Listening Across Experience: A Cultural Rhetorics Approach to Understanding Power Dynamics and Relationality within a University Writing Center

Our project looks to the lived experiences of consultants, the assistant director, and director of our own University Writing Center (UWC) to conduct an institutional ethnography of our internal power structures and their impact on the everyday practices within the UWC. The stories of individuals within our community will provide us with a clearer understanding of the dynamics of our writing center, which can be valuable for other writing center communities to consider. A few central questions that panelists will discuss include: 1) How can we make visible the productive nature of power?, 2)How do we work with and against institutional constraints to produce/create meaningful change?, and 3) How can the practice of studying the power within institutions/organizations that we are a part of, shift or add to our conceptualization of Writing Center work? In our project, we recognize that we come to the UWC with different orientations to the work, which impacts how we conceptualize and engage in the work of the UWC. In addition, we see our project as one that supports a re-imagining and re-making of administrative structures and practices within the UWC (or, at the very least, making them more visible and relatable). In this presentation, we will emphasize relationality and how it contributes to and disrupts the making of community and WC work

Multi-objective improvement of software using co-evolution and smart seeding

Optimising non-functional properties of software is an important part of the implementation process. One such property is execution time, and compilers target a reduction in execution time using a variety of optimisation techniques. Compiler optimisation is not always able to produce semantically equivalent alternatives that improve execution times, even if such alternatives are known to exist. Often, this is due to the local nature of such optimisations. In this paper we present a novel framework for optimising existing software using a hybrid of evolutionary optimisation techniques. Given as input the implementation of a program or function, we use Genetic Programming to evolve a new semantically equivalent version, optimised to reduce execution time subject to a given probability distribution of inputs. We employ a co-evolved population of test cases to encourage the preservation of the program’s semantics, and exploit the original program through seeding of the population in order to focus the search. We carry out experiments to identify the important factors in maximising efficiency gains. Although in this work we have optimised execution time, other non-functional criteria could be optimised in a similar manner

Can the appropriateness of eye care be measured through cross-sectional retrospective patient record review in eye care practices in Australia? the icaretrack feasibility study

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives The CareTrack study found that a wide range of appropriateness of care (ie, care in line with evidence-based or consensus-based guidelines) was delivered across many health conditions in Australia. This study therefore aimed to demonstrate the feasibility of using the CareTrack method (a retrospective onsite record review) to measure the appropriateness of eye care delivery. Design Cross-sectional feasibility study. Setting and participants Two hundred and thirteen patient records randomly selected from eight optometry and ophthalmology practices in Australia, selected through a combination of convenience and maximum variation sampling. Methods Retrospective record review designed to assess the alignment between eye care delivered and 93 clinical indicators (Delphi method involving 11 experts) extracted from evidence-based clinical practice guidelines. Primary outcome measure Number of eligible patient records, sampling rates and data collection time. This feasibility study also tested the ability of 93 clinical indicators to measure percentage appropriate eye care for preventative, glaucoma and diabetic eye care. A secondary outcome was the percentage of practitioner-patient encounters at which appropriate eye care was received. Results A median of 20 records (range 9 to 63) per practice were reviewed. Data collection time ranged from 3 to 5.5 hours (median 3.5). The most effective sampling strategy involved random letter generation followed by sequential sampling. The appropriateness of care was 69% (95% CI 67% to 70%) for preventative eye care, 60% (95% CI 56% to 58%) for glaucoma and 63% (95% CI 57% to 69%) for diabetic eye care. Conclusions Appropriateness of eye care can be measured effectively using retrospective record review of eye care practices and consensus-based care indicators

Analysis and Prediction of the Metabolic Stability of Proteins Based on Their Sequential Features, Subcellular Locations and Interaction Networks

The metabolic stability is a very important idiosyncracy of proteins that is related to their global flexibility, intramolecular fluctuations, various internal dynamic processes, as well as many marvelous biological functions. Determination of protein's metabolic stability would provide us with useful information for in-depth understanding of the dynamic action mechanisms of proteins. Although several experimental methods have been developed to measure protein's metabolic stability, they are time-consuming and more expensive. Reported in this paper is a computational method, which is featured by (1) integrating various properties of proteins, such as biochemical and physicochemical properties, subcellular locations, network properties and protein complex property, (2) using the mRMR (Maximum Relevance & Minimum Redundancy) principle and the IFS (Incremental Feature Selection) procedure to optimize the prediction engine, and (3) being able to identify proteins among the four types: “short”, “medium”, “long”, and “extra-long” half-life spans. It was revealed through our analysis that the following seven characters played major roles in determining the stability of proteins: (1) KEGG enrichment scores of the protein and its neighbors in network, (2) subcellular locations, (3) polarity, (4) amino acids composition, (5) hydrophobicity, (6) secondary structure propensity, and (7) the number of protein complexes the protein involved. It was observed that there was an intriguing correlation between the predicted metabolic stability of some proteins and the real half-life of the drugs designed to target them. These findings might provide useful insights for designing protein-stability-relevant drugs. The computational method can also be used as a large-scale tool for annotating the metabolic stability for the avalanche of protein sequences generated in the post-genomic age

How primary care can contribute to good mental health in adults.

The need for support for good mental health is enormous. General support for good mental health is needed for 100% of the population, and at all stages of life, from early childhood to end of life. Focused support is needed for the 17.6% of adults who have a mental disorder at any time, including those who also have a mental health problem amongst the 30% who report having a long-term condition of some kind. All sectors of society and all parts of the NHS need to play their part. Primary care cannot do this on its own. This paper describes how primary care practitioners can help stimulate such a grand alliance for health, by operating at four different levels - as individual practitioners, as organisations, as geographic clusters of organisations and as policy-makers

Retrofitting parallelism onto OCaml.

OCaml is an industrial-strength, multi-paradigm programming language, widely used in industry and academia. OCaml is also one of the few modern managed system programming languages to lack support for shared memory parallel programming. This paper describes the design, a full-fledged implementation and evaluation of a mostly-concurrent garbage collector (GC) for the multicore extension of the OCaml programming language. Given that we propose to add parallelism to a widely used programming language with millions of lines of existing code, we face the challenge of maintaining backwards compatibility--not just in terms of the language features but also the performance of single-threaded code running with the new GC. To this end, the paper presents a series of novel techniques and demonstrates that the new GC strikes a balance between performance and feature backwards compatibility for sequential programs and scales admirably on modern multicore processors

Phenotypic relationships between docility and reproduction in Angus heifers

Citation: White, K. L., Bormann, J. M., Olson, K. C., Jaeger, J. R., Johnson, S., Downey, B., . . . Weaber, R. L. (2016). Phenotypic relationships between docility and reproduction in Angus heifers. Journal of Animal Science, 94(2), 483-489. doi:10.2527/jas2015-9327The objective of this study was to elucidate the phenotypic relationships between docility and first-service AI conception rate in heifers. Data (n = 337) collected from 3 cooperator herds in Kansas at the start of synchronization protocol included exit velocity (EV), chute score (CS), fecal cortisol (FC), and blood serum cortisol (BC). Data were analyzed using logistic regression with 30-d pregnancy rate as the dependent variable. The model included the fixed effect of contemporary group and the covariates FC, BC, EV, CS, BW, and age. Correlation coefficients were calculated between all continuous traits. Pregnancy rate ranged from 34% to 60% between herds. Blood cortisol positively correlated with EV (r = 0.22, P < 0.01), negatively correlated with age (r = -0.12, P < 0.03), and tended to be negatively correlated with BW (r = -0.10, P = 0.09). Exit velocity was positively correlated with CS (r = 0.24, P < 0.01) and negatively correlated with BW (r = -0.15, P < 0.01) and age (r = -0.12, P < 0.03). Chute score negatively correlated with age (r = -0.14, P < 0.01), and age and BW were moderately positively correlated (r = 0.42, P < 0.01), as expected. Older, heavier animals generally had better temperament, as indicated by lower BC, EV, and CS. The power of our test could detect no significant predictors of 30-d pregnancy for the combined data from all ranches. When the data were divided by ranch, CS (P < 0.03) and BW (P < 0.01) were both significant predictors for 30-d pregnancy for ranch 1. The odds ratio estimate for CS has an inverse relationship with pregnancy, meaning that a 1-unit increase in average CS will reduce the probability of pregnancy at ranch 1 by 48.1%. Weight also has a negative impact on pregnancy because a 1-kg increase in BW will decrease the probability of pregnancy by 2.2%. Fertility is a complex trait that depends on many factors; our data suggest that docility is 1 factor that warrants further investigation

Independent Commission on UK Public Health Emergency Powers:Final Report

The Independent Commission on UK Public Health Emergency Powers reviewed emergency public health laws and parliamentary procedures in the four UK nations. We considered how far these laws and procedures could be enhanced so as to better protect the rule of law and promote accountability, transparency and parliamentary control of executive action. We also undertook comparative research; reviewing public health emergency powers in ten foreign jurisdictions chosen because of their similarities to the UK’s parliamentary system and the efficacy of their legal responses to Covid-19. Throughout our inquiry we kept foremost in our minds the need for governments to act quickly in an emergency to secure timely and effective public health outcomes

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation.

Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geometric remodeling and intrinsic changes in myocardial mechanical properties in a monocrotaline (MCT) animal model. In a longitudinal study of PAH, ventricular morphology and function were assessed weekly during the first four weeks after MCT exposure. Using invasive measurements of RV pressure and volume, heart performance was evaluated at end of systole and diastole to quantify contractility (end-systolic elastance) and chamber stiffness (end-diastolic elastance). To distinguish between morphological and intrinsic mechanisms, a computational model of the RV was developed and used to determine the level of prediction when accounting for wall masses and unloaded volume measurements changes. By four weeks, mean pulmonary arterial pressure and elastance rose significantly. RV pressures rose significantly after the second week accompanied by significant RV hypertrophy, but RV stroke volume and cardiac output were maintained. The model analysis suggested that, after two weeks, this compensation was only possible due to a significant increase in the intrinsic inotropy of RV myocardium. We conclude that this MCT-PAH rat is a model of RV compensation during the first month after treatment, where geometric remodeling on EDPVR and increased myocardial contractility on ESPVR are the major mechanisms by which stroke volume is preserved in the setting of elevated pulmonary arterial pressure. The mediators of this compensation might themselves promote longer-term adverse remodeling and decompensation in this animal model