Fluid pressure penetration for advanced FEA of metal-to-metal seals

This numerical study investigates the behaviour of the contact faces in the metal-to-metal seal of a typical pressure relief valve in the commercial FE-package ANSYS. The valve geometry is simplified to an axisymmetric problem, which comprises a simple representative geometry consisting of only three components. A cylindrical nozzle, which has a valve seat on top, contacts with a disk, which is preloaded by a compressed linear spring. Analysis considerations include the effects of the Fluid Pressure Penetration (FPP) across the valve seat which exists at two different scales. In-service observations show that there is certain limited fluid leakage through the valve seat at operational pressures about 90% of the set pressure, which is caused by the fluid penetrating into surface asperities at the microscale. At the macroscale, non-linear FE-analysis using the FPP technique available in ANSYS revealed that there is also a limited amount of fluid penetrating into gap, which is caused primarily by the global plastic deformation of the valve seat. Accurate prediction of the fluid pressure profile over the valve seat is addressed in this study by considering the FPP interaction on both scales. The shape of this pressure profile introduces an additional component of the spring force, which needs to be considered to provide a reliable sealing

Study of mechanical aspects of leak tightness in a pressure relief valve using advanced FE-analysis

This paper presents a numerical study involving the deformation of contact faces in the metal-to-metal seal in a typical pressure relief valve. The valve geometry is simplified to an axisymmetric problem, which comprises a simple geometry consisting of only 3 components. A cylindrical nozzle, which has a valve seat on top, contacts with a disk, which is preloaded by a compressed linear spring. All the components are made of AISI type 316N(L) steel defined using the multilinear kinematic hardening model based on monotonic and cyclic tests at 20°C. In-service observations show that there is a limited fluid leakage through the valve seat at operational pressures about 90% of the set pressure, which is caused by the fluid penetrating into surface asperities at the microscale. Nonlinear FEA in ANSYS using the fluid pressure penetration (FPP) technique revealed that there is a limited amount of fluid penetrating into gap, which is caused by the plastic deformation of the valve seat at the macroscale. Prediction of the fluid pressure distribution over the valve seat just before the valve lift is addressed in this study considering the FPP interaction on multiscale. This is the principal scope, since it allows adjustment of the valve spring force in order to improve the leak tightness

The effect of fuel sprays on emissions from a gas turbine combustor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76889/1/AIAA-1979-1321.pd

Reference intervals for serum 24,25-Dihydroxyvitamin D and the ratio with 25-Hydroxyvitamin established using a newly developed LC-MS/MS method

24,25(OH)2D is the product of 25(OH)D catabolism by CYP24A1.The measurement of serum 24,25(OH)2D concentration may serve as an indicator of vitamin D catabolic status and the relative ratio with 25(OH)D can be used to identify patients with inactivating mutations in CYP24A1. We describe a LC-MS/MS method to determine: 1) the relationships between serum 24,25(OH)2D and 25(OH)D; 2) serum reference intervals in healthy individuals; 3) the diagnostic accuracy of 24,25(OH)2D measurement as an indicator for vitamin D status; 4) 24,25(OH)2D cut-off value for clinically significant change between inadequate and sufficient 25(OH)D status. Serum samples of healthy participants (n=1996) from Army recruits and patients (n=294) were analysed. The LC-MS/MS assay satisfied industry standards for method validation. We found a positive, concentration-dependent relationship between serum 24,25(OH)2D and 25(OH)2D concentrations. The 25(OH)D:24,25(OH)2D ratio was significantly higher (p4.2 nmol/L was identified as a diagnostic cut-off for 25(OH)D replete status. One patient sample with an elevated 25(OH)D:24,25(OH)2D ratio of 32 and hypercalcaemia who on genetic testing confirmed to have a biallelic mutation of CYP24A1. Our study demonstrated the feasibility of a combined 24,25(OH)2D and 25(OH)D assessment profile. Our established cut-off value for 24,25(OH)2D and ratio reference ranges can be useful to clinicians in the investigation of patients with an impaired calcium/phosphate metabolism and may point towards the existence of CYP24A1 gene abnormalities

Towards a fully unstructured ocean model for ice shelf cavity environments: Model development and verification using the Firedrake finite element framework

Numerical studies of ice flow have consistently identified the grounding zone of outlet glaciers and ice streams (the region where ice starts to float) as crucial for predicting the rate of grounded ice loss to the ocean. Owing to the extreme environments and difficulty of access to ocean cavities beneath ice shelves, field observations are rare. Estimates of melt rates derived from satellites are also difficult to make near grounding zones with confidence. Therefore, numerical ocean models are important tools to investigate these critical and remote regions. The relative inflexibility of structured grid models means, however, that they can struggle to resolve these processes in irregular cavity geometries near grounding zones. To help solve this issue, we present a new nonhydrostatic unstructured mesh model for flow under ice shelves built using the Firedrake finite element framework. We demonstrate our ability to simulate full ice shelf cavity domains using the community standard ISOMIP+ Ocean0 test case and compare our results against those obtained with the popular MITgcm model. Good agreement is found between the two models, despite their use of different discretisation schemes and the sensitivity of the melt rate parameterisation to grid resolution. Verification tests based on the Method of Manufactured Solutions (MMS) show that the new model discretisation is sound and second-order accurate. A main driver behind using Firedrake is the availability of an automatically generated adjoint model. Our first adjoint calculations, of sensitivities of melt rate with respect to different inputs in an idealised grounding zone domain, are promising and point to the ability to address a number of important questions on ocean influence on ice shelf vulnerability in the future

Intelligence within BAOR and NATO's Northern Army Group

During the Cold War the UK's principal military role was its commitment to the North Atlantic Treaty Organisation (NATO) through the British Army of the Rhine (BAOR), together with wartime command of NATO's Northern Army Group. The possibility of a surprise attack by the numerically superior Warsaw Pact forces ensured that great importance was attached to intelligence, warning and rapid mobilisation. As yet we know very little about the intelligence dimension of BAOR and its interface with NATO allies. This article attempts to address these neglected issues, ending with the impact of the 1973 Yom Kippur War upon NATO thinking about warning and surprise in the mid-1970s. It concludes that the arrangements made by Whitehall for support to BAOR from national assets during crisis or transition to war were - at best - improbable. Accordingly, over the years, BAOR developed its own unique assets in the realm of both intelligence collection and special operations in order to prepare for the possible outbreak of conflict

Surfactant protein D modulates HIV infection of both T-cells and dendritic cells

Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract. SP-D binds to the enveloped viruses, influenza A virus and respiratory syncytial virus and inhibits their replication in vitro and in vivo. SP-D has been shown to bind to HIV via the HIV envelope protein gp120 and inhibit infectivity in vitro. Here we show that SP-D binds to different strains of HIV (BaL and IIIB) and the binding occurs at both pH 7.4 and 5.0 resembling physiological relevant pH values found in the body and the female urogenital tract, respectively. The binding of SP-D to HIV particles and gp120 was inhibited by the presence of several hexoses with mannose found to be the strongest inhibitor. Competition studies showed that soluble CD4 and CVN did not interfere with the interaction between SP-D and gp120. However, soluble recombinant DC-SIGN was shown to inhibit the binding between SP-D and gp120. SP-D agglutinated HIV and gp120 in a calcium dependent manner. SP-D inhibited the infectivity of HIV strains at both pH values of 7.4 and 5.0 in a concentration dependent manner. The inhibition of the infectivity was abolished by the presence of mannose. SP-D enhanced the binding of HIV to immature monocyte derived dendritic cells (iMDDCs) and was also found to enhance HIV capture and transfer to the T-cell like line PM1. These results suggest that SP-D can bind to and inhibit direct infection of T-cells by HIV but also enhance the transfer of infectious HIV particles from DCs to T-cells in vivo

Understanding English alcohol policy as a neoliberal condemnation of the carnivalesque

Much academic work has argued that alcohol policy in England over the past 25 years can be characterised as neoliberal, particularly in regard to the night-time economy and attempts to address “binge” drinking. Understanding neoliberalism as a particular “mentality of government” that circumscribes the range of policy options considered appropriate and practical for a government to take, this article notes how the particular application of policy can vary by local context. This article argues that the approach of successive governments in relation to alcohol should be seen as based on a fear and condemnation of the carnivalesque, understood as a time when everyday norms and conventions are set aside, and the world is – for a limited period only – turned inside out. This analysis is contrasted with previous interpretations that have characterised government as condemning intoxication and particular forms of pleasure taken in drinking. Although these concepts are useful in such analysis, this article suggests that government concerns are broader and relate to wider cultures surrounding drunkenness. Moreover, there is an ambivalence to policy in relation to alcohol that is better conveyed by the concept of the carnivalesque than imagining simply a condemnation of pleasure or intoxication

Influenza Outbreaks during World Youth Day 2008 Mass Gathering

Novel viruses were introduced and seasonal viruses were amplified