230 research outputs found

    Associative Cortex Features in the First Olfactory Brain Relay Station

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    SummarySynchronized firing of mitral cells (MCs) in the olfactory bulb (OB) has been hypothesized to help bind information together in olfactory cortex (OC). In this survey of synchronized firing by suspected MCs in awake, behaving vertebrates, we find the surprising result that synchronized firing conveys information on odor value (“Is it rewarded?”) rather than odor identity (“What is the odor?”). We observed that as mice learned to discriminate between odors, synchronous firing responses to the rewarded and unrewarded odors became divergent. Furthermore, adrenergic blockage decreases the magnitude of odor divergence of synchronous trains, suggesting that MCs contribute to decision-making through adrenergic-modulated synchronized firing. Thus, in the olfactory system information on stimulus reward is found in MCs one synapse away from the sensory neuron

    Advanced Spectroscopic and Thermal Imaging Instrumentation for Shock Tube and Ballistic Range Facilities

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    The Electric Arc Shock Tube (EAST) facility and Hypervelocity Free Flight Aerodynamic Facility (HFFAF, an aeroballistic range) at NASA Ames support basic research in aerothermodynamic phenomena of atmospheric entry, specifically shock layer radiation spectroscopy, convective and radiative heat transfer, and transition to turbulence. Innovative optical instrumentation has been developed and implemented to meet the challenges posed from obtaining such data in these impulse facilities. Spatially and spectrally resolved measurements of absolute radiance of a travelling shock wave in EAST are acquired using multiplexed, time-gated imaging spectrographs. Nearly complete spectral coverage from the vacuum ultraviolet to the near infrared is possible in a single experiment. Time-gated thermal imaging of ballistic range models in flight enables quantitative, global measurements of surface temperature. These images can be interpreted to determine convective heat transfer rates and reveal transition to turbulence due to isolated and distributed surface roughness at hypersonic velocities. The focus of this paper is a detailed description of the optical instrumentation currently in use in the EAST and HFFAF

    Shock Tube and Ballistic Range Facilities at NASA Ames Research Center

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    The Electric Arc Shock Tube (EAST) facility and the Hypervelocity Free Flight Aerodynamic Facility (HFFAF) at NASA Ames Research Center are described. These facilities have been in operation since the 1960s and have supported many NASA missions and technology development initiatives. The facilities have world-unique capabilities that enable experimental studies of real-gas aerothermal, gas dynamic, and kinetic phenomena of atmospheric entry

    Race and the Legacy of the First World War in French Anti-Colonial Politics of the 1920s

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    There has been relatively little historical research on the small number of African veterans who stayed on in France after the First World War and became militants in the radical anti-colonial movements created in the 1920s. From his entry onto the political stage in late 1924 until his early death three years later, the most celebrated and feared of these anti-colonial militants was Lamine Senghor, a decorated war veteran from Senegal. This chapter will chart Senghor’s brief career as an activist, focusing primarily on the ways in which he projected his identity as a veteran in his speeches and writings, as well as exploring, more generally, how France’s “blood debt” to its colonial subjects became a key theme of anti-colonial discourse in the interwar period

    Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis

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    Only a minority of heavy drinking individuals develop alcoholic hepatitis (AH), for unclear reasons. We analyzed data from the Translational Research and Evolving Alcoholic Hepatitis Treatment cohort: subjects who drink heavily with normal results from liver tests (controls) and patients with AH. We examined risk factors for the development of AH including body mass index (BMI), drinking pattern and quantity, and sex

    Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients

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    To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function measures in a diverse, population-based cancer sample
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