HiPERCAM: A high-speed quintuple-beam CCD camera for the study of rapid variability in the universe

HiPERCAM is a high-speed camera for the study of rapid variability in the Universe. The project is funded by a ϵ3.5M European Research Council Advanced Grant. HiPERCAM builds on the success of our previous instrument, ULTRACAM, with very significant improvements in performance thanks to the use of the latest technologies. HiPERCAM will use 4 dichroic beamsplitters to image simultaneously in 5 optical channels covering the u'g'r'I'z' bands. Frame rates of over 1000 per second will be achievable using an ESO CCD controller (NGC), with every frame GPS timestamped. The detectors are custom-made, frame-transfer CCDs from e2v, with 4 low noise (2.5e -) outputs, mounted in small thermoelectrically-cooled heads operated at 180 K, resulting in virtually no dark current. The two reddest CCDs will be deep-depletion devices with anti-etaloning, providing high quantum efficiencies across the red part of the spectrum with no fringing. The instrument will also incorporate scintillation noise correction via the conjugate-plane photometry technique. The opto-mechanical chassis will make use of additive manufacturing techniques in metal to make a light-weight, rigid and temperature-invariant structure. First light is expected on the 4.2m William Herschel Telescope on La Palma in 2017 (on which the field of view will be 10' with a 0.3"/pixel scale), with subsequent use planned on the 10.4m Gran Telescopio Canarias on La Palma (on which the field of view will be 4' with a 0.11"/pixel scale) and the 3.5m New Technology Telescope in Chile

Psychiatric framing affects positive but not negative schizotypy scores in psychology and medical students

When testing risk for psychosis, we regularly rely on self-report questionnaires. Yet, the more that people know about this condition, the more they might respond defensively, in particular with regard to the more salient positive symptom dimension. In two studies, we investigated whether framing provided by questionnaire instructions might modulate responses on self-reported positive and negative schizotypy. The O-LIFE (UK study) or SPQ (New Zealand study) questionnaire was framed in either a “psychiatric” “creativity” or “personality” (NZ only) context. We tested psychology students (without taught knowledge about psychosis) and medical students (with taught knowledge about psychosis; UK only). We observed framing effects in psychology students in both studies: positive schizotypy scores were lower after the psychiatric compared to the creativity instruction. However, schizotypy scores did not differ between the creativity and personality framing conditions, suggesting that the low scores with psychiatric framing reflect defensive responding. The same framing effect was also observed in medical students, despite their lower positive schizotypy scores overall. Negative schizotypy scores were not affected by framing in either study. These results highlight the need to reduce response biases when studying schizotypy, because these might blur schizotypy-behaviour relationships.</p

Suckler Bulls Slaughtered at 15 Months of Age: Effect of Different Production Systems on the Fatty Acid Profile and Selected Quality Characteristics of Longissimus Thoracis

peer-reviewedThe objective was to compare the quality of beef from bulls reared in typical Irish indoor systems or in novel grass-based systems. Bulls were assigned to one of the following systems: (a) grass silage plus barley-based concentrate ad libitum (CON); (b) grass silage ad libitum plus 5 kg of concentrate (SC); (c) grazed grass without supplementation (G0); (d) grazed grass plus 0.5 kg of the dietary dry matter intake as concentrate (GC) for (100 days) until slaughter (14.99 months). Carcass characteristics and pH decline were recorded. Longissimus thoracis was collected for analytical and sensory analysis. Lower carcass weight, conformation and fatness scores were found for grazing compared to CON and SC groups. CON bulls had highest intramuscular fat and lighter meat colour compared with grazing bulls. The SC meat (14 days aged) was rated higher for tenderness, texture, flavour and acceptability compared with grazing groups. CON saturated and monounsaturated fatty acid (FA) concentration was highest, conversely, omega-3 FA concentration was higher for GC compared with CON, while no differences were found in polyunsaturated FA. In conclusion, while market fatness specification was not reached by grazed grass treatments, beef eating quality was not detrimentally affected and nutritional quality was improved

The Colour, Composition and Eating Quality of Beef from Late- or Early-Maturing Suckler Bulls Finished at Pasture with or without Concentrate Supplementation

Carcasses from pasture-finished early-maturing (EM), rather than late-maturing (LM), breed bulls may be more suited to meet the minimum carcass fatness classification of 2+ (6.0 on a 15-point scale) required for some markets. The comparative colour and eating quality of beef from grass-fed bulls of different maturities are unknown. Sixty yearling suckler-bred bulls were assigned to a 2 (maturities: EM and LM) × 2 (finishing strategies: grass only (G0) or grass + 4.0 kg concentrate daily (GC)) factorial design. Bulls were at pasture from 7 April, concentrates were introduced (or not) 97 days later, and bulls were slaughtered at 192 d post-turnout (approximately 19 mo of age). Carcass fat scores averaged 5.02, 6.20, 6.33 and 7.30 for LMG0, LMGC, EMG0 and EMGC bulls, respectively. Muscle colour did not differ between treatments. Muscle from LM had lower intramuscular fat concentration, collagen solubility and a tendency (p < 0.1) towards lower ratings for tenderness, texture, and acceptability of 14 d aged beef. Concentrate supplementation decreased the ratings for muscle tenderness but ratings for acceptability were not affected. Achieving the minimum carcass fatness was therefore not required to produce beef of acceptable eating quality and suckler bulls can access the “grass-fed” beef market.This project (11/SF/322, “BullBeef”) was funded by the Irish Department of Agriculture, Food and the Marine’s competitive research programmes

Hunting For Eclipses: High Speed Observations of Cataclysmic Variables

We present new time-resolved photometry of 74 cataclysmic variables (CVs), 47 of which are eclipsing. 13 of these eclipsing systems are newly discovered. For all 47 eclipsing systems we show high cadence (1-20 seconds) light curves obtained with the high-speed cameras ultracam and ultraspec. We provide new or refined ephemerides, and supply mid-eclipse times for all observed eclipses. We assess the potential for light curve modelling of all 47 eclipsing systems to determine their system parameters, finding 20 systems which appear to be suitable for future study

Noise-induced hearing loss and hearing conservation in the iron and steel industry in South Africa

BACKGROUND AND PURPOSE: The iron and steel industry in South Africa has been identified as one of the highest risk industries in terms of noise induced hearing loss (NIHL). The National Institute for Occupational Health was commissioned by the Department of Labour to audit the current noise exposure levels and hearing conservation practices in eight major producers of iron and steel, and to make recommendations regarding prevention strategies. METHODS: The audit was conducted in two parts: the noise exposure levels and hearing conservation practices were assessed by the occupational hygiene department. The occupational medicine department assessed the hearing conservation policies and procedures, reviewed employees’ medical records to ascertain the number of NIHL cases, and conducted verification of audiograms on a sample of employees working in noise zones. RESULTS: Area noise levels exceeding 105 dB(A) were measured in four of the eight workplaces. The estimated average annual incidence of NIHL varied from 0.7 - 8.3/1000/year. All companies did baseline, periodic and exit audiometric testing, but there were notable discrepancies between companies and verification audiograms and differences of more than 20 dB(A) were found. Although information and training on noise was reportedly done in all worksites, a high proportion of workers could not demonstrate correct fitting of hearing protection devices or recall when last they were trained. CONCLUSION: A detailed standard operating procedure should be implemented for medical surveillance for NIHL with action timelines that initiate remedial processes prior to employee developing compensable disease. Aggregated audiometric testing results should be communicated to managers and health and safety teams to provide guidance to prioritise areas for control measures. A quality assurance programme for audiometric testing must be implemented. An evaluation tool to measure the effectiveness of the noise and hearing conservation training provided to employees, including contracted employees, should be adopted.http://www.occhealth.co.zaam201

Qualitative documentary analysis of guidance on information provision and consent for the introduction of innovative invasive procedures including surgeries within NHS organisations' policies in England and Wales

OBJECTIVE: To review guidance, included in written local UK National Health Service (NHS) organisation policies, on information provision and consent for the introduction of new invasive procedures- including surgeries, and devices (IPs/Ds). DESIGN: A qualitative documentary analysis of data on patient information provision and consent extracted from policies for the introduction of IP/Ds from NHS organisations in England and Wales. SETTING: NHS trusts in England and health boards in Wales, UK. PARTICIPANTS: Between December 2017 and July 2018, 150 acute trusts in England and 7 health boards in Wales were approached for their policies for the introduction of new IP/Ds. In total, 123 policies were received, 11 did not fit the inclusion criteria and a further policy was included from a trust website resulting in 113 policies included for review. RESULTS: From the 113 policies, 22 did not include any statements on informed consent/information provision or lacked guidance on the information to be provided to patients and were hence excluded. Consequently, 91 written local NHS policies were included in the final dataset. Within the guidance obtained, variation existed on disclosure of the procedure’s novelty, potential risks, benefits, uncertainties, alternative treatments and surgeon’s experience. Few policies stated that clinicians should discuss the existing evidence associated with a procedure. Additionally, while the majority of policies referred to patients needing written information, this was often not mandated and few policies specified the information to be included. CONCLUSIONS: Nearly a fifth of all the policies lacked guidance on information to be provided to patients. There was variability in the policy documents regarding what patients should be told about innovative procedures. Further research is needed to ascertain the information and level of detail appropriate for patients when considering innovative procedures. A core information set including patients’ and clinicians’ views is required to address variability around information provision/consent for innovative procedures

Identification of outcomes to inform the development of a core outcome set for surgical innovation:a targeted review of case studies of novel surgical devices

OBJECTIVE: Outcome selection and reporting in studies of novel surgical procedures and devices lacks standardisation, hindering safe and effective evaluation. A core outcome set (COS) to measure and report in all studies of surgical innovation is needed. We explored outcomes in a specific sample of innovative surgical device case studies to identify outcome domains specifically relevant to innovation to inform the development of a COS. DESIGN: A targeted review of 11 purposive selected case studies of innovative surgical devices. METHODS: Electronic database searches in PubMed (July 2018) identified publications reporting the introduction and evaluation of each device. Outcomes were extracted and categorised into domains until no new domains were conceptualised. Outcomes specifically relevant to evaluating innovation were further scrutinised. RESULTS: 112 relevant publications were identified, and 5926 outcomes extracted. Heterogeneity in study type, outcome selection and reporting was observed across surgical devices. Categorisation of outcomes was performed for 2689 (45.4%) outcomes into five broad outcome domains. Outcomes considered key to the evaluation of innovation (n=66; 2.5%) were further categorised as surgeon/operator experience (n=40; 1.5%), unanticipated events (n=15, 0.6%) and modifications (n=11; 0.4%). CONCLUSION: Outcome domains unique to evaluating innovative surgical devices have been identified. Findings have been combined with multiple other data sources relevant to the evaluation of surgical innovation to inform the development of a COS to measure and report in all studies evaluating novel surgical procedures/devices

Regional variation in pesticide concentrations in plasma of delivering women residing in rural Indian Ocean coastal regions of South Africa

Exposure to pesticides places pregnant women and the developing foetus at the highest risk. The objective of this study is to obtain an exposure assessment by investigating levels of pesticides in blood plasma of delivering women. We report on the concentrations of a, b, g HCH, endosulfan, HCB and the pyrethroids: cis-permethrin, cyfluthrin, cypermethrin and deltamethrin found in the maternal blood plasma of delivering women (n ¼ 241) in three coastal sites of KwaZulu Natal. g-HCH and endosulfan 1 and 2 were the most dominant pesticides in all three sites. Significantly, higher levels of g-HCH and endosulfan were found in site 3 (vicinity of Empangeni) compared to the other two sites (p < 0.05). The GMlevels for g-HCH, endosulfan 1 and 2 were 956, 141 and 21 ng g 1 lipids in site 3, respectively. The pyrethroid pesticides, HCB, a-HCH and b-HCH were detected in less than 31% of the samples in all sites. g-HCH correlated positively and strongly to both endosulfan 1 and 2 (r > 0.47), indicating a common source of exposure. The high levels of g-HCH and endosulfan in maternal plasma samples in site 3 indicate the current and on-going exposure, which is of great concern for reproductive health and prenatal exposure.Part of this work was presented at the Environmental Health Conference 2011 – Resetting our Priorities, Salvador, Brazil, 6–9 February 2011.The Research Council of Norway and the National Research Foundation, South Africa (Grant 64528), the Arctic Monitoring and Assessment Programme (AMAP), the Royal Norwegian Ministry for Foreign Affairs and the SA Medical Research Council.http://www.rsc.org/jemam2013ay201

Does a 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine prevent respiratory exacerbations in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: protocol for a randomised c

BackgroundRecurrent protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are characterised by a chronic wet cough and are important causes of childhood respiratory morbidity globally. Haemophilus influenzae and Streptococcus pneumoniae are the most commonly associated pathogens. As respiratory exacerbations impair quality of life and may be associated with disease progression, we will determine if the novel 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) reduces exacerbations in these children. MethodsA multi-centre, parallel group, double-blind, randomised controlled trial in tertiary paediatric centres from three Australian cities is planned. Two hundred six children aged 18 months to 14 years with recurrent PBB, CSLD or bronchiectasis will be randomised to receive either two doses of PHiD-CV or control meningococcal (ACYW135) conjugate vaccine 2 months apart and followed for 12 months after the second vaccine dose. Randomisation will be stratified by site, age (&lt;6 years and &ge;6 years) and aetiology (recurrent PBB or CSLD/bronchiectasis). Clinical histories, respiratory status (including spirometry in children aged &ge;6 years), nasopharyngeal and saliva swabs, and serum will be collected at baseline and at 2, 3, 8 and 14 months post-enrolment. Local and systemic reactions will be recorded on daily diaries for 7 and 30 days, respectively, following each vaccine dose and serious adverse events monitored throughout the trial. Fortnightly, parental contact will help record respiratory exacerbations. The primary outcome is the incidence of respiratory exacerbations in the 12 months following the second vaccine dose. Secondary outcomes include: nasopharyngeal carriage of H. influenzae and S. pneumoniae vaccine and vaccine- related serotypes; systemic and mucosal immune responses to H. influenzae proteins and S. pneumoniae vaccine and vaccine-related serotypes; impact upon lung function in children aged &ge;6 years; and vaccine safety. DiscussionAs H. influenzae is the most common bacterial pathogen associated with these chronic respiratory diseases in children, a novel pneumococcal conjugate vaccine that also impacts upon H. influenzae and helps prevent respiratory exacerbations would assist clinical management with potential short- and long-term health benefits. Our study will be the first to assess vaccine efficacy targeting H. influenzae in children with recurrent PBB, CSLD and bronchiectasis