Election Flops on YouTube

In an election campaign as drawn out as this, you'd have to have excellent memory to remember the hype around John Howard's use of YouTube to make policy announcements. Some months ago, the media were all over the story - but unfortunately for the Prime Minister, much like the widely-predicted poll 'narrowing', the YouTube effect has been missing in action

Beyond Gotcha: Blogs as a Space for Debate

The mainstream media and critics of Web 2.0’s "cult of the amateur" often suggest that blogs and citizen journalism will never replace their mainstream counterparts because they "don’t break stories". Notwithstanding the fundamental furphy – who ever said anything about "replacing" the MSM anyway? – there is some truth in this. It goes without saying that most bloggers don’t have the resources, pulling power or proximity to the pollies to do much original political reporting: this is something that most sensible public affairs bloggers concede. (Though how often the mainstream media really break stories – as against exploiting deliberate, calculated ‘leaks’ from party spinsters – is a separate question.

Blogging outside the Echo Chamber

In the current political climate, it's no surprise that a number of sessions at the recent Australian Blogging Conference at Queensland University of Technology in Brisbane focussed on the potential for blogs and other citizen journalism sites to impact on political news and punditry. In a previous article, we've already noted the continuing skirmishes between psephologist bloggers and the political commentators, whose rather unscientific interpretation of opinion poll results that some bloggers have challenged fervently

A Simple Method for Computing Singular or Nearly Singular Integrals on Closed Surfaces

We present a simple, accurate method for computing singular or nearly singular integrals on a smooth, closed surface, such as layer potentials for harmonic functions evaluated at points on or near the surface. The integral is computed with a regularized kernel and corrections are added for regularization and discretization, which are found from analysis near the singular point. The surface integrals are computed from a new quadrature rule using surface points which project onto grid points in coordinate planes. The method does not require coordinate charts on the surface or special treatment of the singularity other than the corrections. The accuracy is about $O(h^3)$, where $h$ is the spacing in the background grid, uniformly with respect to the point of evaluation, on or near the surface. Improved accuracy is obtained for points on the surface. The treecode of Duan and Krasny for Ewald summation is used to perform sums. Numerical examples are presented with a variety of surfaces.Comment: to appear in Commun. Comput. Phy

Moderate exercise increases affinity of large very low density lipoproteins for hydrolysis by lipoprotein lipase

Context: Postprandial triglyceride (TG) concentration is independently associated with cardiovascular disease risk. Exercise reduces postprandial TG concentrations but the mechanisms responsible are unclear. Objective: To determine the effects of exercise on affinity of chylomicrons, large very low density lipoproteins (VLDL1) and smaller VLDL (VLDL2) for lipoprotein lipase (LPL) mediated TG hydrolysis. Design: Within-participant cross-over study. Setting: A University metabolic investigation unit. Participants: Ten overweight/obese men. Interventions: Participants undertook two oral fat tolerance tests, separated by 7–14 days, in which they had blood taken fasting and for 4 hours after a high-fat mixed meal. On the afternoon before one test, they performed a 90-minute treadmill walk at 50% maximal oxygen uptake (EX); no exercise was performed before the control test (CON). Main outcome measures: Circulating TG-rich lipoprotein concentrations; affinity of chylomicrons, VLDL1, VLDL2 for LPL-mediated TG hydrolysis. Results: Exercise significantly reduced fasting VLDL1-TG concentration (CON: 0.49(0.33–0.72) mmol.l−1, EX: 0.36(0.22–0.59) mmol.l−1, [geometric means (95% confidence interval)]; p=0.04). Time-averaged postprandial chylomicron-TG (CON: 0.55±0.10 mmol.l−1, EX: 0.39±0.08 mmol.l−1, [mean±SEM], p=0.03) and VLDL1-TG (CON: 0.85±0.13 mmol.l−1, EX: 0.66±0.10 mmol.l−1, p=0.01) concentrations were both lower in EX than CON. Affinity of VLDL1 for LPL-mediated TG hydrolysis increased by 2.2(1.3–3.7) fold (geometric mean (95% confidence interval)) (p=0.02) in the fasted state and 2.6(1.8–2.6) fold (p=0.001) postprandially. Affinity of chylomicrons and VLDL2 was not significantly different between trials. Conclusions: Exercise increases affinity of VLDL1 for LPL-mediated TG hydrolysis both fasting and postprandially. This mechanism is likely to contribute to exercise's TG-lowering effect

2019 Kansas State University Industrial Hemp CBD Variety Trial

Hemp is a broad term used to describe the many varieties of Cannabis sativa L. that produce less than 0.3% tetrahydrocannabinol (THC). The crop is globally significant, but only recently allowed to be grown again in the United States. Varieties have been selected and are currently grown with a wide range of cannabinoid profiles. Cannabinoids are of interest for their putative medical and therapeutic role in humans and pets. Cannabidiol (CBD) and THC are the two cannabinoids of primary interest. THC is of interest because it determines whether the final product is considered hemp (0.3% THC). CBD is of interest because of its potential therapeutic properties and its legal status across many states. Currently, there is no information available regarding adaptability or cannabinoid production of these varieties in Kansas. In 2019, Kansans were allowed to apply for research licenses to grow industrial hemp. It was assumed the crop would grow well throughout Kansas since there are wild remnant populations of C. sativa flourishing at numerous locations across the state. However, controlled variety trials are necessary to determine which varieties are best adapted to Kansas. Currently, growers must rely on information generated from other states with vastly different growing conditions than Kansas. Variety selection is vital in CBD hemp production considering that environmental conditions strongly influence cannabinoid ratios and ultimately, total cannabinoid content. The objective of this study was to evaluate commercially available varieties of CBD hemp in south-central Kansas grown in containers outdoors or inside of a high tunnel. Outdoor hemp production is of interest because of reduced infrastructure cost. However, pollination is a concern with outdoor hemp. Unpollinated female flowers contain the highest concentration of cannabinoids. When flowers are pollinated and seeds are produced, the total concentration of all cannabinoids is greatly diminished. In Kansas, naturalized populations of C. sativa can be found throughout the state. With pollen easily traveling as far as 3 miles there is concern regarding the viability of outdoor CBD hemp potential. We wanted to test whether a covered high tunnel could effectively reduce pollination of the plants within

Exercise, type 1 diabetes mellitus and blood glucose: The implications of exercise timing

The scientific literature shows that exercise has many benefits for individuals with type 1 diabetes. Yet, several barriers to exercise in this population exist, such as post-exercise hypoglycaemia or hyperglycaemia. Several studies suggest that the timing of exercise may be an important factor in preventing exercise-induced hypoglycaemia or hyperglycaemia. However, there is a paucity of evidence solely focused on summarising findings regarding exercise timing and the impact it has on glucose metabolism in type 1 diabetes. This report suggests that resistance or high-intensity interval exercise/training (often known as HIIT) may be best commenced at the time of day when an individual is most likely to experience a hypoglycaemic event (i.e., afternoon/evening) due to the superior blood glucose stability resistance and HIIT exercise provides. Continuous aerobic-based exercise is advised to be performed in the morning due to circadian elevations in blood glucose at this time, thereby providing added protection against a hypoglycaemic episode. Ultimately, the evidence concerning exercise timing and glycaemic control remains at an embryonic stage. Carefully designed investigations of this nexus are required, which could be harnessed to determine the most effective, and possibly safest, time to exercise for those with type 1 diabetes

The Impact of the COVID-19 Pandemic on State Court Proceedings: Five Key Findings

The University of Illinois System’s Institute for Government and Public Affairs and the National Center for State Courts jointly conducted the COVID-19 and the State Courts Study between August 2020 and July 2021. The first stage of the study involved focus groups of attorneys, judges, court administrators, court staff, jurors, and litigants in four states. This report describes some results of the second stage of the study, which involved nationwide surveys of judges, court personnel, and attorneys. The surveys asked participants questions about access to courts during the pandemic and their experiences with the new strategies courts adopted to continue hearing and processing cases. This report summarizes five key findings from the surveys concerning access to the courts. • • First, early in the pandemic, most attorneys thought that litigants’ access to judicial proceedings was worse than usual. • Second, attorneys reported that litigants’ experiences in courts improved after September 2020. Over time, participants believed that some early access difficulties abated. • Third, court personnel had a more positive view than did attorneys about the ability of individuals to participate in the judicial system during the pandemic. • Fourth, attorneys with practices concentrated in landlord-tenant law and criminal law perceived somewhat greater problems than did attorneys who practice in other areas of the law. • Fifth, while participants identified many benefits to online court proceedings, they also saw drawbacks. Assessing whether and under what circumstances to conduct court proceedings online after the pandemic is over will require careful consideration of benefits and downsides and balancing some competing factors.Ope

Modeling payback from research into the efficacy of left-ventricular assist devices as destination therapy

Objectives: Ongoing developments in design have improved the outlook for left-ventricular assist device (LVAD) implantation as a therapy in end-stage heart failure. Nevertheless, early cost-effectiveness assessments, based on first-generation devices, have not been encouraging. Against this background, we set out (i) to examine the survival benefit that LVADs would need to generate before they could be deemed cost-effective; (ii) to provide insight into the likelihood that this benefit will be achieved; and (iii) from the perspective of a healthcare provider, to assess the value of discovering the actual size of this benefit by means of a Bayesian value of information analysis. Methods: Cost-effectiveness assessments are made from the perspective of the healthcare provider, using current UK norms for the value of a quality-adjusted life-year (QALY). The treatment model is grounded in published analyses of the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) trial of first-generation LVADs, translated into a UK cost setting. The prospects for patient survival with second-generation devices is assessed using Bayesian prior distributions, elicited from a group of leading clinicians in the field. Results: Using established thresholds, cost-effectiveness probabilities under these priors are found to be low (.2 percent) for devices costing as much as £60,000. Sensitivity of the conclusions to both device cost and QALY valuation is examined. Conclusions: In the event that the price of the device in use would reduce to £40,000, the value of the survival information can readily justify investment in further trials

X-ray computed tomography (XCT) and chemical analysis (EDX and XRF) used in conjunction for cultural conservation: the case of the earliest scientifically described dinosaur Megalosaurus bucklandii

This paper demonstrates the combined use of X-ray computed tomography (XCT), energy dispersive X-ray spectroscopy (EDX) and X-ray fluorescence (XRF) to evaluate the conservational history of the dentary (lower jaw) of Megalosaurus bucklandii Mantell, 1827, the first scientifically described dinosaur. Previous analysis using XCT revealed that the specimen had undergone at least two phases of repair using two different kinds of plaster, although their composition remained undetermined. Additional chemical analysis using EDX and XRF has allowed the determination of the composition of these unidentified plasters, revealing that they are of similar composition, composed dominantly of ‘plaster of Paris’ mixed with quartz sand and calcite, potentially from the matrix material of the Stonesfield Slate, with the trace presence of chlorine. One of the plasters unusually contains the pigment minium (naturally occurring lead tetroxide; Pb22+Pb4+O4) whilst the other seems to have an additional coating of barium hydroxide (Ba(OH)2), indicating that these likely represent two separate stages of repair. The potential of this combined approach for evaluating problematic museum objects for conservation is further discussed as is its usage in cultural heritage today