Double window viewing chamber assembly

A viewing chamber which permits observation of a sample retained therein includes a pair of double window assemblies mounted in opposed openings in the walls thereof so that a light beam can directly enter and exit from the chamber. A flexible mounting arrangement for the outer windows of the window assemblies enables the windows to be brought into proper alignment. An electrical heating arrangement prevents fogging of the outer windows whereas desiccated air in the volume between the outer and inner windows prevents fogging of the latter

Modelling and Simulation at The University of Liverpool in Support of UK Naval Aviation

Along with the restricted landing area and the rolling, pitching and heaving of the ship's deck, the pilot also needs to contend with the turbulent wake produced by the air flow over the ship's superstructure. There has been significant research in the past decade or more to better understand the flying environment around the ship and how it impacts the helicopter’s handling qualities and pilot workload. Central to this research has been the use of modelling and simulation, with a particular emphasis on understanding the unsteady airflow over the ship and how this is affected by the superstructure geometry. In the UK, this flight simulation research has been led by the Flight Science and Technology Research Group at the University of Liverpool. This paper reviews the research that has been carried out at Liverpool, and how this has led to simulated flight trials to establish a simulated Ship-Helicopter Operating Limits envelope and how modelling and simulation is being used to assess the aerodynamic characteristics of the ship while it is still in the design phase, and to inform at-sea first of class flight trials

Using GIS to Prioritize Green Infrastructure Installation Strategies in an Urbanized Watershed

2014 S.C. Water Resources Conference - Informing Strategic Water Planning to Address Natural Resource, Community and Economic Challenge

High-resolution VLA Imaging of SDSS Stripe 82 at 1.4 GHz

We present a high-resolution radio survey of the Sloan Digital Sky Survey (SDSS) Southern Equatorial Stripe, a.k.a. Stripe 82. This 1.4 GHz survey was conducted with the Very Large Array (VLA) primarily in the A-configuration, with supplemental B-configuration data to increase sensitivity to extended structure. The survey has an angular resolution of 1.8" and achieves a median rms noise of 52 microJy/bm over 92 deg^2. This is the deepest 1.4 GHz survey to achieve this large of an area, filling a gap in the phase space between small, deep and large, shallow surveys. It also serves as a pilot project for a larger high-resolution survey with the Expanded Very Large Array (EVLA). We discuss the technical design of the survey and details of the observations, and we outline our method for data reduction. We present a catalog of 17,969 isolated radio components, for an overall source density of ~195 sources/deg^2. The astrometric accuracy of the data is excellent, with an internal check utilizing multiply-observed sources yielding an rms scatter of 0.19" in both right ascension and declination. A comparison to the SDSS DR7 Quasar Catalog further confirms that the astrometry is well tied to the optical reference frame, with mean offsets of 0.02" +/- 0.01" in right ascension, and 0.01" +/- 0.02" in declination. A check of our photometry reveals a small, negative CLEAN-like bias on the level of 35 microJy. We report on the catalog completeness, finding that 97% of FIRST-detected quasars are recovered in the new Stripe 82 radio catalog, while faint, extended sources are more likely to be resolved out by the resolution bias. We conclude with a discussion of the optical counterparts to the catalog sources, including 76 newly-detected radio quasars. The full catalog as well as a search page and cutout server are available online at http://third.ucllnl.org/cgi-bin/stripe82cutout.Comment: 18 pages, 22, figures. Submitted to AJ, revised to address referee's comment

Superstructure Aerodynamics of the Type 26 Global Combat Ship

The Type 26 City class Global Combat Ship is the latest design of UK frigate. Construction of the first ship, HMS Glasgow, began in July 2017 and the expectation is that it will enter service in the mid-2020s as a replacement for the Royal Navy’s Type 23 Duke class frigates. The main contractor for the design and construction of the ship is BAE Systems Maritime – Naval Ships. The Type 26 superstructure is characterised by its smooth sloping surfaces that are continuous along the ship from the fore deck to the flight deck. The tumblehome design reduces the ship’s radar cross-section, as does the minimisation of curved surfaces and internal corners. The Type 26 also has a bulky mast, also with flat sloping sides, while the funnel casing around the gas turbine exhaust uptake is located aft of the main mast and relatively low on the superstructure. In comparison, the earlier Type 23 has a much more fragmented superstructure with few geometric features for reduced radar reflection; it also has a more slender mast from which the anemometers are mounted, and the exhaust uptakes are higher. Overall the aerodynamics of the stealthy Type 26 frigate will be very different to the previous Type 23, and this will affect the operational envelope of the ship’s helicopters. Recognising the importance of superstructure aerodynamics to the ship design, the University of Liverpool has been working closely with colleagues from BAE to ensure that the air flow over the ship was considered as the superstructure design evolved. The paper will describe how, within the design cycle, Computational Fluid Dynamics (CFD) has been used to analyse the unsteady flow over the full-scale ship. It will show how CFD, together with helicopter flight dynamics modelling, was used to inform design options for the superstructure geometry ahead of the landing deck. CFD was also used to inform options for locating the ship’s anemometers and has been used to predict the dispersion of the ship’s engine exhaust gases and the air temperature distribution in the vicinity of the flight deck. </jats:p

Aeolian transport layer

We investigate the airborne transport of particles on a granular surface by the saltation mechanism through numerical simulation of particle motion coupled with turbulent flow. We determine the saturated flux $q_{s}$ and show that its behavior is consistent with a classical empirical relation obtained from wind tunnel measurements. Our results also allow to propose a new relation valid for small fluxes, namely, $q_{s}=a(u_{*}-u_{t})^{\alpha}$, where $u_{*}$ and $u_{t}$ are the shear and threshold velocities of the wind, respectively, and the scaling exponent is $\alpha \approx 2$. We obtain an expression for the velocity profile of the wind distorted by the particle motion and present a dynamical scaling relation. We also find a novel expression for the dependence of the height of the saltation layer as function of the wind velocity.Comment: 4 pages, 4 figure

School physical activity intervention effect on adolescents' performance in mathematics

Purpose: The primary aim of this study was to test the effect of a school-based physical activity intervention on adolescents’ performance in mathematics. A secondary aim was to explore potential mechanisms that might explain the intervention effect. Methods: The Activity and Motivation in Physical EDucation intervention was evaluated using a two-arm cluster randomized controlled trial in 14 secondary schools located in low socioeconomic areas of Western Sydney, Australia. Study participants (n = 1173) were grade 8 students (mean age = 12.94 yr, SD = 0.54). The multicomponent intervention was designed to help teachers maximize students’ opportunities for moderate-to-vigorous physical activity (MVPA) during physical education (PE) and enhance students’ motivation toward PE. Mathematics performance was assessed as part of national testing in grade 7, which was the year before the trial began and then again in grade 9. Potential mediators were: (i) proportion of PE lesson time that students spent in MVPA and leisure time MVPA (%), measured using Actigraph GT3X+ accelerometers, and (ii) students’ self-reported engagement (behavioral, emotional, and cognitive) during mathematics lessons. Mediators were assessed at baseline (grade 8) and follow-up (grade 9, 14–15 months after baseline). Results: The effect of the intervention on mathematics performance was small-to-medium (β = 0.16, P < 0.001). An intervention effect was observed for MVPA% in PE (β = 0.59, P < 0.001), but not for leisure time MVPA or any of the engagement mediators. There were no significant associations between changes in potential mediators and mathematics performance. Conclusions: The Activity and Motivation in Physical EDucation intervention had a significant positive effect on mathematics performance in adolescents. However, findings should be interpreted with caution as the effect was small and not associated with changes in hypothesized mediators

Inhibition of Ral GTPases Using a Stapled Peptide Approach.

Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back to the forefront of targeting efforts. Activated Ras has proved extremely difficult to target directly, and the focus has moved to the main downstream Ras-signaling pathways. In particular, the Ras-Raf and Ras-PI3K pathways have provided conspicuous enzyme therapeutic targets that were more accessible to conventional drug-discovery strategies. The Ras-RalGEF-Ral pathway is a more difficult challenge for traditional medicinal development, and there have, therefore, been few inhibitors reported that disrupt this axis. We have used our structure of a Ral-effector complex as a basis for the design and characterization of α-helical-stapled peptides that bind selectively to active, GTP-bound Ral proteins and that compete with downstream effector proteins. The peptides have been thoroughly characterized biophysically. Crucially, the lead peptide enters cells and is biologically active, inhibiting isoform-specific RalB-driven cellular processes. This, therefore, provides a starting point for therapeutic inhibition of the Ras-RalGEF-Ral pathway.This work was supported by a Cambridge Cancer Centre Pump Priming award to CA, DO and HRM, a BBSRC Studentship to NSC, and a National Institutes for Health grant (CA71443) and the Welch Foundation (grant number I-1414) to MAW.This is the final version of the article. It first appeared from the American Society for Biochemistry and Molecular Biology via https://doi.org/10.1074/jbc.M116.72024