Cognitive Mechanisms in Chronic Tinnitus: Psychological Markers of a Failure to Switch Attention

The cognitive mechanisms underpinning chronic tinnitus (CT; phantom auditory perceptions) are underexplored but may reflect a failure to switch attention away from a tinnitus sound. Here, we investigated a range of components that influence the ability to switch attention, including cognitive control, inhibition, working memory and mood, on the presence and severity of CT. Our participants with tinnitus showed significant impairments in cognitive control and inhibition as well as lower levels of emotional well-being, compared to healthy-hearing participants. Moreover, the subjective cognitive complaints of tinnitus participants correlated with their emotional well-being whereas complaints in healthy participants correlated with objective cognitive functioning. Combined, cognitive control and depressive symptoms correctly classified 67% of participants. These results demonstrate the core role of cognition in CT. They also provide the foundations for a neurocognitive account of the maintenance of tinnitus, involving impaired interactions between the neurocognitive networks underpinning attention-switching and mood

Old World Monkeys are More Similar to Humans Than New World Monkeys When Playing a Coordination Game

There is much debate about how humans’ decision-making compares to that of other primates. One way to explore this is to compare species’ performance using identical methodologies in games with strategic interactions. We presented a computerized Assurance Game, which was either functionally simultaneous or sequential, to investigate how humans, rhesus monkeys, and capuchin monkeys utilized information in decision-making. All species coordinated via sequential play on the payoff-dominant Nash equilibrium, indicating that information about the partner’s choice improved decisions. Furthermore, some humans and rhesus monkeys found the payoff-dominant Nash equilibrium in the simultaneous game, even when it was the first condition presented. Thus, Old World primates solved the task without any external cues to their partner’s choice. Finally, when not explicitly prohibited, humans spontaneously used language to coordinate on the payoff-dominant Nash equilibrium, indicating an alternate mechanism for converting a simultaneous move game into a sequential move game. This phylogenetic distribution implies that no single mechanism drives coordination decisions across the primates, while humans’ ability to spontaneously use language to change the structure of the game emphasizes that multiple mechanisms may be used even within the same species. These results provide insight into the evolution of decision-making strategies across the primates

Preserved singing in aphasia: A case study of the efficacy of melodic intonation therapy

This study examined the efficacy of Melodic Intonation Therapy (MIT) in a male singer (KL) with severe Broca’s aphasia. Thirty novel phrases were allocated to one of three experimental conditions: unrehearsed, rehearsed verbal production (repetition), and rehearsed verbal production with melody (MIT). The results showed superior production of MIT phrases during therapy. Comparison of performance at baseline, 1 week, and 5 weeks after therapy revealed an initial beneficial effect of both types of rehearsal; however, MIT was more durable, facilitating longer-term phrase production. Our findings suggest that MIT facilitated KL’s speech praxis, and that combining melody and speech through rehearsal promoted separate storage and/or access to the phrase representation

Crossing the Educational Rubicon without the TAH: Collaboration among University and Secondary-Level History Educators

In April 2011, Congress slashed funding for a majority of programs tied to education. Several programs related to professional development for teachers did not survive. While cut severely—from $119 million in Fiscal Year 2010 to$46 million (a loss of $73 million or 61% of its funding)—Teaching American History (TAH) grants lived, albeit by their fingertips, another day. Yet, given the economic challenges the United States faces and what appear to be prevailing attitudes in regard to social services and teacher development, it has become clear that history educators cannot rely on federal funding to support efforts to improve the teaching of history. Nevertheless, meaningful collaboration among K-12 teachers and academic and public historians continues to be vital. This essay describes in detail a current collaborative relationship between a history department and high school in western Michigan. Focusing specifically on four levels of interlocking benefits of collaboration—benefits for high school teachers, for teaching candidates, for high school students, and for historians—the essay documents the strengths of this collaborative effort and notes areas where purposeful concentration and improvement might benefit all parties. Significantly, the relationship examined here, between the history department at Western Michigan University (WMU) and Portage Central High School (PCHS), developed without a promise or expectation of financial incentives. It demonstrates that collaboration, while challenging, can survive in the twenty-first century without funding from a TAH grant

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs

A series of Pt(IV) prodrugs has been obtained by oxidative halogenation of either cisplatin or carboplatin. Iodobenzene dichloride is a general reagent that cleanly provides prodrugs bearing axial chlorides without the need to prepare intervening Pt(IV) intermediates or handle chlorine gas. Elemental bromine and iodine afford Pt(IV) compounds as well, although in the case of the iodine-mediated oxidation of carboplatin, an amido-bridged Pt(IV) side product also formed. A detailed analysis of the changes in spectroscopic and structural parameters induced by varying the axial halide is presented. A number of recurring motifs are observed in the solid state structures of these compounds.National Cancer Institute (U.S.) (Grant CA034992

Emergency supply of prescription-only medicines to patients by community pharmacists: a mixed methods evaluation incorporating patient, pharmacist and GP perspectives

Objective To evaluate and inform emergency supply of prescription-only medicines by community pharmacists (CPs), including how the service could form an integral component of established healthcare provision to maximise adherence. Design Mixed methods. 4 phases: prospective audit of emergency supply requests for prescribed medicines (October–November 2012 and April 2013); interviews with CPs (February–April 2013); follow-up interviews with patients (April–May 2013); interactive feedback sessions with general practice teams (October–November 2013). Setting 22 community pharmacies and 6 general practices in Northwest England. Participants 27 CPs with experience of dealing with requests for emergency supplies; 25 patients who received an emergency supply of a prescribed medicine; 58 staff at 6 general practices. Results Clinical audit in 22 pharmacies over two 4-week periods reported that 526 medicines were requested by 450 patients. Requests peaked over a bank holiday and around weekends. A significant number of supplies were made during practice opening hours. Most requests were for older patients and for medicines used in long-term conditions. Difficulty in renewing repeat medication (forgetting to order, or prescription delays) was the major reason for requests. The majority of medicines were ‘loaned’ in advance of a National Health Service (NHS) prescription. Interviews with CPs and patients indicated that continuous supply had a positive impact on medicines adherence, removing the need to access urgent care. General practice staff were surprised and concerned by the extent of emergency supply episodes. Conclusions CPs regularly provide emergency supplies to patients who run out of their repeat medication, including during practice opening hours. This may aid adherence. There is currently no feedback loop, however, to general practice. Patient care and interprofessional communication may be better served by the introduction of a formally structured and funded NHS emergency supply service from community pharmacies, with ongoing optimisation of repeat prescribing

Generation of strongly-coupled plasma using Argon-based capillary discharge lasers

Argon based capillary discharge lasers operate in the extreme ultra violet (EUV) at 46.9 nm with an output of up to 0.5 mJ energy per pulse and up to a 10 Hz repetition rate. Focussed irradiances of up to 1012 W cm-2 are achievable and can be used to generate plasma in the warm dense matter regime by irradiating solid material. To model the interaction between such an EUV laser and solid material, the 2D radiative-hydrodynamic code POLLUX has been modified to include absorption via direct photo-ionisation, a super-configuration model to describe the ionisation dependant electronic configurations and a calculation of plasma refractive indices for ray tracing of the incident EUV laser radiation. A simulation study is presented, demonstrating how capillary discharge lasers of 1.2ns pulse duration can be used to generate strongly coupled plasma at close to solid density with temperatures of a few eV and energy densities up to 1×105 J cm-3. Plasmas produced by EUV laser irradiation are shown to be useful for examining the equation-of-state properties of warm dense matter. One difficulty with this technique is the reduction of the strong temperature and density gradients which are produced during the interaction. Methods to inhibit and control these gradients will be examined

Differential Responding by Rhesus Monkeys (Macaca mulatta) and Humans (Homo sapiens) to Variable Outcomes in the Assurance Game

Behavioral flexibility in how one responds to variable partner play can be examined using economic coordination games in which subjects play against a variety of partners and therefore may need to alter their behavior to produce the highest payoff. But how do we study this behavioral flexibility once players have settled on a response? Here, we investigated how responding by rhesus monkeys (Macaca mulatta) and humans (Homo sapiens) playing a computerized single-player version of a coordination game, the Assurance game, changed as a function of the variable responses (Stag/Hare) generated by multiple simulations (SIMs). We were interested in whether individuals could track and differentially respond to changing frequencies of Stag and Hare play by the SIMs, especially with regard to the payoff dominant (Stag-Stag) outcome, something that could not be done with real partners as they quickly settled on the Stag response. For both monkeys and humans, there was a linear relationship between proportion of Stag play by the subject and the likelihood of the Stag choice by the SIM such that both species increased their use of Stag as the SIM increased its use of the Stag response. However, humans more closely matched their proportion of Stag responses to that of the SIM, whereas monkeys adopted a different, but equally effective, strategy of exploiting the higher-paying Stag alternative. These results suggest that monkeys and humans demonstrate sensitivity to a dynamic game environment in which they encounter variable contingencies for the same response options, although they may employ different strategies to maximize reward

Using Spatial Manipulation to Examine Interactions between Visual and Auditory Encoding of Pitch and Time

Music notations use both symbolic and spatial representation systems. Novice musicians do not have the training to associate symbolic information with musical identities, such as chords or rhythmic and melodic patterns. They provide an opportunity to explore the mechanisms underpinning multimodal learning when spatial encoding strategies of feature dimensions might be expected to dominate. In this study, we applied a range of transformations (such as time reversal) to short melodies and rhythms and asked novice musicians to identify them with or without the aid of notation. Performance using a purely spatial (graphic) notation was contrasted with the more symbolic, traditional western notation over a series of weekly sessions. The results showed learning effects for both notation types, but performance improved more for graphic notation. This points to greater compatibility of auditory and visual neural codes for novice musicians when using spatial notation, suggesting that pitch and time may be spatially encoded in multimodal associative memory. The findings also point to new strategies for training novice musicians