The emergence of Inka dominion: Historical and chronometric assessments

Este data set fue realizado en base a una exhaustiva compilación de fechados radiocarbónicos realizados en contextos arqueológicos a lo largo del imperio Inca. La primera versión de la misma data de 1998 y fue utilizada como dato primario para una publicación científica donde se ponía en cuestión la cronología tradicional del Imperio Inca basada en fuentes escritas. Por causas ajenas a los investigadores, este manuscrito nunca fue publicado, pero sí ampliamente circulado dentro de la comunidad científica internacional. Posteriormente, en el año 2007 se realizó una revisión de bibliografía, se actualizó la base de datos y se escribió un nuevo manuscrito inédito que fue presentado por sus autores en una mesa redonda sobre cronología Inca organizada por Dumbarton Oaks Precolumbian Studies, pero nunca publicado. En esa misma mesa redonda, y utilizándolos mismos datos primarios, Verónica Williams presentó “Southern Empire Chronology: Some Questions about Inca Archaeology“. En este dataset se incluye la versión actualizada de la planilla de fechados radiocarbónicos (con fecha 2007) y los manuscritos inéditos de 1998 y 2007.Fil: D'Altroy, Terence N.. Columbia University; Estados UnidosFil: Williams, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de las Culturas. Universidad de Buenos Aires. Instituto de las Culturas; ArgentinaFil: Bauer, Brian S.. University of Illinois; Estados Unido

Out of the Recent Darkness and into the New Light: Managerial Implications Emerging from the Martin-Zimmerman Encounter

This paper revisits the encounter between George Zimmerman and Trayvon Martin from two perspectives: the co-production of public safety and public order and black crimmythology. Co-production is associated with the expanding and often unpredictable role that community residents, formal and informal communal organizations and nongovernmental institutions play in assisting public agencies in developing and implementing public services (Whitaker 1980; Parks et al. 1981). Black crimmythology is a term used to describe the historical and contemporary conflation of blackness, maleness, and criminality in the mind of the American public (Close 1997). The objectives of this analysis goes beyond ascertaining the guilt, innocence, or proper role of Mr. Zimmerman, but seek to illumine the various historical and contemporary challenges that impact the co-production of police services which this encounter has dramatically underscored and highlight the managerial implications that have emerged

Short-Term Forest Management Effects on a Long-Lived Ectotherm

Timber harvesting has been shown to have both positive and negative effects on forest dwelling species. We examined the immediate effects of timber harvests (clearcuts and group selection openings) on ectotherm behavior, using the eastern box turtle as a model. We monitored the movement and thermal ecology of 50 adult box turtles using radiotelemetry from May–October for two years prior to, and two years following scheduled timber harvests in the Central Hardwoods Region of the U.S. Annual home ranges (7.45 ha, 100% MCP) did not differ in any year or in response to timber harvests, but were 33% larger than previous estimates (range 0.47–187.67 ha). Distance of daily movements decreased post-harvest (from 22 m±1.2 m to 15 m±0.9 m) whereas thermal optima increased (from 23±1°C to 25±1°C). Microclimatic conditions varied by habitat type, but monthly average temperatures were warmer in harvested areas by as much as 13°C. Animals that used harvest openings were exposed to extreme monthly average temperatures (~40°C). As a result, the animals made shorter and more frequent movements in and out of the harvest areas while maintaining 9% higher body temperatures. This experimental design coupled with radiotelemetry and behavioral observation of a wild ectotherm population prior to and in response to anthropogenic habitat alteration is the first of its kind. Our results indicate that even in a relatively contiguous forested landscape with small-scale timber harvests, there are local effects on the thermal ecology of ectotherms. Ultimately, the results of this research can benefit the conservation and management of temperature-dependent species by informing effects of timber management across landscapes amid changing climates

Addressing Social Inequity: A Case Study of Success

Social equity is relatively easy to define but much harder to accomplish. As a result, achieving social equity continues to be difficult in American society and across the globe. We present a case study of a collaborative effort by two nonprofits to conduct a program for public high schools and local law-enforcement agencies across the United States. The program was designed to acknowledge and address the historic harms that impact police-community relations. Our paper delineates the origins of the problem and our approach, presents data that demonstrate the positive impact the program had on bridging gaps, changing perceptions, and lessening social bias and inequity, and concludes with lessons learned

Intracranial EEG fluctuates over months after implanting electrodes in human brain.

OBJECTIVE: Implanting subdural and penetrating electrodes in the brain causes acute trauma and inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior and its potential impact on clinical decision-making and algorithms for implanted devices have not been assessed in detail. In this study we aim to characterize the temporal and spatial variability of continuous, prolonged human iEEG recordings. APPROACH: Intracranial electroencephalography from 15 patients with drug-refractory epilepsy, each implanted with 16 subdural electrodes and continuously monitored for an average of 18 months, was included in this study. Time and spectral domain features were computed each day for each channel for the duration of each patient\u27s recording. Metrics to capture post-implantation feature changes and inflexion points were computed on group and individual levels. A linear mixed model was used to characterize transient group-level changes in feature values post-implantation and independent linear models were used to describe individual variability. MAIN RESULTS: A significant decline in features important to seizure detection and prediction algorithms (mean line length, energy, and half-wave), as well as mean power in the Berger and high gamma bands, was observed in many patients over 100 d following implantation. In addition, spatial variability across electrodes declines post-implantation following a similar timeframe. All selected features decreased by 14-50% in the initial 75 d of recording on the group level, and at least one feature demonstrated this pattern in 13 of the 15 patients. Our findings indicate that iEEG signal features demonstrate increased variability following implantation, most notably in the weeks immediately post-implant. SIGNIFICANCE: These findings suggest that conclusions drawn from iEEG, both clinically and for research, should account for spatiotemporal signal variability and that properly assessing the iEEG in patients, depending upon the application, may require extended monitoring

Development of Crop.LCA, an adaptable screening life cycle assessment tool for agricultural systems: a Canadian scenario assessment

There is an increasing demand for sustainable agricultural production as part of the transition towards a globally sustainable economy. To quantify impacts of agricultural systems on the environment, life cycle assessment (LCA) is ideal because of its holistic approach. Many tools have been developed to conduct LCAs in agriculture, but they are not publicly available, not open-source, and have a limited scope. Here, a new adaptable open-source tool (Crop.LCA) for carrying out LCA of cropping systems is presented and tested in an evaluation study with a scenario assessment of 4 cropping systems using an agroecosystem model (DNDC) to predict soil GHG emissions. The functional units used are hectares (ha) of land and gigajoules (GJ) of harvested energy output, and 4 impact categories were evaluated: cumulative energy demand (CED), 100-year global warming potential (GWP), eutrophication and acidification potential. DNDC was used to simulate 28 years of cropping system dynamics, and the results were used as input in Crop.LCA. Data were aggregated for each 4-year rotation and statistically analyzed. Introduction of legumes into the cropping system reduced CED by 6%, GWP by 23%, and acidification by 19% per ha. These results highlight the ability of Crop.LCA to capture cropping system characteristics in LCA, and the tool constitutes a step forward in increasing the accuracy of LCA of cropping systems as required for bio-economy system assessments. Furthermore, the tool is open-source, highly transparent and has the necessary flexibility to assess agricultural systems

Development of Crop.LCA, an adaptable screening life cycle assessment tool for agricultural systems: a Canadian scenario assessment

There is an increasing demand for sustainable agricultural production as part of the transition towards a globally sustainable economy. To quantify impacts of agricultural systems on the environment, life cycle assessment (LCA) is ideal because of its holistic approach. Many tools have been developed to conduct LCAs in agriculture, but they are not publicly available, not open-source, and have a limited scope. Here, a new adaptable open-source tool (Crop.LCA) for carrying out LCA of cropping systems is presented and tested in an evaluation study with a scenario assessment of 4 cropping systems using an agroecosystem model (DNDC) to predict soil GHG emissions. The functional units used are hectares (ha) of land and gigajoules (GJ) of harvested energy output, and 4 impact categories were evaluated: cumulative energy demand (CED), 100-year global warming potential (GWP), eutrophication and acidification potential. DNDC was used to simulate 28 years of cropping system dynamics, and the results were used as input in Crop.LCA. Data were aggregated for each 4-year rotation and statistically analyzed. Introduction of legumes into the cropping system reduced CED by 6%, GWP by 23%, and acidification by 19% per ha. These results highlight the ability of Crop.LCA to capture cropping system characteristics in LCA, and the tool constitutes a step forward in increasing the accuracy of LCA of cropping systems as required for bio-economy system assessments. Furthermore, the tool is open-source, highly transparent and has the necessary flexibility to assess agricultural systems

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.

ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC). This randomised phase I study evaluated the safety and pharmacology of etrolizumab in patients with moderate to severe UC.DesignIn the single ascending dose (SAD) stage, etrolizumab (0.3, 1.0, 3.0, 10 mg/kg intravenous, 3.0 mg/kg subcutaneous (SC) or placebo) was administered 4:1 (n=25) in each cohort. In the multiple dose (MD) stage, new patients received monthly etrolizumab (0.5 mg/kg SC (n=4), 1.5 mg/kg SC (n=5), 3.0 mg/kg SC (n=4), 4.0 mg/kg intravenous (n=5)) or placebo (n=5). The pharmacokinetics was studied and Mayo Clinic Score evaluated at baseline, day 29 (SAD), and days 43 and 71 (MD).ResultsIn the SAD stage, there were no dose limiting toxicities, infusion or injection site reactions. Two impaired wound healing serious adverse events occurred in two patients receiving etrolizumab. In the MD stage, there were no dose limiting toxicities, and no infusion or injection site reactions. Headache was the most common adverse event, occurring more often in etrolizumab patients. Antietrolizumab antibodies were detected in two subjects. The duration of β7 receptor full occupancy was dose related. A clinical response was observed in 12/18 patients, and clinical remission in 3/18 patients treated with etrolizumab in the MD stage, compared with 4/5 and 1/5 placebo patients, respectively.ConclusionEtrolizumab is well tolerated in moderate to severe UC. Further investigation is warranted

Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer

Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple quadrupole mass spectrometry and tandem mass spectrometry and the analysis of the noncovalent hexameric holotoxin usingelectrospray ionization time-of-flight mass spectrometry over a range of pH values that correlate with those encountered by this toxin after cellular uptake. We show that noncovalent interactions within the toxin assemblies were maintained under both acidic and neutral conditions in the gas phase. However, unlike the related Escherichia coli Shiga-like toxin B5 pentamer (SLTx B), the CTx B5 pentamer was stable at low pH, indicating that additional interactions must be present within the latter. Structural comparison of the CTx B monomer interface reveals an additional α-helix that is absent in the SLTx B monomer. In silico energy calculations support interactions between this helix and the adjacent monomer. These data provide insight into the apparent stabilization of CTx B relative to SLTx B

Experimental study of Taylor's hypothesis in a turbulent soap film

An experimental study of Taylor's hypothesis in a quasi-two-dimensional turbulent soap film is presented. A two probe laser Doppler velocimeter enables a non-intrusive simultaneous measurement of the velocity at spatially separated points. The breakdown of Taylor's hypothesis is quantified using the cross correlation between two points displaced in both space and time; correlation is better than 90% for scales less than the integral scale. A quantitative study of the decorrelation beyond the integral scale is presented, including an analysis of the failure of Taylor's hypothesis using techniques from predictability studies of turbulent flows. Our results are compared with similar studies of 3D turbulence.Comment: 27 pages, + 19 figure