976 research outputs found
The effects of rapid increases in desflurane and sevoflurane concentrations on spirometry in humans during balanced anesthesia with remifentanil
The effect of rapid increase in desflurane and sevoflurane concentrations on spirometry in humans during balanced anesthesia with remifentanil
Le système karstique de la Lomme. Quelques points d'observation remarquable
Présentation de quelques sites karstiques remarquables situés sur la commune de Rochefor
How HTLV-1 may subvert miRNAs for persistence and transformation
Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response
Le virus de la leucémie bovine et l’homéostasie du compartiment lymphocytaire périphérique
Bovine leukaemia virus and peripheral blood lymphocytes homeostasis. Bovine leukaemia virus (BLV) is the etiological agent of a lymphoproliferative disease in cattle. This retrovirus can also be transmitted experimentally to the ovine species, in which pathology is more rapid and more frequent. In this model, infection leads to an increased cell turnover. This accelerated lymphocyte dynamics might be related to viral expression which induces cellular proliferation and host cell destruction by the immune system
Prognostic Factors Associated with Ocriplasmin Efficacy for the Treatment of Symptomatic Vitreomacular Adhesion and Full-thickness Macular Hole: Analysis from Four Studies
Purpose: To assess the effect of patient baseline characteristics on the efficacy of ocriplasmin treatment for symptomatic vitreomacular adhesion (VMA) with full-thickness macular hole (FTMH) from phase 3/4 studies.
Methods: Patients with symptomatic VMA and FTMH at baseline and receiving ocriplasmin treatment 12
Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads
BACKGROUND: Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced. Here, we investigated the involvement of reactive oxygen species (ROS) in this process. RESULTS: We demonstrate that (i) the levels of ROS and a major product of oxidative stress (8-OHdG) are reduced, while the thioredoxin antioxidant protein is highly expressed in BLV-infected B lymphocytes, (ii) induction of ROS by valproate (VPA) is pro-apoptotic, (iii) inversely, the scavenging of ROS with N-acetylcysteine inhibits apoptosis, and finally (iv) the levels of ROS inversely correlate with the proviral loads. CONCLUSION: Together, these observations underline the importance of ROS in the mechanisms of inhibition of apoptosis linked to BLV infection
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