1,397 research outputs found
Systematic Renormalization in Hamiltonian Light-Front Field Theory: The Massive Generalization
Hamiltonian light-front field theory can be used to solve for hadron states
in QCD. To this end, a method has been developed for systematic renormalization
of Hamiltonian light-front field theories, with the hope of applying the method
to QCD. It assumed massless particles, so its immediate application to QCD is
limited to gluon states or states where quark masses can be neglected. This
paper builds on the previous work by including particle masses
non-perturbatively, which is necessary for a full treatment of QCD. We show
that several subtle new issues are encountered when including masses
non-perturbatively. The method with masses is algebraically and conceptually
more difficult; however, we focus on how the methods differ. We demonstrate the
method using massive phi^3 theory in 5+1 dimensions, which has important
similarities to QCD.Comment: 7 pages, 2 figures. Corrected error in Eq. (11), v3: Added extra
disclaimer after Eq. (2), and some clarification at end of Sec. 3.3. Final
published versio
The Modification of Spousal Interaction After Aphasia
Researchers have investigated the ways spouses collaboratively overcome the communication barriers they face subsequent to aphasia in one of the partners (e.g., Oelschlaeger & Damico, 2003). These studies have demonstrated ways that the interactional dynamic is employed to re-establish social action after aphasia. However, little has been done to determine how spousal dyads created these modifications. This study was undertaken to investigate how the evolution of the described adaptations to conversation within spousal dyads was accomplished
The Origins of [CII] Emission in Local Star-forming Galaxies
The [CII] 158um fine-structure line is the brightest emission line observed
in local star-forming galaxies. As a major coolant of the gas-phase
interstellar medium, [CII] balances the heating, including that due to
far-ultraviolet photons, which heat the gas via the photoelectric effect.
However, the origin of [CII] emission remains unclear, because C+ can be found
in multiple phases of the interstellar medium. Here we measure the fractions of
[CII] emission originating in the ionized and neutral gas phases of a sample of
nearby galaxies. We use the [NII] 205um fine-structure line to trace the
ionized medium, thereby eliminating the strong density dependence that exists
in the ratio of [CII]/[NII] 122um. Using the FIR [CII] and [NII] emission
detected by the KINGFISH and Beyond the Peak Herschel programs, we show that
60-80% of [CII] emission originates from neutral gas. We find that the fraction
of [CII] originating in the neutral medium has a weak dependence on dust
temperature and the surface density of star formation, and a stronger
dependence on the gas-phase metallicity. In metal-rich environments, the
relatively cooler ionized gas makes substantially larger contributions to total
[CII] emission than at low abundance, contrary to prior expectations.
Approximate calibrations of this metallicity trend are provided.Comment: 8 pages, accepted for publication in Ap
Glueballs in a Hamiltonian Light-Front Approach to Pure-Glue QCD
We calculate a renormalized Hamiltonian for pure-glue QCD and diagonalize it.
The renormalization procedure is designed to produce a Hamiltonian that will
yield physical states that rapidly converge in an expansion in free-particle
Fock-space sectors. To make this possible, we use light-front field theory to
isolate vacuum effects, and we place a smooth cutoff on the Hamiltonian to
force its free-state matrix elements to quickly decrease as the difference of
the free masses of the states increases. The cutoff violates a number of
physical principles of light-front pure-glue QCD, including Lorentz covariance
and gauge covariance. This means that the operators in the Hamiltonian are not
required to respect these physical principles. However, by requiring the
Hamiltonian to produce cutoff-independent physical quantities and by requiring
it to respect the unviolated physical principles of pure-glue QCD, we are able
to derive recursion relations that define the Hamiltonian to all orders in
perturbation theory in terms of the running coupling. We approximate all
physical states as two-gluon states, and use our recursion relations to
calculate to second order the part of the Hamiltonian that is required to
compute the spectrum. We diagonalize the Hamiltonian using basis-function
expansions for the gluons' color, spin, and momentum degrees of freedom. We
examine the sensitivity of our results to the cutoff and use them to analyze
the nonperturbative scale dependence of the coupling. We investigate the effect
of the dynamical rotational symmetry of light-front field theory on the
rotational degeneracies of the spectrum and compare the spectrum to recent
lattice results. Finally, we examine our wave functions and analyze the various
sources of error in our calculation.Comment: 75 pages, 17 figures, 1 tabl
The Impact of Spontaneous Recovery in Clinical Aphasiology
In clinical aphasiology, there are a number of well-accepted concepts that are considered organizing constructs in the discipline. One such construct is the concept of spontaneous recovery (SR). This construct influences the expectations that we hold regarding the time frame for greatest recovery and for best clinical response, and a host of theoretical and organizing principles that determine much of our planning and research design and that guide our expectations with respect to treatment, recovery, reimbursement, and explanatory mechanisms for recovery. However, the construct itself has been little studied
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low - and high- grade glioma surgery
Biomarkers are indicators of biological processes and hold promise for the diagnosis and treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked intra- and inter-tumor variability. The extent of surgical resection is a significant factor influencing post-surgical recurrence and prognosis. Here, we used fluorescence and reflectance spectral signatures for in vivo quantification of multiple biomarkers during glioma surgery, with fluorescence contrast provided by exogenously-induced protoporphyrin IX (PpIX) following administration of 5-aminolevulinic acid. We performed light-transport modeling to quantify multiple biomarkers indicative of tumor biological processes, including the local concentration of PpIX and associated photoproducts, total hemoglobin concentration, oxygen saturation, and optical scattering parameters.We developed a diagnostic algorithm for intra-operative tissue delineation that accounts for the combined tumor-specific predictive capabilities of these quantitative biomarkers. Tumor tissue delineation achieved accuracies of up to 94% (specificity=94%, sensitivity=94%) across a range of glioma histologies beyond current state-of-the-art optical approaches, including state-of-the-art fluorescence image guidance. This multiple biomarker strategy opens the door to optical methods for surgical guidance that use quantification of well-established neoplastic processes. Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients
Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information regarding the effect of berberine on colon tumor growth is limited. Here, we investigated the mechanisms underlying the effects of berberine on regulating the fate of colon tumor cells, specifically the mouse immorto-Min colonic epithelial (IMCE) cells carrying the Apcmin mutation, and of normal colon epithelial cells, namely young adult mouse colonic epithelium (YAMC) cells. Berberine decreased colon tumor colony formation in agar, and induced cell death and LDH release in a time- and concentration-dependent manner in IMCE cells. In contrast, YAMC cells were not sensitive to berberine-induced cell death. Berberine did not stimulate caspase activation, and PARP cleavage and berberine-induced cell death were not affected by a caspase inhibitor in IMCE cells. Rather, berberine stimulated a caspase-independent cell death mediator, apoptosis-inducing factor (AIF) release from mitochondria and nuclear translocation in a ROS production-dependent manner. Amelioration of berberine-stimulated ROS production or suppression of AIF expression blocked berberine-induced cell death and LDH release in IMCE cells. Furthermore, two targets of ROS production in cells, cathepsin B release from lysosomes and PARP activation were induced by berberine. Blockage of either of these pathways decreased berberine-induced AIF activation and cell death in IMCE cells. Thus, berberine-stimulated ROS production leads to cathepsin B release and PARP activation-dependent AIF activation, resulting in caspase-independent cell death in colon tumor cells. Notably, normal colon epithelial cells are less susceptible to berberine-induced cell death, which suggests the specific inhibitory effects of berberine on colon tumor cell growth
Anastral spindle assembly and γ-tubulin in Drosophila oocytes
<p>Abstract</p> <p>Background</p> <p>Anastral spindles assemble by a mechanism that involves microtubule nucleation and growth from chromatin. It is still uncertain whether γ-tubulin, a microtubule nucleator essential for mitotic spindle assembly and maintenance, plays a role. Not only is the requirement for γ-tubulin to form anastral <it>Drosophila </it>oocyte meiosis I spindles controversial, but its presence in oocyte meiosis I spindles has not been demonstrated and is uncertain.</p> <p>Results</p> <p>We show, for the first time, using a bright GFP fusion protein and live imaging, that the <it>Drosophila </it>maternally-expressed γTub37C is present at low levels in oocyte meiosis I spindles. Despite this, we find that formation of bipolar meiosis I spindles does not require functional γTub37C, extending previous findings by others. Fluorescence photobleaching assays show rapid recovery of γTub37C in the meiosis I spindle, similar to the cytoplasm, indicating weak binding by γTub37C to spindles, and fits of a new, potentially more accurate model for fluorescence recovery yield kinetic parameters consistent with transient, diffusional binding.</p> <p>Conclusions</p> <p>The FRAP results, together with its mutant effects late in meiosis I, indicate that γTub37C may perform a role subsequent to metaphase I, rather than nucleating microtubules for meiosis I spindle formation. Weak binding to the meiosis I spindle could stabilize pre-existing microtubules or position γ-tubulin for function during meiosis II spindle assembly, which follows rapidly upon oocyte activation and completion of the meiosis I division.</p
Magnetic coupling in a hybrid Mn(ii) acetylene dicarboxylate
The design of ligands that mediate through-bond long range super-exchange in metal–organic hybrid materials would expand chemical space beyond the commonly observed short range, low temperature magnetic ordering. Here we examine acetylene dicarboxylate as a potential ligand that could install long range magnetic ordering due to its spatially continuous frontier orbitals. Using a known Mn(II)-containing coordination polymer we compute and measure the electronic structure and magnetic ordering. In this case, the latter is weak owing to the sub-optimal ligand coordination geometry, with a critical temperature of 2.5 K
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