2,273 research outputs found

    Here comes the sun: the promise of solar energy

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    George Harrison, the youngest Beatle, wrote the classic “Here Comes the Sun” in 1969 after spending a glorious day walking around his friend Eric Clapton’s garden. Today, Harrison’s refrain, “And I say, ‘It’s All right’,” accords well with a solar power industry that has grown more than 30 percent in the past six years and received tax-favorable legislative approval in 2006

    War-Affected Children and Youth in Northern Uganda: Toward a Brighter Future

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    Examines current efforts by international organizations and local communities to aid children and youth living in internally displaced camps. Identifies programs to improve health care, education, economic activities, and justice and amnesty mechanisms

    Information Systems for Managing Second Order Dynamics of Organizations

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    From the point of view of information technology the past decade can be designated the “decade of ERP”. A global movement of implementing integrated systems for optimising the fulfilment of orders has dominated both investments from large and medium corporations and the focus of research and educational institutions. The results of these implementations sometimes have been dramatic: Significant improvements of throughput time, and at the same time clear decreases in inventory. Organisations have become like machines. Interesting material - though not in all aspects consistent - on the improvement of productivity is collected in (Potthof, 1998). Unfortunately, and strangely enough, only little research has been done in the consequences of ERP systems on the flexibility and adaptability of organisations

    Orchestrating Efficacy of Synaptic Transmission:The role of Munc18

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    USING BALD EAGLES TO TRACK SPATIAL AND TEMPORAL TRENDS OF CONTAMINANTS IN MICHIGAN\u27S AQUATIC SYSTEMS

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    The bald eagle (Haliaeetus leucocephalus) is an extensively researched tertiary predator. Studies have delineated information about its life history and the influences of various stressors on reproduction. Due to the bald eagles position at the top of the food web, it is susceptible to biomagnification of a wide array of xenobiotics. In Michigan the bald eagle population has recovered strongly since the population bottle-neck of the 1960s. In the 1960s when Michigan\u27s eagle population was first being monitored less than 100 nests were occupied yearly (i.e., active breeding pairs existed). Today there are approximately 500 occupied nests each year and over 700 breeding areas in the state

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    An Evaluation of the Rollout of Aunt Bertha, a Community-Centered Directory, Across the MaineHealth Network

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    Remote interviews were conducted with community-based organizations across Maine to gain insight to their perspective of Aunt Bertha’s use and potential.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1002/thumbnail.jp

    On epigenetic regulation in atherosclerosis pathology

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    Atherosclerosis is one of the primary causes of cardiovascular disease; the number one cause of death in the western society. Atherosclerotic plaque formation is a dynamic multi-cellular process where regulation of different genes essentially determines the activity of the different cell types involved. Gene expression is regulated, amongst others, by epigenetic processes. Epigenetic mechanisms change the accessibility of the DNA sequence and is thought to form a link between environmental factors and gene expression. Epigenetics may therefor play an important role in atherosclerosis pathology. The research described in this thesis evaluated the role of epigenetic regulation on various aspects of atherosclerosis pathology. It was found that the epigenetic H3K27Me3-mark was reduced in later stages of the disease. Monocytes differentiating into dendritic cells and macrophages (an important process in atherosclerosis pathology) showed higher transcription of the epigenetic regulatory gene KMT1c. Specifically blocking this gene resulted in reduction of DC-SIGN (a dendritic cell specific molecule) expression. By specifically blocking other epigenetic proteins, CCR5 (a molecule important to monocyte migration) was re-expressed on cells which did not express CCR5. This shows that epigenetic regulation is an important process in atherosclerosis pathology and might prove to be novel pharmacological target for treatment of atherosclerosis.UBL - phd migration 201
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