Beyond the High Ground: A Taxonomy for Earth-Moon System Operations

Situational and space domain awareness in the space domain can no longer be confined to that which is found in geosynchronous orbit. International activities—commercial and military—and threats to the planet itself exist and are increasing across the entire Earth-Moon system. This reality requires a new taxonomy to accurately classify space domain awareness missions and better apply resources to and development of the same. This work presents such a taxonomy for the classification of space domain awareness regions

Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.

To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is often delayed, and performed systematic reviews in 24 such subtopics. If sufficient evidence was available, we performed meta-analyses; if not, we qualitatively summarized the evidence and based our recommendations on expert opinion. We used the GRADE approach for guideline development. The final recommendations were compiled via Delphi rounds. We formulated 17 recommendations favouring initiation of EEN and seven recommendations favouring delaying EN. We performed five meta-analyses: in unselected critically ill patients, and specifically in traumatic brain injury, severe acute pancreatitis, gastrointestinal (GI) surgery and abdominal trauma. EEN reduced infectious complications in unselected critically ill patients, in patients with severe acute pancreatitis, and after GI surgery. We did not detect any evidence of superiority for early PN or delayed EN over EEN. All recommendations are weak because of the low quality of evidence, with several based only on expert opinion. We suggest using EEN in the majority of critically ill under certain precautions. In the absence of evidence, we suggest delaying EN in critically ill patients with uncontrolled shock, uncontrolled hypoxaemia and acidosis, uncontrolled upper GI bleeding, gastric aspirate >500 ml/6 h, bowel ischaemia, bowel obstruction, abdominal compartment syndrome, and high-output fistula without distal feeding access

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Space Domain Awareness Assessment of Cislunar Periodic Orbits for Lagrange Point Surveillance

Cislunar periodic orbits provide an elegant means to fill the observational capability gaps which are present in ground-based and/or near-Earth spaced-base sensors. This research involves theoretical analysis on the effectiveness of cislunar periodic orbits for Space Domain Awareness (SDA) mission architectures. Specifically, cislunar periodic orbits are analyzed, both individually and in constellations with one another, for their effectiveness at monitoring target satellites in Lyapunov and halo orbits about the Earth - Moon L1 and L2 Lagrange points. All orbits are created and modeled in the Circular Restricted Three-Body Problem (CR3BP), then subject to perturbations in both the Elliptical Restricted Three-Body Problem (ER3BP) and the Bicircular Restricted Four-Body Problem (BCR4BP) to demonstrate how added perturbations affect trajectory and ultimately how stabilizing controllers will be needed to maintain periodicity in these orbits. A new taxonomy for the classification of SDA regions is also presented which will enable a spatial division of the national SDA mission portfolio. Finally, selected cislunar periodic orbits are subject to a catastrophic spacecraft explosion to understand the debris-related consequences of mishaps within this orbital regime

Holding the High Ground: Operational Considerations for the Earth-Moon System

Space operations such as space domain awareness and space control can no longer be confined to that which is found in geosynchronous orbit. International activities—commercial and military—and threats to the planet itself exist or are increasing across the entire Earth-Moon system. This reality requires a new Earth-Moon system (EM-Sys) taxonomy to accurately classify missions such as space domain awareness and better apply resources to and development of the same. This work presents such a taxonomy for the classification of space extending from near- Earth orbit to beyond the Earth sphere of influence. The article discusses space law considerations of Earth- Moon system operations with respect to the patentability and property rights of orbits and trajectories that may provide economic and/or space control advantages