Bleaching in foraminifera with algal symbionts: implications for reef monitoring and risk asessment

Reef-dwelling larger foraminifers share key characteristics with reefbuilding corals: they are prolific producers of calcium carbonate, they are physiologically dependent upon algal endosymbionts, and representatives of both groups have suffered bleaching episodes in recent decades. Since 1991, bleaching has been observed in populations of Amphistegina in all subtropical oceans, with peak bleaching in 1992 and secondary peaks in 1998 and 2005. Amphistegina populations exhibiting chronic, intermediate-intensity bleaching characteristically show anomalously high incidences of shell breakage, shell deformities, evidence of predation, and microbial infestation. Asexual reproduction is profoundly affected; broods from partly bleached parents typically have fewer individuals, many of which are anomalous in shape and size. Key differences between bleaching in corals and Amphistegina are that corals typically bleach by expelling their symbionts, while Amphistegina bleach when damaged symbionts are digested, and that mass coral bleaching requires high light but correlates most consistently with elevated temperatures, while bleaching in Amphistegina is induced by light. Amphistegina are particularly sensitive to the shorter (300-490 nm) wavelengths of solar radiation, which have increased in intensity relative to longer visible wavelengths (>;490-700 nm) in clear reef waters over the past 30 years as a consequence of stratospheric ozone depletion. Abundances and visual assessments of Amphistegina populations can be used as a low-cost risk-assessment tool. These protists are sensitive to environmental conditions over days to weeks, and provide a method to quickly distinguish between water quality (local) and photo-oxidative (global) stresses. Risk assessments based on the combined use of in situ measurements and low-cost indicators can provide resource managers with essential information to decide when more costly chemical or molecular procedures are needed to determine local sources of stress

A community-based oral health self-care intervention for Hispanic families

Objectives A community-based intervention is described that targets oral health self-care practices among Hispanic children in the United States and is being tested in an ongoing trial. Descriptive results of baseline oral health variables are presented. Methods As of January 2013, 284 Hispanic children of ages 5–7 enrolled in the Healthy Families Study in Nashville, TN, USA. Families are randomized to one of two culturally appropriate interventions. Results At baseline, 69.6 % of children brushed at least twice daily, and 40.6 % brushed before bed daily. One-third of parents did not know if their children’s toothpaste contained fluoride. Conclusions This intervention fills the need for community-based interventions to improve oral health self-care practices that are culturally appropriate in Hispanic families

Galaxy Zoo: Exploring the Motivations of Citizen Science Volunteers

The Galaxy Zoo citizen science website invites anyone with an Internet connection to participate in research by classifying galaxies from the Sloan Digital Sky Survey. As of April 2009, more than 200,000 volunteers had made more than 100 million galaxy classifications. In this paper, we present results of a pilot study into the motivations and demographics of Galaxy Zoo volunteers, and define a technique to determine motivations from free responses that can be used in larger multiple-choice surveys with similar populations. Our categories form the basis for a future survey, with the goal of determining the prevalence of each motivation.Comment: 15 pages, 3 figure

The Carnegie Supernova Project: First Photometry Data Release of Low-Redshift Type Ia Supernovae

The Carnegie Supernova Project (CSP) is a five-year survey being carried out at the Las Campanas Observatory to obtain high-quality light curves of ~100 low-redshift Type Ia supernovae in a well-defined photometric system. Here we present the first release of photometric data that contains the optical light curves of 35 Type Ia supernovae, and near-infrared light curves for a subset of 25 events. The data comprise 5559 optical (ugriBV) and 1043 near-infrared (YJHKs) data points in the natural system of the Swope telescope. Twenty-eight supernovae have pre-maximum data, and for 15 of these, the observations begin at least 5 days before B maximum. This is one of the most accurate datasets of low-redshift Type Ia supernovae published to date. When completed, the CSP dataset will constitute a fundamental reference for precise determinations of cosmological parameters, and serve as a rich resource for comparison with models of Type Ia supernovae.Comment: 93 pages, 8 figures, accepted for publication in A

Well-being at a Military Medical School and Implications for Military Retention.

INTRODUCTION: Physical and psychological well-being play a critical role in the academic and professional development of medical students and can alter the trajectory of a student\u27s quality of personal and professional life. Military medical students, given their dual role as officer and student, experience unique stressors and issues that may play a role in their future intentions to continue military service, as well as practice medicine. As such, this study explores well-being across the 4 years of medical school at Uniformed Services University (USU) and how well-being relates to a student\u27s likelihood to continue serving in the military and practicing medicine. METHODS: In September 2019, 678 USU medical students were invited to complete a survey consisting of three sections-the Medical Student Well-being Index (MSWBI), a single-item burnout measure, and six questions regarding their likelihood of staying in the military and medical practice. Survey responses were analyzed using descriptive statistics, analysis of variance (ANOVA), and contingency table analysis. Additionally, thematic analysis was conducted on open-ended responses included as part of the likelihood questions. RESULTS: Our MSWBI and burnout scores suggest that the overall state of well-being among medical students at USU is comparable to other studies of the medical student population. ANOVA revealed class differences among the four cohorts, highlighted by improved well-being scores as students transitioned from clerkships to their fourth-year curriculum. Fewer clinical students (MS3s and MS4s), compared to pre-clerkship students, indicated a desire to stay in the military. In contrast, a higher percentage of clinical students seemed to reconsider their medical career choice compared to their pre-clerkship student counterparts. Medicine-oriented likelihood questions were associated with four unique MSWBI items, whereas military-oriented likelihood questions were associated with one unique MSWBI item. CONCLUSION: The present study found that the overall state of well-being in USU medical students is satisfactory, but opportunities for improvement exist. Medical student well-being seemed to have a stronger association with medicine-oriented likelihood items than with military-oriented likelihood items. To obtain and refine best practices for strengthening engagement and commitment, future research should examine if and how military and medical contexts converge and diverge throughout training. This may enhance the medical school and training experience and, ultimately, reinforce, or strengthen, the desire and commitment to practice and serve in military medicine

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are lacking. MicroRNAs are short, non-coding strands of RNA that are released into the circulation following tissue injury. In this study, we have characterised the release of both global microRNA and specific microRNA species into the plasma using a porcine model of acetaminophen-induced acute liver failure. Pigs were induced to acute liver failure with oral acetaminophen over 19h±2h and death occurred 13h±3h thereafter. Global microRNA concentrations increased 4h prior to acute liver failure in plasma (P<0.0001) but not in isolated exosomes, and were associated with increasing plasma levels of the damage-associated molecular pattern molecule, genomic DNA (P<0.0001). MiR122 increased around the time of onset of acute liver failure (P<0.0001) and was associated with increasing international normalised ratio (P<0.0001). MiR192 increased 8h after acute liver failure (P<0.0001) and was associated with increasing creatinine (P<0.0001). The increase in miR124-1 occurred concurrent with the pre-terminal increase in intracranial pressure (P<0.0001) and was associated with decreasing cerebral perfusion pressure (P<0.002)

Review of factors resulting in systemic biases in the screening, assessment, and treatment of individuals at clinical high-risk for psychosis in the United States

BACKGROUND: Since its inception, research in the clinical high-risk (CHR) phase of psychosis has included identifying and exploring the impact of relevant socio-demographic factors. Employing a narrative review approach and highlighting work from the United States, sociocultural and contextual factors potentially affecting the screening, assessment, and service utilization of youth at CHR were reviewed from the current literature. RESULTS: Existing literature suggests that contextual factors impact the predictive performance of widely used psychosis-risk screening tools and may introduce systemic bias and challenges to differential diagnosis in clinical assessment. Factors reviewed include racialized identity, discrimination, neighborhood context, trauma, immigration status, gender identity, sexual orientation, and age. Furthermore, racialized identity and traumatic experiences appear related to symptom severity and service utilization among this population. CONCLUSIONS: Collectively, a growing body of research from the United States and beyond suggests that considering context in psychosis-risk assessment can provide a more accurate appraisal of the nature of risk for psychosis, render more accurate results improving the field\u27s prediction of conversion to psychosis, and enhance our understanding of psychosis-risk trajectories. More work is needed in the U.S. and across the globe to uncover how structural racism and systemic biases impact screening, assessment, treatment, and clinical and functional outcomes for those at CHR

No evidence for association between polymorphisms in GRM3 and schizophrenia

BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. RESULTS: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. CONCLUSION: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia