeting the needs of Australian residents with chronic conditions and their carers using the nominal group technique

Background Community pharmacies are ideally located as a source of support for people with chronic conditions. Yet, we have limited insight into what innovative pharmacy services would support this consumer group to manage their condition/s. The aim of this study was to identify what innovations people with chronic conditions and their carers want from their ideal community pharmacy, and compare with what pharmacists and pharmacy support staff think consumers want. Methods We elicited ideas using the nominal group technique. Participants included people with chronic conditions, unpaid carers, pharmacists and pharmacy support staff, in four regions of Australia. Themes were identified via thematic analysis using the constant comparison method. Results Fifteen consumer/carer, four pharmacist and two pharmacy support staff groups were conducted. Two overarching themes were identified: extended scope of practice for the pharmacist and new or improved pharmacy services. The most innovative role for Australian pharmacists was medication continuance, within a limited time-frame. Consumers and carers wanted improved access to pharmacists, but this did not necessarily align with a faster or automated dispensing service. Other ideas included streamlined access to prescriptions via medication reminders, electronic prescriptions and a chronic illness card. Conclusions This study provides further support for extending the pharmacist’s role in medication continuance, particularly as it represents the consumer’s voice. How this is done, or the methods used, needs to optimise patient safety. A range of innovative strategies were proposed and Australian community pharmacies should advocate for and implement innovative approaches to improve access and ensure continuity of care

Appointments, pay and performance in UK boardrooms by gender

This article uses UK data to examine issues regarding the scarcity of women in boardroom positions. The article examines appointments, pay and any associated productivity effects deriving from increased diversity. Evidence of gender-bias in the appointment of women as non-executive directors is found together with mixed evidence of discrimination in wages or fees paid. However, the article finds no support for the argument that gender diverse boards enhance corporate performance. Proposals in favour of greater board diversity may be best structured around the moral value of diversity, rather than with reference to an expectation of improved company performance

Reasoning up and down a food chain: Using an assessment framework to investigate students' middle knowledge

Being able to make claims about what students know and can do in science involves gathering systematic evidence of students' knowledge and abilities. This paper describes an assessment system designed to elicit information from students at many placements along developmental trajectories and demonstrates how this system was used to gather principled evidence of how students reason about food web and food chain disturbances. Specifically, this assessment system was designed to gather information about students' intermediary or middle knowledge on a pathway toward more sophisticated understanding. Findings indicate that in association with a curricular intervention, student gains were significant. However, despite overall gains, some students still struggled to explain what might happen during a disturbance to an ecosystem. In addition, this paper discusses the importance of having a cognitive framework to guide task design and interpretation of evidence. This framework allowed for the gathering of detailed information, which provided insights into the intricacies of how students reason about scientific scenarios. In particular, this assessment system allowed for the illustration of multiple types of middle knowledge that students may possess, indicating that there are multiple “messy middles” students may move through as they develop the ability to reason about complex scientific situations. © 2009 Wiley Periodicals, Inc. Sci Ed 94: 259–281, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65025/1/20368_ftp.pd

Effect of sandblasting, etching and resin bonding on the flexural strength/bonding of novel glass-ceramics

Dr Brian Schottlander (Davis Schottlander Davis Ltd.

Advances in ophthalmic drug delivery

Various strategies for ocular drug delivery are considered; from basic formulation techniques for improving availability of drugs; viscosity enhancers and mucoadhesives aid drug retention and penetration enhancers promote drug transport into the eye. The use of drug loaded contact lenses and ocular inserts allows drugs to be better placed where they are needed for more direct delivery. Developments in ocular implants gives a means to overcome the physical barriers that traditionally prevented effective treatment. Implant technologies are under development allowing long term drug delivery from a single procedure, these devices allow posterior chamber diseases to be effectively treated. Future developments could bring artificial corneas to eliminate the need for donor tissue and one-off implantable drug depots lasting the patient’s lifetime