Novel Rubidium Poly-Nitrogen Materials at High Pressure

First-principles crystal structure search is performed to predict novel rubidium poly-nitrogen materials at high pressure by varying the stoichiometry, i. e. relative quantities of the constituent rubidium and nitrogen atoms. Three compounds of high nitrogen content, RbN_{5}, RbN_{2}, and Rb_{4}N_{6}, are discovered. Rubidium pentazolate (RbN5) becomes thermodynamically stable at pressures above \unit[30]{GPa}. The charge transfer from Rb to N atoms enables aromaticity in cyclo-N_{^{_{5}}}^{-} while increasing the ionic bonding in the crystal. Rubidium pentazolate can be synthesized by compressing rubidium azide (RbN3) and nitrogen (N2) precursors above \unit[9.42]{GPa}, and its experimental discovery is aided by calculating the Raman spectrum and identifying the features attributed to N_{^{_{5}}}^{-} modes. The two other interesting compounds, RbN2 containing infinitely-long single-bonded nitrogen chains, and Rb_{4}N_{6} consisting of single-bonded N_{6} hexazine rings, become thermodynamically stable at pressures exceeding \unit[60]{GPa}. In addition to the compounds with high nitrogen content, Rb_{3}N_{3}, a new compound with 1:1 RbN stoichiometry containing bent N_{3} azides is found to exist at high pressures

Teaching Social Justice Through Gothic Young Adult Literature

In this article, authors argue that teaching young adult Gothic novels helps secondary students reflect on social justice issues, such as racism and sexism. We selected four young adult novels (The Dark Descent of Elizabeth Frankenstein by Kiersten White, Dark Companion by Marta Acosta, Open Mic Night at Westminster Abbey by Mary Amato, and Black Spring by Alison Croggon) and paired them with Gothic texts (Mary Shelley’s Frankenstein, Edgar Allan Poe’s tales, Emily Brontë’s Wuthering Heights, and Charlotte Brontë’s Jane Eyre) to draw readers’ attention to issues of privilege and oppression . We offer in-class activities that help connect the paired texts and encourage students to engage with the books’ themes and content. We note how pairing a Gothic classic and a YA novel together provide students the opportunity to identify social justice issues (e.g., gendered and socioeconomic class oppression) in Gothic themes such as the fragmented self, questions of identity, and isolation. In this article, we share our research and pedagogical strategies with readers who might be interested in using them in their own classroom – especially those who teach Gothic literature

Detecting a microbial response in sediment of the Dan River following a coal ash spill

Coal ash is the residual material of coal combustion for electricity generation. It contains heavy metals and other pollutants and is generally deposited into reservoir ponds for storage, although it may spill or leach into nearby water and possibly disrupt aquatic communities. In February of 2014, a coal ash spill occurred in the Dan River in Eden, NC. Coal ash contains constituents that may stimulate the growth of mercury methylating bacteria. This study aimed to determine if a microbial response is detectable 1.5 years following the spill using qPCR. We tested three primers targeting mercury methylation. We detected an elevated signal 0.5 km downstream from the spill site relative to some other upstream and downstream locations. However, the highest abundance of amplified targets was observed in the furthest upstream site. We also undertook a survey of bacteria present in a coal ash sample from the coal ash pond that was the source of the spill, located at the retired Dan River Steam Station in Eden, NC. SSU rDNA extracted from 31 isolated organisms was sequenced and the organisms identified to genus level. The community was predominantly composed of Bacillus and Arthrobacter spp. 14 Isolates were grown in 50% nutrient broth amended with heavy metals commonly found in coal ash waste (As, Cd, Cr, Hg, Pb, Se, Zn) at environmentally relevant concentrations to characterize their metal tolerance. Overall, 1) we could not confirm a spike in our mercury markers, and 2) coal ash isolates exhibited metal tolerance

Examining the association between perceived discrimination and heart rate variability in African Americans.

Previous research attempting to delineate the role of discrimination in racial/ethnic disparities in hypertension has focused largely on blood pressure, which is chiefly governed by the sympathetic branch of the autonomic nervous system. Consequently, few studies have considered the role of the parasympathetic branch and particularly its regulation of the heart via the vagus nerve

Fulfilling Community Health Assessment Requirements: Lessons Learned From Facilitating State-Wide Community Health Forums

Background: A prerequisite for National Public Health Accreditation is completion of a Community Health Assessment (CHA) that presents an exhaustive profile of the population served by a particular public health agency. Methods: The Georgia Department of Public Health (GA DPH) contracted with the Center for Public Health Practice and Research at Georgia Southern University to facilitate five state-wide community health forums. Results: Evaluation of the forums yielded qualitative data illustrating current challenges faced by Georgians, as well as assets that could be leveraged to improve health status. Conclusion: Lessons learned from these state-wide community health forums can be applied to improve the overall process of gathering data for a comprehensive CHA throughout Georgia or other areas interested in pursuing public health agency accreditation

Fulfilling Community Health Assessment Requirements: Lessons Learned From Facilitating State-wide Community Health Forums

Background: A prerequisite for National Public Health Accreditation is completion of a Community Health Assessment (CHA) that presents an exhaustive profile of the population served by a particular public health agency. Methods: The Georgia Department of Public Health (GA DPH) contracted with the Center for Public Health Practice and Research at Georgia Southern University to facilitate five state-wide community health forums. Results: Evaluation of the forums yielded qualitative data illustrating current challenges faced by Georgians, as well as assets that could be leveraged to improve health status. Conclusion: Lessons learned from these state-wide community health forums can be applied to improve the overall process of gathering data for a comprehensive CHA throughout Georgia or other areas interested in pursuing public health agency accreditation

Rewilding the Sea? A Rapid, Low Cost Model for Valuing the Ecosystem Service Benefits of Kelp Forest Recovery Based on Existing Valuations and Benefit Transfers

Kelp forests and seagrasses are important carbon sinks that are declining globally. Rewilding the sea, through restoring these crucial habitats, their related biodiversity and ecosystem contributions, is a movement and concept, gathering pace in the United Kingdom and globally. Yet understanding of the economic costs and benefits for setting areas of the sea aside—and removing some human impacts from them—is not well understood. The potential benefits and distributional impacts on marine users and wider society is critical to make evidence based decisions. Ensuring that areas of the sea recover, and that the impacts (both positive and negative) are understood, requires targeted research to help guide decisions to optimize the opportunity of recovery, while minimizing any negative impacts on sea users and coastal communities. We approach the problem from an ecosystem services perspective, looking at the opportunity of restoring a kelp bed in Sussex by removing fishing activity from areas historically covered in kelp. Development of an ecosystem services valuation model showed restoring kelp to its highest mapped past extent (96% greater, recorded in 1987) would deliver a range of benefits valued at over £ 3.5 million GBP. The application of an ecosystem services approach enabled the full range of benefits from habitat restoration to be assessed. The results and the gaps identified in site specific data and values for this area, have broader implications in fisheries management and natural resource management tools for restoring marine habitats and ecosystems in the United Kingdom.</jats:p

Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial

There is evidence to support the use of supplementation with long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) from oily fish or fish oil for the treatment of various inflammatory diseases such as rheumatoid arthritis. Chronic obstructive pulmonary disease (COPD) is a progressive, terminal disease characterized by persistent airflow limitation, lung and systemic inflammation. To date, one randomized controlled trial has been published that assessed the efficacy of LCn-3PUFA in people with this condition. The aim of this article is to discuss the feasibility of conducting a trial to evaluate fish oil supplementation as adjunct therapy in people with COPD.The study is supported by a University of South Australia, Division of Health Sciences grant (DRDG 2011 (round 2))

Phenotypic and Molecular Analysis of the Effect of 20-hydroxyecdysone on the Human Filarial Parasite Brugia malayi

A homologue of the ecdysone receptor has been identified and shown to be responsive to 20- hydroxyecdysone in Brugia malayi. However, the role of this master regulator of insect development has not been delineated in filarial nematodes. Gravid adult female B. malayi cultured in the presence of 20-hydroxyecdysone produced significantly more microfilariae and abortive immature progeny than control worms, implicating the ecdysone receptor in regulation of embryogenesis and microfilarial development. Transcriptome analyses identified 30 genes whose expression was significantly up-regulated in 20-hydroxyecdysone-treated parasites compared with untreated controls. Of these, 18% were identified to be regulating transcription. A comparative proteomic analysis revealed 932 proteins to be present in greater amounts in extracts of 20- hydroxyecdysone-treated adult females than in extracts prepared from worms cultured in the absence of the hormone. Of the proteins exhibiting a greater than two-fold difference in the 20- hydroxyecdysone-treated versus untreated parasite extracts, 16% were involved in transcriptional regulation. RNA interference (RNAi) phenotype analysis of Caenorhabditis elegans orthologs revealed that phenotypes involved in developmental processes associated with embryogenesis were significantly over-represented in the transcripts and proteins that were up-regulated by exposure to 20-hydroxyecdysone. Taken together, the transcriptomic, proteomic and phenotypic data suggest that the filarial ecdysone receptor may play a role analogous to that in insects, where it serves as a regulator of egg development

Prophylactic Anticonvulsants in Intracerebral Hemorrhage

Background and Purpose Prophylactic anticonvulsants are routinely prescribed in the acute setting for intracerebral hemorrhage (ICH) patients, but some studies have reported an association with worse outcomes. We sought to characterize the prevalence and predictors of prophylactic anticonvulsant administration after ICH as well as guideline adherence. We also sought to determine whether prophylactic anticonvulsants were independently associated with poor outcome. Methods We performed a retrospective study of primary ICH in our two academic centers. We used a propensity matching approach to make treated and non-treated groups comparable. We conducted multiple logistic regression analysis to identify independent predictors of prophylactic anticonvulsant initiation and its association with poor outcome as measured by modified Rankin score. Results We identified 610 patients with primary ICH, of whom 98 were started on prophylactic anticonvulsants. Levetiracetam (97%) was most commonly prescribed. Age (OR 0.97, 95% CI 0.95–0.99, p < .001), lobar location (OR 2.94, 95% CI 1.76–4.91, p < .001), higher initial National Institutes of Health Stroke Scale (NIHSS) score (OR 2.31, 95% CI 1.40–3.79, p = .001), craniotomy (OR 3.06, 95% CI 1.51–6.20, p = .002), and prior ICH (OR 2.36, 95% CI 1.10–5.07, p = .028) were independently associated with prophylactic anticonvulsant initiation. Prophylactic anticonvulsant use was not associated with worse functional outcome [modified Rankin score (mRS) 4–6] at hospital discharge or with increased case-fatality. There was no difference in prescribing patterns after 2010 guideline publication. Discussion Levetiracetam was routinely prescribed following ICH and was not associated with worse outcomes. Future investigations should examine the effect of prophylactic levetiracetam on cost and neuropsychological outcomes as well as the role of continuous EEG in identifying subclinical seizures