2,079 research outputs found
Knowledge for Equitable Mathematics Teaching: The Case of Latino ELLs in U.S. Schools
This paper reports the exploration of an aspect of knowledge needed for equitable mathematics teaching. Pedagogical Content Knowledge for Teaching Mathematics to English Language Learners (PCK-MELL) was proposed as a theoretical knowledge construct, a subdomain of MKT, and the construct was investigated through a process of survey instrument development and administration. The survey contained items intended to measure teachersâ knowledge of the obstacles encountered by ELLs in math classes, of the resources that ELLs draw upon, and of instructional strategies for teaching ELLs. Analysis of middle school mathematics teachersâ responses (N = 42) offered insights into how to improve the reliability and measurement validity of this sort of instrument, as well as directions for further theory development
Connections between Pre-service Teachersâ Mathematical Dispositions and Self-efficacy for Teaching Mathematics
Mathematical dispositions (MD) and self-efficacy for teaching mathematics (SEFTM) are important elements of teachersâ beliefs that significantly influence their behaviors and educational practices in the classroom. This study looked at relationships between pre-service teachersâ (PSTs) MD and their SEFTM in connection with other descriptors related to their progress through the teacher education program and prior mathematical experiences. Survey data were collected from 238 PSTs at a midsized university in the US. Results include the finding that PSTsâ intended grade-level and subject approximately mirror their MD and SEFTM: those planning to be elementary school (generalist) teachers were slightly behind both middle and high school teachers, who had more positive MD, while both elementary and middles school PSTs were slightly behind high school-level mathematics content PSTs, who had the greatest SEFTM. Additionally, MD was a strong predictor of SEFTM, and both MD and SEFTM appear to be mediated by the influence upon PSTs of their prior mathematics teachers. Implications for teacher education and avenues for further research into these associations are offered
Attitudes toward Using and Teaching Confidence Intervals: A Latent Profile Analysis on Elementary Statistics Instructors
The use of confidence intervals (CIs) for making a statistical inference is gaining popularity in research communities. To evaluate college statistics instructorsâ readiness to teach CIs, this study explores their attitudes toward teaching CIs in elementary statistics courses, and toward using CIs in inferential statistics. Data were collected with a survey that classifies instructorsâ attitudes on the basis of three previously established pedagogical components: affective, cognitive, and behavioral. Based on the survey responses from 270 participants, we created three profiles (subgroups) via latent profile analysis, and identified each profileâs pattern of attitudes toward CIs and common characteristics of the instructors that fit each profile. In addition, we compared the profiles across groupings created by six variables: gender, academic background, statistics teaching experience, subject preference, degree level, and desire to improve teaching. The results of the latent profile analysis support three profiles within the population of statistics instructors, and the results of the comparative analysis of teacher characteristics indicate that the six variables are moderate to strong predictors of the grouping of the sample into three profiles
Fungal infections and antifungal prophylaxis in pediatric cardiac extracorporeal life support
ObjectiveInfections acquired by children during extracorporeal membrane oxygenation (ECMO) increase mortality. Our aim was to evaluate the effectiveness of prophylactic fluconazole on the incidence of fungal infections and to assess whether hospital-acquired fungal infection is associated with increased in-hospital mortality in pediatric cardiac patients requiring ECMO.MethodsWe retrospectively reviewed a prospectively maintained database and collected data on all hospital-acquired infections in patients supported for cardiac indications at a tertiary childrenâs hospital from 1989 to 2008.ResultsECMO was deployed 801 times in 767 patients. After exclusion criteria were applied, 261 pediatric patients supported for cardiac indications were studied. Fungal infection (blood, urine, or surgical site) occurred in 12% (31/261) of patients, 9 (7%) of 127 patients receiving fluconazole prophylaxis versus 22 (16.4%) of 134 without antifungal prophylaxis (PÂ =Â .02). Using a multivariable logistic regression model, the absence of fluconazole prophylaxis was associated with an increased risk of fungal infection (odds ratio [OR]Â =Â 2.8; 95% confidence intervals [CI], 1.2, 6.7; PÂ =Â .016). In a multivariable logistic regression model for in-hospital mortality, the presence of fungal infection was associated with increased odds (ORÂ =Â 3.8; 95% CI, 1.5, 9.6; PÂ =Â .005) of in-hospital mortality among cardiac patients requiring ECMO, and the absence of antifungal prophylaxis showed a trend toward the same (ORÂ =Â 1.6; 95% CI, 0.96, 2.8; PÂ =Â .072).ConclusionsChildren with cardiac disease supported with ECMO who acquire fungal infections have increased mortality. Routine fluconazole prophylaxis is associated with lower rates of fungal infections in these patients
Draft Genome Sequence of Acetobacter aceti Strain 1023, a Vinegar Factory Isolate
The genome sequence of Acetobacter aceti 1023, an acetic acid bacterium adapted to traditional vinegar fermentation, comprises 3.0 Mb (chromosome plus plasmids). A. aceti 1023 is closely related to the cocoa fermenter Acetobacter pasteurianus 386B but possesses many additional insertion sequence elements
Murine Fig4 is dispensable for muscle development but required for muscle function
Abstract
Background
Phosphatidylinositol phosphates (PIPs) are low-abundance phospholipids that participate in a range of cellular processes, including cell migration and membrane traffic. PIP levels and subcellular distribution are regulated by a series of lipid kinases and phosphatases. In skeletal muscle, PIPs and their enzymatic regulators serve critically important functions exemplified by mutations of the PIP phosphatase MTM1 in myotubular myopathy (MTM), a severe muscle disease characterized by impaired muscle structure and abnormal excitationâcontraction coupling. FIG4 functions as a PIP phosphatase that participates in both the synthesis and breakdown of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Mutation of FIG4 results in a severe neurodegenerative disorder in mice and a progressive peripheral polyneuropathy in humans. The effect of FIG4 mutation on skeletal muscle has yet to be examined.
Methods
Herein we characterize the impact of FIG4 on skeletal muscle development and function using the spontaneously occurring mouse mutant pale tremor (plt), a mouse line with a loss of function mutation in Fig4.
Results
In plt mice, we characterized abnormalities in skeletal muscle, including reduced muscle size and specific force generation. We also uncovered ultrastructural abnormalities and increased programmed cell death. Conversely, we detected no structural or functional abnormalities to suggest impairment of excitationâcontraction coupling, a process previously shown to be influenced by PI(3,5)P2 levels. Conditional rescue of Fig4 mutation in neurons prevented overt muscle weakness and the development of obvious muscle abnormalities, suggesting that the changes observed in the plt mice were primarily related to denervation of skeletal muscle. On the basis of the ability of reduced FIG4 levels to rescue aspects of Mtmr2-dependent neuropathy, we evaluated the effect of Fig4 haploinsufficiency on the myopathy of Mtm1-knockout mice. Male mice with a compound Fig4
+/â/Mtm1
â/Y genotype displayed no improvements in muscle histology, muscle size or overall survival, indicating that FIG4 reduction does not ameliorate the Mtm1-knockout phenotype.
Conclusions
Overall, these data indicate that loss of Fig4 impairs skeletal muscle function but does not significantly affect its structural development.http://deepblue.lib.umich.edu/bitstream/2027.42/112676/1/13395_2013_Article_83.pd
Climate warming, marine protected areas and the ocean-scale integrity of coral reef ecosystems
Coral reefs have emerged as one of the ecosystems most vulnerable to climate variation and change. While the contribution
of a warming climate to the loss of live coral cover has been well documented across large spatial and temporal scales, the
associated effects on fish have not. Here, we respond to recent and repeated calls to assess the importance of local
management in conserving coral reefs in the context of global climate change. Such information is important, as coral reef
fish assemblages are the most species dense vertebrate communities on earth, contributing critical ecosystem functions
and providing crucial ecosystem services to human societies in tropical countries. Our assessment of the impacts of the
1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites
and 26 degrees of latitude in the Indian Ocean. Using Bayesian meta-analysis we show that changes in the size structure,
diversity and trophic composition of the reef fish community have followed coral declines. Although the ocean scale
integrity of these coral reef ecosystems has been lost, it is positive to see the effects are spatially variable at multiple scales,
with impacts and vulnerability affected by geography but not management regime. Existing no-take marine protected areas
still support high biomass of fish, however they had no positive affect on the ecosystem response to large-scale disturbance.
This suggests a need for future conservation and management efforts to identify and protect regional refugia, which should
be integrated into existing management frameworks and combined with policies to improve system-wide resilience to
climate variation and change
Educational thought and "Customs"
Background. Social support has been shown to mitigate social barriers to medication adherence and improve tuberculosis (TB) treatment success rates. The use of mobile technology to activate social support systems among TB patients, however, has not been well explored. Moreover, studies that tie supportive SMS (Short Message Service) texts to electronic monitoring of TB medication adherence are lacking. Objective. To explore TB patientsâ current access to social support and perceptions of utilizing real-time adherence monitoring interventions to support medication adherence. Methods. We purposively selected TB patients who owned phones, had been taking TB medications for â„1 month, were receiving their treatment from Mbarara Regional Referral Hospital, and reported having â„1 social supporter. We interviewed these patients and their social supporters about their access to and perceptions of social support. We used STATA 13 to describe participantsâ sociodemographic and social support characteristics. Qualitative data were analyzed using content analysis to derive categories describing accessibility and perceptions. Results. TB patients report requesting and receiving a variety of different forms of social support, including instrumental (e.g., money for transport and other needs and medication reminders), emotional (e.g., adherence counselling), and informational (e.g., medication side effects) support through mobile phones. Participants felt that SMS notifications may motivate medication adherence by creating a personal sense of obligation to take medications regularly. Participants anticipated that limited financial resources and relationship dynamics could constrain the provision of social support especially when patients and social supporters are not oriented about their expectations. Conclusion. Mobile telephones could provide alternative approaches to providing social support for TB medication adherence especially where patients do not stay close to their social supporters. Further efforts should focus on optimized designs of mobile phone-based applications for providing social support to TB patients and training of TB patients and social supporters to match their expectations
Skunk and Raccoon Rabies in the Eastern United States: Temporal and Spatial Analysis
Since 1981, an epizootic of raccoon rabies has spread throughout the eastern United States. A concomitant increase in reported rabies cases in skunks has raised concerns that an independent maintenance cycle of rabies virus in skunks could become established, affecting current strategies of wildlife rabies control programs. Rabies surveillance data from 1981 through 2000 obtained from the health departments of 11 eastern states were used to analyze temporal and spatial characteristics of rabies epizootics in each species. Spatial analysis indicated that epizootics in raccoons and skunks moved in a similar direction from 1990 to 2000. Temporal regression analysis showed that the number of rabid raccoons predicted the number of rabid skunks through time, with a 1-month lag. In areas where the raccoon rabies virus variant is enzootic, spatio-temporal analysis does not provide evidence that this rabies virus variant is currently cycling independently among skunks
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